PH12020500211A1 - Methods of treating behavior alterations - Google Patents
Methods of treating behavior alterationsInfo
- Publication number
- PH12020500211A1 PH12020500211A1 PH12020500211A PH12020500211A PH12020500211A1 PH 12020500211 A1 PH12020500211 A1 PH 12020500211A1 PH 12020500211 A PH12020500211 A PH 12020500211A PH 12020500211 A PH12020500211 A PH 12020500211A PH 12020500211 A1 PH12020500211 A1 PH 12020500211A1
- Authority
- PH
- Philippines
- Prior art keywords
- methods
- behavior alterations
- treating behavior
- treating
- alterations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382544 | 2017-08-03 | ||
| EP17382545 | 2017-08-03 | ||
| EP18382299 | 2018-04-30 | ||
| PCT/EP2018/071120 WO2019025588A1 (en) | 2017-08-03 | 2018-08-03 | METHODS OF TREATING ALTERATIONS IN BEHAVIOR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12020500211A1 true PH12020500211A1 (en) | 2020-10-19 |
Family
ID=63077881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12020500211A PH12020500211A1 (en) | 2017-08-03 | 2020-01-28 | Methods of treating behavior alterations |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20200323828A1 (enExample) |
| EP (2) | EP4512473A3 (enExample) |
| JP (2) | JP2020529995A (enExample) |
| KR (2) | KR102685898B1 (enExample) |
| CN (1) | CN110996949A (enExample) |
| AU (2) | AU2018309372B2 (enExample) |
| BR (1) | BR112020000827A2 (enExample) |
| CA (1) | CA3071804A1 (enExample) |
| DK (1) | DK3661510T3 (enExample) |
| ES (1) | ES3001085T3 (enExample) |
| FI (1) | FI3661510T3 (enExample) |
| HR (1) | HRP20241716T1 (enExample) |
| HU (1) | HUE069697T2 (enExample) |
| IL (1) | IL272092B1 (enExample) |
| LT (1) | LT3661510T (enExample) |
| MX (2) | MX2020001323A (enExample) |
| MY (1) | MY204406A (enExample) |
| PH (1) | PH12020500211A1 (enExample) |
| PL (1) | PL3661510T3 (enExample) |
| RS (1) | RS66336B1 (enExample) |
| SG (1) | SG11202000077RA (enExample) |
| SI (1) | SI3661510T1 (enExample) |
| WO (1) | WO2019025588A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017233886B2 (en) | 2016-03-15 | 2022-10-20 | Oryzon Genomics, S.A. | Combinations of LSD1 inhibitors for the treatment of hematological malignancies |
| CA3130638A1 (en) * | 2019-03-20 | 2020-09-24 | Oryzon Genomics, S.A. | Methods of treating borderline personality disorder |
| CN120837494A (zh) * | 2019-03-20 | 2025-10-28 | 奥莱松基因组股份有限公司 | 使用kdm1a抑制剂如化合物伐菲德司他治疗注意缺陷多动症的方法 |
| WO2021043905A1 (en) * | 2019-09-03 | 2021-03-11 | Oryzon Genomics, S.A. | Vafidemstat for use in treating autism spectrum disorders |
| WO2021058024A1 (zh) * | 2019-09-29 | 2021-04-01 | 南京明德新药研发有限公司 | Lsd1抑制剂 |
| CN118604352B (zh) * | 2024-05-22 | 2025-08-01 | 暨南大学 | Vps13a表达促进剂在制备用于抑郁症诊断和治疗药物中的应用 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| BRPI0614805A2 (pt) | 2005-08-10 | 2011-04-12 | Univ Johns Hopkins | poliaminas úteis como produtos terapêuticos antiparasìticos e anticáncer e como inibidores de demetilase lisina-especìficos |
| WO2008127734A2 (en) | 2007-04-13 | 2008-10-23 | The Johns Hopkins University | Lysine-specific demethylase inhibitors |
| EP2361242B1 (en) | 2008-10-17 | 2018-08-01 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| US8389580B2 (en) | 2009-06-02 | 2013-03-05 | Duke University | Arylcyclopropylamines and methods of use |
| WO2010143582A1 (ja) | 2009-06-11 | 2010-12-16 | 公立大学法人名古屋市立大学 | フェニルシクロプロピルアミン誘導体及びlsd1阻害剤 |
| WO2011022489A2 (en) | 2009-08-18 | 2011-02-24 | The Johns Hopkins University | (bis) urea and (bis) thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders |
| CA2812683C (en) | 2009-09-25 | 2017-10-10 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
| HUE030938T2 (en) | 2010-04-19 | 2017-06-28 | Oryzon Genomics Sa | Lysine-specific demethylase-1 inhibitors and their use |
| JP5934184B2 (ja) | 2010-04-20 | 2016-06-15 | ウニヴェルシタ・デグリ・ストゥディ・ディ・ローマ・ラ・サピエンツァ | ヒストンデメチラーゼlsd1及び/又はlsd2の阻害剤としてのトラニルシプロミン誘導体 |
| MX341732B (es) * | 2010-07-29 | 2016-08-30 | Oryzon Genomics S A * | Inhibidores de la demetilasa lsd1 basados en arilciclopropilamina y sus usos médicos. |
| WO2012013727A1 (en) | 2010-07-29 | 2012-02-02 | Oryzon Genomics S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| US9527805B2 (en) | 2010-09-10 | 2016-12-27 | Robert A. Casero | Small molecules as epigenetic modulators of lysine-specific demethylase 1 and methods of treating disorders |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012071469A2 (en) | 2010-11-23 | 2012-05-31 | Nevada Cancer Institute | Histone demethylase inhibitors and uses thereof for treatment o f cancer |
| SG193241A1 (en) | 2011-03-25 | 2013-10-30 | Glaxosmithkline Ip No 2 Ltd | Cyclopropylamines as lsd1 inhibitors |
| CN103842332B (zh) | 2011-08-09 | 2016-08-17 | 武田药品工业株式会社 | 环丙胺化合物 |
| JP6122006B2 (ja) | 2011-08-15 | 2017-04-26 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | ヒストン脱メチル化酵素阻害剤としての、置換された(e)−n’−(1−フェニルエチリデン)ベンゾヒドラジド類似体 |
| WO2013033688A1 (en) | 2011-09-01 | 2013-03-07 | The Brigham And Women's Hospital, Inc. | Treatment of cancer |
| BR112014009306B1 (pt) | 2011-10-20 | 2021-07-20 | Oryzon Genomics S.A. | Compostos de (hetero)aril ciclopropilamina como inibidores de lsd1 |
| WO2013057322A1 (en) | 2011-10-20 | 2013-04-25 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors |
| WO2014058071A1 (ja) | 2012-10-12 | 2014-04-17 | 武田薬品工業株式会社 | シクロプロパンアミン化合物およびその用途 |
| JP6238908B2 (ja) | 2012-11-28 | 2017-11-29 | 京都府公立大学法人 | リシン構造を有するlsd1選択的阻害薬 |
| US9144555B2 (en) | 2012-11-30 | 2015-09-29 | Darlene E. McCord | Hydroxytyrosol and oleuropein compositions for induction of DNA damage, cell death and LSD1 inhibition |
| EP2740474A1 (en) | 2012-12-05 | 2014-06-11 | Instituto Europeo di Oncologia S.r.l. | Cyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| CN103054869A (zh) | 2013-01-18 | 2013-04-24 | 郑州大学 | 含三唑基的氨基二硫代甲酸酯化合物在制备以lsd1为靶标药物中的应用 |
| WO2014164867A1 (en) | 2013-03-11 | 2014-10-09 | Imago Biosciences | Kdm1a inhibitors for the treatment of disease |
| JP6525162B2 (ja) | 2013-06-19 | 2019-06-05 | ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション | ヒストン脱メチル化酵素阻害剤としての置換(e)−n’−(1−フェニルエチリデン)ベンゾヒドラジド類似体 |
| CN103319466B (zh) | 2013-07-04 | 2016-03-16 | 郑州大学 | 含香豆素母核的1,2,3-三唑-氨基二硫代甲酸酯化合物、制备方法及其应用 |
| MX383590B (es) | 2013-08-06 | 2025-03-11 | Imago Biosciences Inc | Inhibidores de kdm1a para el tratamiento de enfermedades. |
| US9186391B2 (en) | 2013-08-29 | 2015-11-17 | Musc Foundation For Research Development | Cyclic peptide inhibitors of lysine-specific demethylase 1 |
| WO2015031564A2 (en) | 2013-08-30 | 2015-03-05 | University Of Utah | Substituted-1h-benzo[d]imidazole series compounds as lysine-specfic demethylase 1 (lsd1) inhibitors |
| SI3080100T1 (sl) | 2013-12-11 | 2023-04-28 | Celgene Quanticel Research, Inc. | Inhibitorji lizin specifične demetilaze-1 |
| EP3102034A4 (en) | 2014-02-07 | 2017-07-12 | MUSC Foundation For Research Development | Aminotriazole- and aminotetrazole-based kdm1a inhibitors as epigenetic modulators |
| US9493442B2 (en) | 2014-02-13 | 2016-11-15 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| KR102421235B1 (ko) | 2014-02-13 | 2022-07-15 | 인사이트 코포레이션 | Lsd1 저해제로서 사이클로프로필아민 |
| TWI720451B (zh) | 2014-02-13 | 2021-03-01 | 美商英塞特控股公司 | 作為lsd1抑制劑之環丙胺 |
| US9527835B2 (en) | 2014-02-13 | 2016-12-27 | Incyte Corporation | Cyclopropylamines as LSD1 inhibitors |
| EP3114109A4 (en) | 2014-03-07 | 2017-10-18 | The Johns Hopkins University | Inhibitors of histone lysine specific demethylase (lsd1) and histone deacetylases (hdacs) |
| CN103893163B (zh) | 2014-03-28 | 2016-02-03 | 中国药科大学 | 2-([1,1′-联苯]-4-基)2-氧代乙基4-((3-氯-4-甲基苯基)氨基)-4-氧代丁酸酯在制备lsd1抑制剂药物中的应用 |
| CN106459024B (zh) | 2014-04-11 | 2019-11-05 | 武田药品工业株式会社 | 环丙胺化合物及其用途 |
| CN103961340B (zh) | 2014-04-30 | 2019-06-25 | 南通中国科学院海洋研究所海洋科学与技术研究发展中心 | 一类lsd1抑制剂及其应用 |
| WO2015168466A1 (en) | 2014-05-01 | 2015-11-05 | Quanticel Pharmaceuticals, Inc. | Inhibitors of lysine specific demethylase-1 |
| JP6320570B2 (ja) | 2014-05-30 | 2018-05-09 | イエオ−イスティトゥート・エウロペオ・ディ・オンコロジア・エッセ・エッレ・エッレ | ヒストンデメチラーゼ阻害剤としてのシクロプロピルアミン化合物 |
| CN104119280B (zh) | 2014-06-27 | 2016-03-16 | 郑州大学 | 含氨基类脲与端炔结构单元的嘧啶衍生物、制备方法及应用 |
| RS60658B1 (sr) | 2014-06-27 | 2020-09-30 | Celgene Quanticel Research Inc | Inhibitori lizin specifične demetilaze-1 |
| SG11201610975RA (en) | 2014-07-03 | 2017-01-27 | Celgene Quanticel Res Inc | Inhibitors of lysine specific demethylase-1 |
| MX391865B (es) | 2014-07-03 | 2025-03-21 | Celgene Quanticel Res Inc | Inhibidores de demetilasa-1 especifica de lisina. |
| TWI687419B (zh) | 2014-07-10 | 2020-03-11 | 美商英塞特公司 | 作為lsd1抑制劑之咪唑并吡啶及咪唑并吡嗪 |
| WO2016007722A1 (en) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines and triazolopyrazines as lsd1 inhibitors |
| TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
| US9758523B2 (en) | 2014-07-10 | 2017-09-12 | Incyte Corporation | Triazolopyridines and triazolopyrazines as LSD1 inhibitors |
| JP6692350B2 (ja) | 2014-09-05 | 2020-05-13 | セルジーン クオンティセル リサーチ,インク. | リジン特異的なデメチラーゼ−1の阻害剤 |
| EP2993175A1 (en) | 2014-09-05 | 2016-03-09 | IEO - Istituto Europeo di Oncologia Srl | Thienopyrroles as histone demethylase inhibitors |
| JP6636031B2 (ja) | 2015-01-30 | 2020-01-29 | ジェネンテック, インコーポレイテッド | 治療用化合物およびその使用 |
| RS66458B1 (sr) | 2015-02-12 | 2025-02-28 | Imago Biosciences Inc | Kdm1a inhibitor i njegova primena u terapiji |
| CN106146361A (zh) | 2015-03-16 | 2016-11-23 | 四川大学 | 茚-1-亚基磺酰基苯甲酰肼衍生物及其制备方法和用途 |
| SG11201708047UA (en) | 2015-04-03 | 2017-10-30 | Incyte Corp | Heterocyclic compounds as lsd1 inhibitors |
| CN106045862B (zh) | 2015-04-10 | 2019-04-23 | 上海迪诺医药科技有限公司 | 环丙胺类螺(杂)环化合物、其药物组合物及应用 |
| US10526287B2 (en) | 2015-04-23 | 2020-01-07 | Constellation Pharmaceuticals, Inc. | LSD1 inhibitors and uses thereof |
| EP3090998A1 (en) | 2015-05-06 | 2016-11-09 | F. Hoffmann-La Roche AG | Solid forms |
| WO2017004519A1 (en) | 2015-07-02 | 2017-01-05 | University Of Utah Research Foundation | Substituted benzohydrazide analogs as histone demethylase inhibitors |
| CN110402244B (zh) | 2015-08-12 | 2023-02-03 | 因赛特公司 | Lsd1抑制剂的盐 |
| MX373363B (es) | 2015-11-05 | 2020-05-21 | Celgene Quanticel Res Inc | Composiciones que comprenden un inhibidor de demetilasa-1 específico de lisina. |
| US10059668B2 (en) | 2015-11-05 | 2018-08-28 | Mirati Therapeutics, Inc. | LSD1 inhibitors |
| WO2017090756A1 (ja) | 2015-11-27 | 2017-06-01 | 大鵬薬品工業株式会社 | 新規なビフェニル化合物又はその塩 |
| WO2017109061A1 (en) | 2015-12-23 | 2017-06-29 | Ieo - Istituto Europeo Di Oncologia S.R.L. | Spirocyclopropylamine derivatives useful as inhibitors of histone demethylases kdm1a |
| KR102720551B1 (ko) | 2015-12-29 | 2024-10-21 | 미라티 테라퓨틱스, 인크. | Lsd1 억제제 |
| CN109072195A (zh) | 2015-12-30 | 2018-12-21 | 诺华股份有限公司 | 具有增强功效的免疫效应细胞疗法 |
| CN110267945A (zh) | 2016-03-01 | 2019-09-20 | 诺华股份有限公司 | 氰基取代的吲哚化合物及其作为lsd1抑制剂的用途 |
| CN107200706A (zh) | 2016-03-16 | 2017-09-26 | 中国科学院上海药物研究所 | 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途 |
| US20170283397A1 (en) | 2016-03-31 | 2017-10-05 | University Of Utah Research Foundation | Substituted 1-h-indol-3-yl-benzamide and 1, 1'-biphenyl analogs as histone demethylase inhibitors |
| CA3022561A1 (en) | 2016-05-09 | 2017-11-16 | Sridharan Rajagopal | Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors |
| EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
| CN107513068A (zh) | 2016-06-16 | 2017-12-26 | 中国科学院上海药物研究所 | 一种具有fgfr抑制活性的新型化合物及其制备和应用 |
| CN106478639B (zh) | 2016-09-05 | 2018-09-18 | 郑州大学 | 嘧啶并1,2,4–三氮唑类的lsd1抑制剂、其制备方法及应用 |
| CN106432248B (zh) | 2016-09-27 | 2018-11-27 | 郑州大学 | 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用 |
| EP3532459B1 (en) | 2016-10-26 | 2023-08-02 | Constellation Pharmaceuticals, Inc. | Lsd1 inhibitors and medical uses thereof |
| WO2018081342A1 (en) | 2016-10-26 | 2018-05-03 | Constellation Pharmaceuticals, Inc. | Lsd1 inhibitors and uses thereof |
| CN106831489B (zh) | 2017-03-23 | 2018-04-17 | 郑州大学 | 苯环丙胺酰腙类化合物、制备方法及其应用 |
| CN106928235A (zh) | 2017-05-03 | 2017-07-07 | 郑州大学 | 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用 |
-
2018
- 2018-08-03 CN CN201880050319.1A patent/CN110996949A/zh active Pending
- 2018-08-03 CA CA3071804A patent/CA3071804A1/en active Pending
- 2018-08-03 WO PCT/EP2018/071120 patent/WO2019025588A1/en not_active Ceased
- 2018-08-03 EP EP24205125.8A patent/EP4512473A3/en active Pending
- 2018-08-03 AU AU2018309372A patent/AU2018309372B2/en active Active
- 2018-08-03 JP JP2020505367A patent/JP2020529995A/ja active Pending
- 2018-08-03 PL PL18748921.6T patent/PL3661510T3/pl unknown
- 2018-08-03 MX MX2020001323A patent/MX2020001323A/es unknown
- 2018-08-03 FI FIEP18748921.6T patent/FI3661510T3/fi active
- 2018-08-03 ES ES18748921T patent/ES3001085T3/es active Active
- 2018-08-03 HR HRP20241716TT patent/HRP20241716T1/hr unknown
- 2018-08-03 RS RS20241411A patent/RS66336B1/sr unknown
- 2018-08-03 EP EP18748921.6A patent/EP3661510B1/en active Active
- 2018-08-03 MY MYPI2020000100A patent/MY204406A/en unknown
- 2018-08-03 HU HUE18748921A patent/HUE069697T2/hu unknown
- 2018-08-03 KR KR1020207006287A patent/KR102685898B1/ko active Active
- 2018-08-03 SI SI201831191T patent/SI3661510T1/sl unknown
- 2018-08-03 KR KR1020247023305A patent/KR20240122847A/ko active Pending
- 2018-08-03 BR BR112020000827-3A patent/BR112020000827A2/pt unknown
- 2018-08-03 US US16/635,704 patent/US20200323828A1/en not_active Abandoned
- 2018-08-03 IL IL272092A patent/IL272092B1/en unknown
- 2018-08-03 DK DK18748921.6T patent/DK3661510T3/da active
- 2018-08-03 SG SG11202000077RA patent/SG11202000077RA/en unknown
- 2018-08-03 LT LTEPPCT/EP2018/071120T patent/LT3661510T/lt unknown
-
2020
- 2020-01-28 PH PH12020500211A patent/PH12020500211A1/en unknown
- 2020-01-31 MX MX2023009388A patent/MX2023009388A/es unknown
-
2023
- 2023-08-18 US US18/451,897 patent/US20240277673A1/en active Pending
- 2023-08-24 JP JP2023136283A patent/JP2023159354A/ja active Pending
-
2024
- 2024-11-14 AU AU2024264660A patent/AU2024264660A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12020500211A1 (en) | Methods of treating behavior alterations | |
| PH12018501656A1 (en) | Methods for using fxr agonists | |
| IL276779A (en) | Derivatives and related compounds of n-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide as hpk1 inhibitors for cancer treatment | |
| MY205416A (en) | Tyk2 inhibitors and uses thereof | |
| EP3848370A3 (en) | Tyk2 inhibitors and uses thereof | |
| MX2020007799A (es) | Inhibidores de cinasa no derrepresible de control de aminoacido general 2 (gcn2) y sus usos. | |
| BR112018075310A2 (pt) | metódo de tratamento de esclerose múltipla empregando um inibidor de lsd1 | |
| AR108711A1 (es) | Compuestos moduladores de fxr (nr1h4) | |
| DK3169671T3 (da) | 1-(5-(tert.-butyl)isoxazol-3-yl)-3-(4-((phenyl)ethynyl)phenyl)ureaderivater og relaterede forbindelser som flt3-inhibitorer til behandling af kræft | |
| EP4327809A3 (en) | Tyk2 inhibitors and uses thereof | |
| MX2021015102A (es) | Inhibidores del receptor del factor estimulante de colonias 1 (csf-1r). | |
| EA201891024A1 (ru) | Соединения-ингибиторы tank-связывающей киназы | |
| MX386113B (es) | Polimorfos de n-[(3-fluoro-4-metoxipiridin-2-il)metil]-3-(metoximetil)-1-({4-[(2-oxopiridin-1-il)metil]fenil}metil)pirazol-4-carboxamida y sales de los mismos. | |
| MX382905B (es) | 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. | |
| MY179802A (en) | Hydrochloride salt form for ezh2 inhibition | |
| EP4234552A3 (en) | 3-phosphoglycerate dehydrogenase inhibitors and uses thereof | |
| UY37517A (es) | Métodos de síntesis de compuestos tiazoles sustituidos | |
| MX2021006102A (es) | Suministro mejorado de agentes grandes. | |
| EA201892235A1 (ru) | Гранулированная композиция для перорального применения | |
| MX2023001805A (es) | Formas solidas de 2-(5-(4-(2-morfolinoetoxi)fenil)piridin-2-il)-n- bencilacetamida. | |
| MX2020005557A (es) | Agonistas de fxr para el tratamiento de enfermedades hepaticas. | |
| PH12017500123A1 (en) | Crystal of azole benzene derivative | |
| ES2723429T3 (es) | Formulación de nanopartículas que comprende un inhibidor de mPGES-1 | |
| UA94667U (uk) | Заміщені [2-(3-r-1h-[1,2,4]триазол-5-іл)феніл]аміни, що проявляють гіпоглікемічну активність | |
| UA98156U (uk) | 2-((5-(адамантан-1-іл)-4-феніл-4н-1,2,4-триазол-3-іл)тіо)-n'-(2-нітробензиліден)ацетогідразид, який проявляє антигіпоксичну активність |