MX341732B - Inhibidores de la demetilasa lsd1 basados en arilciclopropilamina y sus usos médicos. - Google Patents

Inhibidores de la demetilasa lsd1 basados en arilciclopropilamina y sus usos médicos.

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Publication number
MX341732B
MX341732B MX2013000968A MX2013000968A MX341732B MX 341732 B MX341732 B MX 341732B MX 2013000968 A MX2013000968 A MX 2013000968A MX 2013000968 A MX2013000968 A MX 2013000968A MX 341732 B MX341732 B MX 341732B
Authority
MX
Mexico
Prior art keywords
arylcyclopropylamine
lsd1
medical use
demethylase inhibitors
based demethylase
Prior art date
Application number
MX2013000968A
Other languages
English (en)
Other versions
MX2013000968A (es
Inventor
Matthew Colin Thor Fyfe
Muñoz Alberto Ortega
Pedemonte Marc Martinell
FERNANDEZ DE LA CUESTA Iñigo TIRAPU
Maria De Los Ángeles Estiarte-Martínez
Original Assignee
Oryzon Genomics S A *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oryzon Genomics S A * filed Critical Oryzon Genomics S A *
Publication of MX2013000968A publication Critical patent/MX2013000968A/es
Publication of MX341732B publication Critical patent/MX341732B/es

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La invención se refiere a compuestos de (hetero)aril-ciclopropilam ina, que incluyen particularmente los compuestos de la Fórmula (I), como se describe y define aquí, y su uso en terapia, incluyendo, por ejemplo, en el tratamiento o prevención de cáncer, una enfermedad o trenstorno neuológico o una infección viral. Así en un aspecto específico la invención se refiere. (Ver Formula).
MX2013000968A 2010-07-29 2011-07-27 Inhibidores de la demetilasa lsd1 basados en arilciclopropilamina y sus usos médicos. MX341732B (es)

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