SG11201806538WA - Engineered antigen presenting cells and uses thereof - Google Patents
Engineered antigen presenting cells and uses thereofInfo
- Publication number
- SG11201806538WA SG11201806538WA SG11201806538WA SG11201806538WA SG11201806538WA SG 11201806538W A SG11201806538W A SG 11201806538WA SG 11201806538W A SG11201806538W A SG 11201806538WA SG 11201806538W A SG11201806538W A SG 11201806538WA SG 11201806538W A SG11201806538W A SG 11201806538WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- rule
- epfl
- lausanne
- pct
- Prior art date
Links
- 210000000612 antigen-presenting cell Anatomy 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/001171—Gangliosides, e.g. GM2, GD2 or GD3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4614—Monocytes; Macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464403—Receptors for growth factors
- A61K39/464406—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464469—Tumor associated carbohydrates
- A61K39/464471—Gangliosides, e.g. GM2, GD2 or GD3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7153—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for colony-stimulating factors [CSF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111011111111101011101101111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/134100 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: KP, C07K 14/705 (2006.01) A61K 39/00 (2006.01) MD, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, C07K 16/32 (2006.01) NI, RU, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (21) International Application Number: TH, PCT/EP2017/052145 ZA, ZM, ZW. TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 1 February 2017 (01.02.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, TZ, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (26) Publication Language: English TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (30) Priority Data: DK, 16153966.3 2 February 2016 (02.02.2016) EP LV, SM, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, (71) Applicant: ECOLE POLYTECHNIQUE FEDERALE GW, KM, ML, MR, NE, SN, TD, TG). DE LAUSANNE (EPFL) [CH/CH]; EPFL-TTO, EPFL Innovation Park J, CH-1015 Lausanne (CH). Declarations under Rule 4.17: (72) Inventors: DE PALMA, Michele; Rue du Petit St-Jean 5, as to applicant's entitlement to apply for and be granted a 1003 Lausanne (CH). SQUADRITO, Mario Leonardo; patent (Rule 4.17(u)) Chemin de Belle Vue 14, 1020 Renens (CH). — as to the applicant's entitlement to claim the priority of the _ earlier application (Rule 4.17(iii)) Agent: REUTELER & CIE SA; Chemin de la Vuarpil- (74) here 29, CH-1260 Nyon (CH). — of inventorship (Rule 4.17(iv)) Designated States (unless otherwise indicated, for every Published: (81) = kind of national protection available): AE, AG, AL, AM, _ with international search report (Art. 21(3)) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, — with DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, sequence listing part of description (Rule 5.2(a)) = = = = = = = = = 1-1 © © Il 7r M Il IN 1-1 (54) Title: ENGINEERED ANTIGEN PRESENTING CELLS AND USES THEREOF 0 ei (57) : The present invention relates to engineered extra-cellular vesicle internalizing receptors that have the ability to en- hance uptake, processing, and presentation to T-cells of tumor-associated antigens by an antigen-presenting cell. It further relates to vectors or antigen presenting cells expressing said receptors, composition and uses thereof for the prevention and/or treatment of a cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16153966.3A EP3202783A1 (en) | 2016-02-02 | 2016-02-02 | Engineered antigen presenting cells and uses thereof |
PCT/EP2017/052145 WO2017134100A1 (en) | 2016-02-02 | 2017-02-01 | Engineered antigen presenting cells and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201806538WA true SG11201806538WA (en) | 2018-08-30 |
Family
ID=55310688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201806538WA SG11201806538WA (en) | 2016-02-02 | 2017-02-01 | Engineered antigen presenting cells and uses thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US11591407B2 (en) |
EP (2) | EP3202783A1 (en) |
JP (1) | JP6989523B2 (en) |
KR (1) | KR20180104146A (en) |
CN (1) | CN108602873A (en) |
AU (1) | AU2017216213B2 (en) |
CA (1) | CA3012574A1 (en) |
IL (1) | IL260905B1 (en) |
MX (1) | MX2018009312A (en) |
SG (1) | SG11201806538WA (en) |
WO (1) | WO2017134100A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170151281A1 (en) | 2015-02-19 | 2017-06-01 | Batu Biologics, Inc. | Chimeric antigen receptor dendritic cell (car-dc) for treatment of cancer |
CN112218621A (en) * | 2018-04-10 | 2021-01-12 | 西北大学 | Extracellular vesicles comprising a targeting affinity domain based membrane protein |
CN110612117B (en) * | 2018-04-17 | 2024-04-12 | 分子模板公司 | HER2 targeting molecules comprising deimmunized shiga toxin a subunit scaffolds |
WO2020097193A1 (en) | 2018-11-06 | 2020-05-14 | The Regents Of The University Of California | Chimeric antigen receptors for phagocytosis |
US11026973B2 (en) | 2019-04-30 | 2021-06-08 | Myeloid Therapeutics, Inc. | Engineered phagocytic receptor compositions and methods of use thereof |
CN114173807B (en) * | 2019-09-02 | 2024-03-19 | 庆北大学校产学协力团 | Composition for preventing or treating cancer comprising IL-2 surface expression-extracellular vesicles as active ingredients |
JP2022546592A (en) | 2019-09-03 | 2022-11-04 | マイエロイド・セラピューティクス,インコーポレーテッド | Methods and compositions for genomic integration |
CA3153311A1 (en) * | 2019-09-06 | 2021-03-11 | The Regents Of The University Of California | Chimeric antigen receptors and related methods and compositions for the treatment of cancer |
US10980836B1 (en) | 2019-12-11 | 2021-04-20 | Myeloid Therapeutics, Inc. | Therapeutic cell compositions and methods of manufacturing and use thereof |
WO2021127024A1 (en) * | 2019-12-16 | 2021-06-24 | Washington University | Chimeric antigen receptor dendritic cells (car-dcs) and methods of making and using same |
CN113106067A (en) * | 2020-01-10 | 2021-07-13 | 南京大学 | Construction and application of chimeric antigen receptor-monocyte/macrophage (CAR-M) |
AU2021376354A1 (en) | 2020-11-04 | 2023-06-22 | Myeloid Therapeutics, Inc. | Engineered chimeric fusion protein compositions and methods of use thereof |
US20230071148A1 (en) * | 2021-07-15 | 2023-03-09 | Vcreate, Inc. | Compositions and Methods for Making Novel T-Cell Receptors |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004012817A2 (en) * | 2002-07-31 | 2004-02-12 | Kylix B.V. | Use of genes identified to be involved in tumor development for the development of anti-cancer drugs |
US20060134109A1 (en) * | 2002-09-09 | 2006-06-22 | Nura Inc. | G protein coupled receptors and uses thereof |
US8211852B2 (en) * | 2006-02-17 | 2012-07-03 | Rappaport Family Institute For Research In The Medical Sciences | Molecules and methods of using same for treating CCR5/CCR5 ligands associated diseases |
JP2010531666A (en) * | 2007-06-26 | 2010-09-30 | ユニバーシティ オブ マイアミ | Antibody-endostatin fusion protein and variants thereof |
US8273550B2 (en) | 2007-10-25 | 2012-09-25 | Viventia Biotechnologies Inc. | Antibodies against a cancer-associated epitope of variant HnRNPG and uses thereof |
AU2008329518A1 (en) | 2007-11-27 | 2009-06-04 | Viventia Biotechnologies Inc. | Antibodies against a cancer-associated epitope of variant NFKBIB and uses thereof |
US20110158995A1 (en) * | 2008-07-28 | 2011-06-30 | Renault S.A.S | Multi-Specific Binding Proteins Targeting B Cell Disorders |
EA032828B1 (en) * | 2008-10-10 | 2019-07-31 | Аптево Рисёрч Энд Девелопмент Ллс | Tcr complex immunotherapeutics |
WO2010117448A2 (en) * | 2009-04-05 | 2010-10-14 | Provenance Biopharmaceuticals Corp. | Chimeric immunocytokines and methods of use thereof |
TWI507204B (en) | 2009-05-26 | 2015-11-11 | Oncotherapy Science Inc | Cdc45l peptides and vaccines including the same |
US10093740B2 (en) * | 2012-10-15 | 2018-10-09 | Universitat Zurich | Bispecific HER2 ligands for cancer therapy |
EP2777711A1 (en) * | 2013-03-11 | 2014-09-17 | Icon Genetics GmbH | Her2/Neu cancer vaccine |
US10239948B2 (en) * | 2013-12-20 | 2019-03-26 | Cellectis | Method of engineering multi-input signal sensitive T cell for immunotherapy |
CN106536558A (en) * | 2014-04-10 | 2017-03-22 | 西雅图儿童医院(Dba西雅图儿童研究所) | Transgene genetic tags and methods of use |
GB201410262D0 (en) * | 2014-06-10 | 2014-07-23 | Cambridge Entpr Ltd | Novel method |
JP2018504143A (en) * | 2015-01-26 | 2018-02-15 | セレクティスCellectis | Anti-HSP70-specific chimeric antigen receptor (CAR) for cancer immunotherapy |
-
2016
- 2016-02-02 EP EP16153966.3A patent/EP3202783A1/en not_active Withdrawn
-
2017
- 2017-02-01 JP JP2018558493A patent/JP6989523B2/en active Active
- 2017-02-01 CA CA3012574A patent/CA3012574A1/en active Pending
- 2017-02-01 MX MX2018009312A patent/MX2018009312A/en unknown
- 2017-02-01 WO PCT/EP2017/052145 patent/WO2017134100A1/en active Application Filing
- 2017-02-01 KR KR1020187025166A patent/KR20180104146A/en not_active Application Discontinuation
- 2017-02-01 EP EP17702860.2A patent/EP3411394A1/en active Pending
- 2017-02-01 US US16/074,446 patent/US11591407B2/en active Active
- 2017-02-01 AU AU2017216213A patent/AU2017216213B2/en active Active
- 2017-02-01 SG SG11201806538WA patent/SG11201806538WA/en unknown
- 2017-02-01 CN CN201780009420.8A patent/CN108602873A/en active Pending
-
2018
- 2018-07-31 IL IL260905A patent/IL260905B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
US11591407B2 (en) | 2023-02-28 |
JP2019511244A (en) | 2019-04-25 |
MX2018009312A (en) | 2019-01-28 |
AU2017216213A1 (en) | 2018-09-20 |
CN108602873A (en) | 2018-09-28 |
US20190062450A1 (en) | 2019-02-28 |
IL260905B1 (en) | 2024-01-01 |
EP3411394A1 (en) | 2018-12-12 |
CA3012574A1 (en) | 2017-08-10 |
WO2017134100A1 (en) | 2017-08-10 |
KR20180104146A (en) | 2018-09-19 |
JP6989523B2 (en) | 2022-01-05 |
AU2017216213B2 (en) | 2021-07-01 |
EP3202783A1 (en) | 2017-08-09 |
IL260905A (en) | 2018-09-20 |
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