JP2013519680A5 - - Google Patents
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- Publication number
- JP2013519680A5 JP2013519680A5 JP2012552997A JP2012552997A JP2013519680A5 JP 2013519680 A5 JP2013519680 A5 JP 2013519680A5 JP 2012552997 A JP2012552997 A JP 2012552997A JP 2012552997 A JP2012552997 A JP 2012552997A JP 2013519680 A5 JP2013519680 A5 JP 2013519680A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- chromen
- trifluoromethyl
- group
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 N, N-dimethylamino Chemical group 0.000 claims 30
- 150000003839 salts Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000003536 tetrazoles Chemical class 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- IKNZBNHVVQIRTO-UHFFFAOYSA-N 2h-tetrazole-5-carboxylic acid Chemical compound OC(=O)C=1N=NNN=1 IKNZBNHVVQIRTO-UHFFFAOYSA-N 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 2
- 201000003883 Cystic fibrosis Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- ZVTQYRVARPYRRE-UHFFFAOYSA-N oxadiazol-4-one Chemical compound O=C1CON=N1 ZVTQYRVARPYRRE-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- AQYIDERAMPMQQN-UHFFFAOYSA-N 2-(difluoromethyl)-7-hydroxy-3-[4-(2h-tetrazol-5-yl)phenyl]chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)F)=C2C(C=C1)=CC=C1C1=NN=NN1 AQYIDERAMPMQQN-UHFFFAOYSA-N 0.000 claims 1
- DSPLFQVWRBCFBY-UHFFFAOYSA-N 3-[2-chloro-4-(2h-tetrazol-5-yl)phenyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C(=C1)Cl)=CC=C1C1=NN=NN1 DSPLFQVWRBCFBY-UHFFFAOYSA-N 0.000 claims 1
- SROZAXRHCDMWDN-UHFFFAOYSA-N 3-[3-chloro-4-(2h-tetrazol-5-yl)phenyl]-7-hydroxy-2-(trifluoromethyl)chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1Cl)=CC=C1C1=NN=NN1 SROZAXRHCDMWDN-UHFFFAOYSA-N 0.000 claims 1
- JTJFNTFGSXGQCE-UHFFFAOYSA-N 3-[3-chloro-4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C(=C1)Cl)=CC=C1C1=NOC(=O)N1 JTJFNTFGSXGQCE-UHFFFAOYSA-N 0.000 claims 1
- SEOPFLCETNIRME-UHFFFAOYSA-N 3-[3-fluoro-4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C(=C1)F)=CC=C1C1=NOC(=O)N1 SEOPFLCETNIRME-UHFFFAOYSA-N 0.000 claims 1
- RRVFSAKXCOIFRP-UHFFFAOYSA-N 3-[4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1)=CC=C1C1=NOC(=O)N1 RRVFSAKXCOIFRP-UHFFFAOYSA-N 0.000 claims 1
- HNHMUAMHKJROPF-UHFFFAOYSA-N 3-[4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]phenyl]-2h-1,2,4-thiadiazol-5-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1)=CC=C1C1=NSC(=O)N1 HNHMUAMHKJROPF-UHFFFAOYSA-N 0.000 claims 1
- FUHSYKWZNQTLKC-UHFFFAOYSA-N 3-fluoro-4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]benzoic acid Chemical compound FC1=CC(C(=O)O)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O FUHSYKWZNQTLKC-UHFFFAOYSA-N 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- DYTYZNFCPKSNSW-UHFFFAOYSA-N 4-(7-hydroxy-2-methyl-4-oxothiochromen-3-yl)benzoic acid Chemical compound CC=1SC2=CC(O)=CC=C2C(=O)C=1C1=CC=C(C(O)=O)C=C1 DYTYZNFCPKSNSW-UHFFFAOYSA-N 0.000 claims 1
- BOJHURJUTNFAKS-UHFFFAOYSA-N 4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]-3-methylbenzoic acid Chemical compound CC1=CC(C(O)=O)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O BOJHURJUTNFAKS-UHFFFAOYSA-N 0.000 claims 1
- QUFCZPQVMSDJLQ-UHFFFAOYSA-N 4-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]-n-methylsulfonylbenzamide Chemical compound C1=CC(C(=O)NS(=O)(=O)C)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O QUFCZPQVMSDJLQ-UHFFFAOYSA-N 0.000 claims 1
- LXKDWHZAQSLWQP-UHFFFAOYSA-N 4-[8-fluoro-7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1C1=C(C(F)(F)F)OC2=C(F)C(O)=CC=C2C1=O LXKDWHZAQSLWQP-UHFFFAOYSA-N 0.000 claims 1
- HPCCACKAELJHMO-UHFFFAOYSA-N 4-[[3-(4-carboxyphenyl)-7-hydroxy-4-oxothiochromen-2-yl]methyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CC1=C(C=2C=CC(=CC=2)C(O)=O)C(=O)C2=CC=C(O)C=C2S1 HPCCACKAELJHMO-UHFFFAOYSA-N 0.000 claims 1
- QHJHGEIEGPHPHU-UHFFFAOYSA-N 5-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O QHJHGEIEGPHPHU-UHFFFAOYSA-N 0.000 claims 1
- NTGQSLDMFCZSEC-UHFFFAOYSA-N 5-[7-hydroxy-4-oxo-2-(trifluoromethyl)chromen-3-yl]thiophene-3-carboxylic acid Chemical compound OC(=O)C1=CSC(C=2C(C3=CC=C(O)C=C3OC=2C(F)(F)F)=O)=C1 NTGQSLDMFCZSEC-UHFFFAOYSA-N 0.000 claims 1
- IYLSFMCJATULBG-UHFFFAOYSA-N 7-hydroxy-2-methyl-3-[4-(2h-tetrazol-5-yl)phenyl]chromen-4-one Chemical compound CC=1OC2=CC(O)=CC=C2C(=O)C=1C(C=C1)=CC=C1C1=NN=NN1 IYLSFMCJATULBG-UHFFFAOYSA-N 0.000 claims 1
- ZXBGKUANALHIOU-UHFFFAOYSA-N 7-hydroxy-2-methyl-3-[4-(2h-tetrazol-5-yl)phenyl]thiochromen-4-one Chemical compound CC=1SC2=CC(O)=CC=C2C(=O)C=1C(C=C1)=CC=C1C1=NN=NN1 ZXBGKUANALHIOU-UHFFFAOYSA-N 0.000 claims 1
- FGJSNLPJDMQOJH-UHFFFAOYSA-N 7-hydroxy-3-[4-(2h-tetrazol-5-yl)phenyl]-2-(trifluoromethyl)chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC(C(F)(F)F)=C2C(C=C1)=CC=C1C1=NN=NN1 FGJSNLPJDMQOJH-UHFFFAOYSA-N 0.000 claims 1
- JSURXDDJUXDRSW-UHFFFAOYSA-N 7-hydroxy-3-[4-(2h-tetrazol-5-yl)phenyl]chromen-4-one Chemical compound C=1C(O)=CC=C(C2=O)C=1OC=C2C(C=C1)=CC=C1C1=NN=NN1 JSURXDDJUXDRSW-UHFFFAOYSA-N 0.000 claims 1
- VNVIRBPUPMNXGH-KYZUINATSA-N C1([C@H]2CC[C@@H](CC2)C2=C(OC=3C(C2=O)=CC=C(C=3)O)C(F)(F)F)=NN=NN1 Chemical compound C1([C@H]2CC[C@@H](CC2)C2=C(OC=3C(C2=O)=CC=C(C=3)O)C(F)(F)F)=NN=NN1 VNVIRBPUPMNXGH-KYZUINATSA-N 0.000 claims 1
- VPJXLPFRLZWPRZ-KYZUINATSA-N C1C[C@@H](C(=O)O)CC[C@@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O Chemical compound C1C[C@@H](C(=O)O)CC[C@@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O VPJXLPFRLZWPRZ-KYZUINATSA-N 0.000 claims 1
- VPJXLPFRLZWPRZ-DTORHVGOSA-N C1C[C@@H](C(=O)O)CC[C@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O Chemical compound C1C[C@@H](C(=O)O)CC[C@H]1C1=C(C(F)(F)F)OC2=CC(O)=CC=C2C1=O VPJXLPFRLZWPRZ-DTORHVGOSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- QSSJZLPUHJDYKF-UHFFFAOYSA-N Cc(cc1)ccc1C(OC)=O Chemical compound Cc(cc1)ccc1C(OC)=O QSSJZLPUHJDYKF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30395210P | 2010-02-12 | 2010-02-12 | |
| US61/303,952 | 2010-02-12 | ||
| PCT/US2011/024353 WO2011100433A1 (en) | 2010-02-12 | 2011-02-10 | Novel s-nitrosoglutathione reductase inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015190968A Division JP2016040285A (ja) | 2010-02-12 | 2015-09-29 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519680A JP2013519680A (ja) | 2013-05-30 |
| JP2013519680A5 true JP2013519680A5 (enExample) | 2014-03-20 |
| JP5878484B2 JP5878484B2 (ja) | 2016-03-08 |
Family
ID=44368117
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012552997A Expired - Fee Related JP5878484B2 (ja) | 2010-02-12 | 2011-02-10 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
| JP2015190968A Pending JP2016040285A (ja) | 2010-02-12 | 2015-09-29 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015190968A Pending JP2016040285A (ja) | 2010-02-12 | 2015-09-29 | 新規のｓ−ニトロソグルタチオンレダクターゼ阻害剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US8759548B2 (enExample) |
| EP (1) | EP2533638B1 (enExample) |
| JP (2) | JP5878484B2 (enExample) |
| KR (1) | KR20120138746A (enExample) |
| CN (1) | CN102869255B (enExample) |
| AU (1) | AU2011215833B2 (enExample) |
| BR (1) | BR112012019529A2 (enExample) |
| CA (1) | CA2787633A1 (enExample) |
| DK (1) | DK2533638T3 (enExample) |
| ES (1) | ES2565345T3 (enExample) |
| HR (1) | HRP20160450T1 (enExample) |
| HU (1) | HUE029012T2 (enExample) |
| IL (1) | IL220956A (enExample) |
| PL (1) | PL2533638T3 (enExample) |
| RS (1) | RS54618B1 (enExample) |
| RU (1) | RU2585763C2 (enExample) |
| SI (1) | SI2533638T1 (enExample) |
| SM (1) | SMT201600135B (enExample) |
| WO (1) | WO2011100433A1 (enExample) |
| ZA (1) | ZA201205374B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2533638T1 (sl) | 2010-02-12 | 2016-05-31 | Nivalis Therapeutics, Inc. | Novi inhibitorji S-nitrozoglutation reduktaze |
| WO2011099978A1 (en) | 2010-02-12 | 2011-08-18 | N30 Pharmaceuticals, Llc | Chromone inhibitors of s-nitrosoglutathione reductase |
| ES2553771T3 (es) | 2010-10-08 | 2015-12-11 | Nivalis Therapeutics, Inc. | Nuevos compuestos de quinolina sustituidos como inhibidores de la S-nitrosoglutatión reductasa |
| JP5990187B2 (ja) | 2010-12-16 | 2016-09-07 | ニヴァリス・セラピューティクス・インコーポレーテッド | Ｓ−ニトロソグルタチオン還元酵素阻害薬としての新規な置換二環芳香族化合物 |
| US20140094465A1 (en) * | 2011-06-10 | 2014-04-03 | N30 Pharmaceuticals, Inc. | Compounds as S-Nitrosoglutathione Reductase Inhibitors |
| MX2014005304A (es) | 2011-10-31 | 2015-03-20 | Xenon Pharmaceuticals Inc | Biaril eter sulfonamidas y su uso como agentes terapeuticos. |
| ES2586213T3 (es) | 2011-10-31 | 2016-10-13 | Xenon Pharmaceuticals Inc. | Compuestos de bencenosulfonamida y su uso como agentes terapéuticos |
| CA2874621A1 (en) | 2012-05-22 | 2013-11-28 | Genentech, Inc. | N-substituted benzamides and their use in the treatment of pain |
| US10071957B2 (en) | 2012-07-06 | 2018-09-11 | Genentech, Inc. | N-substituted benzamides and methods of use thereof |
| CN105263490B (zh) | 2013-03-14 | 2018-05-22 | 基因泰克公司 | 取代的三唑并吡啶及其使用方法 |
| CA2898680A1 (en) | 2013-03-15 | 2014-09-18 | Genentech,Inc. | Substituted benzoxazoles and methods of use thereof |
| JP6383418B2 (ja) | 2013-11-27 | 2018-08-29 | ジェネンテック， インコーポレイテッド | 置換ベンズアミド及びその使用方法 |
| CN106715418A (zh) | 2014-07-07 | 2017-05-24 | 基因泰克公司 | 治疗化合物及其使用方法 |
| MA42118A (fr) | 2015-05-22 | 2018-03-28 | Genentech Inc | Benzamides substitués et leurs méthodes d'utilisation |
| WO2017035271A1 (en) | 2015-08-27 | 2017-03-02 | Genentech, Inc. | Therapeutic compounds and methods of use thereof |
| US10399946B2 (en) | 2015-09-10 | 2019-09-03 | Laurel Therapeutics Ltd. | Solid forms of an S-Nitrosoglutathione reductase inhibitor |
| JP6987746B2 (ja) | 2015-09-28 | 2022-01-05 | ジェネンテック， インコーポレイテッド | 治療用化合物及びその使用方法 |
| US10899732B2 (en) | 2015-11-25 | 2021-01-26 | Genentech, Inc. | Substituted benzamides useful as sodium channel blockers |
| US10766858B2 (en) | 2016-03-30 | 2020-09-08 | Genentech, Inc. | Substituted benzamides and methods of use thereof |
| BR112019007763A2 (pt) | 2016-10-17 | 2019-07-02 | Genentech Inc | composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção |
| EP3601273B1 (en) | 2017-03-24 | 2021-12-01 | Genentech, Inc. | 4-piperidin-n-(pyrimidin-4-yl)chroman-7-sulfonamide derivatives as sodium channel inhibitors |
| WO2018177993A1 (de) | 2017-03-31 | 2018-10-04 | Bayer Cropscience Aktiengesellschaft | Pyrazole zur bekämpfung von arthropoden |
| AR114263A1 (es) | 2018-02-26 | 2020-08-12 | Genentech Inc | Compuestos terapéuticos y métodos para utilizarlos |
| WO2019191702A1 (en) | 2018-03-30 | 2019-10-03 | F. Hoffmann-La Roche Ag | Substituted hydro-pyrido-azines as sodium channel inhibitors |
| TW202003490A (zh) | 2018-05-22 | 2020-01-16 | 瑞士商赫孚孟拉羅股份公司 | 治療性化合物及其使用方法 |
| US20210052842A1 (en) * | 2019-08-23 | 2021-02-25 | NOTA Laboratories, LLC | Nitric oxide generating systems for nasal inhalation |
| CN117169201B (zh) * | 2023-08-21 | 2026-07-14 | 杭州师范大学 | 一种基于碱性磷酸酶诱导的双路径复合显色传感器及其应用 |
| CN117088862B (zh) * | 2023-08-22 | 2025-09-12 | 南华大学 | 一种硫代色元酮衍生物和应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8626344D0 (en) | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| US6083978A (en) * | 1996-03-05 | 2000-07-04 | Sterix Limited | Compounds with a sulfamate group |
| WO1997031007A1 (en) | 1996-02-21 | 1997-08-28 | Glycomed Incorporated | SIALYL LEWISx MIMETICS CONTAINING FLAVANOID BACKBONES |
| US6057367A (en) | 1996-08-30 | 2000-05-02 | Duke University | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses |
| US5919813C1 (en) | 1998-03-13 | 2002-01-29 | Univ Johns Hopkins Med | Use of a protein tyrosine kinase pathway inhibitor in the treatment of diabetic retinopathy |
| KR20000001793A (ko) * | 1998-06-13 | 2000-01-15 | 이경하 | 신규한 벤조피란 또는 티오벤조피란 유도체 |
| KR100295206B1 (ko) | 1998-08-22 | 2001-07-12 | 서경배 | 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 |
| US7144880B2 (en) | 1999-04-30 | 2006-12-05 | Regents Of The University Of Michigan | Compositions relating to novel compounds and targets thereof |
| AU2001255696A1 (en) | 2000-04-27 | 2001-11-07 | Geron Corporation | Telomerase inhibitors and methods of their use |
| US6359182B1 (en) | 2000-10-26 | 2002-03-19 | Duke University | C-nitroso compounds and use thereof |
| US7049308B2 (en) | 2000-10-26 | 2006-05-23 | Duke University | C-nitroso compounds and use thereof |
| US7179791B2 (en) | 2001-01-11 | 2007-02-20 | Duke University | Inhibiting GS-FDH to modulate NO bioactivity |
| AUPR255401A0 (en) | 2001-01-16 | 2001-02-08 | Novogen Research Pty Ltd | Regulation of lipids and/or bone density and compositions therefor |
| US20030181510A1 (en) | 2002-03-19 | 2003-09-25 | Robert Baker | Inhibition of muscle regeneration following myectomy |
| MXPA05000122A (es) | 2002-06-27 | 2005-12-14 | Endowment For Res In Human Bio | Compuestos utiles para la inhibicion de aldehido-deshidrogenasa. |
| US20050080024A1 (en) | 2002-08-15 | 2005-04-14 | Joseph Tucker | Nitric oxide donating derivatives for the treatment of cardiovascular disorders |
| US8138165B2 (en) | 2002-10-22 | 2012-03-20 | Jenken Biosciences, Inc. | Chromones and chromone derivatives and uses thereof |
| AU2004251690A1 (en) | 2003-06-04 | 2005-01-06 | Duke University | Compositions and methods for modulating S-nitrosoglutathione reductase |
| CN1241921C (zh) | 2003-07-09 | 2006-02-15 | 东华大学 | 含氟异黄酮衍生物、制造方法及其用途 |
| RU2335501C2 (ru) | 2004-04-08 | 2008-10-10 | Арикс Терапьютикс | Средства и способы для лечения нарушений свертываемости |
| JP5036532B2 (ja) | 2004-04-08 | 2012-09-26 | アルメテオン、インコーポレイテッド | 血液凝固疾患治療のための物質およびその方法 |
| KR20070088798A (ko) * | 2004-12-21 | 2007-08-29 | 에프. 호프만-라 로슈 아게 | 크로만 유도체 및 그의 5-ｈｔ 수용체 리간드로서의 용도 |
| CN101171241A (zh) * | 2005-03-11 | 2008-04-30 | 密执安州立大学董事会 | 抗细胞凋亡的bcl-2家族成员的色烯-4-酮抑制剂及其应用 |
| WO2007016525A2 (en) | 2005-07-29 | 2007-02-08 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| RU2008151762A (ru) * | 2006-07-27 | 2010-06-27 | Си Ви Терапьютикс, Инк. (Us) | Adlh-2 ингибиторы для лечения аддикции |
| GB0618168D0 (en) | 2006-09-15 | 2006-10-25 | Babraham Inst | Compounds |
| CA2668008A1 (en) | 2006-10-30 | 2008-05-08 | Novogen Research Pty Ltd | Prevention and reversal of chemotherapy-induced peripheral neuropathy |
| WO2009026657A1 (en) * | 2007-08-29 | 2009-03-05 | The University Of Sydney | Flavonoid ppar agonists |
| EP2581451B1 (en) * | 2007-12-13 | 2016-03-09 | Indiana University Research and Technology Corporation | Compounds for inhibiting mammalian s-nitrosoglutathione reductase |
| WO2010107476A1 (en) | 2009-03-19 | 2010-09-23 | Duke University | Inhibiting gsnor |
| SI2533638T1 (sl) | 2010-02-12 | 2016-05-31 | Nivalis Therapeutics, Inc. | Novi inhibitorji S-nitrozoglutation reduktaze |
| WO2011099978A1 (en) | 2010-02-12 | 2011-08-18 | N30 Pharmaceuticals, Llc | Chromone inhibitors of s-nitrosoglutathione reductase |
| US20140094465A1 (en) * | 2011-06-10 | 2014-04-03 | N30 Pharmaceuticals, Inc. | Compounds as S-Nitrosoglutathione Reductase Inhibitors |
-
2011
- 2011-02-10 SI SI201130784A patent/SI2533638T1/sl unknown
- 2011-02-10 HU HUE11742796A patent/HUE029012T2/en unknown
- 2011-02-10 KR KR1020127020738A patent/KR20120138746A/ko not_active Ceased
- 2011-02-10 RS RS20160165A patent/RS54618B1/sr unknown
- 2011-02-10 BR BR112012019529-8A patent/BR112012019529A2/pt not_active IP Right Cessation
- 2011-02-10 HR HRP20160450TT patent/HRP20160450T1/hr unknown
- 2011-02-10 CA CA2787633A patent/CA2787633A1/en not_active Abandoned
- 2011-02-10 WO PCT/US2011/024353 patent/WO2011100433A1/en not_active Ceased
- 2011-02-10 PL PL11742796T patent/PL2533638T3/pl unknown
- 2011-02-10 US US13/521,833 patent/US8759548B2/en not_active Expired - Fee Related
- 2011-02-10 DK DK11742796.3T patent/DK2533638T3/en active
- 2011-02-10 RU RU2012132692/04A patent/RU2585763C2/ru not_active IP Right Cessation
- 2011-02-10 ES ES11742796.3T patent/ES2565345T3/es active Active
- 2011-02-10 EP EP11742796.3A patent/EP2533638B1/en active Active
- 2011-02-10 JP JP2012552997A patent/JP5878484B2/ja not_active Expired - Fee Related
- 2011-02-10 AU AU2011215833A patent/AU2011215833B2/en not_active Ceased
- 2011-02-10 CN CN201180008906.2A patent/CN102869255B/zh not_active Expired - Fee Related
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2012
- 2012-07-15 IL IL220956A patent/IL220956A/en not_active IP Right Cessation
- 2012-07-18 ZA ZA2012/05374A patent/ZA201205374B/en unknown
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2014
- 2014-05-30 US US14/291,709 patent/US9187447B2/en not_active Expired - Fee Related
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2015
- 2015-09-29 JP JP2015190968A patent/JP2016040285A/ja active Pending
- 2015-10-27 US US14/924,650 patent/US9707212B2/en not_active Expired - Fee Related
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2016
- 2016-05-10 SM SM201600135T patent/SMT201600135B/it unknown
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