SG11201806127XA - Pharmaceutical or nutritional combination comprising beta-hydroxy-betamethylbutyrate - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101110101111110111011001111101111011111 International Bureau ... .... ..Yjd ..... .„,,,, (10) International Publication Number (43) International Publication Date WO 2017/127333 Al 27 July 2017 (27.07.2017) WIPO I PCT (51) International Patent Classification: (72) Inventor: SATHYAVAGEESWARAN, Shreeram; c/o A61K 31/12 (2006.01) A61P 3/04 (2006.01) Abbott Laboratories, 100 Abbott Park Road, Abbott Park, A61K 31/19 (2006.01) 60064-3500 (US). (21) International Application Number: (74) Agent: KOZLOWSKI, Holly; Porter Wright Morris & PCT/US2017/013672 Arthur LLP, 41 South High Street, Columbus, Ohio 43215 (US). (22) International Filing Date: 16 January 2017 (16.01.2017) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (25) Filing Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 1600990.4 19 January 2016 (19.01.2016) GB KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (71) Applicant: ABBOTT LABORATORIES [US/US]; 100 MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, Abbott Park Road, Abbott Park, Illinois 60064-3500 (US). NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, [Continued on next page] TYRATE - = 380 — = - 360 = (54) Title: PHARMACEUTICAL OR NUTRITIONAL COMBINATION COMPRISING BETA-HYDROXY-BETAMETHYLBU- (57) : The present invention relates to a pharmaceutical or nutri- Lean tional combination comprising beta-hydroxy beta-methylbutyrate (HMB) and tetrahydrocurcumin (THC) and methods comprising administering the combination to a subject. The methods of the invention relate to at- t tenuating muscle protein degradation and/or preserving lean body mass in 340 = = m 320 as = M 300 = _ the subject. * ** * T T 280 = 260 .;' ,,, 240 — Day 21 = = 7 333 Al I I I I 1111 1111 1111 1111111 II II Saline control Path Control HMB 160 HMB 320 White Curcumin 100 . , White Curcumin 200 HMB 160 + White Curcumin 100 i'l 1-1 IN FIG. 3 ,-, © ei O WO 2017/127333 Al MIDEDIMOMOIDEIRMEMOMOHMERMOOMOVOIMIE (84) RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Designated States (unless otherwise indicated, for every DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). kind of regional protection available): ARIPO (BW, GH, Published: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, — TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, with international search report (Art. 21(3)) TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE,