CN101848899B - 作为lxr调节剂的n-苄基，n′-芳基羰基哌嗪衍生物 - Google Patents

作为lxr调节剂的n-苄基，n′-芳基羰基哌嗪衍生物 Download PDF

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CN101848899B
CN101848899B CN200880101573.6A CN200880101573A CN101848899B CN 101848899 B CN101848899 B CN 101848899B CN 200880101573 A CN200880101573 A CN 200880101573A CN 101848899 B CN101848899 B CN 101848899B
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methyl
tert
piperazin
benzamide
butyl
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CN101848899A (zh
Inventor
K-K·霍
A·L·拉夫腾
I·尼古
J-H·单
N·安萨瑞
M·L·莫瑞斯
荣亚京
M·欧梅尔
A·J·库克
A·S·爱德伍兹
D·J·本尼特
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LETOURNEAU JEFFREY CO Ltd
Merck Sharp and Dohme BV
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LETOURNEAU JEFFREY CO Ltd
MSD Oss BV
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US8314091B2 (en) 2007-08-20 2012-11-20 Msd Oss B.V. N-benzyl,N'-arylcarbonylpiperazine derivatives
TW201022230A (en) * 2008-08-28 2010-06-16 Organon Nv 1-(4-ureidobenzoyl)piperazine derivatives
BRPI1016232A2 (pt) * 2009-04-29 2023-04-11 Kowa Co Composto de carbinol, medicamento, regulador de lxr, composição farmacêutica, método para prevenir e/ou tratar doenças, e, uso do composto de carbinol
US8242260B2 (en) 2009-08-28 2012-08-14 Novartis Ag Compounds and compositions as protein kinase inhibitors
US20130274212A1 (en) 2010-09-07 2013-10-17 Snu R&Db Foundation Sesterterpene Compounds and Use Thereof
EP3626309B1 (en) 2012-08-13 2023-03-08 The Rockefeller University Lxrbeta agonist for the treatment of cancer
CN103159687A (zh) * 2013-04-12 2013-06-19 苏州科捷生物医药有限公司 一种2-胺基吡嗪-5甲酸的合成方法
CA3010883A1 (en) 2016-01-11 2017-07-20 The Rockefeller University Methods for the treatment of myeloid derived suppressor cells related disorders
AU2018373028A1 (en) 2017-11-21 2020-04-30 Inspirna, Inc. Polymorphs and uses thereof
WO2021119397A1 (en) 2019-12-13 2021-06-17 Rgenix, Inc. Metal salts and uses thereof
WO2023240376A1 (zh) * 2022-06-12 2023-12-21 中国医学科学院药物研究所 肠道上皮细胞核受体抑制子NCoR作为靶标在筛选药物中的应用

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WO2003015774A1 (en) * 2001-08-17 2003-02-27 Astrazeneca Ab Compounds effecting glucokinase
WO2007051920A1 (fr) * 2005-11-02 2007-05-10 Clinigenetics Composes de type methanone et leur utilisation dans des compositions pharmaceutiques notamment pour le traitement des maladies cardiovasculaires
US20070142369A1 (en) * 2005-12-21 2007-06-21 Margaret Van Heek Combination of an H3 antagonist/inverse agonist and an appetite suppressant
WO2007092065A2 (en) * 2005-11-14 2007-08-16 Irm Llc Compounds and compositions as lxr modulators

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BR0209932A (pt) * 2001-05-22 2004-10-13 Neurogen Corp Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, preparação farmacêutica embalada, métodos para modular ligação de mch a um receptor de mch e de mvc, para alterar a atividade de transdução de sinal de um receptor de mch em uma célula, para tratar uma doença ou distúrbio associado com a ativação de receptor de mch patogênico obesidade e para determinar a presença ou ausência de receptor de mch em uma amostra, e, uso de um composto

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EP0742208A1 (en) * 1995-05-05 1996-11-13 Grelan Pharmaceutical Co., Ltd. 2-Ureido-benzamide derivatives
WO2003015774A1 (en) * 2001-08-17 2003-02-27 Astrazeneca Ab Compounds effecting glucokinase
WO2007051920A1 (fr) * 2005-11-02 2007-05-10 Clinigenetics Composes de type methanone et leur utilisation dans des compositions pharmaceutiques notamment pour le traitement des maladies cardiovasculaires
WO2007092065A2 (en) * 2005-11-14 2007-08-16 Irm Llc Compounds and compositions as lxr modulators
US20070142369A1 (en) * 2005-12-21 2007-06-21 Margaret Van Heek Combination of an H3 antagonist/inverse agonist and an appetite suppressant

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