JP2018048143A5 - - Google Patents
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- Publication number
- JP2018048143A5 JP2018048143A5 JP2017183651A JP2017183651A JP2018048143A5 JP 2018048143 A5 JP2018048143 A5 JP 2018048143A5 JP 2017183651 A JP2017183651 A JP 2017183651A JP 2017183651 A JP2017183651 A JP 2017183651A JP 2018048143 A5 JP2018048143 A5 JP 2018048143A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- group
- methyl
- urea
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014217540 | 2014-10-24 | ||
| JP2014217540 | 2014-10-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Division JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018048143A JP2018048143A (ja) | 2018-03-29 |
| JP2018048143A5 true JP2018048143A5 (enExample) | 2018-11-15 |
| JP6627835B2 JP6627835B2 (ja) | 2020-01-08 |
Family
ID=55761020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Active JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
| JP2017183651A Expired - Fee Related JP6627835B2 (ja) | 2014-10-24 | 2017-09-25 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Active JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9809544B2 (enExample) |
| EP (1) | EP3210969B1 (enExample) |
| JP (2) | JP6217866B2 (enExample) |
| KR (1) | KR20170076673A (enExample) |
| CN (1) | CN107108485B (enExample) |
| AU (1) | AU2015336458B2 (enExample) |
| BR (1) | BR112017008178A2 (enExample) |
| CA (1) | CA2965467A1 (enExample) |
| ES (1) | ES2871673T3 (enExample) |
| IL (1) | IL251827B (enExample) |
| MX (1) | MX373603B (enExample) |
| PH (1) | PH12017500737B1 (enExample) |
| RU (1) | RU2712163C2 (enExample) |
| SG (1) | SG11201703284XA (enExample) |
| TW (1) | TWI664166B (enExample) |
| WO (1) | WO2016063990A1 (enExample) |
| ZA (1) | ZA201703498B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017008178A2 (pt) * | 2014-10-24 | 2017-12-19 | Ono Pharmaceutical Co | ativador do canal de kcnq2-5 |
| JP6943239B2 (ja) * | 2016-04-22 | 2021-09-29 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル活性化剤 |
| JP6197971B1 (ja) * | 2016-04-22 | 2017-09-20 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤 |
| BR112018071654A2 (pt) * | 2016-04-22 | 2019-02-19 | Ono Pharmaceutical Co., Ltd. | polimorfismo de cristal do ativador de canais kcnq2-5 |
| CN118078835A (zh) * | 2017-12-21 | 2024-05-28 | 杏林制药株式会社 | 用于夜间尿频的治疗剂 |
| CN109232380B (zh) * | 2018-10-22 | 2021-08-10 | 新乡市润宇新材料科技有限公司 | 一种4-溴咔唑的合成方法 |
| CN109232383B (zh) * | 2018-12-04 | 2022-02-01 | 河南省科学院高新技术研究中心 | 一种合成4-溴咔唑的方法 |
| FI3921030T3 (fi) * | 2019-02-06 | 2024-01-08 | Lilly Co Eli | 1-((2-(2,2,2-trifluorietoksi)pyridin-4-yyli)metyyli)ureajohdannaisia kcnq:n tehostajina |
| WO2021260090A1 (en) * | 2020-06-25 | 2021-12-30 | Idorsia Pharmaceuticals Ltd | Cyclobutyl-urea derivatives |
| AU2022292554A1 (en) * | 2021-06-14 | 2024-01-04 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES442992A1 (es) * | 1974-12-02 | 1977-08-01 | Scherico Ltd | Un procedimiento para preparar 2-anilino-oxazolinas. |
| US4058612A (en) * | 1974-12-02 | 1977-11-15 | Schering Corporation | 6-(Polyhaloisopropyl)quinazoline-2,4-diones |
| CH623044A5 (en) | 1974-12-02 | 1981-05-15 | Scherico Ltd | Process for the preparation of novel anilino-2-oxazolines |
| JP4503232B2 (ja) * | 2001-01-26 | 2010-07-14 | 中外製薬株式会社 | マロニル−ＣｏＡ脱炭酸酵素阻害剤を用いた疾患の治療法 |
| CA2735267C (en) | 2001-01-26 | 2013-05-07 | Chugai Seiyaku Kabushiki Kaisha | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| JP2003192660A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| US20050154230A1 (en) * | 2001-12-26 | 2005-07-14 | Bayer Healthcare Ag | Urea derivatives |
| CA2511970C (en) | 2003-01-14 | 2012-06-26 | Cytokinetics, Inc. | Urea derivatives useful in the treatment of heart failure |
| UA89503C2 (uk) | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| BRPI0615631A2 (pt) * | 2005-09-09 | 2011-05-24 | Lundbeck & Co As H | composto, composição farmacêutica, e, uso de uma composição farmacêutica |
| UA97847C2 (ru) * | 2007-08-01 | 2012-03-26 | Х. Луннбек А/С | Применение соединений, которые открывают калиевые каналы kcnq, для лечения дефицита внимания/гиперактивности (adhd) или агрессии |
| JP2010037311A (ja) | 2008-08-08 | 2010-02-18 | Bayer Cropscience Ag | 新規殺虫性アシルアミノベンズアミド誘導体 |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| WO2011085351A2 (en) | 2010-01-11 | 2011-07-14 | The Johns Hopkins University | Method of treating kcnq related disorders |
| SI2523669T1 (sl) | 2010-01-11 | 2017-05-31 | Inotek Pharmaceuticals Corporation | Kombinacija, komplet in metoda za zmanjšanje intraokularnega tlaka |
| CN103842357A (zh) * | 2011-07-26 | 2014-06-04 | 格吕伦塔尔有限公司 | 作为类香草素受体配体的被取代的、含有杂芳环吡唑的羧酰胺和脲衍生物 |
| AP2014007670A0 (en) * | 2011-11-02 | 2014-05-31 | Boehringer Ingelheim Int | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| BR112017008178A2 (pt) * | 2014-10-24 | 2017-12-19 | Ono Pharmaceutical Co | ativador do canal de kcnq2-5 |
-
2015
- 2015-10-23 BR BR112017008178A patent/BR112017008178A2/pt not_active Application Discontinuation
- 2015-10-23 CA CA2965467A patent/CA2965467A1/en not_active Abandoned
- 2015-10-23 AU AU2015336458A patent/AU2015336458B2/en not_active Ceased
- 2015-10-23 RU RU2017117566A patent/RU2712163C2/ru active
- 2015-10-23 KR KR1020177010846A patent/KR20170076673A/ko not_active Withdrawn
- 2015-10-23 US US15/515,243 patent/US9809544B2/en not_active Expired - Fee Related
- 2015-10-23 WO PCT/JP2015/080034 patent/WO2016063990A1/ja not_active Ceased
- 2015-10-23 MX MX2017005044A patent/MX373603B/es active IP Right Grant
- 2015-10-23 TW TW104134839A patent/TWI664166B/zh not_active IP Right Cessation
- 2015-10-23 EP EP15852712.7A patent/EP3210969B1/en active Active
- 2015-10-23 ES ES15852712T patent/ES2871673T3/es active Active
- 2015-10-23 SG SG11201703284XA patent/SG11201703284XA/en unknown
- 2015-10-23 JP JP2016555419A patent/JP6217866B2/ja active Active
- 2015-10-23 CN CN201580057252.0A patent/CN107108485B/zh not_active Expired - Fee Related
-
2017
- 2017-04-20 IL IL251827A patent/IL251827B/en active IP Right Grant
- 2017-04-21 PH PH12017500737A patent/PH12017500737B1/en unknown
- 2017-05-22 ZA ZA2017/03498A patent/ZA201703498B/en unknown
- 2017-08-08 US US15/671,428 patent/US10196358B2/en not_active Expired - Fee Related
- 2017-09-25 JP JP2017183651A patent/JP6627835B2/ja not_active Expired - Fee Related
-
2018
- 2018-08-09 US US16/059,270 patent/US10676438B2/en not_active Expired - Fee Related
-
2020
- 2020-01-24 US US16/752,076 patent/US20200157050A1/en not_active Abandoned