HUP0301427A2 - Fotokemoterápiában alkalmazható fotoszenzitizáló, 5-aminolevulinsavészterek azokat tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Fotokemoterápiában alkalmazható fotoszenzitizáló, 5-aminolevulinsavészterek azokat tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0301427A2 HUP0301427A2 HU0301427A HUP0301427A HUP0301427A2 HU P0301427 A2 HUP0301427 A2 HU P0301427A2 HU 0301427 A HU0301427 A HU 0301427A HU P0301427 A HUP0301427 A HU P0301427A HU P0301427 A2 HUP0301427 A2 HU P0301427A2
- Authority
- HU
- Hungary
- Prior art keywords
- photochemotherapy
- aminolevulinic acid
- esters
- pharmaceutical compositions
- alkyl group
- Prior art date
Links
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002749 aminolevulinic acid Drugs 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000003504 photosensitizing agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A találmány 5-aminolevulinsav elágazó szénláncú alkilészterére vagyszubsztituált alkilészterére, ezek származékaira vagy ezekfarmakológiailag alkalmazható sóira vonatkozik, amelyekfotokemoterápiában vagy diagnózisban alkalmazhatók. A találmány tárgyaközelebbről (I) általános képletű vegyület, a képletben R1 jelentéseszubsztituálatlan egyenes szénláncú alkilcsoporttól eltérő, adottesetben szubsztituált alkilcsoport, R2 jelentése az egyes előfordulásihelyeken egymástól függetlenül hidrogénatom vagy adott esetbenszubsztituált alkilcsoport. A találmány kiterjed a fenti vegyületekalkalmazására és előállítására, valamint a vegyületeket tartalmazógyógyszerkészítményre. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0018528.0A GB0018528D0 (en) | 2000-07-27 | 2000-07-27 | Compounds |
PCT/GB2001/003336 WO2002010120A1 (en) | 2000-07-27 | 2001-07-25 | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
Publications (1)
Publication Number | Publication Date |
---|---|
HUP0301427A2 true HUP0301427A2 (hu) | 2003-09-29 |
Family
ID=9896500
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0301427A HUP0301427A2 (hu) | 2000-07-27 | 2001-07-25 | Fotokemoterápiában alkalmazható fotoszenzitizáló, 5-aminolevulinsavészterek azokat tartalmazó gyógyszerkészítmények és alkalmazásuk |
Country Status (19)
Country | Link |
---|---|
US (2) | US7217736B2 (hu) |
EP (1) | EP1313695B1 (hu) |
JP (1) | JP5010088B2 (hu) |
KR (1) | KR20030028554A (hu) |
CN (1) | CN1318388C (hu) |
AT (1) | ATE349417T1 (hu) |
AU (2) | AU2002227495B2 (hu) |
CA (1) | CA2416307C (hu) |
CZ (1) | CZ2003260A3 (hu) |
DE (1) | DE60125555T2 (hu) |
DK (1) | DK1313695T3 (hu) |
ES (1) | ES2276844T3 (hu) |
GB (1) | GB0018528D0 (hu) |
HU (1) | HUP0301427A2 (hu) |
NO (1) | NO20030398L (hu) |
NZ (1) | NZ523927A (hu) |
PT (1) | PT1313695E (hu) |
RU (1) | RU2246483C2 (hu) |
WO (1) | WO2002010120A1 (hu) |
Families Citing this family (63)
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US6492420B2 (en) * | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
CA2348871C (en) * | 1998-11-02 | 2009-04-14 | John G. Devane | Multiparticulate modified release composition |
US20090297602A1 (en) * | 1998-11-02 | 2009-12-03 | Devane John G | Modified Release Loxoprofen Compositions |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
KR100958552B1 (ko) * | 2001-06-11 | 2010-05-17 | 제노포트 인코포레이티드 | Gaba 유사체의 프로드러그, 이의 조성물 및 용도 |
GB0118251D0 (en) * | 2001-07-26 | 2001-09-19 | Photocure Asa | Method |
CA2500908A1 (en) * | 2002-10-04 | 2004-04-22 | Elan Pharma International Limited | Gamma irradiation of solid nanoparticulate active agents |
DE10312659A1 (de) * | 2003-03-21 | 2004-10-07 | Universität Regensburg | 5-Aminolävulinsäurederivate und ihre Verwendung |
CA2523035C (en) | 2003-05-22 | 2011-04-26 | Elan Pharma International Ltd. | Sterilization of dispersions of nanoparticulate active agents with gamma radiation |
CA2437638A1 (en) | 2003-08-20 | 2005-02-20 | John Robert North | Photodynamic therapy |
CA2457214A1 (en) | 2004-02-06 | 2005-08-06 | Qlt Inc. | Photodynamic therapy for the treatment of acne |
GB0406917D0 (en) * | 2004-03-26 | 2004-04-28 | Photocure Asa | Compounds |
JP2005350418A (ja) * | 2004-06-11 | 2005-12-22 | Shibuya Kogyo Co Ltd | 標的細胞の死滅方法と標的細胞を死滅させるための薬剤及び該薬剤の製造装置 |
CA2579032C (en) | 2004-09-02 | 2011-11-29 | Cosmo Oil Co., Ltd. | Use of an .delta.-amino acid as thymocyte growth agent |
CN102429882B (zh) | 2004-11-04 | 2015-03-25 | 什诺波特有限公司 | 加巴喷丁前体药物持续释放口服剂型 |
GB0424833D0 (en) | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
JP2008531721A (ja) * | 2005-03-03 | 2008-08-14 | エラン・ファルマ・インターナショナル・リミテッド | 複素環式アミド誘導体のナノ粒子状組成物 |
JP4934292B2 (ja) * | 2005-07-05 | 2012-05-16 | コスモ石油株式会社 | 5−アミノレブリン酸エステルリン酸類塩、その製造方法及びその用途 |
JP4934293B2 (ja) * | 2005-07-05 | 2012-05-16 | コスモ石油株式会社 | 植物活力剤組成物 |
GB0609809D0 (en) * | 2006-05-17 | 2006-06-28 | Photocure Asa | Product |
CA2657409A1 (en) * | 2006-07-12 | 2008-01-17 | Elan Corporation, Plc | Nanoparticulate formulations of modafinil |
JP5404995B2 (ja) | 2006-08-10 | 2014-02-05 | コスモ石油株式会社 | 植物のポリフェノール増量剤 |
GB0700580D0 (en) * | 2007-01-11 | 2007-02-21 | Photocure Asa | Use |
US20090036952A1 (en) | 2007-07-30 | 2009-02-05 | National Yang-Ming University | Induction driven light module and use thereof |
GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
KR100883560B1 (ko) * | 2007-08-23 | 2009-02-17 | (주) 위디어 | 신규한 5-아미노레불린 산 유도체 및 이의 제조방법 |
GB0724279D0 (en) * | 2007-12-12 | 2008-01-23 | Photocure Asa | Use |
AU2008337067A1 (en) * | 2007-12-14 | 2009-06-25 | Photoderma Sa | Novel compounds useful in therapeutic and cosmetic methods |
GB0804190D0 (en) * | 2008-03-06 | 2008-04-16 | Ge Healthcare Ltd | Ester imaging agents |
JP5496881B2 (ja) | 2008-05-14 | 2014-05-21 | Sbiファーマ株式会社 | 男性不妊治療剤 |
US20110223105A1 (en) * | 2008-09-01 | 2011-09-15 | Eriksson Leif A | New 5-aminolevulinic acid prodrugs for use in photodynamic therapy and photodynamic diagnosis |
GB0823472D0 (en) | 2008-12-23 | 2009-01-28 | Photocure Asa | Product |
GB0900461D0 (en) | 2009-01-12 | 2009-02-11 | Photocure Asa | Photodynamic therapy device |
ES2821831T3 (es) * | 2009-06-11 | 2021-04-27 | Photocure Asa | Composiciones y productos farmacéuticos semisólidos que comprenden ésteres de ácido 5-aminolevulínico |
WO2010142456A1 (en) * | 2009-06-11 | 2010-12-16 | Photocure Asa | Solid compositions comprising 5-aminolevulinic acid |
WO2011107478A1 (en) | 2010-03-01 | 2011-09-09 | Photocure Asa | Cosmetic compositions |
EP2394642A1 (en) | 2010-06-10 | 2011-12-14 | Universite De Geneve | 5-ALA ester formulations and use thereof |
US20130211215A1 (en) | 2010-06-23 | 2013-08-15 | Photocure Asa | Hyperosmotic preparations comprising 5-aminolevulinic acid or derivative as photosensitizing agent |
KR101842732B1 (ko) | 2010-07-09 | 2018-05-14 | 포토큐어 에이에스에이 | 광역동 치료 또는 광역동 진단에 사용하기 위한 건조 조성물 및 이와 같은 건조 조성물을 포함하는 기구 |
WO2012086802A1 (ja) | 2010-12-24 | 2012-06-28 | アークレイ株式会社 | 癌細胞の検出方法 |
KR20140089478A (ko) | 2011-01-13 | 2014-07-15 | 큐엘티 인코포레이티드 | 감광제의 국소 전달용 약학 조성물 및 그의 이용 |
EP2766049A1 (en) | 2011-10-14 | 2014-08-20 | Photocure ASA | Photodynamic diagnosis of abnormalities of the epithelial lining of the oesophagus with the means of a 5-ala ester |
US20140316534A1 (en) | 2011-10-14 | 2014-10-23 | Photocure Asa | Stent |
BR112014014847B1 (pt) | 2011-12-19 | 2022-08-16 | Photocure Asa | Aparelho de aplicação de luz portátil, autônomo, para tratamento fotodinâmico da vulva, e kit |
WO2013092936A2 (en) | 2011-12-20 | 2013-06-27 | Galderma Research & Development | Use of 5-aminolevulinic acid and esters, in combination with a vitamin d derivative or analog in photochemotherapy, and their uses in treating acne |
JP2015522079A (ja) | 2012-07-11 | 2015-08-03 | ダーミラ, インク.Dermira, Inc. | 光線感作物質の局所送達のための医薬組成物及びその使用 |
SG11201500805VA (en) | 2012-08-03 | 2015-02-27 | Photocure Asa | Compounds |
GB201215675D0 (en) * | 2012-09-03 | 2012-10-17 | Univ Exeter | Compound |
GB201221123D0 (en) | 2012-11-23 | 2013-01-09 | Photocure As | Device for photodynamic treatment |
GB201306369D0 (en) | 2013-04-09 | 2013-05-22 | Photocure As | Irradiation device |
US10716855B2 (en) | 2013-12-20 | 2020-07-21 | Galderma Research & Development | Pulse photodynamic treatment of photodamaged skin |
BR112016017997A2 (pt) | 2014-02-03 | 2017-08-08 | Quadriga Biosciences Inc | Beta aminoácidos beta-substituídos e análogos como agentes quimioterapêuticos |
EP3095464A1 (en) | 2015-05-19 | 2016-11-23 | Universite De Geneve | 5-ala derivatives and use thereof |
EP3331851A1 (en) | 2015-08-03 | 2018-06-13 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof |
GB201522309D0 (en) * | 2015-12-17 | 2016-02-03 | Photocure Asa | Use |
GB201522398D0 (en) | 2015-12-18 | 2016-02-03 | Photocure As | Device for photodynamic therapy |
CN106187793A (zh) | 2016-01-26 | 2016-12-07 | 赵鸣 | 5‑氨基酮戊酸及其衍生物的盐化合物和应用 |
HUE053510T2 (hu) | 2017-02-06 | 2021-07-28 | 3Skin As | Fényvédõ készítmény |
WO2018234509A1 (en) * | 2017-06-21 | 2018-12-27 | Photocure Asa | PROCESS FOR PREPARING A LIQUID PHARMACEUTICAL COMPOSITION AND DEVICE FOR USE IN SUCH A METHOD |
EP3868372A1 (en) | 2020-02-19 | 2021-08-25 | JLP Health GmbH | A pharmaceutical combination of an artemisinin compound and a heme synthesis modulator for treating cancer |
CN111635464B (zh) * | 2020-05-12 | 2022-03-25 | 上海易全化学有限公司 | 一种5-氨基酮戊酸葡聚糖酯的制备方法 |
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US5422093A (en) | 1989-07-28 | 1995-06-06 | Queen's University | Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof |
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US7530461B2 (en) | 1995-03-10 | 2009-05-12 | Photocure Asa | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
US6492420B2 (en) | 1995-03-10 | 2002-12-10 | Photocure As | Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy |
US6992107B1 (en) * | 1995-03-10 | 2006-01-31 | Photocure Asa | Esters of 5-aminolevulinic acid and their use as photosensitizing compounds in photochemotherapy |
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GB0018527D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Composition |
GB0118251D0 (en) | 2001-07-26 | 2001-09-19 | Photocure Asa | Method |
GB0128052D0 (en) | 2001-11-22 | 2002-01-16 | Drug Discovery Lab As | Compounds |
-
2000
- 2000-07-27 GB GBGB0018528.0A patent/GB0018528D0/en not_active Ceased
-
2001
- 2001-07-25 DK DK01984415T patent/DK1313695T3/da active
- 2001-07-25 KR KR10-2003-7001213A patent/KR20030028554A/ko not_active Application Discontinuation
- 2001-07-25 US US10/343,209 patent/US7217736B2/en not_active Expired - Fee Related
- 2001-07-25 CN CNB018146953A patent/CN1318388C/zh not_active Expired - Fee Related
- 2001-07-25 NZ NZ523927A patent/NZ523927A/en not_active IP Right Cessation
- 2001-07-25 EP EP01984415A patent/EP1313695B1/en not_active Expired - Lifetime
- 2001-07-25 JP JP2002516252A patent/JP5010088B2/ja not_active Expired - Fee Related
- 2001-07-25 RU RU2003105460/04A patent/RU2246483C2/ru not_active IP Right Cessation
- 2001-07-25 DE DE60125555T patent/DE60125555T2/de not_active Expired - Lifetime
- 2001-07-25 AU AU2002227495A patent/AU2002227495B2/en not_active Ceased
- 2001-07-25 HU HU0301427A patent/HUP0301427A2/hu unknown
- 2001-07-25 AU AU2749502A patent/AU2749502A/xx active Pending
- 2001-07-25 PT PT01984415T patent/PT1313695E/pt unknown
- 2001-07-25 CZ CZ2003260A patent/CZ2003260A3/cs unknown
- 2001-07-25 CA CA2416307A patent/CA2416307C/en not_active Expired - Fee Related
- 2001-07-25 AT AT01984415T patent/ATE349417T1/de active
- 2001-07-25 WO PCT/GB2001/003336 patent/WO2002010120A1/en not_active Application Discontinuation
- 2001-07-25 ES ES01984415T patent/ES2276844T3/es not_active Expired - Lifetime
-
2003
- 2003-01-24 NO NO20030398A patent/NO20030398L/no not_active Application Discontinuation
-
2007
- 2007-04-13 US US11/786,878 patent/US7563819B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PT1313695E (pt) | 2007-01-31 |
AU2002227495B2 (en) | 2006-01-05 |
RU2246483C2 (ru) | 2005-02-20 |
GB0018528D0 (en) | 2000-09-13 |
EP1313695A1 (en) | 2003-05-28 |
AU2749502A (en) | 2002-02-13 |
DE60125555T2 (de) | 2007-10-11 |
NO20030398D0 (no) | 2003-01-24 |
CZ2003260A3 (cs) | 2003-06-18 |
NO20030398L (no) | 2003-03-12 |
US7563819B1 (en) | 2009-07-21 |
US7217736B2 (en) | 2007-05-15 |
CA2416307C (en) | 2013-01-22 |
JP5010088B2 (ja) | 2012-08-29 |
JP2004505105A (ja) | 2004-02-19 |
DE60125555D1 (de) | 2007-02-08 |
ATE349417T1 (de) | 2007-01-15 |
US20040106679A1 (en) | 2004-06-03 |
CN1460099A (zh) | 2003-12-03 |
DK1313695T3 (da) | 2007-04-30 |
EP1313695B1 (en) | 2006-12-27 |
KR20030028554A (ko) | 2003-04-08 |
WO2002010120A1 (en) | 2002-02-07 |
ES2276844T3 (es) | 2007-07-01 |
NZ523927A (en) | 2004-07-30 |
CN1318388C (zh) | 2007-05-30 |
CA2416307A1 (en) | 2002-02-07 |
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