SG11201805570WA - Systems and methods for long term transdermal administration - Google Patents

Systems and methods for long term transdermal administration

Info

Publication number
SG11201805570WA
SG11201805570WA SG11201805570WA SG11201805570WA SG11201805570WA SG 11201805570W A SG11201805570W A SG 11201805570WA SG 11201805570W A SG11201805570W A SG 11201805570WA SG 11201805570W A SG11201805570W A SG 11201805570WA SG 11201805570W A SG11201805570W A SG 11201805570WA
Authority
SG
Singapore
Prior art keywords
international
systems
long term
methods
pct
Prior art date
Application number
SG11201805570WA
Inventor
Eun Lee
Amit Jain
Parminder Singh
Original Assignee
Corium Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corium Int Inc filed Critical Corium Int Inc
Publication of SG11201805570WA publication Critical patent/SG11201805570WA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011101011111101110011111111101111011111 International Bureau ... .... .. (10) International Publication Number (43) International Publication Date ..... .....1 WO 2017/117554 Al 6 July 2017 (06.07.2017) IN I P 0 I PCT (51) International Patent Classification: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 9/70 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/US2016/069558 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 30 December 2016 (30.12.2016) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/273,288 30 December 2015 (30.12.2015) US 62/367,055 26 July 2016 (26.07.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: CORIUM INTERNATIONAL, INC. TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [US/US]; 235 Constitution Drive, Menlo Park, CA 94025 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (72) Inventors: LEE, Eun, Soo; 2575 Hampton Avenue, Red- (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CL CM, GA, GN, GQ, wood City, CA 94061 (US). JAIN, Amit, K.; 825 Carino GW, KM, ML, MR, NE, SN, TD, TG). Terrace, Milpitas, CA 95035 (US). SINGH, Parminder; Published: _ 5504 Alvelais Drive, Union City, CA 94587 (US). — with international search report (Art. 21(3)) (74) Agents: MAHONEY, Jacqueline, F. et al.; McDermott before the expiration of the time limit for amending the = Will & Emery LLP, 500 North Capital Street NW, Wash- claims and to be republished in the event of receipt of = ington, DC 20001 (US). amendments (Rule 48.2(h)) (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, = Title: SYSTEMS AND METHODS FOR LONG TERM TRANSDERMAL ADMINISTRATION = (54) = = = _ -••\-s. ' — \\ - ...\\. s. . .. \ ....,. ..''' .\.,. ' \ &`s, \ \71 , 4 \ . . . . . . • -4. ..- 42 , = = 4 . • 4 • , < t. — . • - ,:•,g • • _ = i s -.0. ri i r, ,,,, ‘,,,,,, • --- , x :,•:•:. ,,,, 4, \\. LL \ \.• 50 7 ; \ 58 / 0 ,-1 • 62 i 62 iv 84 11 in 11 i IN n ,—, ,—, FIG a6C IN 1-1 (57) : Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active 0 agent el are provided. 0
SG11201805570WA 2015-12-30 2016-12-30 Systems and methods for long term transdermal administration SG11201805570WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562273288P 2015-12-30 2015-12-30
US201662367055P 2016-07-26 2016-07-26
PCT/US2016/069558 WO2017117554A1 (en) 2015-12-30 2016-12-30 Systems and methods for long term transdermal administration

Publications (1)

Publication Number Publication Date
SG11201805570WA true SG11201805570WA (en) 2018-07-30

Family

ID=57861282

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201805570WA SG11201805570WA (en) 2015-12-30 2016-12-30 Systems and methods for long term transdermal administration

Country Status (12)

Country Link
US (6) US10835499B2 (en)
EP (1) EP3397250A1 (en)
JP (1) JP6833855B2 (en)
KR (1) KR20180127315A (en)
CN (1) CN108697655B (en)
AU (2) AU2016381351B2 (en)
CA (1) CA3010183A1 (en)
IL (2) IL260290B2 (en)
MX (1) MX2018008190A (en)
RU (1) RU2737464C2 (en)
SG (1) SG11201805570WA (en)
WO (1) WO2017117554A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10213586B2 (en) 2015-01-28 2019-02-26 Chrono Therapeutics Inc. Drug delivery methods and systems
JP2018511127A (en) 2015-03-12 2018-04-19 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Craving input and support system
US10835499B2 (en) * 2015-12-30 2020-11-17 Corium, Inc. Systems and methods for long term transdermal administration
WO2017223402A1 (en) 2016-06-23 2017-12-28 Corium International, Inc. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
US10016372B2 (en) * 2016-07-27 2018-07-10 Corium International, Inc. Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
JP7251033B2 (en) 2016-07-27 2023-04-04 コリウム， エルエルシー Donepezil transdermal delivery system
EP3490544A1 (en) * 2016-07-27 2019-06-05 Corium International, Inc. Memantine transdermal delivery systems
JP2020503950A (en) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Device and method for transdermal drug delivery
US20180303764A1 (en) * 2017-04-19 2018-10-25 Inep Europe Sarl Method for manufacturing a transdermal device
US11052054B2 (en) * 2017-04-19 2021-07-06 Inep Europe Sarl Method for manufacturing a transdermal device
KR20200032153A (en) * 2017-07-26 2020-03-25 코리움, 인크. Transdermal delivery system with a microporous membrane with solvent-filled pores
AU2018392686A1 (en) 2017-12-20 2020-07-09 Corium Pharma Solutions, Inc. Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
WO2019232077A1 (en) 2018-05-29 2019-12-05 Chrono Therapeutics Inc. Drug delivery methods and systems
CN112206222A (en) * 2018-11-09 2021-01-12 北京德默高科医药技术有限公司 Multi-layer transdermal drug delivery system containing ibuprofen structural analogs
RU2705896C1 (en) * 2019-07-26 2019-11-12 Артем Олегович Бахметьев Transdermal plaster
US11471839B2 (en) * 2019-08-06 2022-10-18 Uop Llc High selectivity membranes for hydrogen sulfide and carbon dioxide removal from natural gas
WO2021211915A1 (en) * 2020-04-17 2021-10-21 University Of Connecticut Polycannabinoids, compounds, compositions and methods of use
US20210346207A1 (en) * 2020-05-11 2021-11-11 Marc Sheldon Stevens Four-way stretch therapeutic compress assembly, system, and method
US11596772B2 (en) * 2021-02-07 2023-03-07 Lumen Catheters, LLC Antimicrobial light-emitting percutaneous site dressing

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1880808A (en) 1927-03-28 1932-10-04 Eastman Kodak Co Process of making cellulose esters of carboxylic acids
US1683347A (en) 1927-08-25 1928-09-04 Eastman Kodak Co Process of making chloroform-soluble cellulose acetate
US1698049A (en) 1928-01-18 1929-01-08 Eastman Kodak Co Process of making cellulosic esters containing halogen-substituted fatty-acid groups
US1984147A (en) 1929-10-22 1934-12-11 Eastman Kodak Co Process for the production of cellulose esters and corresponding alkyl esters
US1880560A (en) 1929-12-14 1932-10-04 Eastman Kodak Co Process for the hydrolysis of cellulose acetate
US2129052A (en) 1936-02-04 1938-09-06 Eastman Kodak Co Hydrolyzed cellulose acetate
US3493319A (en) 1967-05-26 1970-02-03 Us Agriculture Esterification of cellulosic textiles with unsaturated long chain fatty acids in the presence of trifluoroacetic anhydride using controlled cellulose-acid-anhydride ratios
DE3634016A1 (en) * 1986-04-17 1987-10-29 Lohmann Gmbh & Co Kg AREA-BASED THERAPEUTIC SYSTEM, METHOD FOR THE PRODUCTION THEREOF AND ITS USE
ES2028074T3 (en) * 1986-06-13 1992-07-01 Alza Corporation ACTIVATION BY MOISTURE OF A TRANSDERMIC PHARMACY SUPPLY SYSTEM.
US5071656A (en) 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
DE3714140A1 (en) * 1987-04-28 1988-11-10 Lohmann Therapie Syst Lts ACTIVE SUBSTANCE PLASTER FOR THE CONTROLLED ADMINISTRATION OF ACTIVE SUBSTANCES TO THE SKIN, ITS USE AND METHOD FOR THE CONTROLLED ADMINISTRATION OF ACTIVE SUBSTANCES TO THE SKIN
US5538736A (en) * 1987-04-28 1996-07-23 Lts Lohmann Therapie-Systeme Gmbh Active substance-containing plaster for the controlled administration of active substances to the skin
US4787888A (en) * 1987-06-01 1988-11-29 University Of Connecticut Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a)
US5123900A (en) * 1991-08-16 1992-06-23 Bertek, Inc. Moisture permeable double disk
US5246705A (en) 1992-04-08 1993-09-21 Cygnus Therapeutic System Occlusive, elastomeric backing materials in transdermal drug delivery systems, and associated methods of manufacture and use
US5612411A (en) * 1992-11-18 1997-03-18 Kimberly-Clark Corporation Absorbent phycocolloids and a method for their manufacture
US5489624A (en) * 1992-12-01 1996-02-06 Minnesota Mining And Manufacturing Company Hydrophilic pressure sensitive adhesives
US5567489A (en) * 1993-09-16 1996-10-22 The Dow Chemical Company Multilayer halogen-free barrier film for ostomy and transdermal drug delivery applications
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
CN1170360A (en) * 1994-12-21 1998-01-14 瑟垃技术有限公司 Transdermal delivery system with adhesive overlay and peel seal disc
US5785991A (en) 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US6174545B1 (en) * 1997-07-01 2001-01-16 Alza Corporation Drug delivery devices and process of manufacture
DE19820999A1 (en) * 1998-05-11 1999-11-18 Lohmann Therapie Syst Lts Layered medicinal adhesive plaster with high holding power and flexibility
EP1390085B1 (en) 2001-05-01 2009-08-05 A.V. Topchiev Institute of Petrochemical Synthesis Hydrogel compositions
US20040024028A1 (en) 2001-08-02 2004-02-05 Burton Steven L. Method for reducing or eliminating smoking
DE10159745A1 (en) 2001-12-05 2003-07-03 Lohmann Therapie Syst Lts Transdermal therapeutic system with improved long-term comfort
CN100340395C (en) 2002-08-30 2007-10-03 阿尔扎公司 Multilaminate backing construction
RS50428B (en) 2003-02-21 2009-12-31 Bayer Schering Pharma Aktiengesellschaft, Uv stable transdermal therapeutic plaster
ES2596809T3 (en) 2004-10-08 2017-01-12 Noven Pharmaceuticals, Inc. Transdermal drug delivery device that includes an occlusive booster
JP2008259629A (en) 2007-04-11 2008-10-30 Hakujuji Co Ltd Wound protective material
WO2009026135A2 (en) 2007-08-17 2009-02-26 Alza Corporation Controlled transdermal bisoprolol delivery system
CN100560157C (en) * 2007-11-13 2009-11-18 重庆市生力医疗设备有限公司 Ultrasonic medicine plaster
CN102123693A (en) * 2008-06-13 2011-07-13 奥洁克公司 Use of hydrogen peroxide-producing bacteria for tooth whitening
CN101518599A (en) * 2009-03-24 2009-09-02 沈阳药科大学 Slow-release patch with daphne giraldii bark extract, and preparation method thereof
TWI433904B (en) 2011-01-12 2014-04-11 Taiwan Biotech Co Ltd Donepezil transdermal patch
US10426739B2 (en) 2011-12-21 2019-10-01 3M Innovative Properties Company Adhesive patch assembly with overlay liner and system and method for making same
KR101239150B1 (en) 2012-02-28 2013-03-06 에스케이케미칼주식회사 Donepezil-containing transdermal delivery system and process for preparing the same
US20140276479A1 (en) * 2013-03-14 2014-09-18 Noven Pharmaceuticals, Inc. Transdermal drug delivery system with overlay
KR101485822B1 (en) 2014-01-22 2015-01-23 주식회사 대웅제약 Transdermal drug delivery system comprising donepezil or its salt
DK3235494T3 (en) 2014-12-18 2020-03-02 Icure Pharm Inc Transdermal preparation containing donepezil as active ingredient
US10835499B2 (en) * 2015-12-30 2020-11-17 Corium, Inc. Systems and methods for long term transdermal administration

Also Published As

Publication number Publication date
US20240108587A1 (en) 2024-04-04
US10966936B2 (en) 2021-04-06
AU2016381351A1 (en) 2018-07-19
IL260290B2 (en) 2023-11-01
RU2018127642A (en) 2020-02-03
CA3010183A1 (en) 2017-07-06
RU2018127642A3 (en) 2020-05-13
EP3397250A1 (en) 2018-11-07
US20240091168A1 (en) 2024-03-21
KR20180127315A (en) 2018-11-28
US20170189534A1 (en) 2017-07-06
US20170189348A1 (en) 2017-07-06
RU2737464C2 (en) 2020-11-30
JP6833855B2 (en) 2021-02-24
US10835499B2 (en) 2020-11-17
CN108697655A (en) 2018-10-23
CN108697655B (en) 2021-12-10
JP2019504052A (en) 2019-02-14
US11648214B2 (en) 2023-05-16
IL303255A (en) 2023-07-01
WO2017117554A1 (en) 2017-07-06
IL260290A (en) 2018-07-31
IL260290B1 (en) 2023-07-01
US20210196650A1 (en) 2021-07-01
US11679086B2 (en) 2023-06-20
AU2016381351B2 (en) 2022-09-29
MX2018008190A (en) 2018-11-12
AU2022235539A1 (en) 2022-10-13
US20210023020A1 (en) 2021-01-28

Similar Documents

Publication Publication Date Title
SG11201805570WA (en) Systems and methods for long term transdermal administration
SG11201807252QA (en) Anti-lag-3 antibodies
SG11201806863WA (en) Tetracyclic pyridone compounds as antivirals
SG11201810628XA (en) Nasal pharmaceutical compositions with a porous excipient
SG11201805044WA (en) Compounds useful as kinase inhibitors
SG11201804901WA (en) Compounds for the treatment of cancer and inflammatory disease
SG11201808990QA (en) Compositions for topical application of compounds
SG11201408261UA (en) Syringe
SG11201810485SA (en) Substituted carbonucleoside derivatives useful as anticancer agents
SG11201805072PA (en) Nicotine powder delivery system
SG11201810280YA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201808222RA (en) Methods of treatment of cholestatic diseases
SG11201900558RA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201808106YA (en) Use of masitinib for treatment of an amyotrophic lateral sclerosis patient subpopulation
SG11201900551WA (en) Spiro-lactam nmda receptor modulators and uses thereof
SG11201900546UA (en) Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
SG11201906436VA (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
SG11201810429UA (en) Anti-cd19 antibody formulations
SG11201901438VA (en) Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate
SG11201901063SA (en) Therapeutic agents for neurodegenerative diseases
SG11201900043TA (en) Antibody formulations
SG11201901048VA (en) Pharmaceutical compositions and uses directed to lysosomal storage disorders
SG11201809882XA (en) Pharmaceutical combinations for treating cancer
SG11201901249YA (en) Aza-indazole compounds for use in tendon and/or ligament injuries
SG11201810934TA (en) Microparticles comprising a sulphur-containing compound