JP2017523972A5 - - Google Patents
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- JP2017523972A5 JP2017523972A5 JP2017504815A JP2017504815A JP2017523972A5 JP 2017523972 A5 JP2017523972 A5 JP 2017523972A5 JP 2017504815 A JP2017504815 A JP 2017504815A JP 2017504815 A JP2017504815 A JP 2017504815A JP 2017523972 A5 JP2017523972 A5 JP 2017523972A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- chloro
- benzamide
- hydroxy
- piperidylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 1H-tetrazolyl Chemical group 0.000 claims description 185
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 81
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 30
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
- 150000001875 compounds Chemical class 0.000 claims description 17
- POVNVOVBMZEQNF-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-[cycloheptyl(methyl)sulfamoyl]benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(N(C)C1CCCCCC1)(=O)=O)=O)O POVNVOVBMZEQNF-UHFFFAOYSA-N 0.000 claims description 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 9
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 8
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 7
- AFFKBANIVDVAJZ-UHFFFAOYSA-N 2-(3-piperidin-1-ylsulfonylphenyl)-1H-benzimidazol-4-ol Chemical compound N1(CCCCC1)S(=O)(=O)C=1C=C(C=CC=1)C=1NC2=C(N=1)C=CC=C2O AFFKBANIVDVAJZ-UHFFFAOYSA-N 0.000 claims description 6
- AKNIMNRBFJJRHU-UHFFFAOYSA-N 2-(3-piperidin-1-ylsulfonylphenyl)benzotriazole Chemical compound N1(CCCCC1)S(=O)(=O)C=1C=C(C=CC=1)N1N=C2C(=N1)C=CC=C2 AKNIMNRBFJJRHU-UHFFFAOYSA-N 0.000 claims description 6
- PLYJLKUDUKDBBL-UHFFFAOYSA-N 2-[[3-[(5-chloro-2-hydroxyphenyl)carbamoyl]phenyl]sulfonyl-cyclohexylamino]acetic acid Chemical compound ClC=1C=CC(=C(C=1)NC(=O)C=1C=C(C=CC=1)S(=O)(=O)N(CC(=O)O)C1CCCCC1)O PLYJLKUDUKDBBL-UHFFFAOYSA-N 0.000 claims description 6
- YFIYZXAOWRTBKF-UHFFFAOYSA-N 3-(1,3-benzoxazol-2-yl)-N-cyclohexyl-N-methylbenzenesulfonamide Chemical compound O1C(=NC2=C1C=CC=C2)C=1C=C(C=CC=1)S(=O)(=O)N(C)C1CCCCC1 YFIYZXAOWRTBKF-UHFFFAOYSA-N 0.000 claims description 6
- FLMVZQMFGDPDRX-UHFFFAOYSA-N 3-(1-adamantylsulfamoyl)-N-(5-chloro-2-hydroxyphenyl)benzamide Chemical compound C12(CC3CC(CC(C1)C3)C2)NS(=O)(=O)C=1C=C(C(=O)NC2=C(C=CC(=C2)Cl)O)C=CC=1 FLMVZQMFGDPDRX-UHFFFAOYSA-N 0.000 claims description 6
- PLLWPDNWVBCYIJ-UHFFFAOYSA-N 3-(4-benzylpiperazin-1-yl)sulfonyl-N-(5-chloro-2-hydroxyphenyl)benzamide Chemical compound C(C1=CC=CC=C1)N1CCN(CC1)S(=O)(=O)C=1C=C(C(=O)NC2=C(C=CC(=C2)Cl)O)C=CC=1 PLLWPDNWVBCYIJ-UHFFFAOYSA-N 0.000 claims description 6
- WAESAKIHRIQDQM-UHFFFAOYSA-N 3-(5-chloro-1,3-benzoxazol-2-yl)-N-cyclohexyl-N-(3-hydroxypropyl)benzenesulfonamide Chemical compound OCCCN(C1CCCCC1)S(=O)(=O)C1=CC(=CC=C1)C1=NC2=C(O1)C=CC(Cl)=C2 WAESAKIHRIQDQM-UHFFFAOYSA-N 0.000 claims description 6
- ZHECZGVEWDLDSU-UHFFFAOYSA-N 3-(5-chloro-1,3-benzoxazol-2-yl)-N-cyclohexyl-N-[3-(dimethylamino)propyl]benzenesulfonamide Chemical compound CN(C)CCCN(C1CCCCC1)S(=O)(=O)C1=CC(=CC=C1)C1=NC2=C(O1)C=CC(Cl)=C2 ZHECZGVEWDLDSU-UHFFFAOYSA-N 0.000 claims description 6
- DBERYRVHZRNFCN-UHFFFAOYSA-N 3-(azepan-1-ylsulfonyl)-n-(5-chloro-2-hydroxyphenyl)benzamide Chemical compound OC1=CC=C(Cl)C=C1NC(=O)C1=CC=CC(S(=O)(=O)N2CCCCCC2)=C1 DBERYRVHZRNFCN-UHFFFAOYSA-N 0.000 claims description 6
- XFWXOLQIOVBGEM-UHFFFAOYSA-N 3-[2-aminoethyl(cyclohexyl)sulfamoyl]-N-(5-chloro-2-hydroxyphenyl)benzamide Chemical compound NCCN(S(=O)(=O)C=1C=C(C(=O)NC2=C(C=CC(=C2)Cl)O)C=CC=1)C1CCCCC1 XFWXOLQIOVBGEM-UHFFFAOYSA-N 0.000 claims description 6
- HRXKUHHUDOMZHG-UHFFFAOYSA-N 3-[3-aminopropyl(cyclohexyl)sulfamoyl]-N-(2-hydroxy-3-methoxyphenyl)benzamide Chemical compound NCCCN(S(=O)(=O)C=1C=C(C(=O)NC2=C(C(=CC=C2)OC)O)C=CC=1)C1CCCCC1 HRXKUHHUDOMZHG-UHFFFAOYSA-N 0.000 claims description 6
- WBIMANPFRLSCOU-UHFFFAOYSA-N 3-[3-aminopropyl(cyclohexyl)sulfamoyl]-N-(2-hydroxyphenyl)benzamide Chemical compound NCCCN(S(=O)(=O)C=1C=C(C(=O)NC2=C(C=CC=C2)O)C=CC=1)C1CCCCC1 WBIMANPFRLSCOU-UHFFFAOYSA-N 0.000 claims description 6
- KCTPFWQJXCELJR-UHFFFAOYSA-N 3-[3-aminopropyl(cyclohexyl)sulfamoyl]-N-(2-methoxyphenyl)benzamide Chemical compound NCCCN(S(=O)(=O)C=1C=C(C(=O)NC2=C(C=CC=C2)OC)C=CC=1)C1CCCCC1 KCTPFWQJXCELJR-UHFFFAOYSA-N 0.000 claims description 6
- QTKXLZCQXKKIJL-UHFFFAOYSA-N 3-[3-aminopropyl(cyclohexyl)sulfamoyl]-N-(4,5-dichloro-2-hydroxyphenyl)benzamide Chemical compound NCCCN(S(=O)(=O)C=1C=C(C(=O)NC2=C(C=C(C(=C2)Cl)Cl)O)C=CC=1)C1CCCCC1 QTKXLZCQXKKIJL-UHFFFAOYSA-N 0.000 claims description 6
- VILVXXZSYPCCAV-UHFFFAOYSA-N 3-[3-aminopropyl(cyclohexyl)sulfamoyl]-N-(5-chloro-2-hydroxyphenyl)benzamide Chemical compound NCCCN(S(=O)(=O)C=1C=C(C(=O)NC2=C(C=CC(=C2)Cl)O)C=CC=1)C1CCCCC1 VILVXXZSYPCCAV-UHFFFAOYSA-N 0.000 claims description 6
- IRHFGYOUFPRAFX-UHFFFAOYSA-N 3-[4-aminobutyl(cyclohexyl)sulfamoyl]-N-(5-chloro-2-hydroxyphenyl)benzamide Chemical compound NCCCCN(S(=O)(=O)C=1C=C(C(=O)NC2=C(C=CC(=C2)Cl)O)C=CC=1)C1CCCCC1 IRHFGYOUFPRAFX-UHFFFAOYSA-N 0.000 claims description 6
- HDHCWTDUGXNEHU-UHFFFAOYSA-N 3-[benzyl(cyclohexyl)sulfamoyl]-N-(5-chloro-2-hydroxyphenyl)benzamide Chemical compound OC1=C(NC(=O)C2=CC(=CC=C2)S(=O)(=O)N(CC2=CC=CC=C2)C2CCCCC2)C=C(Cl)C=C1 HDHCWTDUGXNEHU-UHFFFAOYSA-N 0.000 claims description 6
- SAGRENOEYPVVJS-UHFFFAOYSA-N 4-[[3-[(5-chloro-2-hydroxyphenyl)carbamoyl]phenyl]sulfonyl-cyclohexylamino]butanoic acid Chemical compound ClC=1C=CC(=C(C=1)NC(=O)C=1C=C(C=CC=1)S(=O)(=O)N(CCCC(=O)O)C1CCCCC1)O SAGRENOEYPVVJS-UHFFFAOYSA-N 0.000 claims description 6
- ONBQXUHKQAJMRY-UHFFFAOYSA-N 4-chloro-2-[(3-piperidin-1-ylsulfonylbenzoyl)amino]benzoic acid Chemical compound ClC1=CC(=C(C(=O)O)C=C1)NC(C1=CC(=CC=C1)S(=O)(=O)N1CCCCC1)=O ONBQXUHKQAJMRY-UHFFFAOYSA-N 0.000 claims description 6
- ISLDVUKPWJCSNU-UHFFFAOYSA-N 4-chloro-2-[2-(3-piperidin-1-ylsulfonylphenyl)-1H-imidazol-5-yl]phenol Chemical compound ClC1=CC(=C(C=C1)O)C1=CN=C(N1)C1=CC(=CC=C1)S(=O)(=O)N1CCCCC1 ISLDVUKPWJCSNU-UHFFFAOYSA-N 0.000 claims description 6
- ASERCCCTJAWTRV-UHFFFAOYSA-N 4-chloro-2-[3-(3-piperidin-1-ylsulfonylphenyl)-1H-1,2,4-triazol-5-yl]phenol Chemical compound OC1=C(C=C(Cl)C=C1)C1=NC(=NN1)C1=CC(=CC=C1)S(=O)(=O)N1CCCCC1 ASERCCCTJAWTRV-UHFFFAOYSA-N 0.000 claims description 6
- VCXMHZOOQPCNKP-UHFFFAOYSA-N 4-chloro-2-[4-(3-piperidin-1-ylsulfonylphenyl)pyrimidin-2-yl]phenol Chemical compound ClC1=CC(=C(C=C1)O)C1=NC=CC(=N1)C1=CC(=CC=C1)S(=O)(=O)N1CCCCC1 VCXMHZOOQPCNKP-UHFFFAOYSA-N 0.000 claims description 6
- VLKAAAOFELKTSN-UHFFFAOYSA-N 5,7-dichloro-2-(3-piperidin-1-ylsulfonylphenyl)-3H-benzimidazol-4-ol Chemical compound ClC1=C(C2=C(N=C(N2)C2=CC(=CC=C2)S(=O)(=O)N2CCCCC2)C(=C1)Cl)O VLKAAAOFELKTSN-UHFFFAOYSA-N 0.000 claims description 6
- NGUVSIWCEOPZSI-UHFFFAOYSA-N 5-chloro-2-(3-piperidin-1-ylsulfonylphenyl)-1,3-benzoxazole Chemical compound ClC1=CC2=C(OC(=N2)C2=CC(=CC=C2)S(=O)(=O)N2CCCCC2)C=C1 NGUVSIWCEOPZSI-UHFFFAOYSA-N 0.000 claims description 6
- IJELLJZOWAAJBK-UHFFFAOYSA-N 5-chloro-3-(3-piperidin-1-ylsulfonylbenzoyl)-1H-benzimidazol-2-one Chemical compound ClC1=CC2=C(NC(N2C(C2=CC(=CC=C2)S(=O)(=O)N2CCCCC2)=O)=O)C=C1 IJELLJZOWAAJBK-UHFFFAOYSA-N 0.000 claims description 6
- ZDRWADHUPHQFHN-UHFFFAOYSA-N 5-chloro-N-(3-piperidin-1-ylsulfonylphenyl)-1H-indazol-3-amine Chemical compound ClC=1C=C2C(=NNC2=CC=1)NC1=CC(=CC=C1)S(=O)(=O)N1CCCCC1 ZDRWADHUPHQFHN-UHFFFAOYSA-N 0.000 claims description 6
- BCKFSWAOFTYFDC-UHFFFAOYSA-N 7-chloro-2-(3-piperidin-1-ylsulfonylphenyl)-3H-benzimidazol-4-ol Chemical compound ClC1=CC=C(C2=C1N=C(N2)C1=CC(=CC=C1)S(=O)(=O)N1CCCCC1)O BCKFSWAOFTYFDC-UHFFFAOYSA-N 0.000 claims description 6
- AWIXPFDHIMNZMQ-UHFFFAOYSA-N 9-chloro-3-piperidin-1-ylsulfonyl-11aH-benzo[b][1,4]benzoxazepin-1-one Chemical compound ClC1=CC2=C(C=NC=3C(O2)C(C=C(C=3)S(=O)(=O)N2CCCCC2)=O)C=C1 AWIXPFDHIMNZMQ-UHFFFAOYSA-N 0.000 claims description 6
- MDORFSHEZRYGIY-UHFFFAOYSA-N N-(2-aminoethyl)-3-(5-chloro-1,3-benzoxazol-2-yl)-N-cyclohexylbenzenesulfonamide Chemical compound NCCN(C1CCCCC1)S(=O)(=O)C1=CC(=CC=C1)C1=NC2=C(O1)C=CC(Cl)=C2 MDORFSHEZRYGIY-UHFFFAOYSA-N 0.000 claims description 6
- SKNHCWJVEVFGPD-UHFFFAOYSA-N N-(3-aminopropyl)-3-(1,3-benzothiazol-2-yl)-N-cyclohexylbenzenesulfonamide Chemical compound NCCCN(S(=O)(=O)C1=CC(=CC=C1)C=1SC2=C(N=1)C=CC=C2)C1CCCCC1 SKNHCWJVEVFGPD-UHFFFAOYSA-N 0.000 claims description 6
- VQVRPTDMHPGHAT-UHFFFAOYSA-N N-(3-aminopropyl)-3-(1,3-benzoxazol-2-yl)-N-cyclohexylbenzenesulfonamide Chemical compound NCCCN(S(=O)(=O)C1=CC(=CC=C1)C=1OC2=C(N=1)C=CC=C2)C1CCCCC1 VQVRPTDMHPGHAT-UHFFFAOYSA-N 0.000 claims description 6
- WZAVNKTUJWXJRP-UHFFFAOYSA-N N-(3-aminopropyl)-3-(1H-benzimidazol-2-yl)-N-cyclohexylbenzenesulfonamide Chemical compound NCCCN(S(=O)(=O)C1=CC(=CC=C1)C1=NC2=C(N1)C=CC=C2)C1CCCCC1 WZAVNKTUJWXJRP-UHFFFAOYSA-N 0.000 claims description 6
- ZJLUMTQLKMGGTD-UHFFFAOYSA-N N-(3-aminopropyl)-3-(5-chloro-1,3-benzoxazol-2-yl)-N-cyclohexylbenzenesulfonamide Chemical compound NCCCN(S(=O)(=O)C1=CC(=CC=C1)C=1OC2=C(N=1)C=C(C=C2)Cl)C1CCCCC1 ZJLUMTQLKMGGTD-UHFFFAOYSA-N 0.000 claims description 6
- YQLKSGYGOUHIBS-UHFFFAOYSA-N N-(3-aminopropyl)-N-cyclohexyl-3-(5,6-dichloro-1,3-benzoxazol-2-yl)benzenesulfonamide Chemical compound NCCCN(C1CCCCC1)S(=O)(=O)C1=CC(=CC=C1)C1=NC2=C(O1)C=C(Cl)C(Cl)=C2 YQLKSGYGOUHIBS-UHFFFAOYSA-N 0.000 claims description 6
- XBPKPFRJVBGDIB-UHFFFAOYSA-N N-(3-aminopropyl)-N-cyclohexyl-3-(7-hydroxy-1,3-benzoxazol-2-yl)benzenesulfonamide Chemical compound NCCCN(C1CCCCC1)S(=O)(=O)C1=CC(=CC=C1)C1=NC2=C(O1)C(O)=CC=C2 XBPKPFRJVBGDIB-UHFFFAOYSA-N 0.000 claims description 6
- JYNGSLZZBQVTTA-UHFFFAOYSA-N N-(3-aminopropyl)-N-cyclohexyl-3-(7-methoxy-1,3-benzoxazol-2-yl)benzenesulfonamide Chemical compound COC1=CC=CC2=C1OC(=N2)C1=CC=CC(=C1)S(=O)(=O)N(CCCN)C1CCCCC1 JYNGSLZZBQVTTA-UHFFFAOYSA-N 0.000 claims description 6
- XQOVKULQDAYXSB-UHFFFAOYSA-N N-(3-aminopropyl)-N-cyclohexyl-3-([1,3]thiazolo[4,5-c]pyridin-2-yl)benzenesulfonamide Chemical compound NCCCN(S(=O)(=O)C1=CC(=CC=C1)C=1SC2=C(C=NC=C2)N=1)C1CCCCC1 XQOVKULQDAYXSB-UHFFFAOYSA-N 0.000 claims description 6
- VGJCGHLBTFIAHQ-UHFFFAOYSA-N N-(3-aminopropyl)-N-cyclohexyl-3-([1,3]thiazolo[5,4-b]pyridin-2-yl)benzenesulfonamide Chemical compound NCCCN(S(=O)(=O)C1=CC(=CC=C1)C=1SC2=NC=CC=C2N=1)C1CCCCC1 VGJCGHLBTFIAHQ-UHFFFAOYSA-N 0.000 claims description 6
- XSBODKWMBFFHRA-UHFFFAOYSA-N N-(3-piperidin-1-ylsulfonylphenyl)-1H-indazol-3-amine Chemical compound N1(CCCCC1)S(=O)(=O)C=1C=C(C=CC=1)NC1=NNC2=CC=CC=C12 XSBODKWMBFFHRA-UHFFFAOYSA-N 0.000 claims description 6
- ZYWQEYDMKGSLNI-UHFFFAOYSA-N N-(4-aminobutyl)-3-(5-chloro-1,3-benzoxazol-2-yl)-N-cyclohexylbenzenesulfonamide Chemical compound NCCCCN(S(=O)(=O)C1=CC(=CC=C1)C=1OC2=C(N=1)C=C(C=C2)Cl)C1CCCCC1 ZYWQEYDMKGSLNI-UHFFFAOYSA-N 0.000 claims description 6
- PSAYXBKQGPVIKZ-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(2,3-dihydroindol-1-ylsulfonyl)benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(=O)(=O)N1CCC2=CC=CC=C12)=O)O PSAYXBKQGPVIKZ-UHFFFAOYSA-N 0.000 claims description 6
- VCHFMWIFHZYNJL-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethylsulfamoyl)benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(NCCO)(=O)=O)=O)O VCHFMWIFHZYNJL-UHFFFAOYSA-N 0.000 claims description 6
- ODFNTSAXCLYUMC-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(2-phenylethylsulfamoyl)benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(NCCC1=CC=CC=C1)(=O)=O)=O)O ODFNTSAXCLYUMC-UHFFFAOYSA-N 0.000 claims description 6
- WKOKQTGBNCDUFW-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(4-hydroxybutylsulfamoyl)benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(NCCCCO)(=O)=O)=O)O WKOKQTGBNCDUFW-UHFFFAOYSA-N 0.000 claims description 6
- SJSJAUZZQKWXCO-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(4-methylpiperazin-1-yl)sulfonylbenzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(=O)(=O)N1CCN(CC1)C)=O)O SJSJAUZZQKWXCO-UHFFFAOYSA-N 0.000 claims description 6
- CPUUQWUOEFRQFU-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(4-phenylbutylsulfamoyl)benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(NCCCCC1=CC=CC=C1)(=O)=O)=O)O CPUUQWUOEFRQFU-UHFFFAOYSA-N 0.000 claims description 6
- SWHYSVGDGMKLDY-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(4-phenylpiperazin-1-yl)sulfonylbenzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(=O)(=O)N1CCN(CC1)C1=CC=CC=C1)=O)O SWHYSVGDGMKLDY-UHFFFAOYSA-N 0.000 claims description 6
- JHQTWVLMLXSFAC-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(4-pyrimidin-2-ylpiperazin-1-yl)sulfonylbenzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(=O)(=O)N1CCN(CC1)C1=NC=CC=N1)=O)O JHQTWVLMLXSFAC-UHFFFAOYSA-N 0.000 claims description 6
- UKBQJWGCMHJUNP-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(cyclohexylsulfamoyl)-4-methylbenzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=C(C=C1)C)S(NC1CCCCC1)(=O)=O)=O)O UKBQJWGCMHJUNP-UHFFFAOYSA-N 0.000 claims description 6
- JQKKPOQUCBUVLT-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-(cyclohexylsulfamoyl)benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(NC1CCCCC1)(=O)=O)=O)O JQKKPOQUCBUVLT-UHFFFAOYSA-N 0.000 claims description 6
- ROYDSOGSKVIXLQ-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-[cyclohexyl(3-phenylpropyl)sulfamoyl]benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(N(CCCC1=CC=CC=C1)C1CCCCC1)(=O)=O)=O)O ROYDSOGSKVIXLQ-UHFFFAOYSA-N 0.000 claims description 6
- LNXNOLHQOIRQAJ-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-[cyclohexyl(5-phenylpentyl)sulfamoyl]benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(N(CCCCCC1=CC=CC=C1)C1CCCCC1)(=O)=O)=O)O LNXNOLHQOIRQAJ-UHFFFAOYSA-N 0.000 claims description 6
- KBOSONRAZKXKLK-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-[cyclohexyl-[3-(dimethylamino)propyl]sulfamoyl]benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(N(CCCN(C)C)C1CCCCC1)(=O)=O)=O)O KBOSONRAZKXKLK-UHFFFAOYSA-N 0.000 claims description 6
- MSYGVBVYHRTLNA-UHFFFAOYSA-N N-(5-chloro-2-hydroxyphenyl)-3-[cyclopentyl(methyl)sulfamoyl]benzamide Chemical compound ClC=1C=CC(=C(C=1)NC(C1=CC(=CC=C1)S(N(C)C1CCCC1)(=O)=O)=O)O MSYGVBVYHRTLNA-UHFFFAOYSA-N 0.000 claims description 6
- MLQRPLLANXCIDR-UHFFFAOYSA-N n-(5-chloro-2-hydroxyphenyl)-3-(dimethylsulfamoyl)benzamide Chemical compound CN(C)S(=O)(=O)C1=CC=CC(C(=O)NC=2C(=CC=C(Cl)C=2)O)=C1 MLQRPLLANXCIDR-UHFFFAOYSA-N 0.000 claims description 6
- FEQDTMZRXYQMKY-UHFFFAOYSA-N n-(5-chloro-2-hydroxyphenyl)-3-[cyclohexyl(methyl)sulfamoyl]benzamide Chemical compound C=1C=CC(C(=O)NC=2C(=CC=C(Cl)C=2)O)=CC=1S(=O)(=O)N(C)C1CCCCC1 FEQDTMZRXYQMKY-UHFFFAOYSA-N 0.000 claims description 6
- ARRZHUJAOCFWDX-UHFFFAOYSA-N n-(5-chloro-2-hydroxyphenyl)-3-pyrrolidin-1-ylsulfonylbenzamide Chemical compound OC1=CC=C(Cl)C=C1NC(=O)C1=CC=CC(S(=O)(=O)N2CCCC2)=C1 ARRZHUJAOCFWDX-UHFFFAOYSA-N 0.000 claims description 6
- JNSIZFZAZJGPHD-UHFFFAOYSA-N tert-butyl 2-[[3-[(5-chloro-2-hydroxyphenyl)carbamoyl]phenyl]sulfonyl-cyclohexylamino]acetate Chemical compound ClC=1C=CC(=C(C=1)NC(=O)C=1C=C(C=CC=1)S(=O)(=O)N(CC(=O)OC(C)(C)C)C1CCCCC1)O JNSIZFZAZJGPHD-UHFFFAOYSA-N 0.000 claims description 6
- NNQFZEWDOULIIG-UHFFFAOYSA-N 4-chloro-2-[4-(3-piperidin-1-ylsulfonylphenyl)triazol-1-yl]phenol Chemical compound ClC1=CC(=C(C=C1)O)N1N=NC(=C1)C1=CC(=CC=C1)S(=O)(=O)N1CCCCC1 NNQFZEWDOULIIG-UHFFFAOYSA-N 0.000 claims description 4
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2015
- 2015-07-30 BR BR112017002001-7A patent/BR112017002001B1/pt active IP Right Grant
- 2015-07-30 WO PCT/EP2015/067510 patent/WO2016016370A1/en not_active Ceased
- 2015-07-30 CN CN201580052077.6A patent/CN107001283B/zh active Active
- 2015-07-30 AU AU2015295288A patent/AU2015295288B2/en active Active
- 2015-07-30 US US15/500,174 patent/US10065937B2/en active Active
- 2015-07-30 RU RU2017102713A patent/RU2710928C2/ru active
- 2015-07-30 EP EP15744234.4A patent/EP3174859B1/en active Active
- 2015-07-30 CA CA2956417A patent/CA2956417C/en active Active
- 2015-07-30 JP JP2017504815A patent/JP2017523972A/ja active Pending
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2019
- 2019-11-13 JP JP2019205835A patent/JP6967054B2/ja active Active
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