JP4665076B2 - トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 - Google Patents

トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 Download PDF

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JP4665076B2
JP4665076B2 JP2005502649A JP2005502649A JP4665076B2 JP 4665076 B2 JP4665076 B2 JP 4665076B2 JP 2005502649 A JP2005502649 A JP 2005502649A JP 2005502649 A JP2005502649 A JP 2005502649A JP 4665076 B2 JP4665076 B2 JP 4665076B2
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benzoxazole
carboxy
ttr
pharmaceutically acceptable
acceptable salt
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JP2006511612A5 (enExample
JP2006511612A (ja
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ケリー，ジェフリー，ダブリュ．
ティー． パワーズ，エヴァン
ラザヴィ，ホセイン
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ザ スクリプス リサーチ インスティチュート
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
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  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
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  • General Physics & Mathematics (AREA)
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  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2005502649A 2002-12-19 2003-12-19 トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法 Expired - Lifetime JP4665076B2 (ja)

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US43507902P 2002-12-19 2002-12-19
US46543503P 2003-04-24 2003-04-24
PCT/US2003/040567 WO2004056315A2 (en) 2002-12-19 2003-12-19 Compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding

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JP2010162800A Division JP2010270134A (ja) 2002-12-19 2010-07-20 トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法

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JP2006511612A JP2006511612A (ja) 2006-04-06
JP2006511612A5 JP2006511612A5 (enExample) 2008-06-19
JP4665076B2 true JP4665076B2 (ja) 2011-04-06

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JP2010162800A Pending JP2010270134A (ja) 2002-12-19 2010-07-20 トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法
JP2013170867A Expired - Lifetime JP5756151B2 (ja) 2002-12-19 2013-08-21 トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法

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JP2013170867A Expired - Lifetime JP5756151B2 (ja) 2002-12-19 2013-08-21 トランスチレチンの安定化及びトランスチレチンの誤った折り畳みの阻害のための組成物及び方法

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US (6) US7214695B2 (enExample)
EP (3) EP1988397B8 (enExample)
JP (3) JP4665076B2 (enExample)
KR (1) KR101089904B1 (enExample)
CN (2) CN100448852C (enExample)
AT (2) ATE405840T1 (enExample)
AU (2) AU2003303196C1 (enExample)
BE (1) BE2012C008I2 (enExample)
BR (1) BRPI0317463B8 (enExample)
CA (2) CA2510455C (enExample)
CY (2) CY1108467T1 (enExample)
DE (2) DE60323155D1 (enExample)
DK (2) DK1587821T6 (enExample)
ES (3) ES2312857T7 (enExample)
FI (1) FI1587821T6 (enExample)
FR (1) FR12C0008I2 (enExample)
LU (1) LU91935I2 (enExample)
PT (2) PT1988397E (enExample)
SI (1) SI1587821T2 (enExample)
WO (1) WO2004056315A2 (enExample)

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