JP2013519680A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013519680A5 JP2013519680A5 JP2012552997A JP2012552997A JP2013519680A5 JP 2013519680 A5 JP2013519680 A5 JP 2013519680A5 JP 2012552997 A JP2012552997 A JP 2012552997A JP 2012552997 A JP2012552997 A JP 2012552997A JP 2013519680 A5 JP2013519680 A5 JP 2013519680A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- chromen
- trifluoromethyl
- group
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 N, N-dimethylamino Chemical group 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000003536 tetrazoles Chemical class 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- IKNZBNHVVQIRTO-UHFFFAOYSA-N 2h-tetrazole-5-carboxylic acid Chemical compound OC(=O)C=1N=NNN=1 IKNZBNHVVQIRTO-UHFFFAOYSA-N 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- ZVTQYRVARPYRRE-UHFFFAOYSA-N oxadiazol-4-one Chemical compound O=C1CON=N1 ZVTQYRVARPYRRE-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- AQYIDERAMPMQQN-UHFFFAOYSA-N 2-(difluoromethyl)-7-hydroxy-3-[4-(2h-tetrazol-5-yl)phenyl]chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)F)=C2C(C=C1)=CC=C1C1=NN=NN1 AQYIDERAMPMQQN-UHFFFAOYSA-N 0.000 claims 1
- DSPLFQVWRBCFBY-UHFFFAOYSA-N 3-[2-chloro-4-(2h-tetrazol-5-yl)phenyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C(=C1)Cl)=CC=C1C1=NN=NN1 DSPLFQVWRBCFBY-UHFFFAOYSA-N 0.000 claims 1
- SROZAXRHCDMWDN-UHFFFAOYSA-N 3-[3-chloro-4-(2h-tetrazol-5-yl)phenyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1Cl)=CC=C1C1=NN=NN1 SROZAXRHCDMWDN-UHFFFAOYSA-N 0.000 claims 1
- JTJFNTFGSXGQCE-UHFFFAOYSA-N 3-[3-chloro-4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C(=C1)Cl)=CC=C1C1=NOC(=O)N1 JTJFNTFGSXGQCE-UHFFFAOYSA-N 0.000 claims 1
- SEOPFLCETNIRME-UHFFFAOYSA-N 3-[3-fluoro-4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C(=C1)F)=CC=C1C1=NOC(=O)N1 SEOPFLCETNIRME-UHFFFAOYSA-N 0.000 claims 1
- RRVFSAKXCOIFRP-UHFFFAOYSA-N 3-[4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1)=CC=C1C1=NOC(=O)N1 RRVFSAKXCOIFRP-UHFFFAOYSA-N 0.000 claims 1
- HNHMUAMHKJROPF-UHFFFAOYSA-N 3-[4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-thiadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1)=CC=C1C1=NSC(=O)N1 HNHMUAMHKJROPF-UHFFFAOYSA-N 0.000 claims 1
- FUHSYKWZNQTLKC-UHFFFAOYSA-N 3-fluoro-4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]benzoic acid Chemical compound FC1=CC(C(=O)O)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O FUHSYKWZNQTLKC-UHFFFAOYSA-N 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- DYTYZNFCPKSNSW-UHFFFAOYSA-N 4-(7-hydroxy-2-methyl-4-oxothiochromen-3-yl)benzoic acid Chemical compound CC=1SC2=CC(O)=CC=C2C(=O)C=1C1=CC=C(C(O)=O)C=C1 DYTYZNFCPKSNSW-UHFFFAOYSA-N 0.000 claims 1
- BOJHURJUTNFAKS-UHFFFAOYSA-N 4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]-3-methylbenzoic acid Chemical compound CC1=CC(C(O)=O)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O BOJHURJUTNFAKS-UHFFFAOYSA-N 0.000 claims 1
- QUFCZPQVMSDJLQ-UHFFFAOYSA-N 4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]-n-methylsulfonylbenzamide Chemical compound C1=CC(C(=O)NS(=O)(=O)C)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O QUFCZPQVMSDJLQ-UHFFFAOYSA-N 0.000 claims 1
- LXKDWHZAQSLWQP-UHFFFAOYSA-N 4-[8-fluoro-7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=C(C(F)(F)F)OC2=C(F)C(O)=CC=C2C1=O LXKDWHZAQSLWQP-UHFFFAOYSA-N 0.000 claims 1
- HPCCACKAELJHMO-UHFFFAOYSA-N 4-[[3-(4-carboxyphenyl)-7-hydroxy-4-oxothiochromen-2-yl]methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CC1=C(C=2C=CC(=CC=2)C(O)=O)C(=O)C2=CC=C(O)C=C2S1 HPCCACKAELJHMO-UHFFFAOYSA-N 0.000 claims 1
- QHJHGEIEGPHPHU-UHFFFAOYSA-N 5-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O QHJHGEIEGPHPHU-UHFFFAOYSA-N 0.000 claims 1
- NTGQSLDMFCZSEC-UHFFFAOYSA-N 5-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]thiophene-3-carboxylic acid Chemical compound OC(=O)C1=CSC(C=2C(C3=CC=C(O)C=C3OC=2C(F)(F)F)=O)=C1 NTGQSLDMFCZSEC-UHFFFAOYSA-N 0.000 claims 1
- IYLSFMCJATULBG-UHFFFAOYSA-N 7-hydroxy-2-methyl-3-[4-(2h-tetrazol-5-yl)phenyl]chromen-4-one Chemical compound CC=1OC2=CC(O)=CC=C2C(=O)C=1C(C=C1)=CC=C1C1=NN=NN1 IYLSFMCJATULBG-UHFFFAOYSA-N 0.000 claims 1
- ZXBGKUANALHIOU-UHFFFAOYSA-N 7-hydroxy-2-methyl-3-[4-(2h-tetrazol-5-yl)phenyl]thiochromen-4-one Chemical compound CC=1SC2=CC(O)=CC=C2C(=O)C=1C(C=C1)=CC=C1C1=NN=NN1 ZXBGKUANALHIOU-UHFFFAOYSA-N 0.000 claims 1
- FGJSNLPJDMQOJH-UHFFFAOYSA-N 7-hydroxy-3-[4-(2h-tetrazol-5-yl)phenyl]-2-(trifluoromethyl)chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1)=CC=C1C1=NN=NN1 FGJSNLPJDMQOJH-UHFFFAOYSA-N 0.000 claims 1
- JSURXDDJUXDRSW-UHFFFAOYSA-N 7-hydroxy-3-[4-(2h-tetrazol-5-yl)phenyl]chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC=C2C(C=C1)=CC=C1C1=NN=NN1 JSURXDDJUXDRSW-UHFFFAOYSA-N 0.000 claims 1
- VNVIRBPUPMNXGH-KYZUINATSA-N C1([C@H]2CC[C@@H](CC2)C2=C(OC=3C(C2=O)=CC=C(C=3)O)C(F)(F)F)=NN=NN1 Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(OC=3C(C2=O)=CC=C(C=3)O)C(F)(F)F)=NN=NN1 VNVIRBPUPMNXGH-KYZUINATSA-N 0.000 claims 1
- VPJXLPFRLZWPRZ-KYZUINATSA-N C1C[C@@H](C(=O)O)CC[C@@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O Chemical compound C1C[C@@H](C(=O)O)CC[C@@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O VPJXLPFRLZWPRZ-KYZUINATSA-N 0.000 claims 1
- VPJXLPFRLZWPRZ-DTORHVGOSA-N C1C[C@@H](C(=O)O)CC[C@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O Chemical compound C1C[C@@H](C(=O)O)CC[C@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O VPJXLPFRLZWPRZ-DTORHVGOSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- QSSJZLPUHJDYKF-UHFFFAOYSA-N Cc(cc1)ccc1C(OC)=O Chemical compound Cc(cc1)ccc1C(OC)=O QSSJZLPUHJDYKF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30395210P | 2010-02-12 | 2010-02-12 | |
| US61/303,952 | 2010-02-12 | ||
| PCT/US2011/024353 WO2011100433A1 (en) | 2010-02-12 | 2011-02-10 | Novel s-nitrosoglutathione reductase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015190968A Division JP2016040285A (ja) | 2010-02-12 | 2015-09-29 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519680A JP2013519680A (ja) | 2013-05-30 |
| JP2013519680A5 true JP2013519680A5 (enExample) | 2014-03-20 |
| JP5878484B2 JP5878484B2 (ja) | 2016-03-08 |
Family
ID=44368117
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552997A Expired - Fee Related JP5878484B2 (ja) | 2010-02-12 | 2011-02-10 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
| JP2015190968A Pending JP2016040285A (ja) | 2010-02-12 | 2015-09-29 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015190968A Pending JP2016040285A (ja) | 2010-02-12 | 2015-09-29 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8759548B2 (enExample) |
| EP (1) | EP2533638B1 (enExample) |
| JP (2) | JP5878484B2 (enExample) |
| KR (1) | KR20120138746A (enExample) |
| CN (1) | CN102869255B (enExample) |
| AU (1) | AU2011215833B2 (enExample) |
| BR (1) | BR112012019529A2 (enExample) |
| CA (1) | CA2787633A1 (enExample) |
| DK (1) | DK2533638T3 (enExample) |
| ES (1) | ES2565345T3 (enExample) |
| HR (1) | HRP20160450T1 (enExample) |
| HU (1) | HUE029012T2 (enExample) |
| IL (1) | IL220956A (enExample) |
| PL (1) | PL2533638T3 (enExample) |
| RS (1) | RS54618B1 (enExample) |
| RU (1) | RU2585763C2 (enExample) |
| SI (1) | SI2533638T1 (enExample) |
| SM (1) | SMT201600135B (enExample) |
| WO (1) | WO2011100433A1 (enExample) |
| ZA (1) | ZA201205374B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2533637B1 (en) | 2010-02-12 | 2014-03-26 | N30 Pharmaceuticals, Inc. | Chromone inhibitors of s-nitrosoglutathione reductase |
| HUE029012T2 (en) * | 2010-02-12 | 2017-02-28 | Nivalis Therapeutics Inc | Novel s-nitrosoglutathione reductase inhibitors |
| WO2012048181A1 (en) | 2010-10-08 | 2012-04-12 | N30 Pharmaceuticals, Llc | Novel substituted quinoline compounds as s-nitrosoglutathione reductase inhibitors |
| KR20130138292A (ko) | 2010-12-16 | 2013-12-18 | 엔30 파머수티컬즈 인코포레이티드 | S-나이트로소글루타티온 리덕타제로서의 신규한 치환된 이환식 방향족 화합물 |
| US20140094465A1 (en) * | 2011-06-10 | 2014-04-03 | N30 Pharmaceuticals, Inc. | Compounds as S-Nitrosoglutathione Reductase Inhibitors |
| MX2014005297A (es) | 2011-10-31 | 2014-09-11 | Xenon Pharmaceuticals Inc | Compuestos de bencenosulfonamida y su uso como agentes terapeuticos. |
| WO2013064984A1 (en) | 2011-10-31 | 2013-05-10 | Xenon Pharmaceuticals Inc. | Biaryl ether sulfonamides and their use as therapeutic agents |
| HK1209100A1 (en) * | 2012-05-22 | 2016-03-24 | 基因泰克有限公司 | N-substituted benzamides and their use in the treatment of pain |
| WO2014008458A2 (en) | 2012-07-06 | 2014-01-09 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
| MX2015011436A (es) | 2013-03-14 | 2016-06-06 | Genentech Inc | Triazolopiridinas sustituidas y metodos para usarlas. |
| US9493429B2 (en) | 2013-03-15 | 2016-11-15 | Genentech, Inc. | Substituted benzoxazoles and methods of use thereof |
| EP3450428A1 (en) | 2013-11-27 | 2019-03-06 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| WO2016007534A1 (en) | 2014-07-07 | 2016-01-14 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| HK1252567A1 (zh) | 2015-05-22 | 2019-05-31 | 基因泰克公司 | 被取代的苯甲酰胺和其使用方法 |
| EP3341353A1 (en) | 2015-08-27 | 2018-07-04 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| US10399946B2 (en) | 2015-09-10 | 2019-09-03 | Laurel Therapeutics Ltd. | Solid forms of an S-Nitrosoglutathione reductase inhibitor |
| AU2016330503B2 (en) | 2015-09-28 | 2021-04-08 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| WO2017091592A1 (en) | 2015-11-25 | 2017-06-01 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| CN109071426A (zh) | 2016-03-30 | 2018-12-21 | 基因泰克公司 | 取代的苯甲酰胺及其使用方法 |
| BR112019007763A2 (pt) | 2016-10-17 | 2019-07-02 | Genentech Inc | composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção |
| US10793550B2 (en) | 2017-03-24 | 2020-10-06 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| WO2018177993A1 (de) | 2017-03-31 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Pyrazole zur bekämpfung von arthropoden |
| JP2021514980A (ja) | 2018-02-26 | 2021-06-17 | ジェネンテック， インコーポレイテッド | 疼痛及び関連病態に対するピリジン−スルホンアミド化合物及びその使用 |
| CN111936494A (zh) | 2018-03-30 | 2020-11-13 | 豪夫迈·罗氏有限公司 | 作为钠通道抑制剂的取代的氢-吡啶并-吖嗪 |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| CN114667166A (zh) * | 2019-08-23 | 2022-06-24 | 诺塔实验室有限责任公司 | 一氧化氮生成系统 |
| CN117088862B (zh) * | 2023-08-22 | 2025-09-12 | 南华大学 | 一种硫代色元酮衍生物和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8626344D0 (en) | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| WO1997031007A1 (en) | 1996-02-21 | 1997-08-28 | Glycomed Incorporated | SIALYL LEWISx MIMETICS CONTAINING FLAVANOID BACKBONES |
| DE69732098T2 (de) * | 1996-03-05 | 2005-12-08 | Sterix Ltd. | Verbindungen mit sulfonsäure-amidgruppe |
| US6057367A (en) | 1996-08-30 | 2000-05-02 | Duke University | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses |
| US5919813C1 (en) | 1998-03-13 | 2002-01-29 | Univ Johns Hopkins Med | Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy |
| KR20000001793A (ko) * | 1998-06-13 | 2000-01-15 | 이경하 | 신규한 벤조피란 또는 티오벤조피란 유도체 |
| KR100295206B1 (ko) | 1998-08-22 | 2001-07-12 | 서경배 | 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| AU2001255696A1 (en) | 2000-04-27 | 2001-11-07 | Geron Corporation | Telomerase inhibitors and methods of their use |
| US6359182B1 (en) | 2000-10-26 | 2002-03-19 | Duke University | C-nitroso compounds and use thereof |
| US7049308B2 (en) | 2000-10-26 | 2006-05-23 | Duke University | C-nitroso compounds and use thereof |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| AUPR255401A0 (en) | 2001-01-16 | 2001-02-08 | Novogen Research Pty Ltd | Regulation of lipids and/or bone density and compositions therefor |
| US20030181510A1 (en) | 2002-03-19 | 2003-09-25 | Robert Baker | Inhibition of muscle regeneration following myectomy |
| MXPA05000122A (es) | 2002-06-27 | 2005-12-14 | Endowment For Res In Human Bio | Compuestos utiles para la inhibicion de aldehido-deshidrogenasa. |
| US20050080024A1 (en) | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
| AU2003282999A1 (en) | 2002-10-22 | 2004-05-13 | Jenken Biosciences, Inc. | Chromones and chromone derivatives and uses thereof |
| JP2007525952A (ja) | 2003-06-04 | 2007-09-13 | デューク・ユニバーシティ | Ｓ−ニトロソグルタチオンレダクターゼを調節するための組成物および方法 |
| CN1241921C (zh) | 2003-07-09 | 2006-02-15 | 东华大学 | 含氟异黄酮衍生物、制造方法及其用途 |
| ES2340690T3 (es) | 2004-04-08 | 2010-06-08 | Aryx Therapeutics | Materiales y metodos para tratar trastornos de coagulacion. |
| CN1950353B (zh) | 2004-04-08 | 2011-06-01 | ARYx医疗有限公司 | 治疗凝血紊乱的药物和方法 |
| PL1831191T3 (pl) * | 2004-12-21 | 2008-10-31 | Hoffmann La Roche | Pochodne chromanu i ich zastosowanie jako ligandów receptorów 5-HT |
| CA2600797A1 (en) | 2005-03-11 | 2006-09-21 | The Regents Of The University Of Michigan | Chromen-4-one inhibitors of anti-apoptotic bcl-2 family members and the uses thereof |
| CN101365446B (zh) * | 2005-07-29 | 2013-05-22 | 雷斯弗洛吉克斯公司 | 预防和治疗复杂疾病的药物组合物及其经由可植入医药装置的递送 |
| US20080032995A1 (en) * | 2006-07-27 | 2008-02-07 | Jeff Zablocki | Aldh-2 inhibitors in the treatment of drug addiction |
| GB0618168D0 (en) | 2006-09-15 | 2006-10-25 | Babraham Inst | Compounds |
| EP2084141A4 (en) | 2006-10-30 | 2010-07-21 | Novogen Res Pty Ltd | Prevention and reversal of chemotherapy-induced peripheral neuropathy |
| WO2009026657A1 (en) | 2007-08-29 | 2009-03-05 | The University Of Sydney | Flavonoid ppar agonists |
| JP2011507811A (ja) | 2007-12-13 | 2011-03-10 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | 哺乳動物のｓ−ニトロソグルタチオンレダクターゼを阻害するための材料および方法 |
| WO2010107476A1 (en) | 2009-03-19 | 2010-09-23 | Duke University | Inhibiting gsnor |
| HUE029012T2 (en) | 2010-02-12 | 2017-02-28 | Nivalis Therapeutics Inc | Novel s-nitrosoglutathione reductase inhibitors |
| EP2533637B1 (en) | 2010-02-12 | 2014-03-26 | N30 Pharmaceuticals, Inc. | Chromone inhibitors of s-nitrosoglutathione reductase |
| US20140094465A1 (en) * | 2011-06-10 | 2014-04-03 | N30 Pharmaceuticals, Inc. | Compounds as S-Nitrosoglutathione Reductase Inhibitors |
-
2011
- 2011-02-10 HU HUE11742796A patent/HUE029012T2/en unknown
- 2011-02-10 PL PL11742796T patent/PL2533638T3/pl unknown
- 2011-02-10 RU RU2012132692/04A patent/RU2585763C2/ru not_active IP Right Cessation
- 2011-02-10 RS RS20160165A patent/RS54618B1/sr unknown
- 2011-02-10 CA CA2787633A patent/CA2787633A1/en not_active Abandoned
- 2011-02-10 JP JP2012552997A patent/JP5878484B2/ja not_active Expired - Fee Related
- 2011-02-10 ES ES11742796.3T patent/ES2565345T3/es active Active
- 2011-02-10 BR BR112012019529A patent/BR112012019529A2/pt not_active IP Right Cessation
- 2011-02-10 US US13/521,833 patent/US8759548B2/en not_active Expired - Fee Related
- 2011-02-10 AU AU2011215833A patent/AU2011215833B2/en not_active Ceased
- 2011-02-10 HR HRP20160450TT patent/HRP20160450T1/hr unknown
- 2011-02-10 DK DK11742796.3T patent/DK2533638T3/en active
- 2011-02-10 CN CN201180008906.2A patent/CN102869255B/zh not_active Expired - Fee Related
- 2011-02-10 WO PCT/US2011/024353 patent/WO2011100433A1/en not_active Ceased
- 2011-02-10 KR KR1020127020738A patent/KR20120138746A/ko not_active Ceased
- 2011-02-10 SI SI201130784A patent/SI2533638T1/sl unknown
- 2011-02-10 EP EP11742796.3A patent/EP2533638B1/en active Active
-
2012
- 2012-07-15 IL IL220956A patent/IL220956A/en not_active IP Right Cessation
- 2012-07-18 ZA ZA2012/05374A patent/ZA201205374B/en unknown
-
2014
- 2014-05-30 US US14/291,709 patent/US9187447B2/en not_active Expired - Fee Related
-
2015
- 2015-09-29 JP JP2015190968A patent/JP2016040285A/ja active Pending
- 2015-10-27 US US14/924,650 patent/US9707212B2/en not_active Expired - Fee Related
-
2016
- 2016-05-10 SM SM201600135T patent/SMT201600135B/it unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013519680A5 (enExample) | ||
| RU2012132692A (ru) | Новые ингибиторы s-нитрозоглутатионредуктазы | |
| JP2010513397A5 (enExample) | ||
| JP2009519965A5 (enExample) | ||
| WO2012048181A4 (en) | Novel substituted quinoline compounds as s-nitrosoglutathione reductase inhibitors | |
| JP2010506825A5 (enExample) | ||
| JP2013542937A5 (enExample) | ||
| JP2009525984A5 (enExample) | ||
| RU2439068C2 (ru) | Модуляторы mglur5 | |
| JP2008513500A5 (enExample) | ||
| JP2014510132A5 (enExample) | ||
| JP2006517572A5 (enExample) | ||
| JP2010523692A5 (enExample) | ||
| JP2014530900A5 (enExample) | ||
| JP2006503081A5 (enExample) | ||
| JP2009523165A5 (enExample) | ||
| JP2010275317A5 (enExample) | ||
| JP2009544742A5 (enExample) | ||
| JP2013517281A5 (enExample) | ||
| JP2020516671A5 (enExample) | ||
| JP2006508065A5 (enExample) | ||
| JP2017506237A5 (enExample) | ||
| JP2004534824A5 (enExample) | ||
| JP2012255002A5 (enExample) | ||
| JP2008511586A5 (enExample) |