CN107108485B - Kcnq2～5通道活化剂 - Google Patents

Kcnq2～5通道活化剂 Download PDF

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CN107108485B
CN107108485B CN201580057252.0A CN201580057252A CN107108485B CN 107108485 B CN107108485 B CN 107108485B CN 201580057252 A CN201580057252 A CN 201580057252A CN 107108485 B CN107108485 B CN 107108485B
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methyl
trifluoro
phenyl
dichloro
urea
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CN107108485A (zh
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八代健太郎
若松大将
斋藤哲二
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Ono Pharmaceutical Co Ltd
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Ono Pharmaceutical Co Ltd
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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CN109232383B (zh) * 2018-12-04 2022-02-01 河南省科学院高新技术研究中心 一种合成4-溴咔唑的方法
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GB1507340A (en) * 1974-12-02 1978-04-12 Scherico Ltd Hydroxypolyhaloisopropyl substituted ureido-compounds
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