JP2012255002A5 - - Google Patents
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- Publication number
- JP2012255002A5 JP2012255002A5 JP2012171081A JP2012171081A JP2012255002A5 JP 2012255002 A5 JP2012255002 A5 JP 2012255002A5 JP 2012171081 A JP2012171081 A JP 2012171081A JP 2012171081 A JP2012171081 A JP 2012171081A JP 2012255002 A5 JP2012255002 A5 JP 2012255002A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- methyl
- use according
- ethyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000001363 autoimmune Effects 0.000 claims description 6
- 208000027866 inflammatory disease Diseases 0.000 claims description 5
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 24
- 201000010099 disease Diseases 0.000 claims 22
- 239000003814 drug Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000006002 1,1-difluoroethyl group Chemical group 0.000 claims 10
- 230000001404 mediated effect Effects 0.000 claims 6
- GEAPKHXZFUKEDK-UHFFFAOYSA-N 2-methyl-5-phenyl-1,3-oxazole-4-carboxylic acid Chemical compound O1C(C)=NC(C(O)=O)=C1C1=CC=CC=C1 GEAPKHXZFUKEDK-UHFFFAOYSA-N 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims 4
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 206010069351 acute lung injury Diseases 0.000 claims 4
- 208000006673 asthma Diseases 0.000 claims 4
- OMCWOZYMSYZUTD-UHFFFAOYSA-N 2-methyl-5-(3-methylphenyl)-1,3-oxazole-4-carboxylic acid Chemical compound O1C(C)=NC(C(O)=O)=C1C1=CC=CC(C)=C1 OMCWOZYMSYZUTD-UHFFFAOYSA-N 0.000 claims 2
- NDFZHVTZGZRQMP-UHFFFAOYSA-N 2-methyl-5-[3-(trifluoromethyl)phenyl]-1,3-oxazole-4-carboxylic acid Chemical compound O1C(C)=NC(C(O)=O)=C1C1=CC=CC(C(F)(F)F)=C1 NDFZHVTZGZRQMP-UHFFFAOYSA-N 0.000 claims 2
- MOFHRDAQQJGDIT-UHFFFAOYSA-N 5-(3-chlorophenyl)-2-methyl-1,3-oxazole-4-carboxylic acid Chemical compound O1C(C)=NC(C(O)=O)=C1C1=CC=CC(Cl)=C1 MOFHRDAQQJGDIT-UHFFFAOYSA-N 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 206010020751 Hypersensitivity Diseases 0.000 claims 2
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 102000029797 Prion Human genes 0.000 claims 2
- 108091000054 Prion Proteins 0.000 claims 2
- 206010038997 Retroviral infections Diseases 0.000 claims 2
- 208000026935 allergic disease Diseases 0.000 claims 2
- 230000007815 allergy Effects 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000003959 neuroinflammation Effects 0.000 claims 2
- 201000001119 neuropathy Diseases 0.000 claims 2
- 230000007823 neuropathy Effects 0.000 claims 2
- 230000000414 obstructive effect Effects 0.000 claims 2
- 230000036407 pain Effects 0.000 claims 2
- 208000033808 peripheral neuropathy Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000023504 respiratory system disease Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 208000001204 Hashimoto Disease Diseases 0.000 description 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2009052445 | 2009-06-09 | ||
| IBPCT/IB2009/052445 | 2009-06-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514570A Division JP5095035B2 (ja) | 2009-06-09 | 2010-06-07 | フッ素化アミノトリアゾール誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012255002A JP2012255002A (ja) | 2012-12-27 |
| JP2012255002A5 true JP2012255002A5 (enExample) | 2013-07-18 |
| JP5775496B2 JP5775496B2 (ja) | 2015-09-09 |
Family
ID=42371383
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514570A Expired - Fee Related JP5095035B2 (ja) | 2009-06-09 | 2010-06-07 | フッ素化アミノトリアゾール誘導体 |
| JP2012171081A Expired - Fee Related JP5775496B2 (ja) | 2009-06-09 | 2012-08-01 | フッ素化アミノトリアゾール誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514570A Expired - Fee Related JP5095035B2 (ja) | 2009-06-09 | 2010-06-07 | フッ素化アミノトリアゾール誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8580831B2 (enExample) |
| EP (1) | EP2440555B1 (enExample) |
| JP (2) | JP5095035B2 (enExample) |
| KR (1) | KR101444559B1 (enExample) |
| CN (1) | CN102414207B (enExample) |
| AR (1) | AR077032A1 (enExample) |
| AU (1) | AU2010258334B2 (enExample) |
| BR (1) | BRPI1010738A8 (enExample) |
| CA (1) | CA2760588C (enExample) |
| CL (1) | CL2011003097A1 (enExample) |
| ES (1) | ES2587139T3 (enExample) |
| IL (1) | IL216792A (enExample) |
| MA (1) | MA33420B1 (enExample) |
| MX (1) | MX342440B (enExample) |
| MY (1) | MY161243A (enExample) |
| NZ (1) | NZ597453A (enExample) |
| PL (1) | PL2440555T3 (enExample) |
| RU (1) | RU2544862C2 (enExample) |
| SG (1) | SG175363A1 (enExample) |
| TW (1) | TWI404717B (enExample) |
| WO (1) | WO2010143116A1 (enExample) |
| ZA (1) | ZA201200127B (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| MX2010006241A (es) | 2007-12-18 | 2010-06-30 | Actelion Pharmaceuticals Ltd | Derivados de aminotriazol como agonistas de alx. |
| NZ597122A (en) | 2009-05-18 | 2013-06-28 | Actelion Pharmaceuticals Ltd | Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists |
| KR20120046159A (ko) | 2009-06-12 | 2012-05-09 | 액테리온 파마슈티칼 리미티드 | Ａｌｘ 수용체 아고니스트로서의 옥사졸 및 티아졸 유도체 |
| WO2012066488A2 (en) | 2010-11-17 | 2012-05-24 | Actelion Pharmaceuticals Ltd | Bridged spiro[2.4]heptane ester derivatives |
| HRP20150049T1 (hr) * | 2010-12-07 | 2015-02-27 | Actelion Pharmaceuticals Ltd. | Derivati oksazolil-metiletera kao agonisti alx-receptora |
| US9346793B2 (en) | 2010-12-07 | 2016-05-24 | Actelion Pharmaceuticals, Ltd. | Hydroxylated aminotriazole derivatives as ALX receptor agonists |
| WO2013171687A1 (en) | 2012-05-16 | 2013-11-21 | Actelion Pharmaceuticals Ltd | 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| PT2855453T (pt) | 2012-06-04 | 2017-03-09 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazol-prolina |
| WO2014057435A1 (en) | 2012-10-10 | 2014-04-17 | Actelion Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives |
| EP2970241A1 (en) | 2013-03-12 | 2016-01-20 | Actelion Pharmaceuticals Ltd. | Azetidine amide derivatives as orexin receptor antagonists |
| WO2014174704A1 (ja) * | 2013-04-22 | 2014-10-30 | 国立大学法人東京大学 | 炎症性疾患の予防又は治療剤 |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| TW201536289A (zh) | 2013-07-18 | 2015-10-01 | Actelion Pharmaceuticals Ltd | 作為ａｌｘ受體激動劑之經哌取代橋聯螺［２，４］庚烷衍生物 |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| UA116053C2 (uk) | 2013-12-04 | 2018-01-25 | Ідорсія Фармасьютікалз Лтд | Застосування похідних бензоімідазолу-проліну |
| BR112023024873A2 (pt) | 2021-06-01 | 2024-02-15 | Azcuris Co Ltd | Composto derivado de oxazol, composição farmacêutica compreendendo o mesmo, uso do composto derivado de oxazol e composição de alimento para melhorar os sintomas de doenças alérgicas |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62234018A (ja) | 1986-04-02 | 1987-10-14 | Rooto Seiyaku Kk | 糖尿病併発症治療剤 |
| FR2763337B1 (fr) * | 1997-05-13 | 1999-08-20 | Sanofi Sa | Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant |
| KR20030030029A (ko) | 2000-09-22 | 2003-04-16 | 니혼노야쿠가부시키가이샤 | Ｎ-(4-피라졸릴)아미드 유도체 및 농원예용 약제 그리고그 사용방법 |
| AU2003214249A1 (en) | 2002-04-03 | 2003-10-13 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| TWI335913B (en) * | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| KR20060130064A (ko) | 2003-11-07 | 2006-12-18 | 아카디아 파마슈티칼스 인코포레이티드 | 통증 및 염증 치료에 효과적인 화합물을 동정하기 위한도구로서의 리폭신 수용체, ｆｐｒｌ1의 용도 |
| US7323480B2 (en) * | 2004-05-25 | 2008-01-29 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| PT1791830E (pt) * | 2004-09-17 | 2011-04-04 | Vertex Pharma | Compostos de diaminotriazole úteis como inibidores de proteína-quinase |
| US20060293288A1 (en) | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| WO2007055941A2 (en) | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Histone deacetylase inhibitors with aryl-pyrazolyl motifs |
| RU2522456C2 (ru) | 2007-08-21 | 2014-07-10 | Синомикс, Инк. | Соединения, ингибирующие (блокирующие) горький вкус, способы их применения и получения |
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| MX2010006241A (es) | 2007-12-18 | 2010-06-30 | Actelion Pharmaceuticals Ltd | Derivados de aminotriazol como agonistas de alx. |
| NZ597122A (en) | 2009-05-18 | 2013-06-28 | Actelion Pharmaceuticals Ltd | Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists |
| KR20120046159A (ko) | 2009-06-12 | 2012-05-09 | 액테리온 파마슈티칼 리미티드 | Ａｌｘ 수용체 아고니스트로서의 옥사졸 및 티아졸 유도체 |
-
2010
- 2010-06-07 WO PCT/IB2010/052509 patent/WO2010143116A1/en not_active Ceased
- 2010-06-07 ES ES10725500.2T patent/ES2587139T3/es active Active
- 2010-06-07 NZ NZ597453A patent/NZ597453A/xx not_active IP Right Cessation
- 2010-06-07 US US13/376,966 patent/US8580831B2/en not_active Expired - Fee Related
- 2010-06-07 PL PL10725500.2T patent/PL2440555T3/pl unknown
- 2010-06-07 KR KR1020127000486A patent/KR101444559B1/ko not_active Expired - Fee Related
- 2010-06-07 MX MX2011012739A patent/MX342440B/es active IP Right Grant
- 2010-06-07 BR BRPI1010738A patent/BRPI1010738A8/pt not_active Application Discontinuation
- 2010-06-07 AU AU2010258334A patent/AU2010258334B2/en not_active Ceased
- 2010-06-07 CN CN201080018293.6A patent/CN102414207B/zh not_active Expired - Fee Related
- 2010-06-07 JP JP2012514570A patent/JP5095035B2/ja not_active Expired - Fee Related
- 2010-06-07 CA CA2760588A patent/CA2760588C/en not_active Expired - Fee Related
- 2010-06-07 SG SG2011078706A patent/SG175363A1/en unknown
- 2010-06-07 MY MYPI2011005927A patent/MY161243A/en unknown
- 2010-06-07 EP EP10725500.2A patent/EP2440555B1/en not_active Not-in-force
- 2010-06-07 MA MA34521A patent/MA33420B1/fr unknown
- 2010-06-07 RU RU2011153772/04A patent/RU2544862C2/ru not_active IP Right Cessation
- 2010-06-08 TW TW099118594A patent/TWI404717B/zh not_active IP Right Cessation
- 2010-06-09 AR ARP100102022A patent/AR077032A1/es unknown
-
2011
- 2011-12-06 IL IL216792A patent/IL216792A/en not_active IP Right Cessation
- 2011-12-07 CL CL2011003097A patent/CL2011003097A1/es unknown
-
2012
- 2012-01-06 ZA ZA2012/00127A patent/ZA201200127B/en unknown
- 2012-08-01 JP JP2012171081A patent/JP5775496B2/ja not_active Expired - Fee Related