MX382905B - 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. - Google Patents

2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.

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Publication number
MX382905B
MX382905B MX2019011789A MX2019011789A MX382905B MX 382905 B MX382905 B MX 382905B MX 2019011789 A MX2019011789 A MX 2019011789A MX 2019011789 A MX2019011789 A MX 2019011789A MX 382905 B MX382905 B MX 382905B
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MX
Mexico
Prior art keywords
difluorophenyl
difluoro
pyridin
substituted
ols
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MX2019011789A
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English (en)
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MX2019011789A (es
Inventor
Carl Deamicis
Daniel Knueppel
Gary D Gustafson
Greg Whiteker
Jim Renga
Michael T Sullenberger
Nakyen Choy
William J Hoekstra
Yuanming Zhu
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Viamet Pharmaceuticals Nc Inc
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Application filed by Viamet Pharmaceuticals Nc Inc filed Critical Viamet Pharmaceuticals Nc Inc
Publication of MX2019011789A publication Critical patent/MX2019011789A/es
Publication of MX382905B publication Critical patent/MX382905B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se proporcionan 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-iI)-3-(1H-tetrazol-1-il)propan-2-oles y 1-(2,4-difluorofenil)-2,2-difluoro-2-(5-sustituido-piridin-2-il)etanonas y procesos para su preparación.
MX2019011789A 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion. MX382905B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461955680P 2014-03-19 2014-03-19
PCT/US2015/021527 WO2015143192A1 (en) 2014-03-19 2015-03-19 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation

Publications (2)

Publication Number Publication Date
MX2019011789A MX2019011789A (es) 2019-11-18
MX382905B true MX382905B (es) 2025-03-13

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Family Applications (2)

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MX2019011789A MX382905B (es) 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.
MX2016012060A MX2016012060A (es) 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.

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MX2016012060A MX2016012060A (es) 2014-03-19 2015-03-19 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-sustituido-piridin-2-il)- 3-(1h-tetrazol-1-il)propan-2-oles y procesos para su preparacion.

Country Status (11)

Country Link
US (2) US9988365B2 (es)
EP (1) EP3119756B9 (es)
JP (1) JP6633539B2 (es)
KR (1) KR102441243B1 (es)
CN (2) CN106132947B (es)
BR (1) BR112016021260B1 (es)
CA (1) CA2942982C (es)
IL (1) IL247832B (es)
MX (2) MX382905B (es)
WO (1) WO2015143192A1 (es)
ZA (1) ZA201606386B (es)

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IL247832B (en) 2019-10-31
JP6633539B2 (ja) 2020-01-22
EP3119756B9 (en) 2021-08-25
BR112016021260B1 (pt) 2020-05-26
CN109678791A (zh) 2019-04-26
MX2016012060A (es) 2017-01-19
US20170158667A1 (en) 2017-06-08
EP3119756A1 (en) 2017-01-25
CA2942982A1 (en) 2015-09-24
IL247832A0 (en) 2016-11-30
CA2942982C (en) 2023-09-19
US9988365B2 (en) 2018-06-05
EP3119756B1 (en) 2021-04-21
CN109678791B (zh) 2022-07-01
US20180155324A1 (en) 2018-06-07
ZA201606386B (en) 2020-01-29
US10301283B2 (en) 2019-05-28
WO2015143192A1 (en) 2015-09-24
EP3119756A4 (en) 2017-09-20
CN106132947A (zh) 2016-11-16
CN106132947B (zh) 2019-08-09
KR20160133446A (ko) 2016-11-22
KR102441243B1 (ko) 2022-09-07
JP2017507982A (ja) 2017-03-23
MX2019011789A (es) 2019-11-18

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