JP2018509438A5 - - Google Patents
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- JP2018509438A5 JP2018509438A5 JP2017549483A JP2017549483A JP2018509438A5 JP 2018509438 A5 JP2018509438 A5 JP 2018509438A5 JP 2017549483 A JP2017549483 A JP 2017549483A JP 2017549483 A JP2017549483 A JP 2017549483A JP 2018509438 A5 JP2018509438 A5 JP 2018509438A5
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- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- replaced
- pharmaceutical composition
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 63
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 13
- 239000003862 glucocorticoid Substances 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 9
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052731 fluorine Inorganic materials 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 208000023504 respiratory system disease Diseases 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 claims 2
- 102000008122 Casein Kinase I Human genes 0.000 claims 2
- 108010049812 Casein Kinase I Proteins 0.000 claims 2
- 241000709661 Enterovirus Species 0.000 claims 2
- 241000725643 Respiratory syncytial virus Species 0.000 claims 2
- 239000013566 allergen Substances 0.000 claims 2
- 229960004436 budesonide Drugs 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 206010062106 Respiratory tract infection viral Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 229920002494 Zein Polymers 0.000 claims 1
- 108010055615 Zein Proteins 0.000 claims 1
- 125000005275 alkylenearyl group Chemical group 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 239000000428 dust Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- -1 hydrate Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 229960001664 mometasone Drugs 0.000 claims 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 125000003367 polycyclic group Chemical group 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 208000020017 viral respiratory tract infection Diseases 0.000 claims 1
- 239000005019 zein Substances 0.000 claims 1
- 229940093612 zein Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015901032 | 2015-03-23 | ||
| AU2015901032A AU2015901032A0 (en) | 2015-03-23 | Treatment of respiratory diseases | |
| PCT/AU2016/050209 WO2016149756A1 (en) | 2015-03-23 | 2016-03-23 | Treatment of respiratory diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021007384A Division JP7169693B2 (ja) | 2015-03-23 | 2021-01-20 | 呼吸器疾患の治療 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509438A JP2018509438A (ja) | 2018-04-05 |
| JP2018509438A5 true JP2018509438A5 (enExample) | 2019-05-09 |
| JP6827948B2 JP6827948B2 (ja) | 2021-02-10 |
Family
ID=56976881
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549483A Active JP6827948B2 (ja) | 2015-03-23 | 2016-03-23 | 呼吸器疾患の治療 |
| JP2021007384A Active JP7169693B2 (ja) | 2015-03-23 | 2021-01-20 | 呼吸器疾患の治療 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021007384A Active JP7169693B2 (ja) | 2015-03-23 | 2021-01-20 | 呼吸器疾患の治療 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US10722513B2 (enExample) |
| EP (2) | EP4591936A3 (enExample) |
| JP (2) | JP6827948B2 (enExample) |
| CN (3) | CN113350353A (enExample) |
| ES (1) | ES3055494T3 (enExample) |
| FI (1) | FI3273955T3 (enExample) |
| PT (1) | PT3273955T (enExample) |
| WO (1) | WO2016149756A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4591936A3 (en) | 2015-03-23 | 2025-10-15 | Tianli Biotech Pty Ltd | Treatment of respiratory diseases |
| JP2016193861A (ja) * | 2015-03-31 | 2016-11-17 | 国立大学法人山梨大学 | マスト細胞活性化を抑制するための医薬組成物 |
| NZ755447A (en) * | 2017-02-01 | 2023-05-26 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer |
| AU2018262108A1 (en) * | 2017-05-03 | 2019-11-21 | The University Of Melbourne | Compounds for the treatment of respiratory diseases |
| WO2019090405A1 (pt) * | 2017-11-11 | 2019-05-16 | Carvalho Junior Mario Virgilio De | Medicamento de ciclesonida para cura e prevenção da gripe causada pelo vírus influenza |
| WO2020093098A1 (en) | 2018-11-07 | 2020-05-14 | The University Of Melbourne | Novel compounds for the treatment of respiratory diseases |
| KR102253324B1 (ko) * | 2019-11-27 | 2021-05-18 | 단디바이오사이언스 주식회사 | 호흡기 질환의 예방, 개선 또는 치료용 조성물 |
| CN115243724B (zh) | 2020-02-19 | 2025-10-21 | 纳米医疗有限公司 | 可用于治疗癌症的经调配和/或共调配的含有TFGβ拮抗剂前药的脂质体组合物和其方法 |
| AR122711A1 (es) * | 2020-06-25 | 2022-09-28 | Alchemedicine Inc | COMPUESTO HETEROCÍCLICO COMO INHIBIDOR DE CASEÍNA QUINASA 1d Y/O QUINASA 5 TIPO RECEPTOR DE ACTIVINA |
| TW202246233A (zh) | 2021-02-19 | 2022-12-01 | 英商蘇多生物科學有限公司 | Tyk2抑制劑及其用途 |
| TW202246232A (zh) | 2021-02-19 | 2022-12-01 | 英商蘇多生物科學有限公司 | Ｔｙｋ２抑制劑及其用途 |
| WO2022235621A1 (en) * | 2021-05-03 | 2022-11-10 | Thirona Bio, Inc. | Methods for treating a pulmonary disease with an alk-5 (tgf beta r1) inhibitor |
| CN115792229B (zh) * | 2022-01-28 | 2024-06-18 | 华中科技大学同济医学院附属同济医院 | 鼻分泌物中tPA在制备鼻息肉及其预后检测剂中的应用 |
| WO2024091485A1 (en) * | 2022-10-25 | 2024-05-02 | The Regents Of The University Of California | Compositions and methods for treating or preventing pulmonary fibrosis |
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| US5593992A (en) | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| US5593991A (en) | 1993-07-16 | 1997-01-14 | Adams; Jerry L. | Imidazole compounds, use and process of making |
| IL110296A (en) | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
| US5837699A (en) * | 1994-01-27 | 1998-11-17 | Schering Corporation | Use of mometasone furoate for treating upper airway passage diseases |
| KR19980701374A (ko) * | 1995-01-12 | 1998-05-15 | 스티븐 베네티아너 | 신규 화합물(Novel Compounds) |
| US6369068B1 (en) | 1995-06-07 | 2002-04-09 | Smithkline Beecham Corporation | Amino substituted pyrimidine containing compounds |
| US5658903A (en) | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
| JP2000507558A (ja) | 1996-03-25 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | Ｃｎｓ損傷についての新規な治療 |
| TW517055B (en) | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
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| US6598603B1 (en) | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
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| CN1968716A (zh) * | 2003-01-09 | 2007-05-23 | 阿里泽克药品公司 | 治疗肺疾病的方法 |
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| JP4819699B2 (ja) | 2004-02-06 | 2011-11-24 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト | 喘息及びｃｏｐｄの長期間の治療のための抗コリン作用薬及びグルココルチコイドの組合せ剤 |
| WO2005103240A1 (en) * | 2004-04-24 | 2005-11-03 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with casein kinase 1, delta, isoform 1 (csnk1d iso 1) |
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| EP2589385A1 (en) * | 2011-11-03 | 2013-05-08 | Fundación Centro Nacional de Investigaciones Oncológicas | Triple combination for the treatment of cancer |
| US9988606B2 (en) * | 2012-07-24 | 2018-06-05 | The Trustees Of Columbia University In The City Of New York | Generation of airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres |
| CZ2012538A3 (cs) | 2012-08-08 | 2014-02-19 | Masarykova Univerzita | Inhibitory pro léčbu B-buněčné chronické lymfocytární leukémie |
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| JP6267231B2 (ja) | 2012-12-21 | 2018-01-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | カゼインキナーゼ１δ／ε阻害剤としての新規な置換イミダゾール |
| CN104837844B (zh) * | 2012-12-21 | 2017-08-29 | 百时美施贵宝公司 | 作为酪蛋白激酶1 d/e抑制剂的吡唑取代的咪唑并哌嗪 |
| WO2015114638A2 (en) | 2014-02-03 | 2015-08-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method of eliminating stem cells |
| EP4591936A3 (en) | 2015-03-23 | 2025-10-15 | Tianli Biotech Pty Ltd | Treatment of respiratory diseases |
| JP2016193861A (ja) | 2015-03-31 | 2016-11-17 | 国立大学法人山梨大学 | マスト細胞活性化を抑制するための医薬組成物 |
| WO2017083971A1 (en) | 2015-11-16 | 2017-05-26 | University Of Manitoba | Compositions and methods for treatment of influenza |
| JP7069147B2 (ja) | 2016-10-28 | 2022-05-17 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 小細胞肺癌患者を特定及び治療するための方法ならびに組成物 |
| AU2018262108A1 (en) | 2017-05-03 | 2019-11-21 | The University Of Melbourne | Compounds for the treatment of respiratory diseases |
| US10973820B2 (en) | 2017-12-13 | 2021-04-13 | Facio Intellectual Property B.V. | Compounds for treatment of diseases related to DUX4 expression |
| CN113301900B (zh) | 2018-09-09 | 2024-11-29 | 夸纳特制药股份公司 | 酪蛋白激酶1抑制剂在治疗血管疾病中的应用 |
-
2016
- 2016-03-23 EP EP25174466.0A patent/EP4591936A3/en active Pending
- 2016-03-23 PT PT167675339T patent/PT3273955T/pt unknown
- 2016-03-23 JP JP2017549483A patent/JP6827948B2/ja active Active
- 2016-03-23 CN CN202110650935.4A patent/CN113350353A/zh active Pending
- 2016-03-23 FI FIEP16767533.9T patent/FI3273955T3/fi active
- 2016-03-23 CN CN201680026219.6A patent/CN107847480B/zh active Active
- 2016-03-23 EP EP16767533.9A patent/EP3273955B1/en active Active
- 2016-03-23 US US15/559,360 patent/US10722513B2/en active Active
- 2016-03-23 WO PCT/AU2016/050209 patent/WO2016149756A1/en not_active Ceased
- 2016-03-23 ES ES16767533T patent/ES3055494T3/es active Active
- 2016-03-23 CN CN202110636730.0A patent/CN113350352B/zh active Active
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2020
- 2020-06-30 US US16/917,581 patent/US11564925B2/en active Active
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2021
- 2021-01-20 JP JP2021007384A patent/JP7169693B2/ja active Active
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2022
- 2022-12-22 US US18/087,672 patent/US11975005B2/en active Active
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2024
- 2024-04-04 US US18/627,415 patent/US20240245690A1/en active Pending