JP6217866B2 - Ｋｃｎｑ２〜５チャネル活性化剤 - Google Patents

Ｋｃｎｑ２〜５チャネル活性化剤 Download PDF

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JP6217866B2
JP6217866B2 JP2016555419A JP2016555419A JP6217866B2 JP 6217866 B2 JP6217866 B2 JP 6217866B2 JP 2016555419 A JP2016555419 A JP 2016555419A JP 2016555419 A JP2016555419 A JP 2016555419A JP 6217866 B2 JP6217866 B2 JP 6217866B2
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ethyl acetate
hexane
methyl
trifluoro
compound
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JPWO2016063990A1 (ja
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健太郎 八代
健太郎 八代
大将 若松
大将 若松
哲二 斎藤
哲二 斎藤
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Ono Pharmaceutical Co Ltd
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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SG11201703284XA (en) 2014-10-24 2017-06-29 Ono Pharmaceutical Co Kcnq2-5 channel activator
JP6197971B1 (ja) * 2016-04-22 2017-09-20 小野薬品工業株式会社 Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤
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EP3447047A1 (en) * 2016-04-22 2019-02-27 ONO Pharmaceutical Co., Ltd. Crystal polymorphism of kcnq 2-5 channel activator
JP7291632B2 (ja) * 2017-12-21 2023-06-15 杏林製薬株式会社 夜間頻尿治療剤
CN109232380B (zh) * 2018-10-22 2021-08-10 新乡市润宇新材料科技有限公司 一种4-溴咔唑的合成方法
CN109232383B (zh) * 2018-12-04 2022-02-01 河南省科学院高新技术研究中心 一种合成4-溴咔唑的方法
JP7451543B2 (ja) 2019-02-06 2024-03-18 イーライ リリー アンド カンパニー Ｋｃｎｑ増強剤としての１－（（２－（２，２，２－トリフルオロエトキシ）ピリジン－４－イル）メチル）尿素誘導体
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Family Cites Families (19)

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Publication number Priority date Publication date Assignee Title
US4058612A (en) * 1974-12-02 1977-11-15 Schering Corporation 6-(Polyhaloisopropyl)quinazoline-2,4-diones
ES442992A1 (es) * 1974-12-02 1977-08-01 Scherico Ltd Un procedimiento para preparar 2-anilino-oxazolinas.
CH623044A5 (en) 1974-12-02 1981-05-15 Scherico Ltd Process for the preparation of novel anilino-2-oxazolines
ATE509014T1 (de) * 2001-01-26 2011-05-15 Chugai Pharmaceutical Co Ltd Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
WO2002058690A2 (en) * 2001-01-26 2002-08-01 Chugai Seiyaku Kabushiki Kaisha Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors
JP2003192660A (ja) 2001-12-26 2003-07-09 Bayer Ag 尿素誘導体
WO2003055848A2 (en) 2001-12-26 2003-07-10 Bayer Healthcare Ag Urea derivatives as vr1- antagonists
US7399866B2 (en) * 2003-01-14 2008-07-15 Cytokinetics, Inc. Compounds, compositions, and methods
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
EP1937653A1 (en) * 2005-09-09 2008-07-02 H.Lundbeck A/S Pyrimidine derivatives and their use as kcnq potassium channels openers
CN101790374A (zh) 2007-08-01 2010-07-28 H.隆德贝克有限公司 Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途
JP2010037311A (ja) 2008-08-08 2010-02-18 Bayer Cropscience Ag 新規殺虫性アシルアミノベンズアミド誘導体
WO2010065333A1 (en) 2008-12-01 2010-06-10 Lexicon Pharmaceuticals, Inc. 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis
TWI475020B (zh) * 2009-03-12 2015-03-01 The substituted nicotine amide as a KCNQ2 / 3 modifier
JP2013516495A (ja) 2010-01-11 2013-05-13 イノテック ファーマシューティカルズ コーポレイション 眼圧を低下させる組合せ、キット、および方法
WO2011085351A2 (en) * 2010-01-11 2011-07-14 The Johns Hopkins University Method of treating kcnq related disorders
HK1198697A1 (en) 2011-07-26 2015-05-29 Grünenthal GmbH Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands
NO2773633T3 (enExample) * 2011-11-02 2017-12-30
SG11201703284XA (en) * 2014-10-24 2017-06-29 Ono Pharmaceutical Co Kcnq2-5 channel activator

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