JP2008523126A5 - - Google Patents

Download PDF

Info

Publication number
JP2008523126A5
JP2008523126A5 JP2007545891A JP2007545891A JP2008523126A5 JP 2008523126 A5 JP2008523126 A5 JP 2008523126A5 JP 2007545891 A JP2007545891 A JP 2007545891A JP 2007545891 A JP2007545891 A JP 2007545891A JP 2008523126 A5 JP2008523126 A5 JP 2008523126A5
Authority
JP
Japan
Prior art keywords
lower alkyl
halogen
hydrogen
substituted
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007545891A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008523126A (ja
JP4709849B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2005/012994 external-priority patent/WO2006063709A1/en
Publication of JP2008523126A publication Critical patent/JP2008523126A/ja
Publication of JP2008523126A5 publication Critical patent/JP2008523126A5/ja
Application granted granted Critical
Publication of JP4709849B2 publication Critical patent/JP4709849B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2007545891A 2004-12-15 2005-12-05 アルツハイマー病治療のためのグリシントランスポーターｉ（ｇｌｙｔ−１）インヒビターとしての二環式及び三環式置換フェニルメタノン類 Expired - Fee Related JP4709849B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04106597 2004-12-15
EP04106597.0 2004-12-15
PCT/EP2005/012994 WO2006063709A1 (en) 2004-12-15 2005-12-05 Bi- and tricyclic substituted phenyl methanones as glycine transporter i (glyt-1) inhibitors for the treatment of alzheimer’s disease

Publications (3)

Publication Number Publication Date
JP2008523126A JP2008523126A (ja) 2008-07-03
JP2008523126A5 true JP2008523126A5 (enExample) 2009-02-19
JP4709849B2 JP4709849B2 (ja) 2011-06-29

Family

ID=35841863

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007545891A Expired - Fee Related JP4709849B2 (ja) 2004-12-15 2005-12-05 アルツハイマー病治療のためのグリシントランスポーターｉ（ｇｌｙｔ−１）インヒビターとしての二環式及び三環式置換フェニルメタノン類

Country Status (20)

Country Link
US (1) US7375226B2 (enExample)
EP (1) EP1828200B1 (enExample)
JP (1) JP4709849B2 (enExample)
KR (1) KR100883003B1 (enExample)
CN (1) CN100586951C (enExample)
AR (1) AR052156A1 (enExample)
AT (1) ATE457989T1 (enExample)
AU (1) AU2005315914B2 (enExample)
BR (1) BRPI0519054A2 (enExample)
CA (1) CA2590316A1 (enExample)
DE (1) DE602005019465D1 (enExample)
ES (1) ES2338139T3 (enExample)
IL (1) IL183592A0 (enExample)
MX (1) MX2007006896A (enExample)
NO (1) NO20072833L (enExample)
NZ (1) NZ555476A (enExample)
RU (1) RU2007121768A (enExample)
TW (1) TWI299041B (enExample)
WO (1) WO2006063709A1 (enExample)
ZA (1) ZA200705044B (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485637B2 (en) * 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
RU2338537C2 (ru) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
CN101796051B (zh) * 2007-03-12 2013-11-06 细胞内治疗公司 与取代的杂环稠合的γ-咔啉的合成
MX2010010773A (es) 2008-04-01 2011-04-11 Abbott Gmbh & Co Kg Tetrahidroisoquinolinas, composiciones farmaceuticas que las contienen y su uso en terapia.
KR101812934B1 (ko) 2009-02-06 2018-01-30 스티롤루션 유럽 게엠베하 개선된 내후성을 갖는 스티렌 공중합체 및 폴리아미드 기재 열가소성 성형 조성물
TW201038569A (en) * 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
EP2611298A4 (en) * 2010-08-31 2014-07-30 Univ Vanderbilt BICYCLIC OXAZOLE AND THIAZOL COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR-5 RECEPTORS
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2014006004A (es) 2011-11-18 2015-04-16 Abbvie Deutschland Derivados de aminobenzociclohepteno, aminotetralina, aminoindano y fenalcilamina n-sustituidas, composiciones farmaceuticas que los contienen, y su uso en terapia.
AU2012357169B2 (en) * 2011-12-22 2017-03-30 Merck Patent Gmbh Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
JP6114815B2 (ja) 2012-03-16 2017-04-12 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 肝臓ｘレセプターモジュレーター
EP2825541B1 (en) * 2012-03-16 2016-06-22 Vitae Pharmaceuticals, Inc. Liver x receptor modulators
EP2836211B1 (en) 2012-04-14 2019-03-20 Intra-Cellular Therapies, Inc. Treatment of PTSD and impulse control disorders
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
PT2968320T (pt) 2013-03-15 2021-01-28 Intra Cellular Therapies Inc Compostos orgânicos
MX2016004934A (es) 2013-10-17 2016-12-20 Abbvie Deutschland Derivados de aminotetralina y aminoindano, composiciones farmaceuticas que los contienen, y su uso en terapia.
EP3057960B1 (en) 2013-10-17 2019-02-27 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
IL321987A (en) 2013-12-03 2025-09-01 Intra Cellular Therapies Inc A long-acting injectable preparation containing polymeric microspheres of modified compressed gamma-carboline heterocyclic compounds or a sustained-release pharmaceutical preparation containing these compounds for use in the treatment of bipolar I and/or bipolar II disorders
WO2015154025A1 (en) 2014-04-04 2015-10-08 Intra-Cellular Therapies, Inc. Organic compounds
CN106456638A (zh) 2014-04-04 2017-02-22 细胞内治疗公司 有机化合物
CA3011983A1 (en) 2016-01-26 2017-08-03 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines
EP3407889B1 (en) 2016-03-25 2021-05-19 Intra-Cellular Therapies, Inc. Organic compounds and their use in treating or preventing central nervous system disorders
US10682354B2 (en) 2016-03-28 2020-06-16 Intra-Cellular Therapies, Inc. Compositions and methods
JP2019513143A (ja) 2016-03-28 2019-05-23 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規塩類および結晶
JP6997718B2 (ja) 2016-03-28 2022-01-18 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規共結晶
US11331316B2 (en) 2016-10-12 2022-05-17 Intra-Cellular Therapies, Inc. Amorphous solid dispersions
WO2018126140A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
WO2018126143A1 (en) 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Organic compounds
WO2018175969A1 (en) 2017-03-24 2018-09-27 Intra-Cellular Therapies, Inc. Novel compositions and methods
KR102899502B1 (ko) 2017-07-26 2025-12-11 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
IL272252B2 (en) 2017-07-26 2024-03-01 Intra Cellular Therapies Inc Derivatives of substituted heterocycle fused gamma-carbolines, pharmaceutical compositions comnprising them and their use in treatment
MX2020009928A (es) 2018-03-23 2021-01-08 Intra Cellular Therapies Inc Compuestos organicos.
EP3628007B1 (en) 2018-06-06 2023-05-03 Intra-Cellular Therapies, Inc. Novel salts and crystals
WO2019237037A1 (en) 2018-06-08 2019-12-12 Intra-Cellular Therapies, Inc. Novel methods
EP3609891B1 (en) 2018-06-11 2026-02-11 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
WO2020047241A1 (en) 2018-08-29 2020-03-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2020047407A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
KR20210052472A (ko) 2018-08-31 2021-05-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
AU2019403149B2 (en) 2018-12-17 2025-04-03 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines synthesis
KR102901722B1 (ko) 2018-12-17 2025-12-17 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로사이클 융합 감마-카르볼린 합성
BR112022000231A2 (pt) 2019-07-07 2022-02-22 Intra Cellular Therapies Inc Novos métodos
JP7261942B2 (ja) 2019-12-11 2023-04-20 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2423847A1 (de) 1973-05-28 1975-01-02 Ciba Geigy Ag Neue sulfamoylbenzoesaeureamide
DE2611705A1 (de) 1976-03-18 1977-09-22 Josef Dipl Chem Dr Rer N Klosa N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel
IT1176613B (it) 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
RU2124511C1 (ru) 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
JPH08325234A (ja) * 1995-05-30 1996-12-10 Yamanouchi Pharmaceut Co Ltd 安息香酸誘導体又はその塩
US6001854A (en) * 1996-05-31 1999-12-14 Allelix Neuroscience Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
PL342818A1 (en) * 1998-03-06 2001-07-02 Janssen Pharmaceutica Nv Glycin transport inhibitors
CA2322164A1 (en) * 1998-03-06 1999-09-10 Ludo Edmond Josephine Kennis Glycine transport inhibitors
EP1296950A2 (en) * 2000-04-20 2003-04-02 NPS Allelix Corp. Aminopiperidines for use as glyt-1 inhibitors
GB0021419D0 (en) 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
JP2005502623A (ja) 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペラジンおよびジアゼパン
WO2003035602A1 (en) 2001-10-25 2003-05-01 Sankyo Company, Limited Lipid modulators
TWI329111B (en) * 2002-05-24 2010-08-21 X Ceptor Therapeutics Inc Azepinoindole and pyridoindole derivatives as pharmaceutical agents
US20060052597A1 (en) 2002-10-22 2006-03-09 Best Desmond J Aryloxyalkylamine derivatives as h3 receptor ligands
AU2004263306B2 (en) 2003-08-11 2010-04-22 F. Hoffmann-La Roche Ag Piperazine with or-substituted phenyl group and their use as GLYT1 inhibitors
DK1663232T3 (da) * 2003-09-09 2008-02-04 Hoffmann La Roche Benzimidazolderivater som human chymase-inhibitorer
JP4563387B2 (ja) * 2003-09-09 2010-10-13 エフ．ホフマン−ラ ロシュ アーゲー 精神病の処置のためのグリシン取り込み阻害剤としての１−ベンゾイル−ピペラジン誘導体

Similar Documents

Publication Publication Date Title
JP2008523126A5 (enExample)
JP2010523692A5 (enExample)
JP2010520214A5 (enExample)
JP2005539088A5 (enExample)
JP2005523922A5 (enExample)
JP2018135343A5 (enExample)
JP2007519721A5 (enExample)
JP2010504908A5 (enExample)
JP2006522035A5 (enExample)
JP2010521514A5 (enExample)
JP2006526031A5 (enExample)
JP2005508905A5 (enExample)
JP2005053931A5 (enExample)
JP2002513793A5 (enExample)
JP2010504343A5 (enExample)
JP2008519840A5 (enExample)
JP2006501201A5 (enExample)
JP2007502817A5 (enExample)
JP2013506674A5 (enExample)
JP2008513510A5 (enExample)
JP2005510457A5 (enExample)
JP2010510263A5 (enExample)
JP2009501745A5 (enExample)
JP2012511558A5 (enExample)
JP2005529869A5 (enExample)