SG11201804721SA - Modulators of complement activity - Google Patents
Modulators of complement activityInfo
- Publication number
- SG11201804721SA SG11201804721SA SG11201804721SA SG11201804721SA SG11201804721SA SG 11201804721S A SG11201804721S A SG 11201804721SA SG 11201804721S A SG11201804721S A SG 11201804721SA SG 11201804721S A SG11201804721S A SG 11201804721SA SG 11201804721S A SG11201804721S A SG 11201804721SA
- Authority
- SG
- Singapore
- Prior art keywords
- massachusetts
- international
- modulators
- cambridge
- pct
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Steroid Compounds (AREA)
- Amplifiers (AREA)
- Medicinal Preparation (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau (43) International Publication Date ..... .....r .,„01 22 June 2017(22.06.2017) WIPO I PCT II (10) 11111111111111111111111 WO International EOM 2017/105939 Publication 1111111111111111111111111t111111111IIIIII Number Al (51) International Patent Classification: #1, Cambridge, Massachusetts 02139 (US). TOBE, Sylvia; A61K 38/12 (2006.01) A61P 37/02 (2006.01) 3 Dodge Street, Cambridge, Massachusetts 02139 (US). A61P 7/00 (2006.01) A61M 5/30 (2006.01) TRECO, Douglas A.; 87 Brantwood Road, Arlington, Massachusetts 02476 (US). (21) International Application Number: PCT/US2016/065228 (74) Agents: WARD, Donna T. et al.; DT Ward, P.C., 142A Main Street, Groton, Massachusetts 01450 (US). (22) International Filing Date: 7 December 2016 (07.12.2016) (81) Designated States (unless otherwise indicated, for every (25) Filing Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (26) Publication Language: English BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (30) Priority Data: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 62/268,360 16 December 2015 (16.12.2015) US KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 62/331,320 3 May 2016 (03.05.2016) US MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 62/347,486 8 June 2016 (08.06.2016) US OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (71) Applicant: RA PHARMACEUTICALS, INC. [US/US]; SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 87 Cambridge Park Drive, Cambridge, Massachusetts TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 02140 (US). ZW. (72) Inventors: DEMARCO, Steven James; 80 King George (84) Designated States (unless otherwise indicated, for every Drive, Boxford, Massachusetts 01921 (US). ARATA, kind of regional protection available): ARIPO (BW, GH, Michelle Denise; 10 Overlook Ridge Drive, Unit 328, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ZM, ZW), Eurasian AZ, BY, KG, KZ, RU, Malden, Massachusetts 02148 (US). PARKER, Grace UG, (AM, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Victoria; 49 Dover St., Apt #48, Somerville, Massachu- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, setts 02144 (US). RICARDO, Alonso; 35 Pleasant Street, [Continued on next page] (54) Title: MODULATORS OF COMPLEMENT ACTIVITY (57) : The invention present relates to polypeptide modulators of Fig. 9A complement activity, including cyclic Included polypeptide modulators. are -*-- Plasma Concentration - R5000 methods of utilizing such modulators as therapeutics. - 0 - %Hemolysis - R5000 --*-- %Hemoiysis Placebo - 10000 4 8 000 2 Y . tn , ,,, V. _ XJ >: 000 U'1 0 0 8 E 0 4) C 000 r 3 1-1 .4t en CN IC o 1-1 It - -- 1-1 O ei i?\"-9 i 48 96 time (h) 192 2000 i s O WO 2017/105939 Al MIDEDIM01101DERDEEMOM0101111111111111111011110111011110111111 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Published: SM, GW, TR), KM, OAPI (BF, BJ, CF, CG, CI, ML, MR, NE, SN, TD, TG). CM, GA, GN, GQ, with — with international search report (Art. 21(3)) sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562268360P | 2015-12-16 | 2015-12-16 | |
| US201662331320P | 2016-05-03 | 2016-05-03 | |
| US201662347486P | 2016-06-08 | 2016-06-08 | |
| PCT/US2016/065228 WO2017105939A1 (en) | 2015-12-16 | 2016-12-07 | Modulators of complement activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201804721SA true SG11201804721SA (en) | 2018-07-30 |
Family
ID=57758701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201804721SA SG11201804721SA (en) | 2015-12-16 | 2016-12-07 | Modulators of complement activity |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10835574B2 (en) |
| EP (3) | EP3389692B1 (en) |
| JP (3) | JP7126940B2 (en) |
| KR (1) | KR20180094913A (en) |
| CN (2) | CN108697759B (en) |
| AU (1) | AU2016370210A1 (en) |
| BR (1) | BR112018012174A2 (en) |
| CA (1) | CA3007772A1 (en) |
| CY (1) | CY1123031T1 (en) |
| DK (2) | DK3389692T3 (en) |
| ES (2) | ES2781551T3 (en) |
| FI (1) | FI3685847T3 (en) |
| HR (2) | HRP20230182T1 (en) |
| HU (1) | HUE061759T2 (en) |
| IL (1) | IL259762B (en) |
| LT (2) | LT3685847T (en) |
| MX (2) | MX2018007352A (en) |
| PL (2) | PL3685847T3 (en) |
| PT (2) | PT3685847T (en) |
| RS (2) | RS60134B1 (en) |
| RU (2) | RU2769701C2 (en) |
| SG (1) | SG11201804721SA (en) |
| SI (2) | SI3389692T1 (en) |
| TW (2) | TWI745320B (en) |
| WO (1) | WO2017105939A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3628680B1 (en) | 2014-06-12 | 2021-09-08 | RA Pharmaceuticals, Inc. | Modulation of complement activity |
| ES2900998T3 (en) | 2015-01-28 | 2022-03-21 | Ra Pharmaceuticals Inc | Complement activity modulators |
| DK3389692T3 (en) | 2015-12-16 | 2020-03-30 | Ra Pharmaceuticals Inc | MODULATORS OF COMPLEMENT ACTIVITY |
| CA3045114A1 (en) * | 2016-12-07 | 2018-06-14 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
| US20210000927A1 (en) | 2017-12-04 | 2021-01-07 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
| TW202100179A (en) | 2019-03-08 | 2021-01-01 | 美商Ｒａ製藥公司 | Modulators of complement activity |
| BR112021017820A2 (en) * | 2019-04-24 | 2022-02-08 | Ra Pharmaceuticals Inc | Compositions and methods for modulating complement activity |
| EP3980047B1 (en) | 2019-06-04 | 2024-02-14 | RA Pharmaceuticals, Inc. | Inflammatory disease treatment with complement inhibitors |
| CA3150594A1 (en) | 2019-09-12 | 2021-03-18 | Ra Pharmaceuticals, Inc. | Neurological disease treatment with complement inhibitors |
| KR20230017789A (en) | 2020-04-30 | 2023-02-06 | 알닐람 파마슈티칼스 인코포레이티드 | Complement Factor B (CFB) iRNA Compositions and Methods of Use Thereof |
| IL312399A (en) | 2021-10-29 | 2024-06-01 | Alnylam Pharmaceuticals Inc | Complement factor b (cfb) irna compositions and methods of use thereof |
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