JP2006516626A5 - - Google Patents
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- Publication number
- JP2006516626A5 JP2006516626A5 JP2006503012A JP2006503012A JP2006516626A5 JP 2006516626 A5 JP2006516626 A5 JP 2006516626A5 JP 2006503012 A JP2006503012 A JP 2006503012A JP 2006503012 A JP2006503012 A JP 2006503012A JP 2006516626 A5 JP2006516626 A5 JP 2006516626A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound according
- pyridin
- benzimidazol
- amine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- 125000005843 halogen group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- -1 C 1 -C 6 alkyl Chemical group 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- LPDYFVZTFPDLJH-UHFFFAOYSA-N 2-(2-amino-5-phenylpyridin-3-yl)-3h-benzimidazole-5-sulfonamide Chemical compound C1=C(C=2NC3=CC(=CC=C3N=2)S(N)(=O)=O)C(N)=NC=C1C1=CC=CC=C1 LPDYFVZTFPDLJH-UHFFFAOYSA-N 0.000 claims 1
- IVPCWDBJWBWWLM-UHFFFAOYSA-N 2-[2-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]-3h-benzimidazole-5-sulfonamide Chemical compound COC1=C(OC)C(OC)=CC(C=2C=C(C(N)=NC=2)C=2NC3=CC(=CC=C3N=2)S(N)(=O)=O)=C1 IVPCWDBJWBWWLM-UHFFFAOYSA-N 0.000 claims 1
- FUSVWYRZUBCJBA-UHFFFAOYSA-N 2-[2-amino-5-(3-cyanophenyl)pyridin-3-yl]-3h-benzimidazole-5-sulfonamide Chemical compound C1=C(C=2NC3=CC(=CC=C3N=2)S(N)(=O)=O)C(N)=NC=C1C1=CC=CC(C#N)=C1 FUSVWYRZUBCJBA-UHFFFAOYSA-N 0.000 claims 1
- WMQSQHURLVYITM-UHFFFAOYSA-N 2-[2-amino-5-(3-methoxyphenyl)pyridin-3-yl]-3h-benzimidazole-5-sulfonamide Chemical compound COC1=CC=CC(C=2C=C(C(N)=NC=2)C=2NC3=CC(=CC=C3N=2)S(N)(=O)=O)=C1 WMQSQHURLVYITM-UHFFFAOYSA-N 0.000 claims 1
- MEJJEZUUIVPVSS-UHFFFAOYSA-N 2-[2-amino-5-(4-fluorophenyl)pyridin-3-yl]-3h-benzimidazole-5-sulfonamide Chemical compound C1=C(C=2NC3=CC(=CC=C3N=2)S(N)(=O)=O)C(N)=NC=C1C1=CC=C(F)C=C1 MEJJEZUUIVPVSS-UHFFFAOYSA-N 0.000 claims 1
- HJOBCAIXQIZFSY-UHFFFAOYSA-N 2-[2-amino-5-(4-methoxyphenyl)pyridin-3-yl]-3h-benzimidazole-5-sulfonamide Chemical compound C1=CC(OC)=CC=C1C1=CN=C(N)C(C=2NC3=CC(=CC=C3N=2)S(N)(=O)=O)=C1 HJOBCAIXQIZFSY-UHFFFAOYSA-N 0.000 claims 1
- LWCDOVGPENQJFK-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-5-(3-methoxyphenyl)pyridin-2-amine Chemical compound COC1=CC=CC(C=2C=C(C(N)=NC=2)C=2NC3=CC=CC=C3N=2)=C1 LWCDOVGPENQJFK-UHFFFAOYSA-N 0.000 claims 1
- CLRWMPFUTCKUQH-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-5-phenylpyridin-2-amine Chemical compound C1=C(C=2NC3=CC=CC=C3N=2)C(N)=NC=C1C1=CC=CC=C1 CLRWMPFUTCKUQH-UHFFFAOYSA-N 0.000 claims 1
- YROZFOKSWZOYMK-UHFFFAOYSA-N 3-(4-methyl-1h-benzimidazol-2-yl)-5-phenylpyridin-2-amine Chemical compound N=1C=2C(C)=CC=CC=2NC=1C(C(=NC=1)N)=CC=1C1=CC=CC=C1 YROZFOKSWZOYMK-UHFFFAOYSA-N 0.000 claims 1
- TWWBQGYWZTWEHB-UHFFFAOYSA-N 3-(5-chloro-6-fluoro-1h-benzimidazol-2-yl)-5-(3-methoxyphenyl)pyridin-2-amine Chemical compound COC1=CC=CC(C=2C=C(C(N)=NC=2)C=2NC3=CC(F)=C(Cl)C=C3N=2)=C1 TWWBQGYWZTWEHB-UHFFFAOYSA-N 0.000 claims 1
- HIPALRDMCQACSM-UHFFFAOYSA-N 3-(6-fluoro-1h-benzimidazol-2-yl)-5-(4-fluorophenyl)pyridin-2-amine Chemical compound C1=C(C=2NC3=CC(F)=CC=C3N=2)C(N)=NC=C1C1=CC=C(F)C=C1 HIPALRDMCQACSM-UHFFFAOYSA-N 0.000 claims 1
- KMQXMUPSJARRJE-UHFFFAOYSA-N 3-(6-fluoro-1h-benzimidazol-2-yl)-5-phenylpyridin-2-amine Chemical compound C1=C(C=2NC3=CC(F)=CC=C3N=2)C(N)=NC=C1C1=CC=CC=C1 KMQXMUPSJARRJE-UHFFFAOYSA-N 0.000 claims 1
- SPFWTUFOLVVHTC-UHFFFAOYSA-N 3-(6-methoxy-1h-benzimidazol-2-yl)-5-phenylpyridin-2-amine Chemical compound N1C2=CC(OC)=CC=C2N=C1C(C(=NC=1)N)=CC=1C1=CC=CC=C1 SPFWTUFOLVVHTC-UHFFFAOYSA-N 0.000 claims 1
- ASAPGNUILRWSGQ-UHFFFAOYSA-N 5-(3-methoxyphenyl)-3-(4-methyl-1h-benzimidazol-2-yl)pyridin-2-amine Chemical compound COC1=CC=CC(C=2C=C(C(N)=NC=2)C=2NC3=CC=CC(C)=C3N=2)=C1 ASAPGNUILRWSGQ-UHFFFAOYSA-N 0.000 claims 1
- BIXLAMXENIEOHK-UHFFFAOYSA-N 5-(4-fluorophenyl)-3-(4-methyl-1h-benzimidazol-2-yl)pyridin-2-amine Chemical compound N=1C=2C(C)=CC=CC=2NC=1C(C(=NC=1)N)=CC=1C1=CC=C(F)C=C1 BIXLAMXENIEOHK-UHFFFAOYSA-N 0.000 claims 1
- 101150082971 Sgk1 gene Proteins 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- CINKOKVGIIGBBG-UHFFFAOYSA-N methyl 2-(2-amino-5-phenylpyridin-3-yl)-3h-benzimidazole-5-carboxylate Chemical compound N1C2=CC(C(=O)OC)=CC=C2N=C1C(C(=NC=1)N)=CC=1C1=CC=CC=C1 CINKOKVGIIGBBG-UHFFFAOYSA-N 0.000 claims 1
- IAZXOXWJANJRDV-UHFFFAOYSA-N methyl 2-[2-amino-5-(3-methoxyphenyl)pyridin-3-yl]-3h-benzimidazole-5-carboxylate Chemical compound N1C2=CC(C(=O)OC)=CC=C2N=C1C(C(=NC=1)N)=CC=1C1=CC=CC(OC)=C1 IAZXOXWJANJRDV-UHFFFAOYSA-N 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44346203P | 2003-01-28 | 2003-01-28 | |
| US45233503P | 2003-03-05 | 2003-03-05 | |
| PCT/US2004/002076 WO2004069160A2 (en) | 2003-01-28 | 2004-01-27 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006516626A JP2006516626A (ja) | 2006-07-06 |
| JP2006516626A5 true JP2006516626A5 (enExample) | 2007-03-08 |
Family
ID=32853338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006503012A Pending JP2006516626A (ja) | 2003-01-28 | 2004-01-27 | 化学的化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US7329678B2 (enExample) |
| EP (1) | EP1590339A4 (enExample) |
| JP (1) | JP2006516626A (enExample) |
| WO (1) | WO2004069160A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8093401B2 (en) | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US7855289B2 (en) | 2005-08-04 | 2010-12-21 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US8088928B2 (en) | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| EP2054405B1 (en) | 2006-07-11 | 2013-09-18 | Daewoong Pharmaceutical Co., Ltd. | Novel biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same |
| WO2008021725A2 (en) * | 2006-08-11 | 2008-02-21 | Smithkline Beecham Corporation | Chemical compounds |
| EP1900727A1 (en) * | 2006-08-30 | 2008-03-19 | Cellzome Ag | Aminopyridine derivatives as kinase inhibitors |
| TW200916472A (en) | 2007-06-20 | 2009-04-16 | Sirtris Pharmaceuticals Inc | Sirtuin modulating compounds |
| EP2215085B1 (en) | 2007-10-25 | 2011-09-07 | AstraZeneca AB | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders |
| JP2011511005A (ja) | 2008-02-04 | 2011-04-07 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | ２−アミノピリジン系キナーゼ阻害薬 |
| AR070317A1 (es) | 2008-02-06 | 2010-03-31 | Osi Pharm Inc | Furo (3,2-c) piridina y tieno (3,2-c) piridinas |
| KR101034351B1 (ko) * | 2008-05-14 | 2011-05-16 | 한국화학연구원 | 신규 벤즈옥사졸로 치환된 피리딘 유도체 또는 이의약학적으로 허용가능한 염, 이의 제조방법 및 이를유효성분으로 함유하는 이상세포 성장 질환의 예방 및치료용 약학적 조성물 |
| CN102388054B (zh) | 2008-12-19 | 2015-03-04 | 西特里斯药业公司 | 噻唑并吡啶沉默调节蛋白调节剂的化合物 |
| DE102009033208A1 (de) | 2009-07-15 | 2011-01-20 | Merck Patent Gmbh | Aminopyridinderivate |
| WO2012158866A2 (en) | 2011-05-19 | 2012-11-22 | The Johns Hopkins University | Treatment of autoimmune disorders and infections using antagonists of sgk1 activity |
| CR20200464A (es) | 2018-03-08 | 2021-04-14 | Incyte Corp | Compuestos diólicos de aminopirazina como inhibidores de pi3k-y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| EP4054570A1 (en) * | 2019-11-05 | 2022-09-14 | Dermira, Inc | Mrgprx2 antagonists and uses thereof |
| US20230029266A1 (en) | 2019-11-05 | 2023-01-26 | Dermira, Inc. | MrgprX2 Antagonists for the Treatment of Inflammatory Disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2150671T3 (es) * | 1995-04-21 | 2000-12-01 | Neurosearch As | Compuesto de bencimidazol y su utilizacion como moduladores del complejo de receptores gaba-a. |
| CA2218493C (en) * | 1995-04-21 | 2005-02-22 | Neurosearch A/S | Benzimidazole compounds and their use as modulators of the gabaa receptor complex |
| US6416759B1 (en) * | 1999-09-30 | 2002-07-09 | The Regents Of The University Of California | Antiproliferative Sgk reagents and methods |
| MXPA02003436A (es) | 1999-10-07 | 2002-08-20 | Amgen Inc | Inhibidores de triazina cinasa. |
| JP4341949B2 (ja) * | 2000-09-01 | 2009-10-14 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | アザ複素環式誘導体およびその治療的使用 |
| BRPI0113757B8 (pt) * | 2000-09-11 | 2017-11-07 | Chiron Corp | derivados de quinolinona como inibidores de tirosina quinase |
| CA2442428A1 (en) * | 2001-03-28 | 2002-10-10 | Mark D. Wittman | Novel tyrosine kinase inhibitors |
| KR20040084896A (ko) * | 2002-02-06 | 2004-10-06 | 버텍스 파마슈티칼스 인코포레이티드 | Ｇｓｋ-3의 억제제로서 유용한 헤테로아릴 화합물 |
-
2004
- 2004-01-27 WO PCT/US2004/002076 patent/WO2004069160A2/en not_active Ceased
- 2004-01-27 JP JP2006503012A patent/JP2006516626A/ja active Pending
- 2004-01-27 EP EP04705578A patent/EP1590339A4/en not_active Withdrawn
- 2004-01-27 US US10/543,701 patent/US7329678B2/en not_active Expired - Fee Related
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