JP2006513202A5 - - Google Patents
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- Publication number
- JP2006513202A5 JP2006513202A5 JP2004563361A JP2004563361A JP2006513202A5 JP 2006513202 A5 JP2006513202 A5 JP 2006513202A5 JP 2004563361 A JP2004563361 A JP 2004563361A JP 2004563361 A JP2004563361 A JP 2004563361A JP 2006513202 A5 JP2006513202 A5 JP 2006513202A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- optionally substituted
- compound
- aminocarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 44
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 239000002525 vasculotropin inhibitor Substances 0.000 claims 8
- -1 aralkoxy group Chemical group 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 230000001154 acute effect Effects 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 208000002780 macular degeneration Diseases 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000000547 substituted alkyl group Chemical group 0.000 claims 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004414 alkyl thio group Chemical group 0.000 claims 3
- 125000004659 aryl alkyl thio group Chemical group 0.000 claims 3
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- LELOWRISYMNNSU-UHFFFAOYSA-N Hydrocyanic acid Chemical group N#C LELOWRISYMNNSU-UHFFFAOYSA-N 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- ZQGVXCZSHVLLNA-UHFFFAOYSA-N 2-[1-(1-benzofuran-2-carbonyl)piperidin-4-yl]-n-(5-carbamoyl-2-methoxyphenyl)-1,3-thiazole-4-carboxamide Chemical compound COC1=CC=C(C(N)=O)C=C1NC(=O)C1=CSC(C2CCN(CC2)C(=O)C=2OC3=CC=CC=C3C=2)=N1 ZQGVXCZSHVLLNA-UHFFFAOYSA-N 0.000 claims 1
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- RKRNGWLHGHJULB-UHFFFAOYSA-N n-(5-carbamoyl-2-methoxyphenyl)-2-[1-(4,7-dimethylpyrazolo[5,1-c][1,2,4]triazine-3-carbonyl)piperidin-4-yl]-1,3-thiazole-4-carboxamide Chemical compound COC1=CC=C(C(N)=O)C=C1NC(=O)C1=CSC(C2CCN(CC2)C(=O)C2=C(N3N=C(C)C=C3N=N2)C)=N1 RKRNGWLHGHJULB-UHFFFAOYSA-N 0.000 claims 1
- GNYSPFJSQCPIQD-UHFFFAOYSA-N n-(5-carbamoyl-2-methoxyphenyl)-2-[1-[2-(2-chlorophenyl)acetyl]piperidin-4-yl]-1,3-thiazole-4-carboxamide Chemical compound COC1=CC=C(C(N)=O)C=C1NC(=O)C1=CSC(C2CCN(CC2)C(=O)CC=2C(=CC=CC=2)Cl)=N1 GNYSPFJSQCPIQD-UHFFFAOYSA-N 0.000 claims 1
- JITDERODDZHJOA-UHFFFAOYSA-N n-(5-carbamoyl-2-methoxyphenyl)-2-[1-[2-(3,4-dimethylphenoxy)acetyl]piperidin-4-yl]-1,3-thiazole-4-carboxamide Chemical compound COC1=CC=C(C(N)=O)C=C1NC(=O)C1=CSC(C2CCN(CC2)C(=O)COC=2C=C(C)C(C)=CC=2)=N1 JITDERODDZHJOA-UHFFFAOYSA-N 0.000 claims 1
- HKZCWJKZGLEYBZ-UHFFFAOYSA-N n-(5-carbamoyl-2-methoxyphenyl)-2-[1-[[4-(dimethylamino)phenyl]carbamothioyl]piperidin-4-yl]-1,3-thiazole-4-carboxamide Chemical compound COC1=CC=C(C(N)=O)C=C1NC(=O)C1=CSC(C2CCN(CC2)C(=S)NC=2C=CC(=CC=2)N(C)C)=N1 HKZCWJKZGLEYBZ-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0230162.0A GB0230162D0 (en) | 2002-12-24 | 2002-12-24 | Compounds useful in inhibiting angiogenesis |
| PCT/GB2003/005651 WO2004058750A1 (en) | 2002-12-24 | 2003-12-24 | Piperidinyl-thiazole carboxylic acid derivatives as angiogenesis inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006513202A JP2006513202A (ja) | 2006-04-20 |
| JP2006513202A5 true JP2006513202A5 (enExample) | 2007-02-08 |
Family
ID=9950429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563361A Pending JP2006513202A (ja) | 2002-12-24 | 2003-12-24 | 血管形成インヒビターとしてのピペリジニル−チアゾールカルボン酸誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060135501A1 (enExample) |
| EP (1) | EP1581528B1 (enExample) |
| JP (1) | JP2006513202A (enExample) |
| AT (1) | ATE368662T1 (enExample) |
| AU (2) | AU2003294143A1 (enExample) |
| CA (1) | CA2511506A1 (enExample) |
| DE (1) | DE60315355T2 (enExample) |
| GB (1) | GB0230162D0 (enExample) |
| WO (2) | WO2004058751A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2856685B1 (fr) * | 2003-06-25 | 2005-09-23 | Merck Sante Sas | Derives de thiazolylpiperidine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1735622A2 (en) * | 2004-04-13 | 2006-12-27 | Arena Pharmaceuticals, Inc. | Modulators of human g protein-coupled receptors for the treatment of hyperglycemia and related disorders |
| JP2008513386A (ja) * | 2004-09-20 | 2008-05-01 | ４エスシー アーゲー | 新規な複素環式ＮＦ−κＢ阻害剤 |
| EP1637529A1 (en) | 2004-09-20 | 2006-03-22 | 4Sc Ag | Novel piperidin-4-yl-thiazole-carboxamide analogues as inhibitors of T-cell proliferation and uses thereof |
| US7601745B2 (en) | 2004-09-27 | 2009-10-13 | 4Sc Ag | Heterocyclic NF-kB inhibitors |
| TW200738701A (en) | 2005-07-26 | 2007-10-16 | Du Pont | Fungicidal carboxamides |
| KR20080031038A (ko) * | 2005-07-29 | 2008-04-07 | 4에스체 악티엔게젤샤프트 | 신규의 헤테로환 ＮＦ-κＢ 억제제 |
| GB0518494D0 (en) * | 2005-09-09 | 2005-10-19 | Argenta Discovery Ltd | Thiazole compounds |
| EP1832586A1 (en) * | 2006-03-10 | 2007-09-12 | Oridis Biomed Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas |
| EP1832585A1 (en) * | 2006-03-10 | 2007-09-12 | ORIDIS BIOMED Forschungs- und Entwicklungs GmbH | Thiazole-piperidine derivatives for treatment of hyperproliferative diseases |
| EP1994017A2 (en) * | 2006-03-15 | 2008-11-26 | 4Sc Ag | Novel heterocyclic nf-kb inhibitors |
| EP1834954A1 (en) * | 2006-03-15 | 2007-09-19 | 4Sc Ag | Thiazoles as NF-kB Inhibitors (proteasome inhibitors) |
| BRPI0709595A2 (pt) * | 2006-03-15 | 2011-07-19 | 4Sc Ag | inibidores de nf-kapab heterocìclicos |
| WO2008013622A2 (en) * | 2006-07-27 | 2008-01-31 | E. I. Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| US9090604B2 (en) | 2006-07-27 | 2015-07-28 | E I Du Pont De Nemours And Company | Fungicidal azocyclic amides |
| US7638541B2 (en) * | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| US8420673B2 (en) | 2007-01-25 | 2013-04-16 | E I Du Pont De Nemours And Company | Fungicidal amides |
| CA2693169C (en) * | 2007-07-19 | 2016-01-12 | Metabolex, Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
| WO2009018844A1 (en) * | 2007-08-09 | 2009-02-12 | Oridis Biomed Forschungs- Und Entwicklungs Gmbh | Thiazole-piperidine derivatives for treatment of hyperproliferative diseases |
| DE102007047735A1 (de) | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Thiazolderivate |
| TWI428091B (zh) | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
| EP2070925A1 (de) * | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel |
| EP2070924A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel |
| BRPI0905759A2 (pt) * | 2008-01-25 | 2015-07-14 | Du Pont | Composto selecionado a partir dos compostos de fórmula 1 e n óxidos e sais dos mesmos, método para controlar doenças de planta causadas por patógenos de planta fúngicos oomycota e composição fungicida |
| MX2010007974A (es) * | 2008-01-25 | 2010-08-04 | Du Pont | Amidas fungicidas. |
| BRPI0910837B1 (pt) | 2008-04-30 | 2017-03-07 | Bayer Cropscience Ag | ésteres e tioésteres tiazol-4-carboxílicos, seus usos, e método e composição para controlar fungos fitopatogênicos prejudiciais |
| CN102216296B (zh) * | 2008-10-01 | 2015-03-18 | 拜耳作物科学公司 | 作为作物保护剂的杂环取代的噻唑类 |
| US20110160222A1 (en) * | 2008-11-26 | 2011-06-30 | Metabolex, Inc. | Modulators of glucose homeostasis for the treatment of diabetes and metabolic disorders |
| UY32285A (es) | 2008-12-02 | 2010-06-30 | Du Pont | Compuestos heterocíclicos fungicidas |
| WO2010108503A1 (en) | 2009-03-24 | 2010-09-30 | Life & Brain Gmbh | Promotion of neuronal integration in neural stem cell grafts |
| CN102666553B (zh) * | 2009-10-01 | 2015-05-06 | 赛马拜制药公司 | 取代的四唑-1-基-苯氧基甲基-噻唑-2-基-哌啶基-嘧啶盐 |
| WO2011051243A1 (en) | 2009-10-29 | 2011-05-05 | Bayer Cropscience Ag | Active compound combinations |
| BR112012010242B1 (pt) * | 2009-10-30 | 2018-03-20 | Bayer Intellectual Property Gmbh | Derivados de heteroarilpiperidina e heteroarilpiperazina |
| ES2613066T3 (es) * | 2010-04-28 | 2017-05-22 | Bayer Intellectual Property Gmbh | Derivados de cetoheteroarilpiperidina y -piperazina como fungicidas |
| US8815775B2 (en) * | 2010-05-18 | 2014-08-26 | Bayer Cropscience Ag | Bis(difluoromethyl)pyrazoles as fungicides |
| ES2676209T3 (es) | 2010-06-23 | 2018-07-17 | Metabolex Inc. | Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina |
| BR112013019667B1 (pt) | 2011-02-01 | 2019-07-02 | Bayer Intellectual Property Gmbh | Compostos derivados de heteroaril-piperidina e -piperazina, seus usos, composição, processos de produção de compostos e de composições, método para o controle de fungos fitopatogênicos prejudiciais |
| JP2019527693A (ja) | 2016-08-03 | 2019-10-03 | サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 炎症性胃腸疾患または胃腸状態を治療するためのオキシメチレンアリール化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3966748A (en) * | 1975-05-08 | 1976-06-29 | American Cyanamid Company | Para-fluorophenyl-N-heterocyclic substituted butanes |
| GB9410534D0 (en) * | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | Improvements in or relating to growth factor inhibitors |
| JPH11513382A (ja) * | 1995-10-20 | 1999-11-16 | ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法 |
| US6080767A (en) * | 1996-01-02 | 2000-06-27 | Aventis Pharmaceuticals Products Inc. | Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides |
| AR012443A1 (es) * | 1997-04-16 | 2000-10-18 | Uriach & Cia Sa J | Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos |
| JP2009504707A (ja) * | 2005-08-18 | 2009-02-05 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈ３受容体調節剤として有用なチアゾリルピペリジン誘導体 |
-
2002
- 2002-12-24 GB GBGB0230162.0A patent/GB0230162D0/en not_active Ceased
-
2003
- 2003-12-24 AT AT03789563T patent/ATE368662T1/de not_active IP Right Cessation
- 2003-12-24 WO PCT/GB2003/005654 patent/WO2004058751A1/en not_active Ceased
- 2003-12-24 US US10/540,645 patent/US20060135501A1/en not_active Abandoned
- 2003-12-24 CA CA002511506A patent/CA2511506A1/en not_active Abandoned
- 2003-12-24 DE DE60315355T patent/DE60315355T2/de not_active Expired - Fee Related
- 2003-12-24 JP JP2004563361A patent/JP2006513202A/ja active Pending
- 2003-12-24 AU AU2003294143A patent/AU2003294143A1/en not_active Abandoned
- 2003-12-24 AU AU2003290335A patent/AU2003290335A1/en not_active Abandoned
- 2003-12-24 WO PCT/GB2003/005651 patent/WO2004058750A1/en not_active Ceased
- 2003-12-24 EP EP03789563A patent/EP1581528B1/en not_active Expired - Lifetime
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