JP2020535165A5 - - Google Patents
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- JP2020535165A5 JP2020535165A5 JP2020517472A JP2020517472A JP2020535165A5 JP 2020535165 A5 JP2020535165 A5 JP 2020535165A5 JP 2020517472 A JP2020517472 A JP 2020517472A JP 2020517472 A JP2020517472 A JP 2020517472A JP 2020535165 A5 JP2020535165 A5 JP 2020535165A5
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- Prior art keywords
- optionally substituted
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- hydrogen
- alkyl
- substituted alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 26
- 239000001257 hydrogen Substances 0.000 claims 26
- 125000000547 substituted alkyl group Chemical group 0.000 claims 22
- 150000002431 hydrogen Chemical class 0.000 claims 20
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000013078 crystal Substances 0.000 claims 11
- 229940002612 prodrug Drugs 0.000 claims 11
- 239000000651 prodrug Substances 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000012453 solvate Substances 0.000 claims 11
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 7
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 4
- 208000012902 Nervous system disease Diseases 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 102000014461 Ataxins Human genes 0.000 claims 3
- 108010078286 Ataxins Proteins 0.000 claims 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 3
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- -1 alkyl hydrogen Chemical compound 0.000 claims 3
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 3
- 150000001721 carbon Chemical group 0.000 claims 3
- 229910052805 deuterium Inorganic materials 0.000 claims 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000001914 Fragile X syndrome Diseases 0.000 claims 2
- 208000023105 Huntington disease Diseases 0.000 claims 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 229960000304 folic acid Drugs 0.000 claims 2
- 235000019152 folic acid Nutrition 0.000 claims 2
- 239000011724 folic acid Substances 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 102100032187 Androgen receptor Human genes 0.000 claims 1
- 102000007370 Ataxin2 Human genes 0.000 claims 1
- 108010032951 Ataxin2 Proteins 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 201000008163 Dentatorubral pallidoluysian atrophy Diseases 0.000 claims 1
- 101000775732 Homo sapiens Androgen receptor Proteins 0.000 claims 1
- 208000002569 Machado-Joseph Disease Diseases 0.000 claims 1
- 208000033063 Progressive myoclonic epilepsy Diseases 0.000 claims 1
- 208000035955 Proximal myotonic myopathy Diseases 0.000 claims 1
- 201000003622 Spinocerebellar ataxia type 2 Diseases 0.000 claims 1
- 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 claims 1
- 201000003487 Spinocerebellar ataxia type 31 Diseases 0.000 claims 1
- 201000003620 Spinocerebellar ataxia type 6 Diseases 0.000 claims 1
- 201000003629 Spinocerebellar ataxia type 8 Diseases 0.000 claims 1
- 208000037140 Steinert myotonic dystrophy Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 241000282485 Vulpes vulpes Species 0.000 claims 1
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 1
- 238000009825 accumulation Methods 0.000 claims 1
- 125000004452 carbocyclyl group Chemical group 0.000 claims 1
- 201000004180 corneal endothelial dystrophy Diseases 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000009340 myotonic dystrophy type 1 Diseases 0.000 claims 1
- 201000008709 myotonic dystrophy type 2 Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000003624 spinocerebellar ataxia type 1 Diseases 0.000 claims 1
- 201000003598 spinocerebellar ataxia type 10 Diseases 0.000 claims 1
- 201000003594 spinocerebellar ataxia type 12 Diseases 0.000 claims 1
- 201000003570 spinocerebellar ataxia type 17 Diseases 0.000 claims 1
- 201000003632 spinocerebellar ataxia type 7 Diseases 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762563588P | 2017-09-26 | 2017-09-26 | |
| US62/563,588 | 2017-09-26 | ||
| PCT/US2018/052913 WO2019067587A1 (en) | 2017-09-26 | 2018-09-26 | USE OF METFORMIN AND ANALOGUES THEREOF TO REDUCE RAN PROTEIN RATES DURING TREATMENT OF NEUROLOGICAL DISORDERS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020535165A JP2020535165A (ja) | 2020-12-03 |
| JP2020535165A5 true JP2020535165A5 (enExample) | 2021-11-04 |
| JP7350337B2 JP7350337B2 (ja) | 2023-09-26 |
Family
ID=65903814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020517472A Active JP7350337B2 (ja) | 2017-09-26 | 2018-09-26 | 神経障害の処置においてｒａｎタンパク質レベルを低下させるためのメトホルミンおよびそのアナログの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11903910B2 (enExample) |
| EP (1) | EP3688021A4 (enExample) |
| JP (1) | JP7350337B2 (enExample) |
| AU (1) | AU2018342105B2 (enExample) |
| CA (1) | CA3076214A1 (enExample) |
| WO (1) | WO2019067587A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014159247A1 (en) | 2013-03-14 | 2014-10-02 | University Of Florida Research Foundation, Inc. | Di-amino acid repeat-containing proteins associated with als |
| WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
| EP3440100A4 (en) | 2016-04-04 | 2020-01-22 | University of Florida Research Foundation, Incorporated | HANDLING EIF3 TO MODULATE A NON-ATG TRANSLATION ASSOCIATED WITH A REPETITION (RAN) |
| JP7526455B2 (ja) | 2017-04-17 | 2024-08-01 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ＰＫＲおよびｅＩＦ２Ａ－Ｐ経路によるＲＡＮタンパク質翻訳の調節 |
| AU2018342105B2 (en) | 2017-09-26 | 2023-11-16 | University Of Florida Research Foundation, Incorporated | Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders |
| JP7579589B2 (ja) * | 2019-07-05 | 2024-11-08 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | Ｒａｎタンパク質関連神経学的疾患を処置するための方法 |
| EP4031562A4 (en) | 2019-09-20 | 2023-11-01 | University of Florida Research Foundation, Incorporated | DETECTION OF ANTIBODIES AGAINST RAN PROTEINS FROM SERUM AND TISSUE LYSATES |
| CN115335058B (zh) * | 2020-03-27 | 2024-12-06 | 国立大学法人京都大学 | 神经细胞变性抑制剂 |
| US20250041247A1 (en) | 2021-12-01 | 2025-02-06 | University Of Florida Research Foundation, Incorporated | Small molecule inhibitors of repeat associated non-aug (ran) translation and combination therapies |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5011912A (en) | 1986-12-19 | 1991-04-30 | Immunex Corporation | Hybridoma and monoclonal antibody for use in an immunoaffinity purification system |
| DE69629460T2 (de) | 1995-04-11 | 2004-06-24 | Merck & Co., Inc. | Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden |
| CA2295474A1 (en) | 1997-07-08 | 1999-01-21 | Human Genome Sciences, Inc. | 123 human secreted proteins |
| ATE342920T1 (de) | 1997-08-29 | 2006-11-15 | Innogenetics Nv | Methylierte smd homologe peptide, die mit antikörpern aus sera von lebewesen mit systemischer lupus erythematodes reagieren |
| US6413783B1 (en) | 1997-09-18 | 2002-07-02 | Meso Scale Technologies, Llc | Assay sonication apparatus and methodology |
| US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| EP1278854A2 (en) | 2000-04-21 | 2003-01-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of acne vulgaris |
| WO2002062945A2 (en) | 2000-10-25 | 2002-08-15 | Diadexus, Inc. | Compositions and methods relating to lung specific genes and proteins |
| US6855517B2 (en) | 2000-11-20 | 2005-02-15 | Diadexus, Inc. | Compositions and methods relating to breast specific genes and proteins |
| US7528227B2 (en) | 2004-03-23 | 2009-05-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Histone H2A peptide derivatives and uses thereof |
| US7163943B2 (en) * | 2001-09-21 | 2007-01-16 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| DK3211085T3 (da) | 2003-09-30 | 2021-06-21 | Univ Pennsylvania | Klader af adeno-associeret virus (aav), sekvenser, vektorer indeholdende disse og anvendelser deraf |
| WO2005089164A2 (en) | 2003-12-31 | 2005-09-29 | Pharmexa Inc. | Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions |
| US7481997B1 (en) | 2004-02-12 | 2009-01-27 | Montana State University | Snow mountain virus genome sequence, virus-like particles and methods of use |
| JP4878551B2 (ja) | 2004-04-08 | 2012-02-15 | 貞和 相磯 | 運動ニューロン疾患治療薬 |
| US20060068434A1 (en) | 2004-09-21 | 2006-03-30 | Jay Stoerker | Methods and compositions for detecting cancer using components of the U2 spliceosomal particle |
| CA2596588C (en) | 2005-01-31 | 2017-06-27 | University Of Iowa Research Foundation | Nucleic acid silencing of huntington's disease gene |
| US20090074721A1 (en) | 2005-06-06 | 2009-03-19 | Vgx Pharmaceuticals, Inc. | Methods for treating viral infection with oral or injectibel drug solution |
| JP2009515885A (ja) | 2005-11-11 | 2009-04-16 | オーロゲン インコーポレイテッド | 組織の収縮又は萎縮に関連する成人中枢神経系の疾病又は障害をインスリン投与によって治療する方法 |
| EP2082225B1 (en) | 2006-09-20 | 2014-01-01 | The Queen's University of Belfast | Method to determine whether a tumour cell has invasive and/or metastatic potential and modulating agents of malignant transformation |
| US20080188457A1 (en) | 2007-02-02 | 2008-08-07 | Braincells, Inc. | Modulation of Neurogenesis with Biguanides and GSK3-beta Agents |
| US20090143418A1 (en) | 2007-11-30 | 2009-06-04 | The Regents Of The University Of Michigan | Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions |
| GB0809821D0 (en) | 2008-05-30 | 2008-07-09 | Univ Aberdeen | Treatment and diagnosis of behavioural disorders |
| TW201034684A (en) | 2009-02-18 | 2010-10-01 | Genentech Inc | Method for inhibiting neurodegeneration |
| US20130115603A9 (en) | 2009-04-02 | 2013-05-09 | Regents Of The University Of Minnesota | Nucleotide repeat expansion-associated polypeptides and uses thereof |
| CN102497887A (zh) | 2009-04-17 | 2012-06-13 | Isis创新公司 | 递送遗传物质的组合物 |
| WO2010132982A1 (en) | 2009-05-18 | 2010-11-25 | Ottawa Hospital Research Institute | Treatment of muscle disease characterized by insulin resistance |
| WO2011028912A2 (en) | 2009-09-03 | 2011-03-10 | University Of Tennessee Research Foundation | A biomarker for neurodegeneration in neurological disease |
| US20130085169A1 (en) | 2010-04-02 | 2013-04-04 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1) |
| EP2751284B1 (en) | 2011-08-31 | 2017-01-11 | The University Of Manchester | Method for diagnosing a neurodegenerative disease. |
| AU2013225950B2 (en) | 2012-02-29 | 2018-02-15 | Sangamo Therapeutics, Inc. | Methods and compositions for treating huntington's disease |
| KR101417272B1 (ko) | 2012-05-15 | 2014-07-14 | 경상대학교산학협력단 | 메트포민 및/또는 타이모퀴논을 포함하는 임신중 알코올 노출에 의한 신경질환 치료 또는 예방용 약학적 조성물 |
| US20140100282A1 (en) | 2012-10-10 | 2014-04-10 | Patrick S L Wong | Intranasal administration of pharmaceutical agents for treatment of neurological diseases |
| RS59283B1 (sr) | 2013-01-22 | 2019-10-31 | Deutsches Zentrum Fuer Neurodegenerative Erkrankungen E V | Proteini sa dipeptidnim ponovkom kao terapeutsko ciljno mesto kod neurodegenerativnih bolesti sa ekspanzijom heksanukleotidnog ponovka |
| WO2014114303A1 (en) | 2013-01-22 | 2014-07-31 | Deutsches Zentrum Für Neurodegenerative Erkrankungen | Dipeptide-repeat proteins as therapeutic target in neurodegenerative diseases with hexanucleotide repeat expansion |
| US9448232B2 (en) | 2013-01-24 | 2016-09-20 | Mayo Foundation For Medical Education And Research | Methods and materials for detecting C9ORF72 hexanucleotide repeat expansion positive frontotemporal lobar degeneration or C9ORF72 hexanucleotide repeat expansion positive amyotrophic lateral sclerosis |
| WO2014159247A1 (en) | 2013-03-14 | 2014-10-02 | University Of Florida Research Foundation, Inc. | Di-amino acid repeat-containing proteins associated with als |
| EP2968347B1 (en) | 2013-03-15 | 2023-08-02 | The Regents of the University of California | Modulators of the eif2alpha pathway |
| US10006049B2 (en) | 2013-05-16 | 2018-06-26 | University Of Florida Research Foundation, Incorporated | Hairpin mRNA elements and methods for the regulation of protein translation |
| EP2837390A1 (en) | 2013-08-15 | 2015-02-18 | Universitäts-Kinderspital beider Basel | Combined Pharmaceutical Preparation for Use in Treating Neuromuscular Disorders |
| CA2990161A1 (en) | 2014-08-13 | 2016-02-18 | The Scripps Research Institute | Treatment of c9ftd/als by targeting rna expanded repeat sequences |
| WO2016191241A1 (en) | 2015-05-27 | 2016-12-01 | Mmc & Company Llc | Dual target mitochondrial impinging pharmaceutical compositions affecting mitochondrial redox state and methods of treatment |
| WO2016196324A1 (en) | 2015-05-29 | 2016-12-08 | University Of Floridia Research Foundation, Inc. | Methods for diagnosing huntington's disease |
| EP3440100A4 (en) | 2016-04-04 | 2020-01-22 | University of Florida Research Foundation, Incorporated | HANDLING EIF3 TO MODULATE A NON-ATG TRANSLATION ASSOCIATED WITH A REPETITION (RAN) |
| EP3484452A4 (en) * | 2016-08-18 | 2020-04-01 | Ovid Therapeutics, Inc. | METHODS OF TREATING DEVELOPMENTAL DISORDERS WITH BIGUANIDES |
| JP7526455B2 (ja) * | 2017-04-17 | 2024-08-01 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | ＰＫＲおよびｅＩＦ２Ａ－Ｐ経路によるＲＡＮタンパク質翻訳の調節 |
| CA3075908A1 (en) | 2017-09-25 | 2019-03-28 | University Of Florida Research Foundation, Incorporated | Immunoassays for detection of ran proteins |
| AU2018342105B2 (en) | 2017-09-26 | 2023-11-16 | University Of Florida Research Foundation, Incorporated | Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders |
| JP7579589B2 (ja) | 2019-07-05 | 2024-11-08 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | Ｒａｎタンパク質関連神経学的疾患を処置するための方法 |
| EP4031562A4 (en) | 2019-09-20 | 2023-11-01 | University of Florida Research Foundation, Incorporated | DETECTION OF ANTIBODIES AGAINST RAN PROTEINS FROM SERUM AND TISSUE LYSATES |
-
2018
- 2018-09-26 AU AU2018342105A patent/AU2018342105B2/en active Active
- 2018-09-26 JP JP2020517472A patent/JP7350337B2/ja active Active
- 2018-09-26 EP EP18860923.4A patent/EP3688021A4/en active Pending
- 2018-09-26 US US16/650,721 patent/US11903910B2/en active Active
- 2018-09-26 CA CA3076214A patent/CA3076214A1/en active Pending
- 2018-09-26 WO PCT/US2018/052913 patent/WO2019067587A1/en not_active Ceased
-
2024
- 2024-01-03 US US18/403,100 patent/US20240269093A1/en active Pending