JP2006511612A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006511612A5 JP2006511612A5 JP2005502649A JP2005502649A JP2006511612A5 JP 2006511612 A5 JP2006511612 A5 JP 2006511612A5 JP 2005502649 A JP2005502649 A JP 2005502649A JP 2005502649 A JP2005502649 A JP 2005502649A JP 2006511612 A5 JP2006511612 A5 JP 2006511612A5
- Authority
- JP
- Japan
- Prior art keywords
- benzoxazole
- carboxy
- compound
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 66
- 150000003839 salts Chemical class 0.000 claims 58
- 108010071690 Prealbumin Proteins 0.000 claims 48
- 102000009190 Transthyretin Human genes 0.000 claims 48
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 33
- 206010002022 amyloidosis Diseases 0.000 claims 21
- 238000000034 method Methods 0.000 claims 21
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical class C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 claims 15
- 206010007509 Cardiac amyloidosis Diseases 0.000 claims 11
- -1 2,6-difluorophenyl Chemical group 0.000 claims 8
- 238000010494 dissociation reaction Methods 0.000 claims 8
- 230000005593 dissociations Effects 0.000 claims 8
- 150000003071 polychlorinated biphenyls Chemical group 0.000 claims 8
- 208000034846 Familial Amyloid Neuropathies Diseases 0.000 claims 6
- 206010019889 Hereditary neuropathic amyloidosis Diseases 0.000 claims 6
- 229960000616 diflunisal Drugs 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- 201000007905 transthyretin amyloidosis Diseases 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 210000004185 liver Anatomy 0.000 claims 5
- 238000002054 transplantation Methods 0.000 claims 5
- 208000027121 wild type ATTR amyloidosis Diseases 0.000 claims 5
- PMIIYXSRUSULDH-UHFFFAOYSA-N 2-(2,6-dichlorophenyl)-1,3-benzoxazole-4-carboxylic acid Chemical compound N=1C=2C(C(=O)O)=CC=CC=2OC=1C1=C(Cl)C=CC=C1Cl PMIIYXSRUSULDH-UHFFFAOYSA-N 0.000 claims 4
- VTTCWUHZUXWTPP-UHFFFAOYSA-N 2-(2,6-dichlorophenyl)-1,3-benzoxazole-5-carboxylic acid Chemical compound N=1C2=CC(C(=O)O)=CC=C2OC=1C1=C(Cl)C=CC=C1Cl VTTCWUHZUXWTPP-UHFFFAOYSA-N 0.000 claims 4
- XVNRKPCHMYOPPL-UHFFFAOYSA-N 2-(2,6-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid Chemical compound O1C2=CC(C(=O)O)=CC=C2N=C1C1=C(Cl)C=CC=C1Cl XVNRKPCHMYOPPL-UHFFFAOYSA-N 0.000 claims 4
- QMACGJYSQKQXKH-UHFFFAOYSA-N 2-(2,6-dichlorophenyl)-1,3-benzoxazole-7-carboxylic acid Chemical compound O1C=2C(C(=O)O)=CC=CC=2N=C1C1=C(Cl)C=CC=C1Cl QMACGJYSQKQXKH-UHFFFAOYSA-N 0.000 claims 4
- SYQQJVHDLFNSNY-UHFFFAOYSA-N 2-(2,6-difluorophenyl)-1,3-benzoxazole-4-carboxylic acid Chemical compound N=1C=2C(C(=O)O)=CC=CC=2OC=1C1=C(F)C=CC=C1F SYQQJVHDLFNSNY-UHFFFAOYSA-N 0.000 claims 4
- DLUAYZFBDZUTPO-UHFFFAOYSA-N 2-(2,6-difluorophenyl)-1,3-benzoxazole-5-carboxylic acid Chemical compound N=1C2=CC(C(=O)O)=CC=C2OC=1C1=C(F)C=CC=C1F DLUAYZFBDZUTPO-UHFFFAOYSA-N 0.000 claims 4
- VMEKBDFJIXVYME-UHFFFAOYSA-N 2-(2,6-difluorophenyl)-1,3-benzoxazole-6-carboxylic acid Chemical compound O1C2=CC(C(=O)O)=CC=C2N=C1C1=C(F)C=CC=C1F VMEKBDFJIXVYME-UHFFFAOYSA-N 0.000 claims 4
- UBHVVKLDLAIMBG-UHFFFAOYSA-N 2-(2,6-difluorophenyl)-1,3-benzoxazole-7-carboxylic acid Chemical compound O1C=2C(C(=O)O)=CC=CC=2N=C1C1=C(F)C=CC=C1F UBHVVKLDLAIMBG-UHFFFAOYSA-N 0.000 claims 4
- MQKHRHQZBRWEJP-UHFFFAOYSA-N 2-(3,5-dichlorophenyl)-1,3-benzoxazole-4-carboxylic acid Chemical compound N=1C=2C(C(=O)O)=CC=CC=2OC=1C1=CC(Cl)=CC(Cl)=C1 MQKHRHQZBRWEJP-UHFFFAOYSA-N 0.000 claims 4
- UGNMVUZMIXYKPW-UHFFFAOYSA-N 2-(3,5-dichlorophenyl)-1,3-benzoxazole-5-carboxylic acid Chemical compound N=1C2=CC(C(=O)O)=CC=C2OC=1C1=CC(Cl)=CC(Cl)=C1 UGNMVUZMIXYKPW-UHFFFAOYSA-N 0.000 claims 4
- ZTDDXZWJHRTEDF-UHFFFAOYSA-N 2-(3,5-dichlorophenyl)-1,3-benzoxazole-7-carboxylic acid Chemical compound O1C=2C(C(=O)O)=CC=CC=2N=C1C1=CC(Cl)=CC(Cl)=C1 ZTDDXZWJHRTEDF-UHFFFAOYSA-N 0.000 claims 4
- GLYCSRRIYCGKIR-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-1,3-benzoxazole-4-carboxylic acid Chemical compound N=1C=2C(C(=O)O)=CC=CC=2OC=1C1=CC(F)=CC(F)=C1 GLYCSRRIYCGKIR-UHFFFAOYSA-N 0.000 claims 4
- GAKAUTDPZCHUQY-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-1,3-benzoxazole-5-carboxylic acid Chemical compound N=1C2=CC(C(=O)O)=CC=C2OC=1C1=CC(F)=CC(F)=C1 GAKAUTDPZCHUQY-UHFFFAOYSA-N 0.000 claims 4
- RVLUUNWNVBRPED-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-1,3-benzoxazole-6-carboxylic acid Chemical compound O1C2=CC(C(=O)O)=CC=C2N=C1C1=CC(F)=CC(F)=C1 RVLUUNWNVBRPED-UHFFFAOYSA-N 0.000 claims 4
- JHHHICSUIPNPOX-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-1,3-benzoxazole-7-carboxylic acid Chemical compound O1C=2C(C(=O)O)=CC=CC=2N=C1C1=CC(F)=CC(F)=C1 JHHHICSUIPNPOX-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- TXEIIPDJKFWEEC-UHFFFAOYSA-N tafamidis Chemical compound O1C2=CC(C(=O)O)=CC=C2N=C1C1=CC(Cl)=CC(Cl)=C1 TXEIIPDJKFWEEC-UHFFFAOYSA-N 0.000 claims 4
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 claims 3
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
- 239000002599 prostaglandin synthase inhibitor Substances 0.000 claims 3
- JRUHAIBYXWRVJA-UHFFFAOYSA-N 2-phenyl-1,3-benzoxazole-4-carboxylic acid Chemical compound N=1C=2C(C(=O)O)=CC=CC=2OC=1C1=CC=CC=C1 JRUHAIBYXWRVJA-UHFFFAOYSA-N 0.000 claims 2
- UNJLCBQGDIBMAE-UHFFFAOYSA-N 2-phenyl-1,3-benzoxazole-5-carboxylic acid Chemical compound N=1C2=CC(C(=O)O)=CC=C2OC=1C1=CC=CC=C1 UNJLCBQGDIBMAE-UHFFFAOYSA-N 0.000 claims 2
- ICSRYAQXSYGQSJ-UHFFFAOYSA-N 2-phenyl-1,3-benzoxazole-6-carboxylic acid Chemical compound O1C2=CC(C(=O)O)=CC=C2N=C1C1=CC=CC=C1 ICSRYAQXSYGQSJ-UHFFFAOYSA-N 0.000 claims 2
- RZZURKQUMZPYIZ-UHFFFAOYSA-N 2-phenyl-1,3-benzoxazole-7-carboxylic acid Chemical compound O1C=2C(C(=O)O)=CC=CC=2N=C1C1=CC=CC=C1 RZZURKQUMZPYIZ-UHFFFAOYSA-N 0.000 claims 2
- 125000004211 3,5-difluorophenyl group Chemical group [H]C1=C(F)C([H])=C(*)C([H])=C1F 0.000 claims 2
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical group CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 2
- ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical group [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000010839 body fluid Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000006641 stabilisation Effects 0.000 claims 2
- 238000011105 stabilization Methods 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000368 destabilizing effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 102200150628 rs151220873 Human genes 0.000 claims 1
- 102200049725 rs182983506 Human genes 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43507902P | 2002-12-19 | 2002-12-19 | |
| US46543503P | 2003-04-24 | 2003-04-24 | |
| PCT/US2003/040567 WO2004056315A2 (en) | 2002-12-19 | 2003-12-19 | Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010162800A Division JP2010270134A (ja) | 2002-12-19 | 2010-07-20 | トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006511612A JP2006511612A (ja) | 2006-04-06 |
| JP2006511612A5 true JP2006511612A5 (enExample) | 2008-06-19 |
| JP4665076B2 JP4665076B2 (ja) | 2011-04-06 |
Family
ID=32685364
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005502649A Expired - Lifetime JP4665076B2 (ja) | 2002-12-19 | 2003-12-19 | トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 |
| JP2010162800A Pending JP2010270134A (ja) | 2002-12-19 | 2010-07-20 | トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 |
| JP2013170867A Expired - Lifetime JP5756151B2 (ja) | 2002-12-19 | 2013-08-21 | トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010162800A Pending JP2010270134A (ja) | 2002-12-19 | 2010-07-20 | トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 |
| JP2013170867A Expired - Lifetime JP5756151B2 (ja) | 2002-12-19 | 2013-08-21 | トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (6) | US7214695B2 (enExample) |
| EP (3) | EP2325651B1 (enExample) |
| JP (3) | JP4665076B2 (enExample) |
| KR (1) | KR101089904B1 (enExample) |
| CN (2) | CN101413143B (enExample) |
| AT (2) | ATE405840T1 (enExample) |
| AU (2) | AU2003303196C1 (enExample) |
| BE (1) | BE2012C008I2 (enExample) |
| BR (1) | BRPI0317463B8 (enExample) |
| CA (2) | CA2800237C (enExample) |
| CY (2) | CY1108467T1 (enExample) |
| DE (2) | DE60323155D1 (enExample) |
| DK (2) | DK1988397T3 (enExample) |
| ES (3) | ES2524803T3 (enExample) |
| FI (1) | FI1587821T6 (enExample) |
| FR (1) | FR12C0008I2 (enExample) |
| LU (1) | LU91935I2 (enExample) |
| PT (2) | PT1587821E (enExample) |
| SI (1) | SI1587821T2 (enExample) |
| WO (1) | WO2004056315A2 (enExample) |
Families Citing this family (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06105459B2 (ja) * | 1988-08-11 | 1994-12-21 | 日本電気株式会社 | ベクトル処理装置 |
| CN101413143B (zh) * | 2002-12-19 | 2013-09-18 | 斯克里普斯研究学院 | 稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错折叠的组合物和方法 |
| EP2106790B1 (en) * | 2004-03-12 | 2012-10-24 | Biodel, Inc. | Rapid acting drug delivery compositions |
| AU2005245470A1 (en) * | 2004-05-20 | 2005-12-01 | Foldrx Pharmaceuticals, Inc. | 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| DK1819354T3 (da) * | 2004-08-26 | 2011-09-12 | Biocrine Ab | Fremgangsmåder og forbindelser til behandling af diabetes |
| US20070037875A1 (en) * | 2005-08-11 | 2007-02-15 | The Scripps Research Institute | Genistein inhibition of transthyretin amyloidosis |
| EP2074223A4 (en) * | 2006-09-15 | 2010-03-10 | Foldrx Pharmaceuticals Inc | TEST PROCEDURE FOR THE DETECTION OF PROTEINS IN THE NATIVE CONDITION AND FOR THE IDENTIFICATION OF THE STABILITY OF PROTEINS IN THE NATIVE CONDITION MODULATING COMPOUNDS |
| WO2010054127A1 (en) * | 2008-11-05 | 2010-05-14 | Elan Pharmaceuticals, Inc. | Methods and agents for stabilizing non-pathological amyloidogenic polypeptides |
| TWI665200B (zh) | 2009-01-15 | 2019-07-11 | 英塞特公司 | 製造ｊａｋ抑制劑之方法及相關中間化合物 |
| WO2010091253A1 (en) | 2009-02-06 | 2010-08-12 | Women & Infants' Hospital Of Rhode Island | Compositions, formulations and methods of treating preeclampsia-type disorders of pregnancy |
| WO2011116123A1 (en) * | 2010-03-19 | 2011-09-22 | Irm Llc | Tafamidis for the treatment of ophthalmic diseases |
| ES2526522T3 (es) | 2010-04-21 | 2015-01-13 | Chiesi Farmaceutici S.P.A. | Derivados del ácido 1-(2-fluorobifenil-4-il)alquil carboxílico para la terapia de la amiloidosis transtiretina |
| WO2011140333A1 (en) | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
| WO2014037832A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
| WO2013038351A1 (en) * | 2011-09-16 | 2013-03-21 | Pfizer Inc. | Solid forms of a transthyretin dissociation inhibitor |
| JP2015519333A (ja) | 2012-05-07 | 2015-07-09 | セリックスビオ プライヴェート リミテッド | 神経疾患の治療のための組成物および方法 |
| CN104603096A (zh) | 2012-05-07 | 2015-05-06 | 塞利克斯比奥私人有限公司 | 用于治疗神经肌肉障碍和神经退行性疾病的组合物和方法 |
| WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
| WO2013168025A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of blood clotting disorders |
| US9434704B2 (en) | 2012-05-08 | 2016-09-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological degenerative disorders |
| US9266823B2 (en) | 2012-05-08 | 2016-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of parkinson's disease |
| WO2013167991A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic disorders |
| WO2013167992A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of inflammatory disorders |
| WO2013168001A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| WO2013168014A1 (en) * | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| US9394288B2 (en) | 2012-05-10 | 2016-07-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of asthma and allergy |
| US9242939B2 (en) | 2012-05-10 | 2016-01-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
| US9339484B2 (en) | 2012-05-10 | 2016-05-17 | Cellix Bio Private Limited | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
| WO2013168033A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
| US9403857B2 (en) | 2012-05-10 | 2016-08-02 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| US9346742B2 (en) | 2012-05-10 | 2016-05-24 | Cellix Bio Private Limited | Compositions and methods for the treatment of fibromyalgia pain |
| WO2013168002A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological conditions |
| US9315478B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| US9573927B2 (en) | 2012-05-10 | 2017-02-21 | Cellix Bio Private Limited | Compositions and methods for the treatment of severe pain |
| US9315461B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
| WO2013168011A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of chronic pain |
| JP6202287B2 (ja) | 2012-05-23 | 2017-09-27 | セリックスビオ プライヴェート リミテッド | 炎症性腸疾患の治療のための組成物及び方法 |
| WO2013175344A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
| WO2013175376A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of local pain |
| JP2015518854A (ja) | 2012-05-23 | 2015-07-06 | セリックスビオ プライヴェート リミテッド | 多発性硬化症の治療のための組成物および方法 |
| WO2013175347A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
| EP2852571A4 (en) | 2012-05-23 | 2015-11-25 | Cellix Bio Private Ltd | COMPOSITIONS AND METHOD FOR THE TREATMENT OF MUCOSITIS |
| US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| US9187427B2 (en) | 2012-08-03 | 2015-11-17 | Cellix Bio Private Limited | N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases |
| WO2014037833A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment inflammation and lipid disorders |
| US9670153B2 (en) | 2012-09-08 | 2017-06-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammation and lipid disorders |
| US9169214B2 (en) | 2012-12-21 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
| EP2953970A4 (en) | 2013-02-08 | 2016-06-29 | Misfolding Diagnostics Inc | TRANSTYRETIN ANTIBODIES AND USES THEREOF |
| US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
| US20160045609A1 (en) | 2014-08-14 | 2016-02-18 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
| CN115368313A (zh) * | 2014-09-08 | 2022-11-22 | 辉瑞公司 | 6-羧基-2-(3,5-二氯苯基)苯并噁唑的结晶固体形式 |
| NZ736131A (en) | 2014-09-26 | 2019-04-26 | Cellix Bio Private Ltd | Compositions and methods for the treatment of epilepsy and neurological disorders |
| JP6698643B2 (ja) | 2014-09-29 | 2020-05-27 | セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ | 多発性硬化症の治療のための組成物及び方法 |
| EP3212626B1 (en) | 2014-10-27 | 2018-11-07 | Cellix Bio Private Limited | Three component salts of fumaric acid monomethyl ester with piperazine or ethylene diamine for the treatment of multiple sclerosis |
| US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
| US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
| US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
| US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
| US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| EP3242869B1 (en) | 2015-01-06 | 2021-10-27 | Cellixbio Private Limited | Compositions and methods for the treatment of inflammation and pain |
| CN107344927A (zh) | 2016-05-05 | 2017-11-14 | 苏州晶云药物科技有限公司 | Tafamidis葡甲胺盐的晶型E及其制备方法和用途 |
| CN106496014A (zh) * | 2016-10-17 | 2017-03-15 | 河北美星化工有限公司 | 一种二氟尼柳的制备方法 |
| US11858974B2 (en) | 2017-05-22 | 2024-01-02 | Resq Biotech | Macrocyclic modulators of disease associated protein misfolding and aggregation |
| GB2571950A (en) | 2018-03-13 | 2019-09-18 | Azad Pharma Ag | New polymorph and new path to synthesize tafamidis |
| CN108558599B (zh) * | 2018-03-29 | 2021-01-29 | 浦拉司科技（上海）有限责任公司 | 2-联苯基甲醇的合成工艺 |
| WO2020128816A2 (en) | 2018-12-20 | 2020-06-25 | Pfizer Inc. | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent |
| US12116352B2 (en) | 2019-04-11 | 2024-10-15 | Inke, S.A. | Process for preparing 1-deoxy-1-methylamino-d-glucitol 2-(3,5-dichlorophenyl)-6-benzoxazolecarboxylate |
| KR102911660B1 (ko) | 2019-05-16 | 2026-01-14 | 아시아 케미컬 인더스트리스 리미티드 | 타파미디스의 고상형 및 그 염 |
| CN110215740B (zh) * | 2019-07-15 | 2021-05-04 | 大连医科大学 | 一种两性离子亲水前处理硅胶材料的制备方法 |
| WO2021019448A1 (en) * | 2019-08-01 | 2021-02-04 | Honour (R&D) | Process for the preparation of transthyretin dissociation inhibitor |
| JP2023503833A (ja) | 2019-11-15 | 2023-02-01 | ▲蘇▼州科睿思制▲葯▼有限公司 | タファミジスの結晶形及びその調製方法及びその使用 |
| CA3165298A1 (en) * | 2019-12-20 | 2021-06-24 | Pfizer Ireland Pharmaceuticals | Efficient process for making 6-carboxy benzoxazole derivatives |
| WO2021152623A1 (en) * | 2020-01-27 | 2021-08-05 | Dr. Reddy’S Laboratories Limited | Improved processes for the preparation of tafamidis and its meglumine salt |
| CA3166429A1 (en) | 2020-01-28 | 2021-08-05 | Bradley Dean Tait | Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
| WO2022112919A1 (en) | 2020-11-25 | 2022-06-02 | Pfizer Inc. | (aza)benzothiazolyl substituted pyrazole compounds |
| CN112683844A (zh) * | 2020-12-07 | 2021-04-20 | 东华理工大学 | 一种振动对吲哚美辛-糖精共晶形成影响的研究方法 |
| CN112858690B (zh) * | 2021-01-21 | 2023-11-10 | 宁波职业技术学院 | 一种尿白蛋白/尿肌酐复合质控品及其制备方法 |
| CN114907283B (zh) * | 2021-02-07 | 2025-01-28 | 南京正大天晴制药有限公司 | 一种2-(3，5-二氯苯基)-苯并噁唑-6-羧酸的制备方法 |
| EP4083027A1 (en) | 2021-04-26 | 2022-11-02 | Química Sintética, S.A. | A solid state form of tafamidis and a process for its preparation |
| CN113372290A (zh) * | 2021-05-21 | 2021-09-10 | 遵义医科大学 | 一种药物Tafamidis的合成方法 |
| CN113321627B (zh) * | 2021-06-06 | 2022-05-24 | 湖南第一师范学院 | 一种Tafamidis衍生物及其合成方法 |
| EP4351541A2 (en) | 2021-06-08 | 2024-04-17 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders |
| WO2023020762A1 (en) | 2021-08-16 | 2023-02-23 | Synthon B.V. | Crystalline forms of tafamidis nicotinamide adduct |
| JP2024541422A (ja) | 2021-11-17 | 2024-11-08 | テバ・ファーマシューティカルズ・インターナショナル・ゲーエムベーハー | タファミジスの固体状態の形態 |
| CN114970600B (zh) * | 2022-04-11 | 2024-07-26 | 昆明理工大学 | 基于粒化散布熵和优化kelm的滚动轴承故障诊断方法、装置 |
| EP4559903A1 (en) | 2022-07-22 | 2025-05-28 | Shiratori Pharmaceutical Co., Ltd. | Production method for tafamidis or salt thereof |
| CN119604278A (zh) | 2022-07-28 | 2025-03-11 | 辉瑞大药厂 | 氯苯唑酸药物组合物 |
| US11970468B1 (en) | 2023-10-23 | 2024-04-30 | King Faisal University | 2-(benzo[d]oxazol-2-yl)-N′-(3,5-dichlorobenzoyloxy)acetimidamide as an antimicrobial compound |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US435079A (en) | 1890-08-26 | Lock-nut for axles | ||
| DE602336C (de) | 1933-03-09 | 1934-09-06 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von Kuepenfarbstoffen der Anthrachinonreihe |
| US3551433A (en) * | 1967-06-21 | 1970-12-29 | Us Army | Preparation of 4-phenyl-4-acyloxypiperidine |
| US3551443A (en) | 1968-10-30 | 1970-12-29 | Ciba Ltd | 2-phenylbenzoxazole derivatives |
| USRE29608E (en) * | 1972-05-18 | 1978-04-11 | Lilly Industries Limited | Benzoxazole derivatives |
| DE2314238A1 (de) | 1973-03-22 | 1974-09-26 | Henkel & Cie Gmbh | Neue 2-(tetrazol-5'-yl)-benzoxazole, deren herstellung sowie verwendung als entzuendungshemmer in kosmetischen praeparationen |
| US4025636A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles |
| US4025637A (en) * | 1973-10-23 | 1977-05-24 | Lilly Industries, Ltd. | 2,5 OR 2,6 Disubstituted benzoxazoles |
| DE2619547A1 (de) * | 1976-05-04 | 1977-11-24 | Dynamit Nobel Ag | Verfahren zur herstellung von 2-aryl- benzoxazolen und 2-aryl-benzthiazolen |
| US4416892A (en) | 1981-04-23 | 1983-11-22 | Lilly Industries Limited | Method of treating hypersensitivity disease with benzoxazole derivatives |
| US5254692A (en) | 1990-04-06 | 1993-10-19 | Bayer Aktiengesellschaft | 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines |
| DE4011106A1 (de) * | 1990-04-06 | 1991-10-10 | Bayer Ag | Neue heterocyclisch substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US5037842A (en) * | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
| CA2051518A1 (en) | 1990-10-01 | 1992-04-02 | Robert J. Perry | Synthesis of heterocyclic compounds |
| JP3021028B2 (ja) | 1990-11-19 | 2000-03-15 | 株式会社日本化学工業所 | アゾール型カチオン染料 |
| CH681806A5 (enExample) | 1991-03-19 | 1993-05-28 | Ciba Geigy Ag | |
| JPH0517458A (ja) | 1991-07-04 | 1993-01-26 | Idemitsu Kosan Co Ltd | 芳香族化合物とその製造方法 |
| US5354759A (en) | 1991-09-12 | 1994-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Angiotenin II antagonizing heterocyclic compounds |
| JPH0673051A (ja) | 1992-08-26 | 1994-03-15 | Asahi Glass Co Ltd | ベンズアゾール誘導体 |
| JPH0673050A (ja) | 1992-08-26 | 1994-03-15 | Asahi Glass Co Ltd | ヘテロ環化合物 |
| GB9218334D0 (en) | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
| DE4304650A1 (de) | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| JPH06239849A (ja) | 1993-02-16 | 1994-08-30 | Canon Inc | 光学活性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法及び表示装置 |
| JP3243887B2 (ja) | 1993-05-28 | 2002-01-07 | 三菱化学株式会社 | 有機電界発光素子 |
| JPH0797379A (ja) | 1993-09-06 | 1995-04-11 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
| US5441946A (en) | 1994-04-14 | 1995-08-15 | Rhone-Poulenc-Rorer Pharmaceuticals, Inc. | Phosphonate derivatives of lipophilic amines |
| US5552426A (en) | 1994-04-29 | 1996-09-03 | Eli Lilly And Company | Methods for treating a physiological disorder associated with β-amyloid peptide |
| US5837390A (en) | 1995-05-10 | 1998-11-17 | Sony Corporation | Metal complex, method for producing the same and optical device |
| JP3861930B2 (ja) | 1995-12-15 | 2006-12-27 | ソニー株式会社 | 金属複核錯体、その製造方法及び光学的素子 |
| JPH09227576A (ja) | 1996-02-23 | 1997-09-02 | Sony Corp | 金属複核錯体、その製造方法及び光学的素子 |
| JP3760508B2 (ja) | 1996-06-10 | 2006-03-29 | 東洋インキ製造株式会社 | 有機エレクトロルミネッセンス素子材料およびそれを用いた有機エレクトロルミネッセンス素子 |
| JP4183754B2 (ja) | 1996-06-14 | 2008-11-19 | プロジェニクス・ファーマスーティカルス・インコーポレーテッド | Ｈｉｖ―１感染を阻害するためのケモカイン受容体の使用 |
| AU5727798A (en) | 1996-12-23 | 1998-07-17 | Texas A & M University, The | Anti-amyloidogenic agents |
| FR2767527B1 (fr) | 1997-08-25 | 1999-11-12 | Pf Medicament | Derives de piperazines indoliques, utiles comme medicaments et procede de preparation |
| GB9725782D0 (en) | 1997-12-05 | 1998-02-04 | Pfizer Ltd | Therapeutic agents |
| US6156763A (en) | 1998-02-04 | 2000-12-05 | Board Of Regents, The University Of Texas System | Inhibition of human telomerase by a g-quadruplex-interaction compound |
| US6107491A (en) | 1998-07-20 | 2000-08-22 | Ciba Specialty Chemicals Corporation | Polymerizable diketopyrrolopyrroles |
| GB9816654D0 (en) | 1998-07-30 | 1998-09-30 | Zeneca Ltd | Chemical compounds |
| JP2000100569A (ja) | 1998-09-22 | 2000-04-07 | Toray Ind Inc | 発光素子 |
| JP2001055332A (ja) | 1999-06-07 | 2001-02-27 | Saitama Daiichi Seiyaku Kk | 芳香族アミジン誘導体類含有のイオントフォレ−シス用製剤 |
| CN1356988A (zh) | 1999-06-18 | 2002-07-03 | 拜尔公司 | 苯氧基氟代嘧啶类化合物 |
| JP2001064205A (ja) | 1999-06-25 | 2001-03-13 | Dai Ichi Seiyaku Co Ltd | 製剤組成物 |
| JP2001064166A (ja) | 1999-06-25 | 2001-03-13 | Dai Ichi Seiyaku Co Ltd | 貼付剤 |
| WO2001012183A1 (en) * | 1999-08-16 | 2001-02-22 | Merck & Co., Inc. | Heterocycle amides as cell adhesion inhibitors |
| GB9919673D0 (en) | 1999-08-20 | 1999-10-20 | Cancer Res Campaign Tech | 2-Arlybenzazole compounds |
| JP2001226358A (ja) | 1999-10-12 | 2001-08-21 | Japan Tobacco Inc | Ｌｐｌ活性増強剤 |
| JP2001242165A (ja) | 2000-02-25 | 2001-09-07 | Dai Ichi Seiyaku Co Ltd | 採血用試薬 |
| NZ521028A (en) | 2000-03-16 | 2004-07-30 | F | Carboxylic acid derivatives as IP antagonists |
| GB0007934D0 (en) | 2000-03-31 | 2000-05-17 | Darwin Discovery Ltd | Chemical compounds |
| JP3945123B2 (ja) | 2000-04-10 | 2007-07-18 | 三菱化学株式会社 | 有機電界発光素子 |
| JP2001301329A (ja) | 2000-04-20 | 2001-10-31 | Mitsubishi Chemicals Corp | 光学記録媒体 |
| JP2002003368A (ja) | 2000-06-23 | 2002-01-09 | Saitama Daiichi Seiyaku Kk | 経皮吸収又は経粘膜吸収用の製剤 |
| SI1334091T1 (sl) | 2000-08-24 | 2013-01-31 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Derivati tioflavina in njihova uporaba pri diagnozi in terapiji pri Alzheimerjevi bolezni |
| MXPA03003829A (es) | 2000-11-04 | 2003-07-28 | Aventis Pharma Ltd | Acidos alcanoicos substituidos. |
| AU2002221239A1 (en) | 2000-12-07 | 2002-06-18 | Astrazeneca Ab | Therapeutic benzimidazole compounds |
| JP2004524289A (ja) | 2000-12-22 | 2004-08-12 | アストラゼネカ・アクチエボラーグ | 治療化合物 |
| GB0118357D0 (en) | 2001-07-27 | 2001-09-19 | Syngenta Ltd | Chemical compounds |
| AU2002334355A1 (en) | 2001-09-06 | 2003-03-18 | Prochon Biotech Ltd. | Protein tyrosine kinase inhibitors |
| US6602619B2 (en) | 2001-10-19 | 2003-08-05 | Lightronik Technology Inc. | Organic EL device |
| US7253154B2 (en) | 2001-11-16 | 2007-08-07 | Nippon Chemiphar Co., Ltd. | Substituted thiazolopyrimidines as xanthine oxidase inhibitors |
| WO2003045930A1 (en) | 2001-11-28 | 2003-06-05 | Astrazeneca Ab | Therapeutic compounds |
| UA83620C2 (ru) | 2001-12-05 | 2008-08-11 | Уайт | Замещенные бензоксазолы и их аналоги как эстрогенные агенты |
| MXPA04005864A (es) | 2001-12-19 | 2004-10-29 | Atherogenics Inc | Derivados de charcona y su uso para tratar enfermedades. |
| WO2003053359A2 (en) | 2001-12-19 | 2003-07-03 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propyn-1-ones and their use to treat disorders |
| GB0205256D0 (en) | 2002-03-06 | 2002-04-17 | Oxford Glycosciences Uk Ltd | Novel compounds |
| NZ535603A (en) | 2002-03-20 | 2007-10-26 | Metabolex Inc | Substituted phenylacetic acids |
| UA79755C2 (en) | 2002-04-16 | 2007-07-25 | Bayer Pharmaceuticals Corp | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation |
| GB0226822D0 (en) | 2002-11-16 | 2002-12-24 | Oxford Glycosciences Uk Ltd | Novel compounds |
| CN101413143B (zh) | 2002-12-19 | 2013-09-18 | 斯克里普斯研究学院 | 稳定甲状腺素运载蛋白和抑制甲状腺素运载蛋白错折叠的组合物和方法 |
| AU2004206796A1 (en) | 2003-01-14 | 2004-08-05 | Merck & Co., Inc. | Geminally di-substituted NSAID derivatives as Abeta 42 lowering agents |
| JP2004250411A (ja) | 2003-02-21 | 2004-09-09 | Bf Kenkyusho:Kk | アミロイドβ蓄積性疾患の診断プローブおよび治療用化合物 |
| CA2438032C (en) | 2003-03-14 | 2013-05-07 | University Of Pittsburgh | Benzothiazole derivative compounds, compositions and uses |
| AR044503A1 (es) | 2003-03-18 | 2005-09-14 | Merck & Co Inc | Triazoles sustituidos con biarilo como bloqueantes del canal de sodio |
| US20060293339A1 (en) | 2003-03-24 | 2006-12-28 | Chakravarty Prasun K | Biaryl substituted 6-membered heterocycles as sodium channel blockers |
| JP2004302049A (ja) | 2003-03-31 | 2004-10-28 | Hodogaya Chem Co Ltd | 感光性樹脂組成物 |
| US7589116B2 (en) | 2003-04-03 | 2009-09-15 | Merck & Co. Inc. | Biaryl substituted pyrazoles as sodium channel blockers |
| JP2006523701A (ja) | 2003-04-18 | 2006-10-19 | メルク エンド カムパニー インコーポレーテッド | ナトリウムチャネルブロッカーとしてのビアリール置換チアゾール、オキサゾール、およびイミダゾール |
| WO2004098494A2 (en) | 2003-04-30 | 2004-11-18 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| AU2005245470A1 (en) * | 2004-05-20 | 2005-12-01 | Foldrx Pharmaceuticals, Inc. | 2-((hetero) aryl)-benzoxazole compounds and derivatives, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding |
-
2003
- 2003-12-19 CN CN2008101738900A patent/CN101413143B/zh not_active Expired - Lifetime
- 2003-12-19 JP JP2005502649A patent/JP4665076B2/ja not_active Expired - Lifetime
- 2003-12-19 KR KR1020057011676A patent/KR101089904B1/ko not_active Expired - Lifetime
- 2003-12-19 DK DK08014241.7T patent/DK1988397T3/da active
- 2003-12-19 ES ES10180989.5T patent/ES2524803T3/es not_active Expired - Lifetime
- 2003-12-19 DK DK03813782.4T patent/DK1587821T6/da active
- 2003-12-19 DE DE60323155T patent/DE60323155D1/de not_active Expired - Lifetime
- 2003-12-19 AT AT03813782T patent/ATE405840T1/de active
- 2003-12-19 EP EP10180989.5A patent/EP2325651B1/en not_active Expired - Lifetime
- 2003-12-19 EP EP03813782.4A patent/EP1587821B9/en not_active Expired - Lifetime
- 2003-12-19 CA CA2800237A patent/CA2800237C/en not_active Expired - Fee Related
- 2003-12-19 AT AT08014241T patent/ATE524741T1/de not_active IP Right Cessation
- 2003-12-19 EP EP08014241A patent/EP1988397B8/en not_active Expired - Lifetime
- 2003-12-19 CN CNB2003801097362A patent/CN100448852C/zh not_active Expired - Lifetime
- 2003-12-19 ES ES03813782T patent/ES2312857T7/es active Active
- 2003-12-19 FI FIEP03813782.4T patent/FI1587821T6/fi active
- 2003-12-19 SI SI200331330T patent/SI1587821T2/sl unknown
- 2003-12-19 PT PT03813782T patent/PT1587821E/pt unknown
- 2003-12-19 BR BRPI0317463A patent/BRPI0317463B8/pt active IP Right Grant
- 2003-12-19 US US10/741,649 patent/US7214695B2/en not_active Expired - Lifetime
- 2003-12-19 CA CA2510455A patent/CA2510455C/en not_active Expired - Fee Related
- 2003-12-19 WO PCT/US2003/040567 patent/WO2004056315A2/en not_active Ceased
- 2003-12-19 PT PT08014241T patent/PT1988397E/pt unknown
- 2003-12-19 ES ES08014241T patent/ES2373639T3/es not_active Expired - Lifetime
- 2003-12-19 AU AU2003303196A patent/AU2003303196C1/en active Active
-
2005
- 2005-10-21 US US11/256,026 patent/US7214696B2/en not_active Expired - Lifetime
-
2006
- 2006-09-25 US US11/527,020 patent/US7560488B2/en not_active Expired - Lifetime
-
2008
- 2008-10-30 CY CY20081101229T patent/CY1108467T1/el unknown
-
2009
- 2009-06-09 US US12/481,527 patent/US8168663B2/en not_active Expired - Lifetime
-
2010
- 2010-03-30 AU AU2010201263A patent/AU2010201263B8/en not_active Expired
- 2010-07-20 JP JP2010162800A patent/JP2010270134A/ja active Pending
-
2011
- 2011-11-22 US US13/303,060 patent/US8653119B2/en not_active Expired - Fee Related
-
2012
- 2012-01-17 DE DE201212000007 patent/DE122012000007I1/de active Pending
- 2012-01-25 LU LU91935C patent/LU91935I2/fr unknown
- 2012-01-30 CY CY2012005C patent/CY2012005I1/el unknown
- 2012-02-22 BE BE2012C008C patent/BE2012C008I2/fr unknown
- 2012-02-22 FR FR12C0008C patent/FR12C0008I2/fr active Active
-
2013
- 2013-08-21 JP JP2013170867A patent/JP5756151B2/ja not_active Expired - Lifetime
-
2014
- 2014-01-15 US US14/156,257 patent/US20140134753A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2006511612A5 (enExample) | ||
| JP2007502806A5 (enExample) | ||
| RU2419624C2 (ru) | Сульфонамидные производные как активаторы гликокиназы, применимые для лечения диабета типа 2 | |
| RU2492167C2 (ru) | Производные аминотриазола в качестве агонистов alх | |
| RU2312106C2 (ru) | Замещенные 4-алкоксиоксазолпроизводные в качестве агонистов ppar | |
| ES2522291T3 (es) | Agente activador para el receptor activado por el proliferador de peroxisomas | |
| US20100227809A1 (en) | Combination treatment for metabolic disorders | |
| RU2379299C2 (ru) | Производные 5-(бенз-(z)-илиден)тиазолидин-4-она и их применение в качестве иммуносупрессорных агентов | |
| RU2003134150A (ru) | Замещенные карбоновыми кислотами оксазоловые производные в качестве ppar-альфа и гамма-активаторов при лечении диабета | |
| US8338480B2 (en) | Combination treatment of metabolic disorders | |
| RU2012132692A (ru) | Новые ингибиторы s-нитрозоглутатионредуктазы | |
| ZA200100983B (en) | Substituted oxazoles and thiazoles derivatives as hPPAR gamma and hPPAR alpha activators. | |
| CZ20032927A3 (cs) | Léčení cukrovky typu 2 inhibitory z dipeptidylpeptidázy IV | |
| RU2012120760A (ru) | Новые композиции для предупреждения и/или лечения лизосомных болезней накопления | |
| JP2006077019A5 (enExample) | ||
| PE20081704A1 (es) | Derivados de azacicloalcanos como inhibidores de estearoil-coenzima a delta-9 desaturasa | |
| JP2005536475A5 (enExample) | ||
| JP2020075939A5 (enExample) | ||
| JPWO2006137509A1 (ja) | Ｐｐａｒ調節剤を含有する医薬組成物 | |
| JP2009532372A5 (enExample) | ||
| RU2010148762A (ru) | Тетразольные соединения для снижения концентрации мочевой кислоты | |
| WO2008008650A1 (en) | Methods for treating cystic kidney diseases | |
| JP2008534453A5 (enExample) | ||
| JP2009501775A5 (enExample) | ||
| JP2009528275A5 (enExample) |