MX2018011100A - Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas. - Google Patents
Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas.Info
- Publication number
- MX2018011100A MX2018011100A MX2018011100A MX2018011100A MX2018011100A MX 2018011100 A MX2018011100 A MX 2018011100A MX 2018011100 A MX2018011100 A MX 2018011100A MX 2018011100 A MX2018011100 A MX 2018011100A MX 2018011100 A MX2018011100 A MX 2018011100A
- Authority
- MX
- Mexico
- Prior art keywords
- combinations
- treatment
- hematological malignancies
- lsd1 inhibitors
- lsd1
- Prior art date
Links
- 208000002250 Hematologic Neoplasms Diseases 0.000 title abstract 2
- 229940123628 Lysine (K)-specific demethylase 1A inhibitor Drugs 0.000 title 1
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a combinaciones del compuesto de la fórmula (I) o sales farmacéuticamente aceptables de la misma con otros ingredientes farmacéuticos activos (I), composiciones farmacéuticas que comprenden los mismos, y su uso como medicamentos, en particular para el tratamiento de malignidades hematológicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16382117 | 2016-03-15 | ||
PCT/EP2017/055763 WO2017157813A1 (en) | 2016-03-15 | 2017-03-13 | Combinations of lsd1 inhibitors for the treatment of hematological malignancies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018011100A true MX2018011100A (es) | 2019-01-10 |
Family
ID=55752234
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018011100A MX2018011100A (es) | 2016-03-15 | 2017-03-13 | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas. |
MX2022013612A MX2022013612A (es) | 2016-03-15 | 2018-09-13 | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022013612A MX2022013612A (es) | 2016-03-15 | 2018-09-13 | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas. |
Country Status (15)
Country | Link |
---|---|
US (3) | US11013698B2 (es) |
EP (1) | EP3429570A1 (es) |
JP (1) | JP7082263B2 (es) |
KR (2) | KR102646126B1 (es) |
CN (2) | CN114377137A (es) |
AR (1) | AR108686A1 (es) |
AU (2) | AU2017233886B2 (es) |
BR (1) | BR112018068532A2 (es) |
CA (1) | CA3017408A1 (es) |
IL (1) | IL261717B2 (es) |
MX (2) | MX2018011100A (es) |
MY (1) | MY197785A (es) |
RU (1) | RU2766259C2 (es) |
SG (2) | SG10201913290QA (es) |
WO (1) | WO2017157813A1 (es) |
Families Citing this family (14)
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KR102139537B1 (ko) | 2011-10-20 | 2020-07-31 | 오리존 지노믹스 에스.에이. | Lsd1 억제제로서 (헤테로)아릴 사이클로프로필아민 화합물 |
EP3090998A1 (en) | 2015-05-06 | 2016-11-09 | F. Hoffmann-La Roche AG | Solid forms |
MX2018011100A (es) | 2016-03-15 | 2019-01-10 | Oryzon Genomics Sa | Combinaciones de inhibidores de desmetilasa-1 especifica de lisina (lsd1) para el tratamiento de malignidades hematologicas. |
WO2017157825A1 (en) | 2016-03-15 | 2017-09-21 | F. Hoffmann-La Roche Ag | Combinations of lsd1 inhibitors for use in the treatment of solid tumors |
SG11201710199PA (en) | 2016-06-10 | 2018-05-30 | Oryzon Genomics Sa | Methods of treating multiple sclerosis |
US11685782B2 (en) | 2017-10-23 | 2023-06-27 | Children's Medical Center Corporation | Methods of treating cancer using LSD1 inhibitors in combination with immunotherapy |
EP3787605A1 (en) * | 2018-05-04 | 2021-03-10 | Oryzon Genomics, S.A. | Stable pharmaceutical formulation |
AU2020297596A1 (en) * | 2019-06-20 | 2022-02-03 | Celgene Corporation | Azacitidine in combination with venetoclax, gilteritinib, midostaurin or other compounds for treating leukemia or myelodysplastic syndrome |
WO2021066443A1 (ko) * | 2019-09-30 | 2021-04-08 | 한미약품 주식회사 | Flt3 저해제 및 mdm2 저해제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물 |
KR20230167102A (ko) * | 2021-04-08 | 2023-12-07 | 오리존 지노믹스 에스.에이. | 골수성 암 치료를 위한 lsd1 억제제의 조합물 |
CN113082211A (zh) * | 2021-04-14 | 2021-07-09 | 南方医科大学珠江医院 | 一种治疗npm1突变急性髓系白血病的药物组合物及其应用 |
WO2023063784A1 (ko) * | 2021-10-14 | 2023-04-20 | (주)파로스아이바이오 | 2,3,5-치환된 싸이오펜 화합물을 포함하는 병용 투여용 조성물 |
GB202115017D0 (en) | 2021-10-20 | 2021-12-01 | Univ London Queen Mary | Sequential treatments and biomarkers to reverse resistance to kinase inhibitors |
WO2023067058A1 (en) | 2021-10-20 | 2023-04-27 | Queen Mary University Of London | Sequential treatments and biomarkers to reverse resistance to kinase inhibitors |
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2017
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MY197785A (en) | 2023-07-13 |
WO2017157813A1 (en) | 2017-09-21 |
CA3017408A1 (en) | 2017-09-21 |
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RU2018136153A3 (es) | 2020-06-30 |
KR20230042755A (ko) | 2023-03-29 |
SG11201807972YA (en) | 2018-10-30 |
BR112018068532A2 (pt) | 2019-01-29 |
IL261717B2 (en) | 2023-02-01 |
RU2018136153A (ru) | 2020-04-15 |
KR102646126B1 (ko) | 2024-03-11 |
IL261717B (en) | 2022-10-01 |
AU2017233886B2 (en) | 2022-10-20 |
JP2019508439A (ja) | 2019-03-28 |
CN114377137A (zh) | 2022-04-22 |
US20170281566A1 (en) | 2017-10-05 |
RU2766259C2 (ru) | 2022-02-10 |
SG10201913290QA (en) | 2020-03-30 |
US11013698B2 (en) | 2021-05-25 |
EP3429570A1 (en) | 2019-01-23 |
US20190083417A1 (en) | 2019-03-21 |
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