TWI664166B - Ｋｃｎｑ２至５通道活化劑 - Google Patents

Ｋｃｎｑ２至５通道活化劑 Download PDF

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TWI664166B
TWI664166B TW104134839A TW104134839A TWI664166B TW I664166 B TWI664166 B TW I664166B TW 104134839 A TW104134839 A TW 104134839A TW 104134839 A TW104134839 A TW 104134839A TW I664166 B TWI664166 B TW I664166B
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Taiwan
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methyl
trifluoro
phenyl
dichloro
compound
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TW104134839A
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Chinese (zh)
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TW201625533A (zh
Inventor
八代健太郎
Kentaro YASHIRO
若松大将
Daisuke Wakamatsu
斎藤哲二
Tetsuji Saito
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日商小野藥品工業股份有限公司
Ono Pharmaceutical Co., Ltd.
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    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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EP3447047A1 (en) * 2016-04-22 2019-02-27 ONO Pharmaceutical Co., Ltd. Crystal polymorphism of kcnq 2-5 channel activator
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