JP2002514623A5 - - Google Patents
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- Publication number
- JP2002514623A5 JP2002514623A5 JP2000548303A JP2000548303A JP2002514623A5 JP 2002514623 A5 JP2002514623 A5 JP 2002514623A5 JP 2000548303 A JP2000548303 A JP 2000548303A JP 2000548303 A JP2000548303 A JP 2000548303A JP 2002514623 A5 JP2002514623 A5 JP 2002514623A5
- Authority
- JP
- Japan
- Prior art keywords
- ethyl
- phenyl
- propylamine
- compound
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 description 9
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 3
- -1 benzenesulfonamido Chemical group 0.000 description 3
- YYOHEGJBKTVTLK-UHFFFAOYSA-N 2,4-dichloro-n-[4-[2-(propylamino)ethyl]phenyl]benzenesulfonamide Chemical compound C1=CC(CCNCCC)=CC=C1NS(=O)(=O)C1=CC=C(Cl)C=C1Cl YYOHEGJBKTVTLK-UHFFFAOYSA-N 0.000 description 1
- DOFFSUIUWSPOJI-UHFFFAOYSA-N 2-chloro-4-fluoro-n-[4-[2-(propylamino)ethyl]phenyl]benzenesulfonamide Chemical compound C1=CC(CCNCCC)=CC=C1NS(=O)(=O)C1=CC=C(F)C=C1Cl DOFFSUIUWSPOJI-UHFFFAOYSA-N 0.000 description 1
- XUAUSHRTHCVYEJ-UHFFFAOYSA-N 2-fluoro-n-[3-[2-(propylamino)ethyl]phenyl]benzenesulfonamide Chemical compound CCCNCCC1=CC=CC(NS(=O)(=O)C=2C(=CC=CC=2)F)=C1 XUAUSHRTHCVYEJ-UHFFFAOYSA-N 0.000 description 1
- GYCXCBYOHASGSD-UHFFFAOYSA-N 3-chloro-n-[3-[2-(propylamino)ethyl]phenyl]benzenesulfonamide Chemical compound CCCNCCC1=CC=CC(NS(=O)(=O)C=2C=C(Cl)C=CC=2)=C1 GYCXCBYOHASGSD-UHFFFAOYSA-N 0.000 description 1
- GLBXYJLKQWSMHH-UHFFFAOYSA-N 4-bromo-n-[4-[2-(propylamino)ethyl]phenyl]benzenesulfonamide Chemical compound C1=CC(CCNCCC)=CC=C1NS(=O)(=O)C1=CC=C(Br)C=C1 GLBXYJLKQWSMHH-UHFFFAOYSA-N 0.000 description 1
- VCHHCUQGXMWXAM-UHFFFAOYSA-N 4-chloro-n-[4-[2-(propylamino)ethyl]phenyl]benzenesulfonamide Chemical compound C1=CC(CCNCCC)=CC=C1NS(=O)(=O)C1=CC=C(Cl)C=C1 VCHHCUQGXMWXAM-UHFFFAOYSA-N 0.000 description 1
- 102000004073 Dopamine D3 Receptors Human genes 0.000 description 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 208000015114 central nervous system disease Diseases 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- JGGQWSXZZQPZTR-UHFFFAOYSA-N n-[4-[2-(propylamino)ethyl]phenyl]-4-(trifluoromethoxy)benzenesulfonamide Chemical compound C1=CC(CCNCCC)=CC=C1NS(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1 JGGQWSXZZQPZTR-UHFFFAOYSA-N 0.000 description 1
- XCVNDBIXFPGMIW-UHFFFAOYSA-N n-ethylpropan-1-amine Chemical compound CCCNCC XCVNDBIXFPGMIW-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- GCWGADZVRFZLBG-UHFFFAOYSA-N tert-butyl 2-[2-(4-aminophenyl)ethylamino]butanoate Chemical compound CC(C)(C)OC(=O)C(CC)NCCC1=CC=C(N)C=C1 GCWGADZVRFZLBG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8549398P | 1998-05-14 | 1998-05-14 | |
| US60/085,493 | 1998-05-14 | ||
| PCT/US1999/007023 WO1999058499A1 (en) | 1998-05-14 | 1999-05-07 | Phenylsulfonamide-phenylethylamines useful as dopamine receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002514623A JP2002514623A (ja) | 2002-05-21 |
| JP2002514623A5 true JP2002514623A5 (enExample) | 2006-08-10 |
Family
ID=22191975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000548303A Withdrawn JP2002514623A (ja) | 1998-05-14 | 1999-05-07 | ドーパミン受容体として有用なフェニルスルホンアミド−フェニルエチルアミン |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6103766A (enExample) |
| EP (1) | EP1077935B1 (enExample) |
| JP (1) | JP2002514623A (enExample) |
| KR (1) | KR20010043546A (enExample) |
| CN (1) | CN1152857C (enExample) |
| AT (1) | ATE253045T1 (enExample) |
| AU (1) | AU752543B2 (enExample) |
| BR (1) | BR9910405A (enExample) |
| CA (1) | CA2327345A1 (enExample) |
| DE (1) | DE69912419T2 (enExample) |
| DK (1) | DK1077935T3 (enExample) |
| EA (1) | EA002918B1 (enExample) |
| ES (1) | ES2211078T3 (enExample) |
| HU (1) | HUP0101746A3 (enExample) |
| IL (1) | IL139263A0 (enExample) |
| NO (1) | NO20005732D0 (enExample) |
| NZ (1) | NZ508152A (enExample) |
| PL (1) | PL343891A1 (enExample) |
| PT (1) | PT1077935E (enExample) |
| SK (1) | SK16242000A3 (enExample) |
| TR (1) | TR200003325T2 (enExample) |
| TW (1) | TW450954B (enExample) |
| WO (1) | WO1999058499A1 (enExample) |
| ZA (1) | ZA200005921B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT971878E (pt) * | 1997-02-27 | 2008-07-08 | Takeda Pharmaceutical | Compostos de amina, sua produção e utilização como inibidores da produção de amilóide beta |
| JP2005508852A (ja) * | 2001-05-07 | 2005-04-07 | スミスクライン・ビーチャム・コーポレイション | スルホンアミド |
| WO2002089785A1 (en) * | 2001-05-07 | 2002-11-14 | Smithkline Beecham Corporation | Sulfonamides |
| ATE520659T1 (de) | 2004-10-14 | 2011-09-15 | Abbott Gmbh & Co Kg | Zur behandlung von auf die modulation des dopamin-d3-rezeptors ansprechenden erkrankungen geeignete azabicycloheptylverbindungen |
| CA2583918C (en) * | 2004-10-14 | 2013-01-29 | Abbott Gmbh & Co. Kg | Aminoethylaromatic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| DE602005027382D1 (de) | 2004-10-14 | 2011-05-19 | Abbott Gmbh & Co Kg | Zur behandlung von auf eine modulation des dopamin-d3-rezeptors ansprechende erkrankungen geeignete heterocyclische verbindungen |
| TWI400233B (zh) * | 2006-04-14 | 2013-07-01 | Abbott Gmbh & Co Kg | 適用於治療對多巴胺ｄ3受體之調節有反應的疾病之芳氧基乙胺化合物 |
| CA2648543C (en) * | 2006-04-14 | 2015-06-02 | Abbott Gmbh & Co. Kg | Aryloxyethylamine compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| JP2009534355A (ja) | 2006-04-19 | 2009-09-24 | アボット ゲーエムベーハー ウント カンパニー カーゲー | セロトニン５ｈｔ６受容体の調節に応答する障害を治療するために好適な複素環化合物 |
| MX2008013434A (es) | 2006-04-19 | 2009-01-26 | Abbott Gmbh & Co Kg | Arilsufonas heterociclicas adecuadas para tratar trastornos que responden a la modulacion del receptor de serotonina 5ht6. |
| WO2008026046A1 (en) * | 2006-08-30 | 2008-03-06 | Pfizer Products Inc. | Morpholine d3 dopamine antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3574741A (en) * | 1969-04-14 | 1971-04-13 | Mead Johnson & Co | Sulfonamidophenalkylamines |
| US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| GB9402197D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
| CN1088062C (zh) * | 1994-11-23 | 2002-07-24 | 纽罗根公司 | 某些4－氨基甲基－2－取代的咪唑衍生物2－氨基甲基－4－取代的咪唑衍生物新的一族多巴胺受体亚型特异性配体 |
| EP0917530B1 (en) * | 1996-05-11 | 2003-02-19 | SmithKline Beecham plc | Tetrahydroisoquinoline derivatives as modulators of dopamine d3 receptors |
| US5922770A (en) * | 1996-07-22 | 1999-07-13 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| JPH1180156A (ja) * | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | １−（置換アリール）アルキル−１ｈ−イミダゾピリジン−４−アミン誘導体 |
-
1999
- 1999-04-26 TW TW088106644A patent/TW450954B/zh not_active IP Right Cessation
- 1999-05-07 US US09/306,748 patent/US6103766A/en not_active Expired - Fee Related
- 1999-05-07 CN CNB998052175A patent/CN1152857C/zh not_active Expired - Fee Related
- 1999-05-07 AT AT99919771T patent/ATE253045T1/de not_active IP Right Cessation
- 1999-05-07 IL IL13926399A patent/IL139263A0/xx not_active IP Right Cessation
- 1999-05-07 WO PCT/US1999/007023 patent/WO1999058499A1/en not_active Ceased
- 1999-05-07 AU AU37418/99A patent/AU752543B2/en not_active Ceased
- 1999-05-07 JP JP2000548303A patent/JP2002514623A/ja not_active Withdrawn
- 1999-05-07 NZ NZ508152A patent/NZ508152A/xx unknown
- 1999-05-07 KR KR1020007012661A patent/KR20010043546A/ko not_active Abandoned
- 1999-05-07 DK DK99919771T patent/DK1077935T3/da active
- 1999-05-07 SK SK1624-2000A patent/SK16242000A3/sk unknown
- 1999-05-07 PL PL99343891A patent/PL343891A1/xx unknown
- 1999-05-07 DE DE69912419T patent/DE69912419T2/de not_active Expired - Fee Related
- 1999-05-07 BR BR9910405-9A patent/BR9910405A/pt not_active Application Discontinuation
- 1999-05-07 EP EP99919771A patent/EP1077935B1/en not_active Expired - Lifetime
- 1999-05-07 CA CA002327345A patent/CA2327345A1/en not_active Abandoned
- 1999-05-07 ES ES99919771T patent/ES2211078T3/es not_active Expired - Lifetime
- 1999-05-07 HU HU0101746A patent/HUP0101746A3/hu unknown
- 1999-05-07 PT PT99919771T patent/PT1077935E/pt unknown
- 1999-05-07 TR TR2000/03325T patent/TR200003325T2/xx unknown
- 1999-05-07 EA EA200001184A patent/EA002918B1/ru not_active IP Right Cessation
-
2000
- 2000-10-23 ZA ZA200005921A patent/ZA200005921B/en unknown
- 2000-11-13 NO NO20005732A patent/NO20005732D0/no not_active Application Discontinuation