JP2018150331A5 - - Google Patents

Download PDF

Info

Publication number
JP2018150331A5
JP2018150331A5 JP2018088646A JP2018088646A JP2018150331A5 JP 2018150331 A5 JP2018150331 A5 JP 2018150331A5 JP 2018088646 A JP2018088646 A JP 2018088646A JP 2018088646 A JP2018088646 A JP 2018088646A JP 2018150331 A5 JP2018150331 A5 JP 2018150331A5
Authority
JP
Japan
Prior art keywords
disease
compound according
pharmaceutically acceptable
acceptable salt
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2018088646A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018150331A (ja
JP6654659B2 (ja
Filing date
Publication date
Priority claimed from US13/843,261 external-priority patent/US8957066B2/en
Application filed filed Critical
Publication of JP2018150331A publication Critical patent/JP2018150331A/ja
Publication of JP2018150331A5 publication Critical patent/JP2018150331A5/ja
Application granted granted Critical
Publication of JP6654659B2 publication Critical patent/JP6654659B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2018088646A 2013-03-15 2018-05-02 ヒストン脱アセチル化酵素阻害剤 Expired - Fee Related JP6654659B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/843,261 US8957066B2 (en) 2011-02-28 2013-03-15 Histone deacetylase inhibitors
US13/843,261 2013-03-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016502408A Division JP6336562B2 (ja) 2013-03-15 2014-03-14 ヒストン脱アセチル化酵素阻害剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019188049A Division JP2020019814A (ja) 2013-03-15 2019-10-11 ヒストン脱アセチル化酵素阻害剤

Publications (3)

Publication Number Publication Date
JP2018150331A JP2018150331A (ja) 2018-09-27
JP2018150331A5 true JP2018150331A5 (enExample) 2018-12-13
JP6654659B2 JP6654659B2 (ja) 2020-02-26

Family

ID=49622075

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2016502408A Expired - Fee Related JP6336562B2 (ja) 2013-03-15 2014-03-14 ヒストン脱アセチル化酵素阻害剤
JP2018088646A Expired - Fee Related JP6654659B2 (ja) 2013-03-15 2018-05-02 ヒストン脱アセチル化酵素阻害剤
JP2019188049A Pending JP2020019814A (ja) 2013-03-15 2019-10-11 ヒストン脱アセチル化酵素阻害剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2016502408A Expired - Fee Related JP6336562B2 (ja) 2013-03-15 2014-03-14 ヒストン脱アセチル化酵素阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019188049A Pending JP2020019814A (ja) 2013-03-15 2019-10-11 ヒストン脱アセチル化酵素阻害剤

Country Status (15)

Country Link
US (6) US8957066B2 (enExample)
EP (2) EP2968251B1 (enExample)
JP (3) JP6336562B2 (enExample)
KR (1) KR20150132342A (enExample)
CN (2) CN105120860B (enExample)
AU (1) AU2014239677B2 (enExample)
BR (1) BR112015023434A8 (enExample)
CA (2) CA3105007A1 (enExample)
DK (1) DK2968251T3 (enExample)
ES (1) ES2780693T3 (enExample)
IL (3) IL240938B (enExample)
MX (2) MX375260B (enExample)
PT (1) PT2968251T (enExample)
RU (1) RU2673819C2 (enExample)
WO (1) WO2014152444A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
US8957066B2 (en) * 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
US10059723B2 (en) 2011-02-28 2018-08-28 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
JP6250403B2 (ja) * 2011-02-28 2017-12-20 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤
JP6240063B2 (ja) 2011-04-28 2017-11-29 ザ ブロード インスティテュート, インコーポレイテッド ヒストンデアセチラーゼ阻害剤
WO2014018979A1 (en) 2012-07-27 2014-01-30 The Broad Institute, Inc. Inhibitors of histone deacetylase
US9914717B2 (en) 2012-12-20 2018-03-13 The Broad Institute, Inc. Cycloalkenyl hydroxamic acid derivatives and their use as histone deacetylase inhibitors
JP6503338B2 (ja) 2013-03-15 2019-04-17 バイオマリン ファーマシューティカル インコーポレイテッド Hdac阻害剤
WO2015069693A1 (en) * 2013-11-05 2015-05-14 Dana-Farber Cancer Institute, Inc. Inhibitors of histone deacetylase
KR20180022840A (ko) * 2015-07-02 2018-03-06 바이오마린 파머수티컬 인크. 히스톤 데아세틸라제 저해제
US20180305318A1 (en) 2015-10-30 2018-10-25 Bioventures, Llc Inhibitors of oxidized low-density lipoprotein receptor 1 and methods of use thereof
TW201829381A (zh) * 2016-12-22 2018-08-16 美商拜奧馬林製藥公司 組蛋白脫乙醯基酶抑制劑
ES2914355T3 (es) * 2017-08-07 2022-06-09 Alkermes Inc Inhibidores bicíclicos de la histona desacetilasa
WO2019032652A1 (en) * 2017-08-09 2019-02-14 Children's Hospital Medical Center METHODS OF TREATING DISEASES AND NERVE INJURIES
CN112135610A (zh) * 2018-01-12 2020-12-25 KDAc治疗股份有限公司 用于治疗癌症的选择性组蛋白去乙酰酶3(hdac3)抑制剂及免疫治疗剂的组合
AU2019316858B2 (en) * 2018-08-06 2024-03-28 Moexa Pharmaceuticals Limited Smad3 inhibitors
GB201901559D0 (en) * 2019-02-05 2019-03-27 Syngenta Crop Protection Ag Herbicidal compositions
TWI882012B (zh) * 2019-09-27 2025-05-01 日商武田藥品工業股份有限公司 雜環化合物

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4174958A (en) * 1978-01-09 1979-11-20 Shell Oil Company Anilide derivative herbicides
US4855442A (en) 1988-04-13 1989-08-08 Monsanto Company Substituted 3-hydroxy pyrazoles
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US6794392B1 (en) 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
JPH11269140A (ja) 1998-03-23 1999-10-05 Mitsui Chem Inc 分化誘導剤
JPH11269146A (ja) 1998-03-24 1999-10-05 Mitsui Chem Inc 分化誘導剤
JP4405602B2 (ja) 1998-04-16 2010-01-27 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト ヒストン脱アセチル化酵素阻害剤
US6331545B1 (en) 1998-12-18 2001-12-18 Soo S. Ko Heterocycyclic piperidines as modulators of chemokine receptor activity
JP2000256194A (ja) 1999-01-06 2000-09-19 Mitsui Chemicals Inc 核内レセプタ作動薬およびその効果増強剤
AU3676000A (en) 1999-04-09 2000-11-14 Mochida Pharmaceutical Co., Ltd. 4-hydroxypiperidine derivatives having antiarrhythmic effect
JP2001072592A (ja) * 1999-07-01 2001-03-21 Kyowa Hakko Kogyo Co Ltd テロメラーゼ阻害剤
KR101026205B1 (ko) 1999-11-23 2011-03-31 메틸진 인코포레이티드 히스톤 디아세틸라제의 억제제
AU2001280187A1 (en) 2000-08-28 2002-03-13 Toray Industries, Inc. Cyclic amine derivatives
GB0021419D0 (en) * 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
US20040077690A1 (en) * 2000-09-29 2004-04-22 Bing-Yan Zhu Quaternary amidino based inhibitors of factor xa
EP1390491B1 (en) 2001-05-02 2008-07-16 The Regents of the University of California Method for treating neurodegenerative, psychiatric and other disorders with deacetylase inhibitors
US20040142859A1 (en) 2002-05-02 2004-07-22 Steffan Joan S. Method for treating neurodegenerative, psychiatric, and other disorders with deacetylase inhibitors
US6784173B2 (en) 2001-06-15 2004-08-31 Hoffmann-La Roche Inc. Aromatic dicarboxylic acid derivatives
AR034897A1 (es) 2001-08-07 2004-03-24 Hoffmann La Roche Derivados n-monoacilados de o-fenilendiaminas, sus analogos heterociclicos de seis miembros y su uso como agentes farmaceuticos
US6806272B2 (en) 2001-09-04 2004-10-19 Boehringer Ingelheim Pharma Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
MXPA04002397A (es) 2001-09-14 2004-12-02 Methylgene Inc Inhibidores de histona deacetilasa.
US6897220B2 (en) 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
CN1290715C (zh) 2001-09-27 2006-12-20 株式会社Api 用于热记录材料的显影剂和热记录材料
JP2003137866A (ja) 2001-11-01 2003-05-14 Sankyo Co Ltd フェニレンジアミン誘導体
KR20040090978A (ko) 2002-03-13 2004-10-27 얀센 파마슈티카 엔.브이. 히스톤 디아세틸라제의 신규한 저해제로서의 설포닐-유도체
TWI319387B (en) 2002-04-05 2010-01-11 Astrazeneca Ab Benzamide derivatives
GB0209715D0 (en) 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
US8476280B2 (en) * 2002-05-09 2013-07-02 Versi Group, Llc Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists
US20040072770A1 (en) 2002-07-03 2004-04-15 Besterman Jeffrey M. Methods for specifically inhibiting histone deacetylase-7 and 8
JP2004035485A (ja) 2002-07-04 2004-02-05 Mitsui Chemicals Inc テロメラーゼ阻害剤
US20050215601A1 (en) 2002-09-25 2005-09-29 Santen Pharmaceutical Co., Ltd. Therapeutic agent for rheumatic disease comprising benzamide derivative as active ingredient
US7282608B2 (en) 2002-10-17 2007-10-16 Methylgene, Inc. Inhibitors of histone deacetylase
WO2004039318A2 (en) 2002-10-25 2004-05-13 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
US6852748B1 (en) 2002-10-30 2005-02-08 Boehringer Ingelheim Pharmaceuticals, Inc. Derivatives of [6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide
TW200426138A (en) 2002-12-10 2004-12-01 Hoffmann La Roche Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives, their manufacture and use as pharmaceutical agents
WO2004058234A2 (en) 2002-12-27 2004-07-15 Schering Aktiengesellschaft Pharmaceutical combinations of phthalazine vegf inhibitors and benzamide hdac inhibitors
US7208491B2 (en) 2003-02-07 2007-04-24 Hoffmann-La Roche Inc. N-monoacylated o-phenylenediamines
JP2006517234A (ja) 2003-02-10 2006-07-20 アムジエン・インコーポレーテツド バニロイド受容体リガンドおよび治療におけるこれらのリガンドの使用
US7244751B2 (en) 2003-02-14 2007-07-17 Shenzhen Chipscreen Biosciences Ltd. Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity
US7030112B2 (en) 2003-03-25 2006-04-18 Bristol-Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
TW200424187A (en) 2003-04-04 2004-11-16 Hoffmann La Roche New oxime derivatives and their use as pharmaceutically active agents
GB0315203D0 (en) 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
TWI372050B (en) 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
US7977387B2 (en) 2003-07-24 2011-07-12 Leo Pharma A/S Aminobenzophenone compounds
WO2005026127A1 (ja) * 2003-09-11 2005-03-24 Institute Of Medicinal Molecular Design. Inc. プラスミノゲンアクチベータインヒビター-1阻害剤
EP1663953A1 (en) 2003-09-24 2006-06-07 Methylgene, Inc. Inhibitors of histone deacetylase
WO2005035551A2 (en) 2003-10-08 2005-04-21 Incyte Corporation Inhibitors of proteins that bind phosphorylated molecules
DK1696898T3 (en) 2003-12-02 2016-02-22 Univ Ohio State Res Found ZN2 + -CHELATING DESIGN-BASED SHORT-CHAIN FAT ACIDS AS AN UNKNOWN CLASS OF HISTONDEACETYLASE INHIBITORS
EP1541549A1 (en) 2003-12-12 2005-06-15 Exonhit Therapeutics S.A. Tricyclic hydroxamate and benzaminde derivatives, compositions and methods
KR100848067B1 (ko) * 2003-12-25 2008-07-23 니뽄 신야쿠 가부시키가이샤 아미드 유도체 및 의약
SI1725528T1 (sl) 2004-03-11 2013-11-29 4Sc Ag Sulfonilpiroli kot HDAC inhibitorji
CZ23088U1 (cs) 2004-03-25 2011-12-19 Astellas Pharma Inc. Kompozice pevného farmaceutického prípravku solifenacinu nebo jeho soli
KR101258504B1 (ko) * 2004-03-26 2013-04-26 메틸진 인코포레이티드 히스톤 데아세틸라제의 억제제
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
US20100234409A1 (en) 2004-05-21 2010-09-16 Lihu Yang Amino cyclopentyl heterocyclic and carbocyclic modulators of chemokine receptor activity
WO2005121073A1 (en) 2004-06-10 2005-12-22 Cancer Research Technology Limited Inhibitors of histone deacetylase
US20080262035A1 (en) 2004-07-12 2008-10-23 Chakravarty Prasun K Amide Derivatives as Inhibitors of Histone Deacetylase
ATE468853T1 (de) 2004-07-22 2010-06-15 Merck Sharp & Dohme Substituierte pyrazole, derartige verbindungen enthaltende zusammensetzungen und verfahren zu ihrer verwendung
JP5063351B2 (ja) 2004-09-17 2012-10-31 エグゼリクシス, インコーポレイテッド ピラゾールキナーゼモジュレーターおよび使用方法
CN101080389A (zh) 2004-10-15 2007-11-28 拜尔药品公司 具有抗增殖活性的茚满酰胺
CN100349070C (zh) 2004-11-25 2007-11-14 同济大学 一种偶氮/酞菁复合单层有机光电导体及其制备方法
US7767687B2 (en) 2004-12-13 2010-08-03 Biogen Idec Ma Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
WO2006066133A2 (en) 2004-12-16 2006-06-22 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20080312223A1 (en) 2004-12-30 2008-12-18 Astex Therapeutics Limited Thiazole And Isothiazole Derivatives That Modulate The Activity Of CDK, GSK And Aurora Kinases
NZ560267A (en) 2005-03-15 2010-03-26 4Sc Ag N-sulphonylpyrroles and their use as histone deacetylase inhibitors
US20060223807A1 (en) 2005-03-29 2006-10-05 University Of Massachusetts Medical School, A Massachusetts Corporation Therapeutic methods for type I diabetes
AU2006228957A1 (en) 2005-04-01 2006-10-05 Methylgene Inc. Inhibitors of histone deacetylase
AU2006232773B2 (en) 2005-04-07 2012-04-12 4Sc Ag Sulfonylpyrroles as histone deacetylase inhibitors
WO2006115845A1 (en) 2005-04-20 2006-11-02 Merck & Co., Inc. Benzothiophene derivatives
JP2008540574A (ja) 2005-05-11 2008-11-20 タケダ サン ディエゴ インコーポレイテッド ヒストンデアセチラーゼ阻害剤
JP4528918B2 (ja) 2005-06-21 2010-08-25 学校法人 関西大学 カルボキサミド誘導体
EP1896395B1 (en) 2005-06-24 2015-07-15 Merck Sharp & Dohme Corp. Modified malonate derivatives
US7732475B2 (en) 2005-07-14 2010-06-08 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2007022638A1 (en) 2005-08-26 2007-03-01 Methylgene Inc. Benzodiazepine and benzopiperazine analog inhibitors of histone deacetylase
AU2006284751A1 (en) 2005-09-01 2007-03-08 Array Biopharma Inc. Raf inhibitor compounds and methods of use thereof
NZ566073A (en) 2005-09-21 2011-08-26 4Sc Ag Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors
PL1928872T3 (pl) 2005-09-21 2012-08-31 4Sc Ag Nowe sulfonylopirole jako inhibitory HDAC
CN101355939A (zh) 2005-10-06 2009-01-28 马萨诸塞大学 用于抑制hiv复制的新物质的组合物和合成
GB0521244D0 (en) * 2005-10-19 2005-11-30 Astrazeneca Ab Benzamide compounds
CA2626898A1 (en) 2005-11-03 2007-05-18 Christopher Hamblett Substituted nicotinamide compounds
EP1951656B1 (en) 2005-11-11 2015-08-05 The Scripps Research Institute Histone deacetylase inhibitors as therapeutics for neurological diseases
AR057579A1 (es) 2005-11-23 2007-12-05 Merck & Co Inc Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac)
US20090012075A1 (en) 2006-01-12 2009-01-08 Miller Thomas A Fluorinated Arylamide Derivatives
CA2635210A1 (en) 2006-01-12 2007-08-02 Merck & Co., Inc. Hydroxyalkylarylamide derivatives
WO2007084390A2 (en) 2006-01-13 2007-07-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
ES2376121T3 (es) 2006-01-19 2012-03-09 Janssen Pharmaceutica, N.V. Derivados de heterociclilalquilo como nuevos inhibidores de histona deacetilasa.
CA2635015C (en) 2006-01-19 2014-06-03 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
PT1981874E (pt) 2006-01-19 2009-09-02 Janssen Pharmactuica N V Derivados de aminofenil como novos inibidores de histonadesacetilase
ES2396986T3 (es) 2006-01-19 2013-03-01 Janssen Pharmaceutica N.V. Derivados de piridina y pirimidina como inhibidores de histona desacetilasa
US8101616B2 (en) 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
WO2007100657A2 (en) 2006-02-28 2007-09-07 Merck & Co., Inc. Inhibitors of histone deacetylase
GB0606876D0 (en) 2006-04-05 2006-05-17 Glaxo Group Ltd Compounds
CA2648804C (en) 2006-04-07 2014-05-27 Methylgene Inc. Benzamide derivatives as inhibitors of histone deacetylase
US8119652B2 (en) 2006-05-18 2012-02-21 Merck Sharp & Dohme Corp. Aryl-fused spirocyclic compounds
GB0614070D0 (en) 2006-07-14 2006-08-23 Glaxo Group Ltd Compounds
JP2009544611A (ja) 2006-07-20 2009-12-17 メルク エンド カムパニー インコーポレーテッド ヒストン脱アセチル化酵素阻害剤としてのリン誘導体
AU2007282080B2 (en) 2006-08-03 2013-06-27 Georgetown University Isoform-selective HDAC inhibitors
US7928136B2 (en) 2006-09-11 2011-04-19 Curis, Inc. Substituted 2-indolinone as PTK inhibitors containing a zinc binding moiety
EP2061772A4 (en) 2006-09-11 2011-06-29 Curis Inc MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
ME01514B (me) * 2006-09-15 2014-04-20 Janssen Pharmaceutica Nv Inhibitori histonske deacetilaze sa spojenom aktivnosti protiv histonskih deacetilaza klase-l i klase-IIB u kombinaciji sa inhibitorima proteasoma
EP1973872A4 (en) 2006-12-19 2012-05-09 Methylgene Inc HISTONDEACETYLASE HEMMER AND PROPHARMAKA THEREOF
WO2008078762A1 (ja) 2006-12-26 2008-07-03 Santen Pharmaceutical Co., Ltd. ウレア構造を有する新規n-(2-アミノフェニル)ベンズアミド誘導体
WO2008084218A1 (en) 2007-01-12 2008-07-17 Boehringer Ingelheim International Gmbh Benzazole derivatives for the treatment of inflammations
WO2008089436A2 (en) 2007-01-18 2008-07-24 Takeda San Diego, Inc. Crystalline forms of histone deacetylase inhibitors
US8030344B2 (en) 2007-03-13 2011-10-04 Methylgene Inc. Inhibitors of histone deacetylase
WO2008112913A1 (en) 2007-03-14 2008-09-18 Exelixis, Inc. Inhibitors of the hedgehog pathway
CN103087043A (zh) 2007-03-16 2013-05-08 中国人民解放军军事医学科学院放射与辐射医学研究所 具有抗增殖活性的苯甲酰胺类衍生物及其药用制剂
CN101646460A (zh) 2007-03-28 2010-02-10 参天制药株式会社 含有具有组蛋白脱乙酰化酶抑制作用的化合物作为有效成分的降眼压剂
KR20090128513A (ko) 2007-03-28 2009-12-15 산텐 세이야꾸 가부시키가이샤 우레아 구조를 갖는 신규 피리딘카르복실산(2-아미노페닐)아미드 유도체
CN101679220A (zh) 2007-04-09 2010-03-24 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
US20090005374A1 (en) 2007-06-26 2009-01-01 Melvin Jr Lawrence S Imidazopyridinyl thiazolyl histone deacetylase inhibitors
EP2170076B1 (en) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
LT2170860T (lt) 2007-06-29 2017-01-10 Pfizer Inc. Benzimidazolo dariniai
US20100267779A1 (en) 2007-07-23 2010-10-21 Syndax Pharmaceuticals, Inc. Novel Compounds and Methods of Using Them
AU2008284304A1 (en) 2007-08-09 2009-02-12 Merck & Co., Inc. Silicon derivatives as histone deacetylase inhibitors
US20120004222A1 (en) 2007-08-21 2012-01-05 Zhicai Wu Cb2 receptor ligands for the treatment of pain
WO2009024825A1 (en) 2007-08-21 2009-02-26 Astrazeneca Ab 2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors
TW200918521A (en) 2007-08-31 2009-05-01 Astrazeneca Ab Heterocyclic amides and methods of use thereof
WO2009036057A1 (en) 2007-09-10 2009-03-19 Curis, Inc. Antiproliferative agents containing a zinc binding moiety
TW200924777A (en) 2007-09-14 2009-06-16 Methylgene Inc Combination therapy
AU2008300827B2 (en) 2007-09-19 2013-04-04 4Sc Ag Novel tetrahydrofusedpyridines as histone deacetylase inhibitors
ES2628748T3 (es) 2007-10-01 2017-08-03 Lixte Biotechnology, Inc. Inhibidores de la HDAC
RU2453536C2 (ru) 2007-10-22 2012-06-20 Оркид Рисерч Лабораториз Лимитед Ингибиторы гистондезацетилазы
EP2060565A1 (en) 2007-11-16 2009-05-20 4Sc Ag Novel bifunctional compounds which inhibit protein kinases and histone deacetylases
EP2220066A1 (en) 2007-12-14 2010-08-25 Gilead Colorado, Inc. Benzofuran anilide histone deacetylase inhibitors
WO2009086012A1 (en) 2007-12-20 2009-07-09 Curis, Inc. Aurora inhibitors containing a zinc binding moiety
EP2100882A1 (en) 2008-03-12 2009-09-16 4Sc Ag (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts
PE20110136A1 (es) 2008-06-27 2011-03-17 Novartis Ag Compuestos organicos
EP2303841A1 (en) 2008-07-14 2011-04-06 Gilead Sciences, Inc. Oxindolyl inhibitor compounds
AU2009271019A1 (en) 2008-07-14 2010-01-21 Gilead Sciences, Inc. Fused heterocyclyc inhibitors of histone deacetylase and/or cyclin-dependent kinases
NZ590283A (en) 2008-07-14 2012-11-30 Gilead Sciences Inc Imidazolylpyrimidine compounds as hdac and / or cdk inhibitors
CA2731323A1 (en) 2008-07-28 2010-02-04 Gilead Sciences, Inc. Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds
AU2009289649B2 (en) 2008-09-03 2016-05-05 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
PE20110418A1 (es) 2008-09-05 2011-06-22 Elan Pharm Inc Compuestos n-sulfonamido pirazolil policiclicos
US8202866B2 (en) 2008-09-17 2012-06-19 Hoffmann-La Roche Inc. Ortho-aminoanilides for the treatment of cancer
TW201016676A (en) 2008-10-03 2010-05-01 Astrazeneca Ab Heterocyclic derivatives and methods of use thereof
WO2010043953A2 (en) 2008-10-15 2010-04-22 Orchid Research Laboratories Ltd. Novel bridged cyclic compounds as histone deacetylase inhibitors
WO2010049182A2 (en) 2008-10-29 2010-05-06 Istituto Superiore Di Sanitá Treatment of retroviral reservoirs exploiting oxidative stress
KR20110117194A (ko) 2009-02-23 2011-10-26 에프. 호프만-라 로슈 아게 암 치료를 위한 신규한 오르토-아미노아미드
KR101145345B1 (ko) 2009-04-24 2012-07-09 계명대학교 산학협력단 세포증식 억제제로서 유용한 2-싸이오-4-아미노 피리미딘 유도체 및 그 제조방법
US8362249B2 (en) 2009-04-27 2013-01-29 Boehringer Ingelheim International Gmbh CXCR3 receptor antagonists
WO2010126811A1 (en) 2009-04-27 2010-11-04 Boehringer Ingelheim International Gmbh Cxcr3 receptor antagonists
WO2010127152A2 (en) 2009-04-29 2010-11-04 Irm Llc Compounds and compositions as microsomal prostaglandin e synthase-1 inhibitors
JP5713999B2 (ja) 2009-05-15 2015-05-07 コリア リサーチ インスティテュート オブ ケミカル テクノロジー アミド化合物、その製造方法及びそれを含む薬学組成物
US8211901B2 (en) 2009-05-22 2012-07-03 Shenzhen Chipscreen Biosciences Ltd. Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors
CA2763167A1 (en) 2009-06-08 2010-12-16 Gilead Sciences, Inc. Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds
EP2440519A1 (en) 2009-06-08 2012-04-18 Gilead Sciences, Inc. Alkanoylamino benzamide aniline hdac inihibitor compounds
CN101648922B (zh) 2009-08-20 2011-08-31 苏州东南药物研发有限责任公司 苯甲酰胺类组蛋白去乙酰酶抑制剂及其用途
EP2598133A4 (en) 2010-07-30 2014-03-05 Univ California METHOD AND THERAPEUTIC FOR TREATING AND CONTROLLING MEMBERSHIP EDUCATION
US8957066B2 (en) * 2011-02-28 2015-02-17 Biomarin Pharmaceutical Inc. Histone deacetylase inhibitors
JP6250403B2 (ja) 2011-02-28 2017-12-20 バイオマリン ファーマシューティカル インク ヒストン脱アセチル化酵素阻害剤
WO2013011384A1 (en) 2011-07-21 2013-01-24 Lumos, Inc. Elastic strand for use in kinesiology tape
TWI573792B (zh) * 2012-02-01 2017-03-11 歐陸斯迪公司 新穎治療劑

Similar Documents

Publication Publication Date Title
JP2018150331A5 (enExample)
JP2019038829A5 (enExample)
JP2017533968A5 (enExample)
JP2013514980A5 (enExample)
JP2011526924A5 (enExample)
JP2018135343A5 (enExample)
RU2015143843A (ru) Ингибиторы гистондеацетилазы
JP2018158926A5 (enExample)
JP2013541514A5 (enExample)
JP2011500638A5 (enExample)
JP2006513268A5 (ja) アンタゴニスト活性を有するベンゾアゾリルピペラジン誘導体
JP2008505157A5 (enExample)
JP2017535586A5 (enExample)
JP2017504653A5 (enExample)
JP2020097577A5 (enExample)
JP2016537338A5 (enExample)
JP2012504133A5 (enExample)
JP2017538773A5 (enExample)
JP2010504343A5 (enExample)
JP2015523546A5 (enExample)
JP2018537535A5 (enExample)
JP2012502111A5 (enExample)
JP2018538273A5 (enExample)
JP2018525342A5 (enExample)
JP2016164177A5 (enExample)