JP2010526819A5 - - Google Patents
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- Publication number
- JP2010526819A5 JP2010526819A5 JP2010507607A JP2010507607A JP2010526819A5 JP 2010526819 A5 JP2010526819 A5 JP 2010526819A5 JP 2010507607 A JP2010507607 A JP 2010507607A JP 2010507607 A JP2010507607 A JP 2010507607A JP 2010526819 A5 JP2010526819 A5 JP 2010526819A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- group
- hydrogen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C=C(*)C=C1)C=C1c1nccnc1N1CCN(Cc2c(*)[n](*)nc2*)CC1 Chemical compound CC(C=C(*)C=C1)C=C1c1nccnc1N1CCN(Cc2c(*)[n](*)nc2*)CC1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91743107P | 2007-05-11 | 2007-05-11 | |
| US60/917,431 | 2007-05-11 | ||
| US97420907P | 2007-09-21 | 2007-09-21 | |
| US60/974,209 | 2007-09-21 | ||
| PCT/US2008/062834 WO2008141020A1 (en) | 2007-05-11 | 2008-05-07 | 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines and pyridines and 3-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-2-phenyl pyridines as 5-ht7 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526819A JP2010526819A (ja) | 2010-08-05 |
| JP2010526819A5 true JP2010526819A5 (enExample) | 2011-05-26 |
| JP5210375B2 JP5210375B2 (ja) | 2013-06-12 |
Family
ID=39629131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507607A Expired - Fee Related JP5210375B2 (ja) | 2007-05-11 | 2008-05-07 | ５−ｈｔ７受容体拮抗薬としての２−［４−（ピラゾール−４−イルアルキル）ピペラジン−１−イル］−３−フェニルピラジンおよびピリジンならびに３−［４−（ピラゾール−４−イルアルキル）ピペラジン−１−イル］−２−フェニルピリジン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8202873B2 (enExample) |
| EP (1) | EP2155717B1 (enExample) |
| JP (1) | JP5210375B2 (enExample) |
| KR (1) | KR101119294B1 (enExample) |
| CN (1) | CN101861312B (enExample) |
| AU (1) | AU2008251584B2 (enExample) |
| BR (1) | BRPI0811446A2 (enExample) |
| CA (1) | CA2684563C (enExample) |
| CY (1) | CY1113457T1 (enExample) |
| DK (1) | DK2155717T3 (enExample) |
| EA (1) | EA016529B1 (enExample) |
| ES (1) | ES2395872T3 (enExample) |
| HR (1) | HRP20120919T1 (enExample) |
| MX (1) | MX2009012126A (enExample) |
| PL (1) | PL2155717T3 (enExample) |
| PT (1) | PT2155717E (enExample) |
| WO (1) | WO2008141020A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8410277B2 (en) | 2007-12-26 | 2013-04-02 | Eisai R&D Managment Co., Ltd. | Method for manufacturing heterocycle substituted pyridine derivatives |
| EP2459538B1 (en) * | 2009-07-31 | 2014-10-15 | Syngenta Participations AG | Processes for the alkylation of pyrazoles |
| JPWO2011062194A1 (ja) | 2009-11-18 | 2013-04-04 | 武田薬品工業株式会社 | アミノピリジン誘導体 |
| WO2011140333A1 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
| CN103052625B (zh) | 2010-08-10 | 2016-04-13 | 先正达参股股份有限公司 | 制备3-卤烷基吡唑的方法 |
| CN105829287B (zh) * | 2013-12-20 | 2019-08-27 | 埃斯蒂文制药股份有限公司 | 具有抗疼痛的多重模式活性的哌嗪衍生物 |
| WO2016025129A1 (en) | 2014-08-14 | 2016-02-18 | Alhamadsheh Mamoun M | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
| CN104592199A (zh) * | 2015-01-22 | 2015-05-06 | 杭州利巴医药科技有限公司 | 一种取代的1-(2-吡啶基)-吡唑-4-基乙酸及其衍生物和制备方法 |
| CN104945325B (zh) * | 2015-06-19 | 2017-04-05 | 浙江永太科技股份有限公司 | 一种吡唑甲酸衍生物的制备方法 |
| MX2021015220A (es) | 2017-02-17 | 2022-12-01 | Eidos Therapeutics Inc | Procesos para preparar ácido 3-(3-(3,5-dimetil-1h-pirazol-4-il)pro poxi)-4- 5-fluorobenzoico (ag-10), sus compuestos intermedios, y sales del mismo. |
| CA3094711A1 (en) | 2018-03-23 | 2019-09-26 | Eidos Therapeutics, Inc. | Methods of treating ttr amyloidosis using ag10 |
| WO2020037189A1 (en) | 2018-08-17 | 2020-02-20 | Eidos Therapeutics, Inc. | Formulations of ag10 |
| KR102514860B1 (ko) * | 2020-12-01 | 2023-03-29 | 한국과학기술연구원 | 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물 |
| CN115974785A (zh) * | 2022-12-09 | 2023-04-18 | 南京先进生物材料与过程装备研究院有限公司 | 一种3,5-二取代吡唑类化合物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2079323B1 (es) * | 1994-06-21 | 1996-10-16 | Vita Invest Sa | Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes. |
| EP1676844A1 (en) * | 2004-12-28 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | 5-HT7 receptor antagonists |
| CA2514656A1 (en) * | 2003-01-31 | 2004-08-12 | Pfizer Products Inc. | 5ht7 antagonists and inverse agonists |
| US20050080076A1 (en) * | 2003-10-08 | 2005-04-14 | Xanodyne Pharmacal, Inc. | N-desmethyl levomepromazine |
-
2008
- 2008-05-07 DK DK08747748.5T patent/DK2155717T3/da active
- 2008-05-07 MX MX2009012126A patent/MX2009012126A/es active IP Right Grant
- 2008-05-07 KR KR1020097022901A patent/KR101119294B1/ko not_active Expired - Fee Related
- 2008-05-07 EA EA200971052A patent/EA016529B1/ru not_active IP Right Cessation
- 2008-05-07 HR HRP20120919AT patent/HRP20120919T1/hr unknown
- 2008-05-07 JP JP2010507607A patent/JP5210375B2/ja not_active Expired - Fee Related
- 2008-05-07 PL PL08747748T patent/PL2155717T3/pl unknown
- 2008-05-07 AU AU2008251584A patent/AU2008251584B2/en not_active Ceased
- 2008-05-07 BR BRPI0811446-3A2A patent/BRPI0811446A2/pt not_active Application Discontinuation
- 2008-05-07 CN CN200880015741.XA patent/CN101861312B/zh not_active Expired - Fee Related
- 2008-05-07 EP EP08747748A patent/EP2155717B1/en not_active Not-in-force
- 2008-05-07 PT PT87477485T patent/PT2155717E/pt unknown
- 2008-05-07 US US12/597,255 patent/US8202873B2/en not_active Expired - Fee Related
- 2008-05-07 CA CA2684563A patent/CA2684563C/en not_active Expired - Fee Related
- 2008-05-07 WO PCT/US2008/062834 patent/WO2008141020A1/en not_active Ceased
- 2008-05-07 ES ES08747748T patent/ES2395872T3/es active Active
-
2012
- 2012-12-13 CY CY20121101219T patent/CY1113457T1/el unknown
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