CN1318388C - 在光化学疗法中作为光敏剂的5－氨基乙酰丙酸的酯类 - Google Patents

在光化学疗法中作为光敏剂的5－氨基乙酰丙酸的酯类 Download PDF

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Publication number
CN1318388C
CN1318388C CNB018146953A CN01814695A CN1318388C CN 1318388 C CN1318388 C CN 1318388C CN B018146953 A CNB018146953 A CN B018146953A CN 01814695 A CN01814695 A CN 01814695A CN 1318388 C CN1318388 C CN 1318388C
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amino
compound
ester
group
alkyl
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Expired - Fee Related
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Chinese (zh)
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CN1460099A (zh
Inventor
J·克拉文尼斯
N·O·尼尔森
J·E·布莱顿
A·戈达尔
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Photocure ASA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB018146953A 2000-07-27 2001-07-25 在光化学疗法中作为光敏剂的5－氨基乙酰丙酸的酯类 Expired - Fee Related CN1318388C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0018528.0A GB0018528D0 (en) 2000-07-27 2000-07-27 Compounds
GB0018528.0 2000-07-27
GB00185280 2000-07-27

Publications (2)

Publication Number Publication Date
CN1460099A CN1460099A (zh) 2003-12-03
CN1318388C true CN1318388C (zh) 2007-05-30

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CNB018146953A Expired - Fee Related CN1318388C (zh) 2000-07-27 2001-07-25 在光化学疗法中作为光敏剂的5－氨基乙酰丙酸的酯类

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US (2) US7217736B2 (enExample)
EP (1) EP1313695B1 (enExample)
JP (1) JP5010088B2 (enExample)
KR (1) KR20030028554A (enExample)
CN (1) CN1318388C (enExample)
AT (1) ATE349417T1 (enExample)
AU (2) AU2749502A (enExample)
CA (1) CA2416307C (enExample)
CZ (1) CZ2003260A3 (enExample)
DE (1) DE60125555T2 (enExample)
DK (1) DK1313695T3 (enExample)
ES (1) ES2276844T3 (enExample)
GB (1) GB0018528D0 (enExample)
HU (1) HUP0301427A2 (enExample)
NO (1) NO20030398L (enExample)
NZ (1) NZ523927A (enExample)
PT (1) PT1313695E (enExample)
RU (1) RU2246483C2 (enExample)
WO (1) WO2002010120A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN104718190A (zh) * 2012-09-03 2015-06-17 埃克塞特大学 用于光动力疗法的吡啶酮化合物

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104718190A (zh) * 2012-09-03 2015-06-17 埃克塞特大学 用于光动力疗法的吡啶酮化合物
CN104718190B (zh) * 2012-09-03 2017-03-08 埃克塞特大学 用于光动力疗法的吡啶酮化合物

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KR20030028554A (ko) 2003-04-08
CA2416307C (en) 2013-01-22
JP5010088B2 (ja) 2012-08-29
WO2002010120A1 (en) 2002-02-07
CZ2003260A3 (cs) 2003-06-18
EP1313695A1 (en) 2003-05-28
US20040106679A1 (en) 2004-06-03
US7217736B2 (en) 2007-05-15
DE60125555T2 (de) 2007-10-11
RU2246483C2 (ru) 2005-02-20
JP2004505105A (ja) 2004-02-19
NO20030398L (no) 2003-03-12
US7563819B1 (en) 2009-07-21
CA2416307A1 (en) 2002-02-07
AU2749502A (en) 2002-02-13
ATE349417T1 (de) 2007-01-15
HUP0301427A2 (hu) 2003-09-29
EP1313695B1 (en) 2006-12-27
ES2276844T3 (es) 2007-07-01
NO20030398D0 (no) 2003-01-24
NZ523927A (en) 2004-07-30
AU2002227495B2 (en) 2006-01-05
DK1313695T3 (da) 2007-04-30
GB0018528D0 (en) 2000-09-13
CN1460099A (zh) 2003-12-03
DE60125555D1 (de) 2007-02-08
PT1313695E (pt) 2007-01-31

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