JP2010526819A5 - - Google Patents
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- Publication number
- JP2010526819A5 JP2010526819A5 JP2010507607A JP2010507607A JP2010526819A5 JP 2010526819 A5 JP2010526819 A5 JP 2010526819A5 JP 2010507607 A JP2010507607 A JP 2010507607A JP 2010507607 A JP2010507607 A JP 2010507607A JP 2010526819 A5 JP2010526819 A5 JP 2010526819A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- methyl
- group
- hydrogen
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C=C(*)C=C1)C=C1c1nccnc1N1CCN(Cc2c(*)[n](*)nc2*)CC1 Chemical compound CC(C=C(*)C=C1)C=C1c1nccnc1N1CCN(Cc2c(*)[n](*)nc2*)CC1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91743107P | 2007-05-11 | 2007-05-11 | |
| US60/917,431 | 2007-05-11 | ||
| US97420907P | 2007-09-21 | 2007-09-21 | |
| US60/974,209 | 2007-09-21 | ||
| PCT/US2008/062834 WO2008141020A1 (en) | 2007-05-11 | 2008-05-07 | 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines and pyridines and 3-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-2-phenyl pyridines as 5-ht7 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010526819A JP2010526819A (ja) | 2010-08-05 |
| JP2010526819A5 true JP2010526819A5 (enExample) | 2011-05-26 |
| JP5210375B2 JP5210375B2 (ja) | 2013-06-12 |
Family
ID=39629131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010507607A Expired - Fee Related JP5210375B2 (ja) | 2007-05-11 | 2008-05-07 | ５−ｈｔ７受容体拮抗薬としての２−［４−（ピラゾール−４−イルアルキル）ピペラジン−１−イル］−３−フェニルピラジンおよびピリジンならびに３−［４−（ピラゾール−４−イルアルキル）ピペラジン−１−イル］−２−フェニルピリジン |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8202873B2 (enExample) |
| EP (1) | EP2155717B1 (enExample) |
| JP (1) | JP5210375B2 (enExample) |
| KR (1) | KR101119294B1 (enExample) |
| CN (1) | CN101861312B (enExample) |
| AU (1) | AU2008251584B2 (enExample) |
| BR (1) | BRPI0811446A2 (enExample) |
| CA (1) | CA2684563C (enExample) |
| CY (1) | CY1113457T1 (enExample) |
| DK (1) | DK2155717T3 (enExample) |
| EA (1) | EA016529B1 (enExample) |
| ES (1) | ES2395872T3 (enExample) |
| HR (1) | HRP20120919T1 (enExample) |
| MX (1) | MX2009012126A (enExample) |
| PL (1) | PL2155717T3 (enExample) |
| PT (1) | PT2155717E (enExample) |
| WO (1) | WO2008141020A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101910159B (zh) | 2007-12-26 | 2013-06-19 | 卫材R&D管理有限公司 | 杂环取代吡啶衍生物的制备方法 |
| CN102471279A (zh) * | 2009-07-31 | 2012-05-23 | 先正达参股股份有限公司 | 吡唑的烷基化方法 |
| EP2502909A4 (en) | 2009-11-18 | 2013-04-03 | Takeda Pharmaceutical | aminopyridine derivative |
| US8877795B2 (en) | 2010-05-07 | 2014-11-04 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
| PT2603494T (pt) | 2010-08-10 | 2017-02-03 | Syngenta Participations Ag | Processo para a preparação de 3-haloalquilopirazóis |
| MX2016008130A (es) | 2013-12-20 | 2016-10-13 | Esteve Labor Dr | Derivados de piperidina con actividad multimodal contra el dolor. |
| JP6543342B2 (ja) | 2014-08-14 | 2019-07-10 | アルハマドシャー，マモウン，エム． | 血清半減期を延長するための、調節可能リンカーを介した薬学的活性剤とトランスサイレチンリガンドのコンジュゲーション |
| CN104592199A (zh) * | 2015-01-22 | 2015-05-06 | 杭州利巴医药科技有限公司 | 一种取代的1-(2-吡啶基)-吡唑-4-基乙酸及其衍生物和制备方法 |
| CN104945325B (zh) * | 2015-06-19 | 2017-04-05 | 浙江永太科技股份有限公司 | 一种吡唑甲酸衍生物的制备方法 |
| US10513497B2 (en) | 2017-02-17 | 2019-12-24 | Eidos Therapeutics, Inc. | Process for preparing AG-10, its intermediates, and salts thereof |
| CA3094711A1 (en) | 2018-03-23 | 2019-09-26 | Eidos Therapeutics, Inc. | Methods of treating ttr amyloidosis using ag10 |
| CA3104695A1 (en) | 2018-08-17 | 2020-02-20 | Eidos Therapeutics, Inc. | Formulations of ag10 |
| KR102514860B1 (ko) * | 2020-12-01 | 2023-03-29 | 한국과학기술연구원 | 5-ht7 세로토닌 수용체 활성 저해용 바이페닐 피롤리딘 및 바이페닐 다이하이드로이미다졸 유도체 및 이를 유효성분으로 포함하는 약학 조성물 |
| CN115974785A (zh) * | 2022-12-09 | 2023-04-18 | 南京先进生物材料与过程装备研究院有限公司 | 一种3,5-二取代吡唑类化合物的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2079323B1 (es) * | 1994-06-21 | 1996-10-16 | Vita Invest Sa | Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes. |
| EP1676844A1 (en) * | 2004-12-28 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | 5-HT7 receptor antagonists |
| EP1592772A2 (en) * | 2003-01-31 | 2005-11-09 | Pfizer Products Incorporated | 5ht7 antagonists and inverse agonists |
| US20050080076A1 (en) * | 2003-10-08 | 2005-04-14 | Xanodyne Pharmacal, Inc. | N-desmethyl levomepromazine |
-
2008
- 2008-05-07 WO PCT/US2008/062834 patent/WO2008141020A1/en not_active Ceased
- 2008-05-07 AU AU2008251584A patent/AU2008251584B2/en not_active Ceased
- 2008-05-07 JP JP2010507607A patent/JP5210375B2/ja not_active Expired - Fee Related
- 2008-05-07 PL PL08747748T patent/PL2155717T3/pl unknown
- 2008-05-07 PT PT87477485T patent/PT2155717E/pt unknown
- 2008-05-07 CA CA2684563A patent/CA2684563C/en not_active Expired - Fee Related
- 2008-05-07 EP EP08747748A patent/EP2155717B1/en not_active Not-in-force
- 2008-05-07 DK DK08747748.5T patent/DK2155717T3/da active
- 2008-05-07 HR HRP20120919AT patent/HRP20120919T1/hr unknown
- 2008-05-07 KR KR1020097022901A patent/KR101119294B1/ko not_active Expired - Fee Related
- 2008-05-07 CN CN200880015741.XA patent/CN101861312B/zh not_active Expired - Fee Related
- 2008-05-07 ES ES08747748T patent/ES2395872T3/es active Active
- 2008-05-07 MX MX2009012126A patent/MX2009012126A/es active IP Right Grant
- 2008-05-07 EA EA200971052A patent/EA016529B1/ru not_active IP Right Cessation
- 2008-05-07 US US12/597,255 patent/US8202873B2/en not_active Expired - Fee Related
- 2008-05-07 BR BRPI0811446-3A2A patent/BRPI0811446A2/pt not_active Application Discontinuation
-
2012
- 2012-12-13 CY CY20121101219T patent/CY1113457T1/el unknown
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