DK1446379T3 - Arylanilin-beta2-adrenergiske receptoragonister - Google Patents

Arylanilin-beta2-adrenergiske receptoragonister

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Publication number
DK1446379T3
DK1446379T3 DK02780622T DK02780622T DK1446379T3 DK 1446379 T3 DK1446379 T3 DK 1446379T3 DK 02780622 T DK02780622 T DK 02780622T DK 02780622 T DK02780622 T DK 02780622T DK 1446379 T3 DK1446379 T3 DK 1446379T3
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DK
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Prior art keywords
arylanilin
beta2
receptor agonists
adrenergic receptor
adrenergic
Prior art date
Application number
DK02780622T
Other languages
English (en)
Inventor
John R Jacobsen
Michael R Leadbetter
Sean G Trapp
Timothy J Church
Edmund J Moran
James Aggen
Matthew B Nodwell
Original Assignee
Theravance Inc
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Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
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Publication of DK1446379T3 publication Critical patent/DK1446379T3/da

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    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
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CN1280259C (zh) 2006-10-18
US20040063755A1 (en) 2004-04-01
NZ532030A (en) 2006-08-31
TWI249515B (en) 2006-02-21
CA2466962A1 (en) 2003-05-22
US7553971B2 (en) 2009-06-30
RU2004117887A (ru) 2005-04-20
BR0213795A (pt) 2004-12-07
US7125892B2 (en) 2006-10-24
AU2002343662B2 (en) 2008-06-26
KR20050044400A (ko) 2005-05-12
SI1446379T1 (sl) 2009-08-31
JP2005509024A (ja) 2005-04-07
EP1446379B1 (en) 2009-04-29
EP1446379A1 (en) 2004-08-18
WO2003042164A1 (en) 2003-05-22
CN1585742A (zh) 2005-02-23
DE60232171D1 (de) 2009-06-10
JP4303113B2 (ja) 2009-07-29
IL161174A0 (en) 2004-08-31
HUP0401876A2 (hu) 2004-12-28
PT1446379E (pt) 2009-06-26
KR20090045421A (ko) 2009-05-07
PL371933A1 (en) 2005-07-11
TW200303298A (en) 2003-09-01
MXPA04004505A (es) 2004-09-10
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HUP0401876A3 (en) 2008-03-28
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PE20030567A1 (es) 2003-07-07
NO20041817L (no) 2004-05-04
ES2326310T3 (es) 2009-10-07
JP2009167199A (ja) 2009-07-30
KR100908438B1 (ko) 2009-07-21
RU2298545C2 (ru) 2007-05-10
ATE430124T1 (de) 2009-05-15
US20060178410A1 (en) 2006-08-10
US6670376B1 (en) 2003-12-30

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