|
AR028948A1
(es)
|
2000-06-20 |
2003-05-28 |
Astrazeneca Ab |
Compuestos novedosos
|
|
US20030229058A1
(en)
*
|
2001-11-13 |
2003-12-11 |
Moran Edmund J. |
Aryl aniline beta2 adrenergic receptor agonists
|
|
TWI249515B
(en)
*
|
2001-11-13 |
2006-02-21 |
Theravance Inc |
Aryl aniline beta2 adrenergic receptor agonists
|
|
US6653323B2
(en)
*
|
2001-11-13 |
2003-11-25 |
Theravance, Inc. |
Aryl aniline β2 adrenergic receptor agonists
|
|
MXPA04012783A
(es)
*
|
2002-06-27 |
2005-02-24 |
Fujisawa Pharmaceutical Co |
Derivados de aminoalcohol.
|
|
AR040661A1
(es)
*
|
2002-07-26 |
2005-04-13 |
Theravance Inc |
Diclorhidrato cristalino de n-{2-[-((r)-2-hidroxi-2-feniletilamino)fenil]etil}-(r)-2hidroxi-2-(3-formamido-4-hidroxifenil)etilamina, agonista del receptor adrenergico beta 2
|
|
PE20050130A1
(es)
*
|
2002-08-09 |
2005-03-29 |
Novartis Ag |
Compuestos organicos
|
|
CA2511970C
(en)
|
2003-01-14 |
2012-06-26 |
Cytokinetics, Inc. |
Urea derivatives useful in the treatment of heart failure
|
|
PE20040950A1
(es)
*
|
2003-02-14 |
2005-01-01 |
Theravance Inc |
DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
|
|
WO2004089892A2
(en)
*
|
2003-04-01 |
2004-10-21 |
Theravance, Inc. |
Diarylmethyl and related compounds having beta2 andrenergic receptor agonist and muscarinic receptor antagonist activity
|
|
EP1622875B1
(en)
*
|
2003-05-08 |
2009-12-02 |
Theravance, Inc. |
Crystalline forms of an arylaniline beta-2 adrenergic receptor agonist
|
|
TW200510277A
(en)
*
|
2003-05-27 |
2005-03-16 |
Theravance Inc |
Crystalline form of β2-adrenergic receptor agonist
|
|
ATE435862T1
(de)
*
|
2003-05-28 |
2009-07-15 |
Theravance Inc |
Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
|
|
GB0312832D0
(en)
*
|
2003-06-04 |
2003-07-09 |
Pfizer Ltd |
2-amino-pyridine derivatives useful for the treatment of diseases
|
|
US7375100B2
(en)
|
2003-06-04 |
2008-05-20 |
Pfizer Inc |
2-amino-pyridine derivatives useful for the treatment of diseases
|
|
JP4607112B2
(ja)
|
2003-08-11 |
2011-01-05 |
グラクソ グループ リミテッド |
医薬定量噴霧式吸入器及び前記吸引器に関連する方法
|
|
US7504401B2
(en)
|
2003-08-29 |
2009-03-17 |
Locus Pharmaceuticals, Inc. |
Anti-cancer agents and uses thereof
|
|
TW200526547A
(en)
|
2003-09-22 |
2005-08-16 |
Theravance Inc |
Amino-substituted ethylamino β2 adrenergic receptor agonists
|
|
TW200531692A
(en)
*
|
2004-01-12 |
2005-10-01 |
Theravance Inc |
Aryl aniline derivatives as β2 adrenergic receptor agonists
|
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
|
WO2005092861A1
(en)
*
|
2004-03-11 |
2005-10-06 |
Pfizer Limited |
Quinolinone derivatives pharmaceutical compositions containing them and their use
|
|
EP1574501A1
(en)
*
|
2004-03-11 |
2005-09-14 |
Pfizer Limited |
Quinolinone derivatives, pharmaceutical compositions containing them and their use
|
|
CA2560368A1
(en)
*
|
2004-03-23 |
2005-10-06 |
Pfizer Inc. |
Compounds for the treatment of diseases
|
|
WO2005092841A1
(en)
*
|
2004-03-23 |
2005-10-06 |
Pfizer Limited |
Compounds having beta-agonist activity
|
|
US7538141B2
(en)
|
2004-03-23 |
2009-05-26 |
Alan Daniel Brown |
Compounds for the treatment of diseases
|
|
WO2005092860A1
(en)
*
|
2004-03-23 |
2005-10-06 |
Pfizer Limited |
Compounds for the treatment of diseases
|
|
GB0425054D0
(en)
*
|
2004-03-23 |
2004-12-15 |
Pfizer Ltd |
Formamide derivatives for the treatment of diseases
|
|
WO2005095328A1
(en)
|
2004-04-02 |
2005-10-13 |
Glaxo Group Limited |
Chemical process and new crystalline form
|
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
|
US7402673B2
(en)
*
|
2004-06-03 |
2008-07-22 |
Theravance, Inc. |
Diamine β2 adrenergic receptor agonists
|
|
BRPI0512193B8
(pt)
|
2004-06-17 |
2021-05-25 |
Cytokinetics Inc |
composto ou sal farmaceuticamente aceitável, composição farmacêutica, e, uso do composto ou sal
|
|
GB0413960D0
(en)
*
|
2004-06-22 |
2004-07-28 |
Novartis Ag |
Organic compounds
|
|
US7317023B2
(en)
*
|
2004-07-21 |
2008-01-08 |
Theravance, Inc. |
Diaryl ether β2 adrenergic receptor agonists
|
|
US7176222B2
(en)
|
2004-07-27 |
2007-02-13 |
Cytokinetics, Inc. |
Syntheses of ureas
|
|
WO2006023457A1
(en)
*
|
2004-08-16 |
2006-03-02 |
Theravance, Inc. |
COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
|
|
WO2006023460A2
(en)
*
|
2004-08-16 |
2006-03-02 |
Theravance, Inc. |
COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY
|
|
WO2006031556A2
(en)
*
|
2004-09-10 |
2006-03-23 |
Theravance. Inc. |
Amidine substituted aryl aniline compounds
|
|
GT200500281A
(es)
|
2004-10-22 |
2006-04-24 |
Novartis Ag |
Compuestos organicos.
|
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
|
WO2006051373A1
(en)
*
|
2004-11-12 |
2006-05-18 |
Pfizer Limited |
Compounds for the treatment of diseases
|
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
|
WO2006074897A1
(en)
|
2005-01-11 |
2006-07-20 |
Glaxo Group Limited |
Cinnamate salts of a beta-2 adrenergic agonist
|
|
WO2006105401A2
(en)
|
2005-03-30 |
2006-10-05 |
Schering Corporation |
Medicaments and methods combining an anticholinergic, a corticosteroid, and a long acting beta agonist
|
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
|
ES2265276B1
(es)
|
2005-05-20 |
2008-02-01 |
Laboratorios Almirall S.A. |
Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
|
|
US8429052B2
(en)
*
|
2005-07-19 |
2013-04-23 |
Lincoln National Life Insurance Company |
Method and system for providing employer-sponsored retirement plan
|
|
US7538223B2
(en)
|
2005-08-04 |
2009-05-26 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
|
EP1924553A1
(en)
|
2005-08-08 |
2008-05-28 |
Argenta Discovery Limited |
Bicyclo[2.2.]hept-7-ylamine derivatives and their uses
|
|
GB0516313D0
(en)
|
2005-08-08 |
2005-09-14 |
Argenta Discovery Ltd |
Azole derivatives and their uses
|
|
US7910708B2
(en)
|
2005-10-21 |
2011-03-22 |
Novartis Ag |
Anti-IL13 human antibodies
|
|
EP1959947A2
(en)
*
|
2005-12-15 |
2008-08-27 |
Cytokinetics, Inc. |
Certain chemical entities, compositions and methods
|
|
ES2419007T3
(es)
*
|
2005-12-15 |
2013-08-19 |
Cytokinetics, Inc. |
Ciertas entidades químicas, composiciones y procedimientos
|
|
US7825120B2
(en)
|
2005-12-15 |
2010-11-02 |
Cytokinetics, Inc. |
Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
|
|
US20070208000A1
(en)
*
|
2005-12-15 |
2007-09-06 |
Morgan Bradley P |
Certain chemical entities, compositions and methods
|
|
US7718657B2
(en)
|
2005-12-16 |
2010-05-18 |
Cytokinetics, Inc. |
Certain indanyl urea modulators of the cardiac sarcomere
|
|
EP1962852B1
(en)
*
|
2005-12-19 |
2017-01-25 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
GB0602778D0
(en)
*
|
2006-02-10 |
2006-03-22 |
Glaxo Group Ltd |
Novel compound
|
|
ATE549337T1
(de)
|
2006-04-21 |
2012-03-15 |
Novartis Ag |
Purinderivate zur verwendung als adenosin-a2a- rezeptoragonisten
|
|
TW200811105A
(en)
*
|
2006-04-25 |
2008-03-01 |
Theravance Inc |
Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
|
|
TW200811104A
(en)
*
|
2006-04-25 |
2008-03-01 |
Theravance Inc |
Crystalline forms of a dimethylphenyl compound
|
|
GB0613154D0
(en)
*
|
2006-06-30 |
2006-08-09 |
Novartis Ag |
Organic Compounds
|
|
TW200821316A
(en)
|
2006-07-19 |
2008-05-16 |
Astrazeneca Ab |
Novel compounds 243
|
|
ES2302447B1
(es)
*
|
2006-10-20 |
2009-06-12 |
Laboratorios Almirall S.A. |
Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
|
|
TW200825084A
(en)
|
2006-11-14 |
2008-06-16 |
Astrazeneca Ab |
New compounds 521
|
|
WO2008075005A1
(en)
|
2006-12-19 |
2008-06-26 |
Astrazeneca Ab |
Quinuclidinol derivatives as muscarinic receptor antagonists
|
|
US20100056508A1
(en)
*
|
2006-12-20 |
2010-03-04 |
Astrazeneca Ab |
Amine derivatives and their use in beta-2-adrenoreceptor mediated diseases
|
|
RS51644B
(sr)
|
2007-01-10 |
2011-10-31 |
Irm Llc. |
Jedinjenja i preparati kao inhibitori kanal aktivirajuće proteaze
|
|
ES2306595B1
(es)
|
2007-02-09 |
2009-09-11 |
Laboratorios Almirall S.A. |
Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
|
|
EP2117541A1
(en)
|
2007-02-09 |
2009-11-18 |
Irm Llc |
Compounds and compositions as channel activating protease inhibitors
|
|
KR20100005730A
(ko)
|
2007-05-07 |
2010-01-15 |
노파르티스 아게 |
유기 화합물
|
|
ES2320961B1
(es)
*
|
2007-11-28 |
2010-03-17 |
Laboratorios Almirall, S.A. |
Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
|
|
EA017919B1
(ru)
|
2007-12-10 |
2013-04-30 |
Новартис Аг |
Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов
|
|
EP2231642B1
(en)
|
2008-01-11 |
2013-10-23 |
Novartis AG |
Pyrimidines as kinase inhibitors
|
|
EP2096105A1
(en)
*
|
2008-02-28 |
2009-09-02 |
Laboratorios Almirall, S.A. |
Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
|
|
NZ589091A
(en)
|
2008-05-13 |
2011-07-29 |
Astrazeneca Ab |
Quinuclidine derivatives as muscarinic m3 receptor antagonists
|
|
CN102105448B
(zh)
|
2008-05-27 |
2013-11-13 |
阿斯利康(瑞典)有限公司 |
苯氧基吡啶基酰胺衍生物和它们在治疗由pde4介导的病症中的用途
|
|
KR20110040818A
(ko)
|
2008-06-10 |
2011-04-20 |
노파르티스 아게 |
상피 나트륨 채널 차단제로서의 피라진 유도체
|
|
US8236786B2
(en)
|
2008-08-07 |
2012-08-07 |
Pulmagen Therapeutics (Inflammation) Limited |
Respiratory disease treatment
|
|
WO2010067102A1
(en)
|
2008-12-09 |
2010-06-17 |
Astrazeneca Ab |
Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders
|
|
UY32297A
(es)
|
2008-12-22 |
2010-05-31 |
Almirall Sa |
Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
|
|
SI2379507T1
(sl)
|
2008-12-30 |
2014-02-28 |
Pulmagen Therapeutics (Inflammation) Limited |
Spojine sulfonamida za zdravljenje respiratornih motenj
|
|
EP2228368A1
(en)
|
2009-03-12 |
2010-09-15 |
Almirall, S.A. |
Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
|
|
WO2010126025A1
(ja)
*
|
2009-04-30 |
2010-11-04 |
帝人ファーマ株式会社 |
四級アンモニウム塩化合物
|
|
WO2010150014A1
(en)
|
2009-06-24 |
2010-12-29 |
Pulmagen Therapeutics (Inflammation) Limited |
5r- 5 -deuterated glitazones for respiratory disease treatment
|
|
BR112012000977A2
(pt)
|
2009-07-15 |
2019-09-24 |
Sharp Kk |
dispositivo de exibição de cristal líquido
|
|
EP2813227A1
(en)
|
2009-10-22 |
2014-12-17 |
Vertex Pharmaceuticals Incorporated |
Compositions for treatment of cystic fibrosis and other chronic diseases
|
|
GB0918923D0
(en)
|
2009-10-28 |
2009-12-16 |
Vantia Ltd |
Aminothiazole derivatives
|
|
GB0918924D0
(en)
|
2009-10-28 |
2009-12-16 |
Vantia Ltd |
Azaindole derivatives
|
|
GB0918922D0
(en)
|
2009-10-28 |
2009-12-16 |
Vantia Ltd |
Aminopyridine derivatives
|
|
WO2011061527A1
(en)
|
2009-11-17 |
2011-05-26 |
Astrazeneca Ab |
Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
|
|
WO2011098746A1
(en)
|
2010-02-09 |
2011-08-18 |
Pulmagen Therapeutics (Inflammation) Limited |
Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone
|
|
GB201002224D0
(en)
|
2010-02-10 |
2010-03-31 |
Argenta Therapeutics Ltd |
Respiratory disease treatment
|
|
GB201002243D0
(en)
|
2010-02-10 |
2010-03-31 |
Argenta Therapeutics Ltd |
Respiratory disease treatment
|
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
|
US8637516B2
(en)
|
2010-09-09 |
2014-01-28 |
Irm Llc |
Compounds and compositions as TRK inhibitors
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
US8372845B2
(en)
|
2010-09-17 |
2013-02-12 |
Novartis Ag |
Pyrazine derivatives as enac blockers
|
|
GB201016912D0
(en)
|
2010-10-07 |
2010-11-24 |
Astrazeneca Ab |
Novel combination
|
|
AU2012220572A1
(en)
|
2011-02-25 |
2013-08-29 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
CN102199099B
(zh)
*
|
2011-04-11 |
2013-12-18 |
常州大学 |
3-溴-4-甲氧基苯胺的制备方法
|
|
US8883819B2
(en)
|
2011-09-01 |
2014-11-11 |
Irm Llc |
Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
|
|
ES2882807T3
(es)
|
2011-09-16 |
2021-12-02 |
Novartis Ag |
Heterociclil carboxamidas N-sustituidas
|
|
WO2013038378A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
WO2013038386A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Heterocyclic compounds for the treatment of cystic fibrosis
|
|
WO2013038381A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine/pyrazine amide derivatives
|
|
WO2013038373A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
EP2578570A1
(en)
|
2011-10-07 |
2013-04-10 |
Almirall, S.A. |
Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
|
|
US8809340B2
(en)
|
2012-03-19 |
2014-08-19 |
Novartis Ag |
Crystalline form
|
|
EP2641900A1
(en)
|
2012-03-20 |
2013-09-25 |
Almirall, S.A. |
Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
|
|
US9073921B2
(en)
|
2013-03-01 |
2015-07-07 |
Novartis Ag |
Salt forms of bicyclic heterocyclic derivatives
|
|
US10112926B2
(en)
|
2014-04-24 |
2018-10-30 |
Novartis Ag |
Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
PL3134395T3
(pl)
|
2014-04-24 |
2018-07-31 |
Novartis Ag |
Pochodne pirazyny jako inhibitory 3-kinazy fosfatydyloinozytolu
|
|
EP3134397A1
(en)
|
2014-04-24 |
2017-03-01 |
Novartis AG |
Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
EP3190103A1
(en)
*
|
2016-01-08 |
2017-07-12 |
Rijksuniversiteit Groningen |
Inhibitors of the pd-1/pd-l1 protein/protein interaction
|
|
EP3787637A4
(en)
|
2018-02-07 |
2021-12-08 |
Duke University |
SYSTEM AND METHOD FOR PHOSPHORYLATION OF HOMOGENEOUS GPCR AND IDENTIFICATION OF POSITIVE ALLOSTERIC MODULATORS OF BETA-2 ADRENERGIC RECEPTOR
|
|
EP3980121A1
(en)
|
2019-06-10 |
2022-04-13 |
Novartis AG |
Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis
|
|
PH12022550468A1
(en)
|
2019-08-28 |
2023-03-06 |
Novartis Ag |
Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease
|
|
CN110698352B
(zh)
*
|
2019-10-29 |
2023-01-17 |
邢台学院 |
一种3-溴-5-氨基邻苯二酚二甲醚的合成方法
|