JP2007502806A5 - - Google Patents
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- Publication number
- JP2007502806A5 JP2007502806A5 JP2006523683A JP2006523683A JP2007502806A5 JP 2007502806 A5 JP2007502806 A5 JP 2007502806A5 JP 2006523683 A JP2006523683 A JP 2006523683A JP 2006523683 A JP2006523683 A JP 2006523683A JP 2007502806 A5 JP2007502806 A5 JP 2007502806A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- phenoxy
- phenyl
- acetic acid
- methylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0302281-1 | 2003-08-21 | ||
| SE0302281A SE0302281D0 (sv) | 2003-08-21 | 2003-08-21 | Novel compounds |
| GB0412448A GB0412448D0 (en) | 2004-06-04 | 2004-06-04 | Novel compounds |
| GB0412448.3 | 2004-06-04 | ||
| PCT/GB2004/003551 WO2005018529A2 (en) | 2003-08-21 | 2004-08-18 | Phenoxiacetic acid derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007502806A JP2007502806A (ja) | 2007-02-15 |
| JP2007502806A5 true JP2007502806A5 (enExample) | 2007-07-12 |
| JP5025264B2 JP5025264B2 (ja) | 2012-09-12 |
Family
ID=34219638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006523683A Expired - Fee Related JP5025264B2 (ja) | 2003-08-21 | 2004-08-18 | フェノキシ酢酸誘導体 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8003703B2 (enExample) |
| EP (1) | EP1660431B1 (enExample) |
| JP (1) | JP5025264B2 (enExample) |
| KR (1) | KR101136175B1 (enExample) |
| AR (1) | AR045470A1 (enExample) |
| AT (1) | ATE427296T1 (enExample) |
| AU (1) | AU2004266485B2 (enExample) |
| BR (1) | BRPI0413490A (enExample) |
| CA (1) | CA2535714C (enExample) |
| CO (1) | CO5670367A2 (enExample) |
| CY (1) | CY1110318T1 (enExample) |
| DE (1) | DE602004020356D1 (enExample) |
| DK (1) | DK1660431T3 (enExample) |
| ES (1) | ES2322653T3 (enExample) |
| HR (1) | HRP20090280T1 (enExample) |
| IL (1) | IL173522A (enExample) |
| IS (1) | IS2693B (enExample) |
| MX (1) | MXPA06001954A (enExample) |
| MY (1) | MY142029A (enExample) |
| NZ (1) | NZ545450A (enExample) |
| PL (1) | PL1660431T3 (enExample) |
| PT (1) | PT1660431E (enExample) |
| RU (1) | RU2360901C2 (enExample) |
| SA (1) | SA04250253B1 (enExample) |
| SI (1) | SI1660431T1 (enExample) |
| TW (1) | TWI347313B (enExample) |
| UY (1) | UY28482A1 (enExample) |
| WO (1) | WO2005018529A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| RU2387652C2 (ru) | 2004-03-11 | 2010-04-27 | Актелион Фармасьютиклз Лтд | Производные тетрагидропиридоиндола |
| WO2005115374A1 (en) * | 2004-05-29 | 2005-12-08 | 7Tm Pharma A/S | Crth2 receptor ligands for therapeutic use |
| US8022063B2 (en) * | 2004-05-29 | 2011-09-20 | 7Tm Pharma A/S | CRTH2 receptor ligands for medicinal uses |
| GB0415320D0 (en) * | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| JP5208510B2 (ja) * | 2004-11-23 | 2013-06-12 | アストラゼネカ・アクチエボラーグ | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
| GB0510585D0 (en) * | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| GB0510584D0 (en) * | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| EA015358B1 (ru) * | 2005-09-30 | 2011-06-30 | Пульмаджен Терапьютикс (Эсме) Лимитед | Хинолины и их терапевтическое применение |
| JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| GB0520324D0 (en) * | 2005-10-06 | 2005-11-16 | Astrazeneca Ab | Novel compounds |
| RU2424229C2 (ru) * | 2005-10-06 | 2011-07-20 | Астразенека Аб | Производные бифенилоксиуксусной кислоты, их применение для изготовления лекарственного средства и промежуточные соединения |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| US20080255150A1 (en) * | 2005-11-05 | 2008-10-16 | Astrazeneca Ab | Novel Compounds |
| WO2007062678A1 (en) * | 2005-11-29 | 2007-06-07 | 7Tm Pharma A/S | Phenoxyacetic acid derivatives as crth2 receptor ligands |
| GB0524428D0 (en) | 2005-11-30 | 2006-01-11 | 7Tm Pharma As | Medicinal use of receptor ligands |
| EP1963259B1 (en) | 2005-12-15 | 2012-02-15 | AstraZeneca AB | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
| US7741360B2 (en) | 2006-05-26 | 2010-06-22 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
| EP2037967B1 (en) | 2006-06-16 | 2016-12-07 | The Trustees Of The University Of Pennsylvania | Prostaglandin d2 receptor antagonists for treating androgenetic alopecia |
| WO2013142295A1 (en) | 2012-03-21 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for regulating hair growth |
| GB0702456D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | New combination |
| EA017093B1 (ru) * | 2007-04-04 | 2012-09-28 | Пульмаджен Терапьютикс (Эсме) Лимитед | Хинолины и их терапевтическое применение |
| UA100983C2 (ru) * | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| CA2707785C (en) | 2007-12-14 | 2015-11-03 | Pulmagen Therapeutics (Asthma) Limited | Indoles and their therapeutic use |
| WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
| GB0818365D0 (en) * | 2008-10-07 | 2008-11-12 | Argenta Discovery Ltd | Quinoline compounds |
| MX2011005120A (es) * | 2008-11-17 | 2011-05-30 | Hoffmann La Roche | Acidos naftilaceticos. |
| CN102471355B (zh) | 2009-07-09 | 2015-10-07 | 杏林制药株式会社 | 二苯硫醚衍生物和含有其作为活性成分的药物 |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| WO2011073662A1 (en) | 2009-12-17 | 2011-06-23 | Astrazeneca Ab | Combination of a benzoxazinone and a further agent for treating respiratory diseases |
| JP5800898B2 (ja) | 2010-07-05 | 2015-10-28 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | １−フェニル−置換ヘテロシクリル誘導体及びプロスタグランジンｄ２受容体調節剤としてのそれらの使用 |
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
| EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
| EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
| SG11201402796SA (en) | 2011-12-16 | 2014-06-27 | Atopix Therapeutics Ltd | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| RU2014129613A (ru) | 2011-12-21 | 2016-02-10 | Актелион Фармасьютиклз Лтд | Гетероциклильные производные и их применение в качестве модуляторов рецептора простагландина d2 |
| US9169270B2 (en) | 2012-07-05 | 2015-10-27 | Actelion Pharmaceuticals Ltd. | 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators |
| AU2015242219A1 (en) | 2014-03-29 | 2016-10-06 | Lupin Limited | Sulfonamide compounds as Voltage gated sodium channel modulators |
| ES2991300T3 (es) | 2015-02-13 | 2024-12-03 | Inserm Institut Nat De La Sante Et De Larecherche Medicale | Antagonistas de PTGDR-1 y/o PTGDR-2 para prevenir y/o tratar lupus eritematoso sistémico |
| BR112017022505A2 (pt) * | 2015-05-27 | 2018-07-17 | Jiangsu Hengrui Medicine Co., Ltd. | sal de sódio de inibidor de transportador de ácido úrico e forma cristalina do mesmo |
| MX2018001217A (es) | 2015-07-30 | 2018-09-12 | Univ Pennsylvania | Alelos polimorficos de nucleotidos individuales del gen humano dp-2 para la deteccion de la susceptibilidad a la inhibicion del crecimiento del cabello por pgd2. |
| US10450274B2 (en) * | 2015-12-07 | 2019-10-22 | Hinova Pharmaceuticals Inc. | Quinoline compounds, preparation methods thereof, and uses thereof as urate transporter inhibitor drug |
| GB201709396D0 (en) | 2017-06-13 | 2017-07-26 | Astrazeneca Ab | Compounds for use as radioligands |
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|---|---|---|---|---|
| GB690816A (en) | 1950-01-02 | 1953-04-29 | British Drug Houses Ltd | Improvements in or relating to the manufacture of substituted phenoxy acetic acids |
| US3278524A (en) | 1962-03-13 | 1966-10-11 | Beecham Group Ltd | Penicillins and their production |
| CH432119A (de) * | 1963-02-22 | 1967-03-15 | Geigy Ag J R | Verwendung von Halogen-o-hydroxy-diphenyläthern als antimikrobielle Mittel |
| BE790679A (fr) | 1971-11-03 | 1973-04-27 | Ici Ltd | Derives de l'indole |
| DD113545A5 (enExample) | 1973-03-30 | 1975-06-12 | ||
| JPS5239888B2 (enExample) * | 1973-05-28 | 1977-10-07 | ||
| US3954852A (en) | 1973-10-19 | 1976-05-04 | Merck & Co., Inc. | Indenylacetic acid compounds |
| CA1041531A (en) | 1973-10-29 | 1978-10-31 | Eisai Co. Ltd. | M-phenoxyphenyl propionic acid derivatives and preparation thereof |
| CH582476A5 (enExample) * | 1973-10-29 | 1976-12-15 | Ciba Geigy Ag | |
| GB1585963A (en) * | 1976-10-14 | 1981-03-11 | Lilly Industries Ltd | Aryl sulphur compounds |
| US4248618A (en) | 1977-05-06 | 1981-02-03 | Ici Australia Limited | Derivatives of (pyrimidyloxy)phenoxy-alkanecarboxylic acid and herbicidal compositions thereof |
| DE2832435A1 (de) | 1977-07-27 | 1979-02-08 | Ciba Geigy Ag | Phenoxy-phenoxy-alkancarbonsaeurederivate |
| FR2428629A1 (fr) | 1978-06-14 | 1980-01-11 | Hexachimie | Nouveaux composes bis(aryloxycarboxyliques), leur preparation et leur utilisation en therapeutique |
| JPS5951943B2 (ja) * | 1978-08-21 | 1984-12-17 | キツセイ薬品工業株式会社 | 新規なイミダゾ−ル誘導体 |
| GB2041363B (en) | 1979-01-19 | 1982-10-06 | Pfizer Ltd | N-benzyl-imidazoles |
| US4670566A (en) | 1979-07-12 | 1987-06-02 | A. H. Robins Company, Incorporated | 3-methyl-hio-4-(5-, 6-, or 7-)phenylindolindolin-2-ones |
| US4486593A (en) | 1983-01-19 | 1984-12-04 | The Upjohn Company | 2-,3-, or 4-Pyridinylmethylamino arylic acids as thromboxane A2 synthetase and 5-lipoxygenase inhibitors |
| DE3419009A1 (de) * | 1984-05-22 | 1985-11-28 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue substituierte bis(4-aminophenyl)sulfone, ihre herstellung und ihre verwendung als arzneimittel |
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| EP0540165A1 (en) | 1991-10-03 | 1993-05-05 | Zeneca Limited | Alkanoic acid derivatives |
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| DE19544828A1 (de) | 1995-12-01 | 1997-06-05 | Hoechst Ag | Hochmolekulare Copolymere |
| PT939628E (pt) | 1996-07-22 | 2003-07-31 | Monsanto Co | Inibidores tiolsulfona de metaloproteases |
| CA2219269A1 (en) | 1996-10-29 | 1998-04-29 | Novartis Ag | Novel herbicides |
| FR2763588B1 (fr) | 1997-05-23 | 1999-07-09 | Cird Galderma | Composes triaromatiques, compositions les contenant et utilisations |
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| KR100340273B1 (ko) | 1997-10-14 | 2002-06-14 | 야마모토 카즈모토 | 비페닐-5-알칸산 유도체 및 이의 용도 |
| DE60025368T2 (de) | 1999-08-23 | 2006-09-14 | Bml Inc. | Verfahren zum identifizieren von prostaglandin d2 rezeptor modulatoren |
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| US6770666B2 (en) | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
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| WO2001081312A2 (en) | 2000-04-24 | 2001-11-01 | Merck Frosst Canada & Co. | Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| US6699997B2 (en) | 2000-06-28 | 2004-03-02 | Teva Pharmaceutical Industries Ltd. | Carvedilol |
| US6878522B2 (en) | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| US20040097555A1 (en) | 2000-12-26 | 2004-05-20 | Shinegori Ohkawa | Concomitant drugs |
| EP1389185A2 (en) | 2001-05-24 | 2004-02-18 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
| BR0210391A (pt) | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
| CA2459515A1 (en) | 2001-09-07 | 2003-03-20 | Kazuhiko Torisu | Indole derivatives |
| BR0307406A (pt) | 2002-02-01 | 2004-12-28 | Hoffmann La Roche | Indóis substituìdos como agonistas alfa-1 |
| SE0200411D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| WO2003068744A1 (en) * | 2002-02-18 | 2003-08-21 | Ishihara Sangyo Kaisha, Ltd. | Pyridine derivatives or salts thereof and cytokine production inhibitors containing the same |
| NZ535603A (en) | 2002-03-20 | 2007-10-26 | Metabolex Inc | Substituted phenylacetic acids |
| JPWO2003097042A1 (ja) * | 2002-05-16 | 2005-09-15 | 塩野義製薬株式会社 | Ｐｇｄ２受容体拮抗剤 |
| JP4484108B2 (ja) | 2002-05-16 | 2010-06-16 | 塩野義製薬株式会社 | Ｐｇｄ２受容体拮抗作用を有する化合物 |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| AR042206A1 (es) | 2002-11-26 | 2005-06-15 | Novartis Ag | Acidos fenilaceticos y derivados |
| AU2003297398B2 (en) | 2002-12-20 | 2009-09-24 | Amgen Inc. | Asthma and allergic inflammation modulators |
| AU2004232682B2 (en) | 2003-03-28 | 2006-12-07 | Eli Lilly And Company | Isoquinoline-5-sulfonic acid amides as inhibitors of Akt (protein kinase B) |
| SE0301009D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| ATE316077T1 (de) | 2003-04-25 | 2006-02-15 | Actimis Pharmaceuticals Inc | Pyrimidin-essigsäure derivate geeignet zur behandlung von crth2-bedingten krankheiten |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| GB0409921D0 (en) | 2004-05-04 | 2004-06-09 | Novartis Ag | Organic compounds |
| US8022063B2 (en) | 2004-05-29 | 2011-09-20 | 7Tm Pharma A/S | CRTH2 receptor ligands for medicinal uses |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| GB0422057D0 (en) | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| JP5208510B2 (ja) | 2004-11-23 | 2013-06-12 | アストラゼネカ・アクチエボラーグ | 呼吸器疾患の処置に有用なフェノキシ酢酸誘導体 |
| GB0510584D0 (en) | 2005-05-24 | 2005-06-29 | Novartis Ag | Organic compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| JP5155171B2 (ja) | 2005-10-06 | 2013-02-27 | アストラゼネカ・アクチエボラーグ | 新規化合物 |
| US20080255150A1 (en) | 2005-11-05 | 2008-10-16 | Astrazeneca Ab | Novel Compounds |
| EP1963259B1 (en) | 2005-12-15 | 2012-02-15 | AstraZeneca AB | Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
-
2004
- 2004-08-15 SA SA4250253A patent/SA04250253B1/ar unknown
- 2004-08-16 TW TW093124572A patent/TWI347313B/zh not_active IP Right Cessation
- 2004-08-18 US US10/569,065 patent/US8003703B2/en not_active Expired - Fee Related
- 2004-08-18 AU AU2004266485A patent/AU2004266485B2/en not_active Ceased
- 2004-08-18 MX MXPA06001954A patent/MXPA06001954A/es active IP Right Grant
- 2004-08-18 JP JP2006523683A patent/JP5025264B2/ja not_active Expired - Fee Related
- 2004-08-18 HR HR20090280T patent/HRP20090280T1/xx unknown
- 2004-08-18 RU RU2006107653/04A patent/RU2360901C2/ru not_active IP Right Cessation
- 2004-08-18 DE DE602004020356T patent/DE602004020356D1/de not_active Expired - Lifetime
- 2004-08-18 DK DK04768111T patent/DK1660431T3/da active
- 2004-08-18 BR BRPI0413490-7A patent/BRPI0413490A/pt not_active IP Right Cessation
- 2004-08-18 ES ES04768111T patent/ES2322653T3/es not_active Expired - Lifetime
- 2004-08-18 EP EP04768111A patent/EP1660431B1/en not_active Expired - Lifetime
- 2004-08-18 CA CA2535714A patent/CA2535714C/en not_active Expired - Fee Related
- 2004-08-18 PT PT04768111T patent/PT1660431E/pt unknown
- 2004-08-18 SI SI200431118T patent/SI1660431T1/sl unknown
- 2004-08-18 NZ NZ545450A patent/NZ545450A/en not_active IP Right Cessation
- 2004-08-18 PL PL04768111T patent/PL1660431T3/pl unknown
- 2004-08-18 AT AT04768111T patent/ATE427296T1/de active
- 2004-08-18 KR KR1020067003429A patent/KR101136175B1/ko not_active Expired - Fee Related
- 2004-08-18 WO PCT/GB2004/003551 patent/WO2005018529A2/en not_active Ceased
- 2004-08-19 MY MYPI20043374A patent/MY142029A/en unknown
- 2004-08-20 AR ARP040102990A patent/AR045470A1/es not_active Application Discontinuation
- 2004-08-20 UY UY28482A patent/UY28482A1/es not_active Application Discontinuation
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2006
- 2006-02-02 IL IL173522A patent/IL173522A/en not_active IP Right Cessation
- 2006-02-16 CO CO06015646A patent/CO5670367A2/es not_active Application Discontinuation
- 2006-03-13 IS IS8350A patent/IS2693B/is unknown
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2009
- 2009-05-28 CY CY20091100565T patent/CY1110318T1/el unknown
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2011
- 2011-07-26 US US13/190,881 patent/US8394986B2/en not_active Expired - Fee Related