ATE526018T1 - Verbindungen zur behandlung von stoffwechselstörungen - Google Patents

Verbindungen zur behandlung von stoffwechselstörungen

Info

Publication number
ATE526018T1
ATE526018T1 AT04750363T AT04750363T ATE526018T1 AT E526018 T1 ATE526018 T1 AT E526018T1 AT 04750363 T AT04750363 T AT 04750363T AT 04750363 T AT04750363 T AT 04750363T AT E526018 T1 ATE526018 T1 AT E526018T1
Authority
AT
Austria
Prior art keywords
carbon atoms
ring
alkyl
hydrogen
treatment
Prior art date
Application number
AT04750363T
Other languages
English (en)
Inventor
Kirvin Hodge
Shalini Sharma
Borstel Reid Von
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Application granted granted Critical
Publication of ATE526018T1 publication Critical patent/ATE526018T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT04750363T 2003-04-30 2004-04-20 Verbindungen zur behandlung von stoffwechselstörungen ATE526018T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46666303P 2003-04-30 2003-04-30
PCT/US2004/012141 WO2004098496A2 (en) 2003-04-30 2004-04-20 Compounds for the treatment of metabolic disorders

Publications (1)

Publication Number Publication Date
ATE526018T1 true ATE526018T1 (de) 2011-10-15

Family

ID=33434973

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04750363T ATE526018T1 (de) 2003-04-30 2004-04-20 Verbindungen zur behandlung von stoffwechselstörungen

Country Status (12)

Country Link
US (2) US7442796B2 (de)
EP (1) EP1617835B1 (de)
JP (1) JP4837557B2 (de)
KR (1) KR101192272B1 (de)
CN (1) CN100348186C (de)
AT (1) ATE526018T1 (de)
AU (1) AU2004237602B2 (de)
CA (1) CA2522738C (de)
IL (1) IL171638A (de)
MX (1) MXPA05011592A (de)
NZ (1) NZ543789A (de)
WO (1) WO2004098496A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20033394A3 (cs) * 2001-06-12 2005-03-16 Wellstat Therapeutics Corporation Sloučeniny pro léčení metabolických poruch a způsob jejich přípravy
EP2266946A3 (de) * 2003-02-13 2012-12-12 Wellstat Therapeutics Corporation Verbindung zur Behandlung metabolischer Störungen
DE602004030004D1 (de) * 2003-04-15 2010-12-23 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
US7361686B2 (en) * 2003-04-22 2008-04-22 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1617835B1 (de) * 2003-04-30 2011-09-28 Wellstat Therapeutics Corporation Verbindungen zur behandlung von stoffwechselstörungen
CN1835743A (zh) * 2003-08-20 2006-09-20 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
US8022249B2 (en) * 2005-04-01 2011-09-20 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
UA95613C2 (ru) * 2005-11-09 2011-08-25 Уеллстат Терепьютикс Корпорейшн Соединения для лечения расстройсв метаболизма
CA2636290A1 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1976377A4 (de) * 2006-01-25 2010-06-23 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
WO2007087504A2 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1978948A4 (de) * 2006-02-02 2010-06-16 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
CA2637884A1 (en) * 2006-02-13 2007-08-23 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
JP2009528375A (ja) * 2006-02-28 2009-08-06 ウェルスタット セラピューティクス コーポレイション 代謝障害を処置するための化合物
AU2007235145B2 (en) * 2006-03-31 2011-09-22 Wellstat Therapeutics Corporation Combination treatment of metabolic disorders
WO2007137008A2 (en) * 2006-05-18 2007-11-29 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US20100234464A1 (en) * 2006-06-09 2010-09-16 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP2056673A4 (de) * 2006-08-17 2010-06-16 Wellstat Therapeutics Corp Kombinationsbehandlung für stoffwechselerkrankungen
US8481595B2 (en) * 2008-01-15 2013-07-09 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
DK2268141T3 (da) 2008-03-13 2019-07-29 Wellstat Therapeutics Corp Forbindelse og fremgangsmåde til at reducere urinsyre
US8664433B2 (en) * 2008-05-05 2014-03-04 Wellstat Therapeutics Corporation Synthesis of 4-[3-(2,6-dimethylbenzyloxy)phenyl]-4-oxobutanoic acid
WO2010053910A1 (en) 2008-11-04 2010-05-14 Wellstat Therapeutics Corporation Synthesis of (phenylalkyloxy)phenyl-oxobutanoic acids
US8337835B2 (en) * 2009-04-10 2012-12-25 Washington University Use of an endogenous ligand for peroxisome proliferator activated receptor alpha to treat liver disorders

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE949521C (de) * 1955-01-09 1956-09-20 Merck Ag E Lichtschutzmittel
DK43476A (da) * 1975-02-04 1976-08-05 Fujisawa Pharmaceutical Co Fremgangsmade til fremstilling af cephemcarboxylsyrer
AU543804B2 (en) * 1980-10-31 1985-05-02 Takeda Chemical Industries Ltd. Amides having bicyclic substituents on nitrogen
US4474809A (en) 1983-01-20 1984-10-02 American Cyanamid Company Arylglyoxals
JPS6261587A (ja) * 1985-09-12 1987-03-18 Ajinomoto Co Inc 光学活性(r)−ヒドロキシマンデル酸エステル中間体の製造法
DE3806874A1 (de) * 1988-03-03 1989-09-14 Basf Ag Substituierte hydrazone und diese enthaltende fungizide
JP2533651B2 (ja) * 1988-09-13 1996-09-11 財団法人相模中央化学研究所 2―オキソ―3―芳香族カルボン酸誘導体の製造方法
ATE136018T1 (de) * 1991-05-09 1996-04-15 Hoffmann La Roche Substituierte carbonsäurederivate
US5589492A (en) * 1992-04-10 1996-12-31 Smithkline Beecham Plc Heterocyclic compounds and their use in the treatment of Type-II diabetes
IL111613A0 (en) * 1993-11-12 1995-01-24 Rhone Poulenc Rorer Ltd Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
US5453443A (en) * 1994-07-20 1995-09-26 Merck Frosst Canada, Inc. Bis(aryloxy)alkanes as inhibitors of phospholipase A2 enzymes
US5665387A (en) * 1994-09-01 1997-09-09 K.U. Leuven Research & Development Methods and compositions for primary and secondary prevention of autoimmune diabetes
AU8750298A (en) * 1997-08-28 1999-03-22 Ono Pharmaceutical Co. Ltd. Peroxisome proliferator-activated receptor controllers
EP1085846A2 (de) * 1998-06-08 2001-03-28 Advanced Medicine, Inc. Mehrfachbindende inhibitoren des microsomalen triglyceridtransferase-proteins
AU7313200A (en) * 1999-09-16 2001-04-17 Takeda Chemical Industries Ltd. Alpha-keto esters and processes for the preparation thereof
GB9927056D0 (en) * 1999-11-17 2000-01-12 Karobio Ab Thyroid receptor antagonists for the treatment of cardiac and metabolic disorders
CZ20033394A3 (cs) * 2001-06-12 2005-03-16 Wellstat Therapeutics Corporation Sloučeniny pro léčení metabolických poruch a způsob jejich přípravy
AU2003286728A1 (en) * 2002-11-01 2004-06-07 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP2266946A3 (de) * 2003-02-13 2012-12-12 Wellstat Therapeutics Corporation Verbindung zur Behandlung metabolischer Störungen
DE602004030004D1 (de) * 2003-04-15 2010-12-23 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
US7361686B2 (en) * 2003-04-22 2008-04-22 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
EP1617835B1 (de) * 2003-04-30 2011-09-28 Wellstat Therapeutics Corporation Verbindungen zur behandlung von stoffwechselstörungen
CN1835743A (zh) * 2003-08-20 2006-09-20 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
EP1976377A4 (de) * 2006-01-25 2010-06-23 Wellstat Therapeutics Corp Verbindungen zur behandlung von stoffwechselstörungen
CA2636290A1 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
WO2007087504A2 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders

Also Published As

Publication number Publication date
CN1780614A (zh) 2006-05-31
US7442796B2 (en) 2008-10-28
HK1083460A1 (en) 2006-07-07
US20070173544A1 (en) 2007-07-26
CN100348186C (zh) 2007-11-14
EP1617835B1 (de) 2011-09-28
JP2006525331A (ja) 2006-11-09
CA2522738C (en) 2011-11-08
WO2004098496A3 (en) 2005-03-31
WO2004098496A2 (en) 2004-11-18
US20090005451A1 (en) 2009-01-01
EP1617835A4 (de) 2009-11-18
KR20060006075A (ko) 2006-01-18
MXPA05011592A (es) 2005-12-15
AU2004237602B2 (en) 2009-05-28
EP1617835A2 (de) 2006-01-25
IL171638A (en) 2011-06-30
AU2004237602A1 (en) 2004-11-18
US7749990B2 (en) 2010-07-06
CA2522738A1 (en) 2004-11-18
NZ543789A (en) 2008-03-28
JP4837557B2 (ja) 2011-12-14
KR101192272B1 (ko) 2012-10-17

Similar Documents

Publication Publication Date Title
CY1111310T1 (el) Ενωσεις για την αγωγη μεταβολικων διαταραχων
ATE530066T1 (de) Verbindungen zur behandlung von stoffwechselstörungen
ATE526018T1 (de) Verbindungen zur behandlung von stoffwechselstörungen
WO2004073611A3 (en) Compounds for the treatment of metabolic disorders
ATE450496T1 (de) Verbindungen zur behandlung von stoffwechselstörungen
WO2007087505A3 (en) Compounds for the treatment of metabolic disorders
WO2007137008A3 (en) Compounds for the treatment of metabolic disorders
WO2007095462A3 (en) Compounds for the treatment of metabolic disorders
NO20081821L (no) Forbindelser for behandling av metabolske forstyrrelser
WO2005105732A8 (en) Substituted methyl aryl or heteroaryl amide compounds
NO20003399D0 (no) <Alfa>-amionoamidderivater som er nyttige som smertestillende midler
TW200604175A (en) Ortho substituted aryl or heteroaryl amide compounds
UA88772C2 (ru) Соединения для лечения расстройств метаболизма
ATE540675T1 (de) Verbindungen zur behandlung von stoffwechselstörungen
WO2007087504A3 (en) Compounds for the treatment of metabolic disorders
WO2007092729A3 (en) Compounds for the treatment of metabolic disorders

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties