JP2004505105A5 - - Google Patents
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- Publication number
- JP2004505105A5 JP2004505105A5 JP2002516252A JP2002516252A JP2004505105A5 JP 2004505105 A5 JP2004505105 A5 JP 2004505105A5 JP 2002516252 A JP2002516252 A JP 2002516252A JP 2002516252 A JP2002516252 A JP 2002516252A JP 2004505105 A5 JP2004505105 A5 JP 2004505105A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- compound according
- ala
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 7
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 230000005856 abnormality Effects 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000003745 diagnosis Methods 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 125000006267 biphenyl group Chemical group 0.000 claims 2
- 210000001124 body fluid Anatomy 0.000 claims 2
- 239000002738 chelating agent Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 230000035515 penetration Effects 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000004018 acid anhydride group Chemical group 0.000 claims 1
- 125000004423 acyloxy group Chemical group 0.000 claims 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- -1 benzyl ester Chemical class 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 229940039227 diagnostic agent Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0018528.0 | 2000-07-27 | ||
| GBGB0018528.0A GB0018528D0 (en) | 2000-07-27 | 2000-07-27 | Compounds |
| PCT/GB2001/003336 WO2002010120A1 (en) | 2000-07-27 | 2001-07-25 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004505105A JP2004505105A (ja) | 2004-02-19 |
| JP2004505105A5 true JP2004505105A5 (enExample) | 2005-04-14 |
| JP5010088B2 JP5010088B2 (ja) | 2012-08-29 |
Family
ID=9896500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002516252A Expired - Fee Related JP5010088B2 (ja) | 2000-07-27 | 2001-07-25 | 光化学治療における光増感剤としての５−アミノレブリン酸のエステル |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7217736B2 (enExample) |
| EP (1) | EP1313695B1 (enExample) |
| JP (1) | JP5010088B2 (enExample) |
| KR (1) | KR20030028554A (enExample) |
| CN (1) | CN1318388C (enExample) |
| AT (1) | ATE349417T1 (enExample) |
| AU (2) | AU2002227495B2 (enExample) |
| CA (1) | CA2416307C (enExample) |
| CZ (1) | CZ2003260A3 (enExample) |
| DE (1) | DE60125555T2 (enExample) |
| DK (1) | DK1313695T3 (enExample) |
| ES (1) | ES2276844T3 (enExample) |
| GB (1) | GB0018528D0 (enExample) |
| HU (1) | HUP0301427A2 (enExample) |
| NO (1) | NO20030398L (enExample) |
| NZ (1) | NZ523927A (enExample) |
| PT (1) | PT1313695E (enExample) |
| RU (1) | RU2246483C2 (enExample) |
| WO (1) | WO2002010120A1 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492420B2 (en) * | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| CA2653839A1 (en) * | 1998-11-02 | 2000-05-11 | John G. Devane | Multiparticulate modified release composition |
| US20090297602A1 (en) * | 1998-11-02 | 2009-12-03 | Devane John G | Modified Release Loxoprofen Compositions |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| PT1404324E (pt) | 2001-06-11 | 2008-03-05 | Xenoport Inc | Formas de dosagem administradas oralmente de pró-fármacos análogas de gaba tendo toxicidade reduzida |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| GB0118251D0 (en) * | 2001-07-26 | 2001-09-19 | Photocure Asa | Method |
| EP1556091A1 (en) * | 2002-10-04 | 2005-07-27 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
| DE10312659A1 (de) * | 2003-03-21 | 2004-10-07 | Universität Regensburg | 5-Aminolävulinsäurederivate und ihre Verwendung |
| WO2004105809A1 (en) * | 2003-05-22 | 2004-12-09 | Elan Pharma International Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
| CA2437638A1 (en) | 2003-08-20 | 2005-02-20 | John Robert North | Photodynamic therapy |
| CA2457214A1 (en) | 2004-02-06 | 2005-08-06 | Qlt Inc. | Photodynamic therapy for the treatment of acne |
| GB0406917D0 (en) * | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
| JP2005350418A (ja) * | 2004-06-11 | 2005-12-22 | Shibuya Kogyo Co Ltd | 標的細胞の死滅方法と標的細胞を死滅させるための薬剤及び該薬剤の製造装置 |
| AU2005278649B8 (en) | 2004-09-02 | 2010-07-22 | Cosmo Ala Co., Ltd. | Constitutional function-improving agents |
| US8795725B2 (en) | 2004-11-04 | 2014-08-05 | Xenoport, Inc. | GABA analog prodrug sustained release oral dosage forms |
| GB0424833D0 (en) | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| JP2008531721A (ja) * | 2005-03-03 | 2008-08-14 | エラン・ファルマ・インターナショナル・リミテッド | 複素環式アミド誘導体のナノ粒子状組成物 |
| JP4934292B2 (ja) * | 2005-07-05 | 2012-05-16 | コスモ石油株式会社 | ５−アミノレブリン酸エステルリン酸類塩、その製造方法及びその用途 |
| JP4934293B2 (ja) * | 2005-07-05 | 2012-05-16 | コスモ石油株式会社 | 植物活力剤組成物 |
| GB0609809D0 (en) * | 2006-05-17 | 2006-06-28 | Photocure Asa | Product |
| BRPI0714173A2 (pt) * | 2006-07-12 | 2012-12-25 | Elan Pharma Int Ltd | composiÇço nanoparticulada estÁvel,mÉtodos para preparar a composiÇço, para prevenir e/ou tratar estados de doenÇas, sintomas, sÍndromes e condiÇÕes do sistema nervoso central, para melhorar ou manter a biodisponibilidade de modafinil, e para tratar distérbio com base neurolàgica, composiÇço farmacÊutica, e forma de dosagem |
| JP5404995B2 (ja) | 2006-08-10 | 2014-02-05 | コスモ石油株式会社 | 植物のポリフェノール増量剤 |
| GB0700580D0 (en) | 2007-01-11 | 2007-02-21 | Photocure Asa | Use |
| US20090036952A1 (en) | 2007-07-30 | 2009-02-05 | National Yang-Ming University | Induction driven light module and use thereof |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| KR100883560B1 (ko) * | 2007-08-23 | 2009-02-17 | (주) 위디어 | 신규한 5-아미노레불린 산 유도체 및 이의 제조방법 |
| GB0724279D0 (en) * | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
| EP2231105A1 (en) * | 2007-12-14 | 2010-09-29 | Photoderma SA | Novel compounds useful in therapeutic and cosmetic methods |
| GB0804190D0 (en) * | 2008-03-06 | 2008-04-16 | Ge Healthcare Ltd | Ester imaging agents |
| US8563605B2 (en) | 2008-05-14 | 2013-10-22 | Sbi Pharmaceuticals Co., Ltd. | Therapeutic agent for male sterility |
| WO2010024775A1 (en) * | 2008-09-01 | 2010-03-04 | Swedish Pharma Ab | New 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis |
| GB0823472D0 (en) | 2008-12-23 | 2009-01-28 | Photocure Asa | Product |
| GB0900461D0 (en) | 2009-01-12 | 2009-02-11 | Photocure Asa | Photodynamic therapy device |
| PE20120858A1 (es) * | 2009-06-11 | 2012-08-01 | Photocure Asa | Composiciones solidas que comprenden acido 5-aminolevulinico |
| CN102458388B (zh) * | 2009-06-11 | 2016-09-28 | 光治疗Asa公司 | 半固体组合物及药物制品 |
| EP2542208A1 (en) | 2010-03-01 | 2013-01-09 | Photocure ASA | Cosmetic compositions |
| EP2394642A1 (en) | 2010-06-10 | 2011-12-14 | Universite De Geneve | 5-ALA ester formulations and use thereof |
| US20130211215A1 (en) | 2010-06-23 | 2013-08-15 | Photocure Asa | Hyperosmotic preparations comprising 5-aminolevulinic acid or derivative as photosensitizing agent |
| KR101842732B1 (ko) | 2010-07-09 | 2018-05-14 | 포토큐어 에이에스에이 | 광역동 치료 또는 광역동 진단에 사용하기 위한 건조 조성물 및 이와 같은 건조 조성물을 포함하는 기구 |
| EP2657346B1 (en) | 2010-12-24 | 2017-08-23 | ARKRAY, Inc. | Method for detecting cancer cell |
| WO2012097264A2 (en) | 2011-01-13 | 2012-07-19 | Qlt Inc. | Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof |
| US20140316534A1 (en) | 2011-10-14 | 2014-10-23 | Photocure Asa | Stent |
| US20140276107A1 (en) | 2011-10-14 | 2014-09-18 | Photocure Asa | Photodynamic diagnosis |
| KR102057349B1 (ko) | 2011-12-19 | 2019-12-18 | 포토큐어 에이에스에이 | 광 조사 기구 |
| WO2013092936A2 (en) | 2011-12-20 | 2013-06-27 | Galderma Research & Development | Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne |
| CA2878846A1 (en) | 2012-07-11 | 2014-01-16 | Delphine Caroline Imbert | Pharmaceutical compositions for topical delivery of photosensitizers and uses thereof |
| US9249086B2 (en) | 2012-08-03 | 2016-02-02 | Photocure Asa | Carboxylic acid ALA esters |
| GB201215675D0 (en) * | 2012-09-03 | 2012-10-17 | Univ Exeter | Compound |
| GB201221123D0 (en) | 2012-11-23 | 2013-01-09 | Photocure As | Device for photodynamic treatment |
| GB201306369D0 (en) | 2013-04-09 | 2013-05-22 | Photocure As | Irradiation device |
| EP3082787B1 (en) | 2013-12-20 | 2020-11-25 | Galderma Research & Development | Pulse photodynamic treatment of photodamaged skin |
| NZ723940A (en) | 2014-02-03 | 2017-12-22 | Quadriga Biosciences Inc | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| EP3095464A1 (en) | 2015-05-19 | 2016-11-23 | Universite De Geneve | 5-ala derivatives and use thereof |
| KR20180035894A (ko) | 2015-08-03 | 2018-04-06 | 콰드리가 바이오사이언시스 인코포레이티드 | 화학치료제로서의 베타-치환된 베타-아미노산 및 유사체 및 이들의 용도 |
| GB201522309D0 (en) * | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
| GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
| CN106187793A (zh) | 2016-01-26 | 2016-12-07 | 赵鸣 | 5‑氨基酮戊酸及其衍生物的盐化合物和应用 |
| ES2859777T3 (es) | 2017-02-06 | 2021-10-04 | 3Skin As | Composición de filtro solar |
| PL3641882T3 (pl) * | 2017-06-21 | 2024-02-26 | Photocure Asa | Sposób przygotowania ciekłej kompozycji farmaceutycznej oraz urządzenie do stosowania w takim sposobie |
| EP3868372A1 (en) | 2020-02-19 | 2021-08-25 | JLP Health GmbH | A pharmaceutical combination of an artemisinin compound and a heme synthesis modulator for treating cancer |
| CN111635464B (zh) * | 2020-05-12 | 2022-03-25 | 上海易全化学有限公司 | 一种5-氨基酮戊酸葡聚糖酯的制备方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2411382C3 (de) | 1974-03-09 | 1979-09-06 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung |
| US4087532A (en) | 1974-03-09 | 1978-05-02 | Boehringer Ingelheim Gmbh | Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof |
| GB2058077B (en) | 1979-06-08 | 1983-03-09 | Szelke M | Enkephalin analogues |
| CA1236029A (en) | 1984-05-14 | 1988-05-03 | Edmund Sandborn | Pharmaceutical solutions comprising dimethyl sulfoxide |
| SE460947B (sv) | 1986-08-26 | 1989-12-11 | Lejus Medical Ab | En multiple-unit-dos komposition av l-dopa |
| JPS6452778A (en) * | 1987-05-30 | 1989-02-28 | Tokuyama Soda Kk | Fulgide compound and production thereof |
| JPH0745502B2 (ja) * | 1987-11-10 | 1995-05-17 | 株式会社トクヤマ | 新規化合物及びそれを含む組成物 |
| US5422093A (en) | 1989-07-28 | 1995-06-06 | Queen's University | Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof |
| US5234940A (en) | 1989-07-28 | 1993-08-10 | Queen's University | Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof |
| US5079262A (en) | 1989-07-28 | 1992-01-07 | Queen's University At Kingston | Method of detection and treatment of malignant and non-malignant lesions utilizing 5-aminolevulinic acid |
| US5955490A (en) | 1989-07-28 | 1999-09-21 | Queen's University At Kingston | Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins |
| JP2767318B2 (ja) | 1990-04-11 | 1998-06-18 | 株式会社コスモ総合研究所 | ５―アミノレブリン酸アルキルエステル又はその塩及びその製造方法並びにこれを有効成分とする除草剤 |
| AU655942B2 (en) | 1990-10-05 | 1995-01-19 | Queen's University At Kingston | Porphyrin derivatives |
| US5219878A (en) | 1990-10-05 | 1993-06-15 | Queen's University | Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents |
| JP2747644B2 (ja) | 1993-08-19 | 1998-05-06 | 株式会社コスモ総合研究所 | 植物成長調節剤 |
| GB9318841D0 (en) | 1993-09-10 | 1993-10-27 | Res Foundation Of The Norwegia | Composition |
| JP2896963B2 (ja) * | 1994-11-28 | 1999-05-31 | 株式会社コスモ総合研究所 | 植物の耐塩性向上剤 |
| KR100444007B1 (ko) | 1995-03-10 | 2004-12-03 | 포토큐레 에이에스에이 | 광화학치료또는진단에사용하기위한5-아미노레불린산의에스테르 |
| US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| US6992107B1 (en) * | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
| GB9504948D0 (en) * | 1995-03-10 | 1995-04-26 | Norwegian Radium Hospital Rese | Compounds |
| US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
| GB9700396D0 (en) * | 1997-01-10 | 1997-02-26 | Photocure As | Photochemotherapeutic compositions |
| FR2777782B1 (fr) | 1998-04-22 | 2001-05-18 | Alexandre Marti | Solution pour la preparation d'une substance pharmaceutique pour le diagnostic et/ou le traitement de lesions tissulaires |
| GB0018527D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
| GB0118251D0 (en) | 2001-07-26 | 2001-09-19 | Photocure Asa | Method |
| GB0128052D0 (en) | 2001-11-22 | 2002-01-16 | Drug Discovery Lab As | Compounds |
-
2000
- 2000-07-27 GB GBGB0018528.0A patent/GB0018528D0/en not_active Ceased
-
2001
- 2001-07-25 NZ NZ523927A patent/NZ523927A/en not_active IP Right Cessation
- 2001-07-25 HU HU0301427A patent/HUP0301427A2/hu unknown
- 2001-07-25 KR KR10-2003-7001213A patent/KR20030028554A/ko not_active Withdrawn
- 2001-07-25 DK DK01984415T patent/DK1313695T3/da active
- 2001-07-25 PT PT01984415T patent/PT1313695E/pt unknown
- 2001-07-25 CN CNB018146953A patent/CN1318388C/zh not_active Expired - Fee Related
- 2001-07-25 RU RU2003105460/04A patent/RU2246483C2/ru not_active IP Right Cessation
- 2001-07-25 CA CA2416307A patent/CA2416307C/en not_active Expired - Fee Related
- 2001-07-25 CZ CZ2003260A patent/CZ2003260A3/cs unknown
- 2001-07-25 AT AT01984415T patent/ATE349417T1/de active
- 2001-07-25 AU AU2002227495A patent/AU2002227495B2/en not_active Ceased
- 2001-07-25 DE DE60125555T patent/DE60125555T2/de not_active Expired - Lifetime
- 2001-07-25 AU AU2749502A patent/AU2749502A/xx active Pending
- 2001-07-25 WO PCT/GB2001/003336 patent/WO2002010120A1/en not_active Ceased
- 2001-07-25 ES ES01984415T patent/ES2276844T3/es not_active Expired - Lifetime
- 2001-07-25 US US10/343,209 patent/US7217736B2/en not_active Expired - Fee Related
- 2001-07-25 EP EP01984415A patent/EP1313695B1/en not_active Expired - Lifetime
- 2001-07-25 JP JP2002516252A patent/JP5010088B2/ja not_active Expired - Fee Related
-
2003
- 2003-01-24 NO NO20030398A patent/NO20030398L/no not_active Application Discontinuation
-
2007
- 2007-04-13 US US11/786,878 patent/US7563819B1/en not_active Expired - Fee Related
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