JP2006522035A5 - - Google Patents
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- Publication number
- JP2006522035A5 JP2006522035A5 JP2006504584A JP2006504584A JP2006522035A5 JP 2006522035 A5 JP2006522035 A5 JP 2006522035A5 JP 2006504584 A JP2006504584 A JP 2006504584A JP 2006504584 A JP2006504584 A JP 2006504584A JP 2006522035 A5 JP2006522035 A5 JP 2006522035A5
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- JP
- Japan
- Prior art keywords
- atoms
- hal
- cycloalkyl
- unsubstituted
- het
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 125000000962 organic group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10315572A DE10315572A1 (de) | 2003-04-05 | 2003-04-05 | Substituierte Pyrazole |
| DE10315572.4 | 2003-04-05 | ||
| PCT/EP2004/002353 WO2004089931A1 (de) | 2003-04-05 | 2004-03-08 | Substituierte pyrazole |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011037046A Division JP2011148803A (ja) | 2003-04-05 | 2011-02-23 | 置換ピラゾール |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006522035A JP2006522035A (ja) | 2006-09-28 |
| JP2006522035A5 true JP2006522035A5 (enExample) | 2011-04-14 |
| JP4740115B2 JP4740115B2 (ja) | 2011-08-03 |
Family
ID=32981073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006504584A Expired - Fee Related JP4740115B2 (ja) | 2003-04-05 | 2004-03-08 | 置換ピラゾール |
| JP2011037046A Pending JP2011148803A (ja) | 2003-04-05 | 2011-02-23 | 置換ピラゾール |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011037046A Pending JP2011148803A (ja) | 2003-04-05 | 2011-02-23 | 置換ピラゾール |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060264419A1 (enExample) |
| EP (1) | EP1626967A1 (enExample) |
| JP (2) | JP4740115B2 (enExample) |
| KR (1) | KR20050119193A (enExample) |
| CN (1) | CN1768051A (enExample) |
| AR (1) | AR043837A1 (enExample) |
| AU (1) | AU2004228120B2 (enExample) |
| BR (1) | BRPI0409164A (enExample) |
| CA (1) | CA2521201A1 (enExample) |
| DE (1) | DE10315572A1 (enExample) |
| MX (1) | MXPA05010652A (enExample) |
| PL (1) | PL377844A1 (enExample) |
| WO (1) | WO2004089931A1 (enExample) |
| ZA (1) | ZA200508948B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
| DE10315571A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
| DE10315573A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| US7932272B2 (en) | 2003-09-30 | 2011-04-26 | Eisai R&D Management Co., Ltd. | Antifungal agent containing heterocyclic compound |
| US7517900B2 (en) | 2003-10-10 | 2009-04-14 | Bristol-Myers Squibb Company | Pyrazole derivatives as cannabinoid receptor modulators |
| US20050241110A1 (en) * | 2004-04-09 | 2005-11-03 | Bruce Baker | Ergonomic handles, especially for garden tools |
| US20090227799A1 (en) * | 2004-08-09 | 2009-09-10 | Kazutaka Nakamoto | Novel Antimalarial Agent Containing Heterocyclic Compound |
| WO2006106711A1 (ja) | 2005-03-30 | 2006-10-12 | Eisai R & D Management Co., Ltd. | ピリジン誘導体を含有する抗真菌剤 |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| KR101003569B1 (ko) | 2005-10-31 | 2010-12-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 헤테로환 치환 피리딘 유도체 및 이들을 함유하는 항진균제 |
| GB0524814D0 (en) * | 2005-12-05 | 2006-01-11 | Glaxo Group Ltd | Compounds |
| WO2007120600A2 (en) * | 2006-04-10 | 2007-10-25 | Arena Pharmaceuticals, Inc. | 3-pyridinyl-pyrazole derivatives as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto |
| WO2008035726A1 (en) * | 2006-09-21 | 2008-03-27 | Eisai R & D Management Co., Ltd. | Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same |
| EP1938686A1 (de) * | 2006-12-29 | 2008-07-02 | Bayer CropScience AG | Substituierte 1-(3-Pyridinyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| TW200841879A (en) | 2007-04-27 | 2008-11-01 | Eisai R&D Man Co Ltd | Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same |
| EP2143723A4 (en) | 2007-04-27 | 2011-05-18 | Eisai R&D Man Co Ltd | SALT OF A PYRIDINE DERIVATIVE SUBSTITUTED BY HETEROCYCLE OR CRYSTALS OF THE SAME |
| US7977358B2 (en) | 2007-07-26 | 2011-07-12 | Hoffmann-La Roche Inc. | Pyrazol derivatives |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| EP2135865A1 (de) * | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| US20110201649A1 (en) * | 2008-09-19 | 2011-08-18 | Sumitomo Chemical Company, Limited | agricultural composition |
| US8188119B2 (en) | 2008-10-24 | 2012-05-29 | Eisai R&D Management Co., Ltd | Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same |
| EP2194052A1 (de) | 2008-12-06 | 2010-06-09 | Bayer CropScience AG | Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| WO2011073098A1 (de) | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
| ES2565193T3 (es) | 2010-07-15 | 2016-04-01 | Sumitomo Dainippon Pharma Co., Ltd. | Compuesto de pirazol |
| US9120757B2 (en) | 2013-03-14 | 2015-09-01 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| HRP20202008T1 (hr) | 2013-03-14 | 2021-02-19 | Epizyme, Inc. | Inhibitori arginin-metiltransferaze i njihove uporabe |
| WO2014144659A1 (en) | 2013-03-14 | 2014-09-18 | Epizyme, Inc. | Pyrazole derivatives as prmt1 inhibitors and uses thereof |
| WO2014153235A2 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| AU2014260433A1 (en) | 2013-03-14 | 2015-09-10 | Epizyme, Inc. | Pyrazole derivatives as arginine methyltransferase inhibitors and uses thereof |
| WO2014153208A1 (en) | 2013-03-14 | 2014-09-25 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9133189B2 (en) | 2013-03-14 | 2015-09-15 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| US9447079B2 (en) | 2013-03-14 | 2016-09-20 | Epizyme, Inc. | PRMT1 inhibitors and uses thereof |
| US9365527B2 (en) | 2013-03-14 | 2016-06-14 | Epizyme, Inc. | Arginine methyltransferase inhibitors and uses thereof |
| JP2016518336A (ja) * | 2013-03-14 | 2016-06-23 | エピザイム，インコーポレイティド | Ｐｒｍｔ１阻害剤としてのピラゾール誘導体およびその使用 |
| EP3886854A4 (en) | 2018-11-30 | 2022-07-06 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN116554144B (zh) * | 2022-01-27 | 2025-12-19 | 司马健 | 一种sj系列芳基苯胺类化合物及其制备方法与医药用途 |
| DE202022104072U1 (de) | 2022-07-19 | 2022-07-29 | Siva Subramanian Narayanasamy | Heterozyklisch substituierte pyridinderivate antimykotische Mittel |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146721A (en) * | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
| BE793955A (fr) * | 1972-01-15 | 1973-07-12 | Merck Patent Gmbh | Arylpiperazines et leur procede de preparation |
| DE2906252A1 (de) * | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
| US4631343A (en) * | 1983-11-07 | 1986-12-23 | Eli Lilly And Company | Cyanopyrazole intermediates |
| ES2206571T3 (es) * | 1995-04-20 | 2004-05-16 | G.D. SEARLE & CO. | Agentes de amidino ciclico utiles como inhibidores de la oxido nitrico sintasa. |
| US6150393A (en) * | 1998-12-18 | 2000-11-21 | Arena Pharmaceuticals, Inc. | Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors |
| US20010044445A1 (en) * | 1999-04-08 | 2001-11-22 | Bamaung Nwe Y. | Azole inhibitors of cytokine production |
| US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| BR0210391A (pt) * | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
| DE10149370A1 (de) * | 2001-10-06 | 2003-04-10 | Merck Patent Gmbh | Pyrazolderivate |
| MXPA04009352A (es) * | 2002-04-18 | 2005-01-25 | Pharmacia Corp | Terapia de combinacion para el tratamiento de la enfermedad de parkinson con inhibidores de ciclooxigenasa-2 (cox2). |
| DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
| DE10315571A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
| DE10315573A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| US20070093492A1 (en) * | 2004-03-09 | 2007-04-26 | Weir-Torn Jiaang | Pyrrolidine derivatives |
-
2003
- 2003-04-05 DE DE10315572A patent/DE10315572A1/de not_active Withdrawn
-
2004
- 2004-03-08 JP JP2006504584A patent/JP4740115B2/ja not_active Expired - Fee Related
- 2004-03-08 MX MXPA05010652A patent/MXPA05010652A/es not_active Application Discontinuation
- 2004-03-08 EP EP04718277A patent/EP1626967A1/de not_active Withdrawn
- 2004-03-08 CA CA002521201A patent/CA2521201A1/en not_active Abandoned
- 2004-03-08 AU AU2004228120A patent/AU2004228120B2/en not_active Ceased
- 2004-03-08 KR KR1020057018895A patent/KR20050119193A/ko not_active Withdrawn
- 2004-03-08 CN CNA2004800085729A patent/CN1768051A/zh active Pending
- 2004-03-08 US US10/552,065 patent/US20060264419A1/en not_active Abandoned
- 2004-03-08 BR BRPI0409164-7A patent/BRPI0409164A/pt not_active Application Discontinuation
- 2004-03-08 WO PCT/EP2004/002353 patent/WO2004089931A1/de not_active Ceased
- 2004-03-08 PL PL377844A patent/PL377844A1/pl unknown
- 2004-04-02 AR ARP040101119A patent/AR043837A1/es unknown
-
2005
- 2005-11-04 ZA ZA200508948A patent/ZA200508948B/en unknown
-
2011
- 2011-02-23 JP JP2011037046A patent/JP2011148803A/ja active Pending