JP2009532372A5 - - Google Patents
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- Publication number
- JP2009532372A5 JP2009532372A5 JP2009503119A JP2009503119A JP2009532372A5 JP 2009532372 A5 JP2009532372 A5 JP 2009532372A5 JP 2009503119 A JP2009503119 A JP 2009503119A JP 2009503119 A JP2009503119 A JP 2009503119A JP 2009532372 A5 JP2009532372 A5 JP 2009532372A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- agent according
- hydrogen
- agent
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003795 chemical substances by application Substances 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 7
- -1 hydroxy, methyl Chemical group 0.000 claims 7
- 229940080774 Peroxisome proliferator-activated receptor gamma agonist Drugs 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 208000031773 Insulin resistance syndrome Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 208000010706 fatty liver disease Diseases 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 150000004677 hydrates Chemical class 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 238000011287 therapeutic dose Methods 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- WMUIIGVAWPWQAW-XMMPIXPASA-N (2r)-2-ethoxy-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]propanoic acid Chemical compound C1=CC(C[C@@H](OCC)C(O)=O)=CC=C1OCCN1C2=CC=CC=C2OC2=CC=CC=C21 WMUIIGVAWPWQAW-XMMPIXPASA-N 0.000 claims 1
- AFENDNXGAFYKQO-GSVOUGTGSA-N (R)-2-hydroxybutyric acid Chemical compound CC[C@@H](O)C(O)=O AFENDNXGAFYKQO-GSVOUGTGSA-N 0.000 claims 1
- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims 1
- GFGJCAMOIIXWCC-UHFFFAOYSA-N 2-[3-[(2,6-dimethylphenyl)methoxy]phenyl]-n-hydroxyacetamide Chemical compound CC1=CC=CC(C)=C1COC1=CC=CC(CC(=O)NO)=C1 GFGJCAMOIIXWCC-UHFFFAOYSA-N 0.000 claims 1
- FIIULAILAPDPJC-UHFFFAOYSA-N 2-[3-[(2,6-dimethylphenyl)methoxy]phenyl]acetic acid Chemical compound CC1=CC=CC(C)=C1COC1=CC=CC(CC(O)=O)=C1 FIIULAILAPDPJC-UHFFFAOYSA-N 0.000 claims 1
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- HFVDIZNJYLODRP-UHFFFAOYSA-N 4-[3-[(2,6-dimethylphenyl)methoxy]phenyl]-4-oxobutanoic acid Chemical compound CC1=CC=CC(C)=C1COC1=CC=CC(C(=O)CCC(O)=O)=C1 HFVDIZNJYLODRP-UHFFFAOYSA-N 0.000 claims 1
- QBQLYIISSRXYKL-UHFFFAOYSA-N 4-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,2-oxazolidine-3,5-dione Chemical compound CC=1OC(C=2C=CC=CC=2)=NC=1CCOC(C=C1)=CC=C1CC1C(=O)NOC1=O QBQLYIISSRXYKL-UHFFFAOYSA-N 0.000 claims 1
- NFFXEUUOMTXWCX-UHFFFAOYSA-N 5-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxy-n-[[4-(trifluoromethyl)phenyl]methyl]benzamide Chemical group C1=C(C(=O)NCC=2C=CC(=CC=2)C(F)(F)F)C(OC)=CC=C1CC1SC(=O)NC1=O NFFXEUUOMTXWCX-UHFFFAOYSA-N 0.000 claims 1
- YVQKIDLSVHRBGZ-UHFFFAOYSA-N 5-[[4-[2-hydroxy-2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound CC=1OC(C=2C=CC=CC=2)=NC=1C(O)COC(C=C1)=CC=C1CC1SC(=O)NC1=O YVQKIDLSVHRBGZ-UHFFFAOYSA-N 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000002177 Cataract Diseases 0.000 claims 1
- 208000003790 Foot Ulcer Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 206010038923 Retinopathy Diseases 0.000 claims 1
- 206010040943 Skin Ulcer Diseases 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 230000004596 appetite loss Effects 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 235000021266 loss of appetite Nutrition 0.000 claims 1
- 208000019017 loss of appetite Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229960005095 pioglitazone Drugs 0.000 claims 1
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 1
- 229960004586 rosiglitazone Drugs 0.000 claims 1
- CXGTZJYQWSUFET-IBGZPJMESA-N tesaglitazar Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(OS(C)(=O)=O)C=C1 CXGTZJYQWSUFET-IBGZPJMESA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 208000016261 weight loss Diseases 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74402106P | 2006-03-31 | 2006-03-31 | |
| PCT/US2007/063288 WO2007117791A2 (en) | 2006-03-31 | 2007-03-05 | Combination treatment of metabolic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009532372A JP2009532372A (ja) | 2009-09-10 |
| JP2009532372A5 true JP2009532372A5 (enExample) | 2010-04-22 |
Family
ID=38581719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503119A Pending JP2009532372A (ja) | 2006-03-31 | 2007-03-05 | 代謝障害の併用治療 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8338480B2 (enExample) |
| EP (1) | EP2001461A4 (enExample) |
| JP (1) | JP2009532372A (enExample) |
| KR (1) | KR20080106455A (enExample) |
| CN (1) | CN101410105A (enExample) |
| AU (1) | AU2007235145B2 (enExample) |
| CA (1) | CA2647258A1 (enExample) |
| IL (1) | IL194189A0 (enExample) |
| MX (1) | MX2008012506A (enExample) |
| NZ (1) | NZ571118A (enExample) |
| WO (1) | WO2007117791A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101059776B1 (ko) * | 2001-06-12 | 2011-08-26 | 웰스테트 테라퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
| US8022249B2 (en) | 2005-04-01 | 2011-09-20 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| JP2009525982A (ja) * | 2006-02-02 | 2009-07-16 | ウェルスタット セラピューティクス コーポレイション | 代謝障害の治療のための化合物 |
| MX2010002562A (es) * | 2007-09-07 | 2011-04-11 | Inst Nac De Ciencias Medicas Y Nutricion | Uso de los niveles de antigeno secretor, de lewis y de sialilo como predictores para enfermedad. |
| US8481595B2 (en) * | 2008-01-15 | 2013-07-09 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| EP2085120A1 (en) * | 2008-02-01 | 2009-08-05 | Merz Pharma GmbH & Co. KGaA | The use of substances for the treatment of central or peripheral insulin receptor impairment and insulin resistance |
| AU2009258040B8 (en) * | 2008-03-13 | 2014-04-24 | Wellstat Therapeutics Corporation | Compounds and method for reducing uric acid |
| EP2451462B1 (en) | 2009-07-06 | 2017-09-06 | Children's Hospital Medical Center | Inhibiting inflammation with milk oligosaccharides |
| US20130331452A1 (en) | 2010-09-08 | 2013-12-12 | Wellstat Therapeutics Corporation | Benzoic acid compounds for reducing uric acid |
| CN104885151B (zh) | 2012-12-21 | 2017-12-22 | 杜比实验室特许公司 | 用于基于感知准则呈现基于对象的音频内容的对象群集 |
| US10626460B2 (en) | 2013-02-21 | 2020-04-21 | Children's Hospital Medical Center | Use of glycans and glycosyltransferases for diagnosing/monitoring inflammatory bowel disease |
| JP6553375B2 (ja) * | 2014-06-24 | 2019-07-31 | 花王株式会社 | Ｕｃｐ−１発現促進剤 |
| JP6660668B2 (ja) * | 2014-06-24 | 2020-03-11 | 花王株式会社 | Ｕｃｐ−１発現促進剤 |
| WO2015199097A1 (ja) * | 2014-06-24 | 2015-12-30 | 花王株式会社 | Ｕｃｐ－１発現促進剤 |
| US10758519B2 (en) | 2014-06-24 | 2020-09-01 | Kao Corporation | UCP-1 expression promoter |
| EP3288389A4 (en) | 2015-04-28 | 2018-10-10 | Children's Hospital Medical Center | Use of oligosaccharide compositions to enhance weight gain |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE186724T1 (de) * | 1987-09-04 | 1999-12-15 | Beecham Group Plc | Substituierte thiazolidindionderivate |
| TW438587B (en) * | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US6172046B1 (en) * | 1997-09-21 | 2001-01-09 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection |
| US6472373B1 (en) * | 1997-09-21 | 2002-10-29 | Schering Corporation | Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection |
| IL158873A0 (en) * | 2001-06-07 | 2004-05-12 | Lilly Co Eli | Modulators of peroxisome proliferator activated receptors |
| KR101059776B1 (ko) * | 2001-06-12 | 2011-08-26 | 웰스테트 테라퓨틱스 코포레이션 | 대사 질환의 치료용 화합물 |
| AU2003286728A1 (en) * | 2002-11-01 | 2004-06-07 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| RU2005128501A (ru) * | 2003-02-13 | 2006-04-27 | Веллстат Терапьютикс Корпорейшн (Us) | Соединение для лечения метаболических расстройств |
| MXPA05011042A (es) * | 2003-04-15 | 2005-12-15 | Wellstat Therapeutics Corp | Compuestos para el tratamieno de trastornos metabolicos. |
| WO2004093806A2 (en) * | 2003-04-22 | 2004-11-04 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| CN100348186C (zh) * | 2003-04-30 | 2007-11-14 | 维尔斯达医疗公司 | 用于治疗代谢紊乱的化合物 |
| BRPI0413758A (pt) * | 2003-08-20 | 2006-10-31 | Wellstat Therapeutics Corp | compostos para o tratamento de transtornos metabólicos |
| US8022249B2 (en) * | 2005-04-01 | 2011-09-20 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| FR2887881B1 (fr) | 2005-07-01 | 2009-10-09 | Pierre Fabre Medicament Sa | Inhibiteurs de proteines kinases |
| JP2009528275A (ja) | 2006-01-25 | 2009-08-06 | ウェルスタット セラピューティクス コーポレイション | 代謝障害を処置するための化合物 |
| WO2007087505A2 (en) * | 2006-01-25 | 2007-08-02 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
-
2007
- 2007-03-05 CA CA002647258A patent/CA2647258A1/en not_active Abandoned
- 2007-03-05 CN CNA2007800110442A patent/CN101410105A/zh active Pending
- 2007-03-05 MX MX2008012506A patent/MX2008012506A/es not_active Application Discontinuation
- 2007-03-05 WO PCT/US2007/063288 patent/WO2007117791A2/en not_active Ceased
- 2007-03-05 US US12/294,530 patent/US8338480B2/en not_active Expired - Fee Related
- 2007-03-05 KR KR1020087023632A patent/KR20080106455A/ko not_active Ceased
- 2007-03-05 AU AU2007235145A patent/AU2007235145B2/en not_active Ceased
- 2007-03-05 EP EP07757896A patent/EP2001461A4/en not_active Withdrawn
- 2007-03-05 NZ NZ571118A patent/NZ571118A/en not_active IP Right Cessation
- 2007-03-05 JP JP2009503119A patent/JP2009532372A/ja active Pending
-
2008
- 2008-09-17 IL IL194189A patent/IL194189A0/en unknown