EA201892235A1 - Гранулированная композиция для перорального применения - Google Patents

Гранулированная композиция для перорального применения

Info

Publication number
EA201892235A1
EA201892235A1 EA201892235A EA201892235A EA201892235A1 EA 201892235 A1 EA201892235 A1 EA 201892235A1 EA 201892235 A EA201892235 A EA 201892235A EA 201892235 A EA201892235 A EA 201892235A EA 201892235 A1 EA201892235 A1 EA 201892235A1
Authority
EA
Eurasian Patent Office
Prior art keywords
granular composition
oral application
cariprazine hydrochloride
granular
ensures
Prior art date
Application number
EA201892235A
Other languages
English (en)
Inventor
Ясуси Имада
Фуминори Одзаки
Акихиро Судзуки
Кейдзи Мии
Original Assignee
Рихтер Гедеон Нирт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Нирт. filed Critical Рихтер Гедеон Нирт.
Publication of EA201892235A1 publication Critical patent/EA201892235A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к гранулированной композиции, которая обеспечивает стабильность карипразина гидрохлорида при хранении. Решение предусматривает гранулированную композицию, содержащую карипразина гидрохлорид, причем эта гранулированная композиция содержит лактозу в качестве главного разбавителя.
EA201892235A 2016-04-14 2017-04-13 Гранулированная композиция для перорального применения EA201892235A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16165247.4A EP3231418A1 (en) 2016-04-14 2016-04-14 Granule formulation for oral administration
PCT/IB2017/052129 WO2017178999A1 (en) 2016-04-14 2017-04-13 Granule formulation for oral administration

Publications (1)

Publication Number Publication Date
EA201892235A1 true EA201892235A1 (ru) 2019-03-29

Family

ID=55802213

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201892235A EA201892235A1 (ru) 2016-04-14 2017-04-13 Гранулированная композиция для перорального применения

Country Status (13)

Country Link
US (1) US20190117647A1 (ru)
EP (2) EP3231418A1 (ru)
JP (1) JP2019511513A (ru)
KR (1) KR20180131579A (ru)
CN (1) CN109069429A (ru)
AU (1) AU2017250640A1 (ru)
BR (1) BR112018070615A2 (ru)
CA (1) CA3020981A1 (ru)
EA (1) EA201892235A1 (ru)
IL (1) IL262204A (ru)
MX (1) MX2018012562A (ru)
TN (1) TN2018000326A1 (ru)
WO (1) WO2017178999A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0916241A2 (pt) 2008-07-16 2017-06-27 Richter Gedeon Nyrt formulações farmacêuticas contendo ligantes de receptores de dopamina
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US11273156B2 (en) * 2018-11-20 2022-03-15 Aurobindo Pharma Ltd Stable cariprazine formulations for oral use
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
US11344503B2 (en) 2019-12-13 2022-05-31 Halo Science LLC Cariprazine release formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
WO2009104739A1 (ja) 2008-02-21 2009-08-27 田辺三菱製薬株式会社 経口投与用固形製剤
BRPI0916241A2 (pt) * 2008-07-16 2017-06-27 Richter Gedeon Nyrt formulações farmacêuticas contendo ligantes de receptores de dopamina

Also Published As

Publication number Publication date
EP3442508A1 (en) 2019-02-20
US20190117647A1 (en) 2019-04-25
TN2018000326A1 (en) 2020-01-16
CA3020981A1 (en) 2017-10-19
KR20180131579A (ko) 2018-12-10
EP3231418A1 (en) 2017-10-18
MX2018012562A (es) 2019-06-10
WO2017178999A1 (en) 2017-10-19
BR112018070615A2 (pt) 2019-02-05
JP2019511513A (ja) 2019-04-25
IL262204A (en) 2018-11-29
CN109069429A (zh) 2018-12-21
AU2017250640A1 (en) 2018-11-08

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