CN102414207B - 氟化氨基三唑衍生物 - Google Patents

氟化氨基三唑衍生物 Download PDF

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Publication number
CN102414207B
CN102414207B CN201080018293.6A CN201080018293A CN102414207B CN 102414207 B CN102414207 B CN 102414207B CN 201080018293 A CN201080018293 A CN 201080018293A CN 102414207 B CN102414207 B CN 102414207B
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methyl
ethyl
oxazole
difluoro
carboxylic acid
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Expired - Fee Related
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CN102414207A (zh
Inventor
丹尼尔·布尔
奥利维尔·考米波夫
塞尔文·库恩
科琳娜·格里索斯托米
泽维尔·莱罗尔
西尔维娅·里卡德-比尔德斯滕
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Aidu West Pharmaceutical Co Ltd
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Actelion Pharmaceuticals Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Cardiology (AREA)
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  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
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  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
CN201080018293.6A 2009-06-09 2010-06-07 氟化氨基三唑衍生物 Expired - Fee Related CN102414207B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2009052445 2009-06-09
IBPCT/IB2009/052445 2009-06-09
PCT/IB2010/052509 WO2010143116A1 (en) 2009-06-09 2010-06-07 Fluorinated aminotriazole derivatives

Publications (2)

Publication Number Publication Date
CN102414207A CN102414207A (zh) 2012-04-11
CN102414207B true CN102414207B (zh) 2015-09-30

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US (1) US8580831B2 (enExample)
EP (1) EP2440555B1 (enExample)
JP (2) JP5095035B2 (enExample)
KR (1) KR101444559B1 (enExample)
CN (1) CN102414207B (enExample)
AR (1) AR077032A1 (enExample)
AU (1) AU2010258334B2 (enExample)
BR (1) BRPI1010738A8 (enExample)
CA (1) CA2760588C (enExample)
CL (1) CL2011003097A1 (enExample)
ES (1) ES2587139T3 (enExample)
IL (1) IL216792A (enExample)
MA (1) MA33420B1 (enExample)
MX (1) MX342440B (enExample)
MY (1) MY161243A (enExample)
NZ (1) NZ597453A (enExample)
PL (1) PL2440555T3 (enExample)
RU (1) RU2544862C2 (enExample)
SG (1) SG175363A1 (enExample)
TW (1) TWI404717B (enExample)
WO (1) WO2010143116A1 (enExample)
ZA (1) ZA201200127B (enExample)

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NZ597122A (en) 2009-05-18 2013-06-28 Actelion Pharmaceuticals Ltd Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists
KR20120046159A (ko) 2009-06-12 2012-05-09 액테리온 파마슈티칼 리미티드 Ａｌｘ 수용체 아고니스트로서의 옥사졸 및 티아졸 유도체
WO2012066488A2 (en) 2010-11-17 2012-05-24 Actelion Pharmaceuticals Ltd Bridged spiro[2.4]heptane ester derivatives
HRP20150049T1 (hr) * 2010-12-07 2015-02-27 Actelion Pharmaceuticals Ltd. Derivati oksazolil-metiletera kao agonisti alx-receptora
US9346793B2 (en) 2010-12-07 2016-05-24 Actelion Pharmaceuticals, Ltd. Hydroxylated aminotriazole derivatives as ALX receptor agonists
WO2013171687A1 (en) 2012-05-16 2013-11-21 Actelion Pharmaceuticals Ltd 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
PT2855453T (pt) 2012-06-04 2017-03-09 Actelion Pharmaceuticals Ltd Derivados de benzimidazol-prolina
WO2014057435A1 (en) 2012-10-10 2014-04-17 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives
EP2970241A1 (en) 2013-03-12 2016-01-20 Actelion Pharmaceuticals Ltd. Azetidine amide derivatives as orexin receptor antagonists
WO2014174704A1 (ja) * 2013-04-22 2014-10-30 国立大学法人東京大学 炎症性疾患の予防又は治療剤
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
TW201536289A (zh) 2013-07-18 2015-10-01 Actelion Pharmaceuticals Ltd 作為ａｌｘ受體激動劑之經哌取代橋聯螺［２，４］庚烷衍生物
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
UA116053C2 (uk) 2013-12-04 2018-01-25 Ідорсія Фармасьютікалз Лтд Застосування похідних бензоімідазолу-проліну
BR112023024873A2 (pt) 2021-06-01 2024-02-15 Azcuris Co Ltd Composto derivado de oxazol, composição farmacêutica compreendendo o mesmo, uso do composto derivado de oxazol e composição de alimento para melhorar os sintomas de doenças alérgicas

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US20120101138A1 (en) 2012-04-26
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US8580831B2 (en) 2013-11-12
JP5775496B2 (ja) 2015-09-09
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CA2760588C (en) 2017-08-08
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IL216792A (en) 2014-05-28
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EP2440555A1 (en) 2012-04-18
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MX342440B (es) 2016-09-29
AR077032A1 (es) 2011-07-27
MA33420B1 (fr) 2012-07-03
CL2011003097A1 (es) 2012-07-06
BRPI1010738A2 (pt) 2016-03-15
AU2010258334A1 (en) 2012-02-02
PL2440555T3 (pl) 2016-11-30
KR101444559B1 (ko) 2014-09-26
ES2587139T3 (es) 2016-10-20
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SG175363A1 (en) 2011-12-29
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KR20120089380A (ko) 2012-08-09
ZA201200127B (en) 2014-06-25
EP2440555B1 (en) 2016-05-18
CN102414207A (zh) 2012-04-11
TW201102383A (en) 2011-01-16
JP2012255002A (ja) 2012-12-27
BRPI1010738A8 (pt) 2017-12-26
TWI404717B (zh) 2013-08-11
RU2544862C2 (ru) 2015-03-20

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