DE69912419T2 - Phenylsulfonamid-phenylethylamine nützlich als dopamin-rezeptoren - Google Patents
Phenylsulfonamid-phenylethylamine nützlich als dopamin-rezeptoren Download PDFInfo
- Publication number
- DE69912419T2 DE69912419T2 DE69912419T DE69912419T DE69912419T2 DE 69912419 T2 DE69912419 T2 DE 69912419T2 DE 69912419 T DE69912419 T DE 69912419T DE 69912419 T DE69912419 T DE 69912419T DE 69912419 T2 DE69912419 T2 DE 69912419T2
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- Prior art keywords
- ethyl
- phenyl
- propylamine
- compound
- formula
- Prior art date
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- 102000015554 Dopamine receptor Human genes 0.000 title description 2
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- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical class NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- CBHYFZKCNVQNMV-UHFFFAOYSA-N n-[2-[2-(methylamino)ethyl]phenyl]benzenesulfonamide Chemical compound CNCCC1=CC=CC=C1NS(=O)(=O)C1=CC=CC=C1 CBHYFZKCNVQNMV-UHFFFAOYSA-N 0.000 description 1
- JGGQWSXZZQPZTR-UHFFFAOYSA-N n-[4-[2-(propylamino)ethyl]phenyl]-4-(trifluoromethoxy)benzenesulfonamide Chemical compound C1=CC(CCNCCC)=CC=C1NS(=O)(=O)C1=CC=C(OC(F)(F)F)C=C1 JGGQWSXZZQPZTR-UHFFFAOYSA-N 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- DKGZKTPJOSAWFA-UHFFFAOYSA-N spiperone Chemical compound C1=CC(F)=CC=C1C(=O)CCCN1CCC2(C(NCN2C=2C=CC=CC=2)=O)CC1 DKGZKTPJOSAWFA-UHFFFAOYSA-N 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8549398P | 1998-05-14 | 1998-05-14 | |
| US85493P | 1998-05-14 | ||
| PCT/US1999/007023 WO1999058499A1 (en) | 1998-05-14 | 1999-05-07 | Phenylsulfonamide-phenylethylamines useful as dopamine receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69912419D1 DE69912419D1 (de) | 2003-12-04 |
| DE69912419T2 true DE69912419T2 (de) | 2004-07-22 |
Family
ID=22191975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69912419T Expired - Fee Related DE69912419T2 (de) | 1998-05-14 | 1999-05-07 | Phenylsulfonamid-phenylethylamine nützlich als dopamin-rezeptoren |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6103766A (enExample) |
| EP (1) | EP1077935B1 (enExample) |
| JP (1) | JP2002514623A (enExample) |
| KR (1) | KR20010043546A (enExample) |
| CN (1) | CN1152857C (enExample) |
| AT (1) | ATE253045T1 (enExample) |
| AU (1) | AU752543B2 (enExample) |
| BR (1) | BR9910405A (enExample) |
| CA (1) | CA2327345A1 (enExample) |
| DE (1) | DE69912419T2 (enExample) |
| DK (1) | DK1077935T3 (enExample) |
| EA (1) | EA002918B1 (enExample) |
| ES (1) | ES2211078T3 (enExample) |
| HU (1) | HUP0101746A3 (enExample) |
| IL (1) | IL139263A0 (enExample) |
| NO (1) | NO20005732D0 (enExample) |
| NZ (1) | NZ508152A (enExample) |
| PL (1) | PL343891A1 (enExample) |
| PT (1) | PT1077935E (enExample) |
| SK (1) | SK16242000A3 (enExample) |
| TR (1) | TR200003325T2 (enExample) |
| TW (1) | TW450954B (enExample) |
| WO (1) | WO1999058499A1 (enExample) |
| ZA (1) | ZA200005921B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6310107B1 (en) * | 1997-02-27 | 2001-10-30 | Takeda Chemical Industries, Ltd. | Amine compounds, their production and use as amyloid-β production inhibitors |
| WO2002089785A1 (en) * | 2001-05-07 | 2002-11-14 | Smithkline Beecham Corporation | Sulfonamides |
| AU2002256497A1 (en) * | 2001-05-07 | 2002-11-18 | Smithkline Beecham Corporation | Sulfonamides |
| EP1812389B1 (en) | 2004-10-14 | 2011-08-17 | Abbott GmbH & Co. KG | Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| CA2583918C (en) * | 2004-10-14 | 2013-01-29 | Abbott Gmbh & Co. Kg | Aminoethylaromatic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| ES2364488T3 (es) | 2004-10-14 | 2011-09-05 | ABBOTT GMBH & CO. KG | Compuestos heterocíclicos adecuados para el tratamiento de trastornos que responden a la modulación del receptor de dopamina. |
| CA2648543C (en) | 2006-04-14 | 2015-06-02 | Abbott Gmbh & Co. Kg | Aryloxyethylamine compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
| ATE496031T1 (de) * | 2006-04-14 | 2011-02-15 | Abbott Gmbh & Co Kg | Für die behandlung von auf die modulierung des dopamin-d3-rezeptors ansprechende erkrankungen geeignete aryloxyethylaminverbindungen |
| US8642642B2 (en) | 2006-04-19 | 2014-02-04 | Abbott Laboratories | Heterocyclic arylsulphones suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor |
| MX2008013206A (es) | 2006-04-19 | 2008-10-22 | Abbott Gmbh & Co Kg | Compuestos heterociclicos adecuados para el tratamiento de trastornos que responden a modulacion del receptor de serotonina 5ht6. |
| WO2008026046A1 (en) * | 2006-08-30 | 2008-03-06 | Pfizer Products Inc. | Morpholine d3 dopamine antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3574741A (en) * | 1969-04-14 | 1971-04-13 | Mead Johnson & Co | Sulfonamidophenalkylamines |
| US5451677A (en) * | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| GB9402197D0 (en) * | 1994-02-04 | 1994-03-30 | Smithkline Beecham Plc | Compounds |
| CN1088062C (zh) * | 1994-11-23 | 2002-07-24 | 纽罗根公司 | 某些4－氨基甲基－2－取代的咪唑衍生物2－氨基甲基－4－取代的咪唑衍生物新的一族多巴胺受体亚型特异性配体 |
| ATE232850T1 (de) * | 1996-05-11 | 2003-03-15 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivate als modulatoren von dopamine d3 rezeptoren |
| DE69734215T2 (de) * | 1996-07-22 | 2006-06-29 | Novo Nordisk A/S | Verbindungen mit Wachstumshormon-freisetzenden Eigenschaften |
| JPH1180156A (ja) * | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | １−（置換アリール）アルキル−１ｈ−イミダゾピリジン−４−アミン誘導体 |
-
1999
- 1999-04-26 TW TW088106644A patent/TW450954B/zh not_active IP Right Cessation
- 1999-05-07 KR KR1020007012661A patent/KR20010043546A/ko not_active Abandoned
- 1999-05-07 ES ES99919771T patent/ES2211078T3/es not_active Expired - Lifetime
- 1999-05-07 IL IL13926399A patent/IL139263A0/xx not_active IP Right Cessation
- 1999-05-07 CA CA002327345A patent/CA2327345A1/en not_active Abandoned
- 1999-05-07 EA EA200001184A patent/EA002918B1/ru not_active IP Right Cessation
- 1999-05-07 SK SK1624-2000A patent/SK16242000A3/sk unknown
- 1999-05-07 AU AU37418/99A patent/AU752543B2/en not_active Ceased
- 1999-05-07 JP JP2000548303A patent/JP2002514623A/ja not_active Withdrawn
- 1999-05-07 DK DK99919771T patent/DK1077935T3/da active
- 1999-05-07 PL PL99343891A patent/PL343891A1/xx unknown
- 1999-05-07 CN CNB998052175A patent/CN1152857C/zh not_active Expired - Fee Related
- 1999-05-07 NZ NZ508152A patent/NZ508152A/xx unknown
- 1999-05-07 EP EP99919771A patent/EP1077935B1/en not_active Expired - Lifetime
- 1999-05-07 WO PCT/US1999/007023 patent/WO1999058499A1/en not_active Ceased
- 1999-05-07 HU HU0101746A patent/HUP0101746A3/hu unknown
- 1999-05-07 AT AT99919771T patent/ATE253045T1/de not_active IP Right Cessation
- 1999-05-07 TR TR2000/03325T patent/TR200003325T2/xx unknown
- 1999-05-07 DE DE69912419T patent/DE69912419T2/de not_active Expired - Fee Related
- 1999-05-07 US US09/306,748 patent/US6103766A/en not_active Expired - Fee Related
- 1999-05-07 BR BR9910405-9A patent/BR9910405A/pt not_active Application Discontinuation
- 1999-05-07 PT PT99919771T patent/PT1077935E/pt unknown
-
2000
- 2000-10-23 ZA ZA200005921A patent/ZA200005921B/en unknown
- 2000-11-13 NO NO20005732A patent/NO20005732D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101746A3 (en) | 2002-10-28 |
| ES2211078T3 (es) | 2004-07-01 |
| SK16242000A3 (sk) | 2001-06-11 |
| US6103766A (en) | 2000-08-15 |
| CA2327345A1 (en) | 1999-11-18 |
| DK1077935T3 (da) | 2004-02-16 |
| AU752543B2 (en) | 2002-09-19 |
| HUP0101746A2 (hu) | 2002-03-28 |
| TW450954B (en) | 2001-08-21 |
| CN1152857C (zh) | 2004-06-09 |
| EA200001184A1 (ru) | 2001-04-23 |
| ZA200005921B (en) | 2001-11-14 |
| WO1999058499A1 (en) | 1999-11-18 |
| EP1077935B1 (en) | 2003-10-29 |
| AU3741899A (en) | 1999-11-29 |
| ATE253045T1 (de) | 2003-11-15 |
| PT1077935E (pt) | 2004-03-31 |
| EA002918B1 (ru) | 2002-10-31 |
| BR9910405A (pt) | 2001-01-09 |
| KR20010043546A (ko) | 2001-05-25 |
| TR200003325T2 (tr) | 2001-04-20 |
| JP2002514623A (ja) | 2002-05-21 |
| DE69912419D1 (de) | 2003-12-04 |
| NO20005732L (no) | 2000-11-13 |
| IL139263A0 (en) | 2001-11-25 |
| NO20005732D0 (no) | 2000-11-13 |
| EP1077935A1 (en) | 2001-02-28 |
| PL343891A1 (en) | 2001-09-10 |
| CN1297431A (zh) | 2001-05-30 |
| HK1036049A1 (en) | 2001-12-21 |
| NZ508152A (en) | 2003-03-28 |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8339 | Ceased/non-payment of the annual fee |