JP2008523126A5 - - Google Patents

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Publication number
JP2008523126A5
JP2008523126A5 JP2007545891A JP2007545891A JP2008523126A5 JP 2008523126 A5 JP2008523126 A5 JP 2008523126A5 JP 2007545891 A JP2007545891 A JP 2007545891A JP 2007545891 A JP2007545891 A JP 2007545891A JP 2008523126 A5 JP2008523126 A5 JP 2008523126A5
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JP
Japan
Prior art keywords
lower alkyl
halogen
hydrogen
substituted
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007545891A
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English (en)
Japanese (ja)
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JP4709849B2 (ja
JP2008523126A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/EP2005/012994 external-priority patent/WO2006063709A1/en
Publication of JP2008523126A publication Critical patent/JP2008523126A/ja
Publication of JP2008523126A5 publication Critical patent/JP2008523126A5/ja
Application granted granted Critical
Publication of JP4709849B2 publication Critical patent/JP4709849B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2007545891A 2004-12-15 2005-12-05 アルツハイマー病治療のためのグリシントランスポーターｉ（ｇｌｙｔ−１）インヒビターとしての二環式及び三環式置換フェニルメタノン類 Expired - Fee Related JP4709849B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04106597 2004-12-15
EP04106597.0 2004-12-15
PCT/EP2005/012994 WO2006063709A1 (en) 2004-12-15 2005-12-05 Bi- and tricyclic substituted phenyl methanones as glycine transporter i (glyt-1) inhibitors for the treatment of alzheimer’s disease

Publications (3)

Publication Number Publication Date
JP2008523126A JP2008523126A (ja) 2008-07-03
JP2008523126A5 true JP2008523126A5 (enExample) 2009-02-19
JP4709849B2 JP4709849B2 (ja) 2011-06-29

Family

ID=35841863

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007545891A Expired - Fee Related JP4709849B2 (ja) 2004-12-15 2005-12-05 アルツハイマー病治療のためのグリシントランスポーターｉ（ｇｌｙｔ−１）インヒビターとしての二環式及び三環式置換フェニルメタノン類

Country Status (20)

Country Link
US (1) US7375226B2 (enExample)
EP (1) EP1828200B1 (enExample)
JP (1) JP4709849B2 (enExample)
KR (1) KR100883003B1 (enExample)
CN (1) CN100586951C (enExample)
AR (1) AR052156A1 (enExample)
AT (1) ATE457989T1 (enExample)
AU (1) AU2005315914B2 (enExample)
BR (1) BRPI0519054A2 (enExample)
CA (1) CA2590316A1 (enExample)
DE (1) DE602005019465D1 (enExample)
ES (1) ES2338139T3 (enExample)
IL (1) IL183592A0 (enExample)
MX (1) MX2007006896A (enExample)
NO (1) NO20072833L (enExample)
NZ (1) NZ555476A (enExample)
RU (1) RU2007121768A (enExample)
TW (1) TWI299041B (enExample)
WO (1) WO2006063709A1 (enExample)
ZA (1) ZA200705044B (enExample)

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US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
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US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2014001457A (es) 2011-08-05 2014-08-21 Abbvie Deutschland Derivados de aminocromano, de aminotiocromano y de amino-1,2,3,4-tetrahidroquinolina composiciones farmaceuticas que los contienen, y su uso en terapia.
WO2013072520A1 (en) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9403835B2 (en) * 2011-12-22 2016-08-02 Ares Trading S.A. Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
SG11201405328SA (en) 2012-03-16 2014-11-27 Vitae Pharmaceuticals Inc Liver x receptor modulators
ES2607113T3 (es) 2012-03-16 2017-03-29 Vitae Pharmaceuticals, Inc. Moduladores de los receptores X del hígado
US9428506B2 (en) 2012-04-14 2016-08-30 Intra-Cellular Therapies, Inc. Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2014145192A1 (en) 2013-03-15 2014-09-18 Intra-Cellular Therapies, Inc. Organic compounds
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
CA2924689A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2016533375A (ja) 2013-10-17 2016-10-27 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー アミノテトラリン誘導体およびアミノインダン誘導体、これらを含有する医薬組成物、および治療におけるこれらの使用
KR102967223B1 (ko) 2013-12-03 2026-05-19 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
US9745300B2 (en) 2014-04-04 2017-08-29 Intra-Cellular Therapies, Inc. Organic compounds
KR20220054908A (ko) 2014-04-04 2022-05-03 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
RU2743513C2 (ru) 2016-01-26 2021-02-19 Интра-Селлулар Терапиз, Инк. Органические соединения
IL281050B2 (en) 2016-03-25 2023-04-01 Intra Cellular Therapies Inc A controlled or delayed release pharmaceutical preparation containing a deuterated compound
WO2017172811A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel co-crystals
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
WO2017172784A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel salts and crystals
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
EP3562484B1 (en) 2016-12-29 2021-08-25 Intra-Cellular Therapies, Inc. Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders
EP3600325A4 (en) 2017-03-24 2021-01-06 Intra-Cellular Therapies, Inc. UNIQUE COMPOSITIONS AND PROCESSES
WO2019023062A1 (en) 2017-07-26 2019-01-31 Intra-Cellular Therapies, Inc. ORGANIC COMPOUNDS
JP7224333B2 (ja) 2017-07-26 2023-02-17 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
AU2019240226B2 (en) 2018-03-23 2024-11-28 Intra-Cellular Therapies, Inc. Organic compounds
SMT202600133T1 (it) 2018-03-23 2026-05-12 Intra Cellular Therapies Inc Composti organici
BR112020024885A2 (pt) 2018-06-06 2021-03-09 Intra-Cellular Therapies, Inc. Novos sais e cristais
EP3801527B1 (en) 2018-06-08 2025-02-19 Intra-Cellular Therapies, Inc. Fused gamma-carbolines for acute treatment of anxiety or depression
RS67906B1 (sr) 2018-06-11 2026-04-30 Intra Cellular Therapies Inc Sinteza supstituisanih heterociklično fuzionisanih gama-karbolina
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
AU2019328528B2 (en) 2018-08-31 2025-01-23 Intra-Cellular Therapies, Inc. Novel methods
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
IL315005B2 (en) 2018-12-17 2026-04-01 Intra Cellular Therapies Inc Substituted heterocycle fused gamma-carbolines synthesis
ES3047409T3 (en) 2018-12-17 2025-12-03 Intra Cellular Therapies Inc Substituted heterocycle fused gamma-carbolines synthesis
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US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods

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