JP2016537338A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016537338A5 JP2016537338A5 JP2016528225A JP2016528225A JP2016537338A5 JP 2016537338 A5 JP2016537338 A5 JP 2016537338A5 JP 2016528225 A JP2016528225 A JP 2016528225A JP 2016528225 A JP2016528225 A JP 2016528225A JP 2016537338 A5 JP2016537338 A5 JP 2016537338A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- treatment
- group
- prodrug
- following formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 4
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 201000011452 Adrenoleukodystrophy Diseases 0.000 claims 1
- 208000023434 Alpers-Huttenlocher syndrome Diseases 0.000 claims 1
- 208000004986 Diffuse Cerebral Sclerosis of Schilder Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010070511 Hypoxic-ischaemic encephalopathy Diseases 0.000 claims 1
- 208000035177 MELAS Diseases 0.000 claims 1
- 102000009030 Member 1 Subfamily D ATP Binding Cassette Transporter Human genes 0.000 claims 1
- 108010049137 Member 1 Subfamily D ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 208000037212 Neonatal hypoxic and ischemic brain injury Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 208000009973 brain hypoxia - ischemia Diseases 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 201000011540 mitochondrial DNA depletion syndrome 4a Diseases 0.000 claims 1
- 208000033300 perinatal asphyxia Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 *C([C@](CS1)NC1=O)=O Chemical compound *C([C@](CS1)NC1=O)=O 0.000 description 3
- YTZKOQUCBOVLHL-UHFFFAOYSA-N CC(C)(C)c1ccccc1 Chemical compound CC(C)(C)c1ccccc1 YTZKOQUCBOVLHL-UHFFFAOYSA-N 0.000 description 1
- LEAJWPFHMHVEKV-UHFFFAOYSA-N CCC(c(cccc1)c1OC)=O Chemical compound CCC(c(cccc1)c1OC)=O LEAJWPFHMHVEKV-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020069560A JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902052P | 2013-11-08 | 2013-11-08 | |
| US61/902,052 | 2013-11-08 | ||
| US201361902669P | 2013-11-11 | 2013-11-11 | |
| US61/902,669 | 2013-11-11 | ||
| PCT/US2014/064581 WO2015070034A1 (en) | 2013-11-08 | 2014-11-07 | Substituted n-acetyl-l-cysteine derivatives and related compounds |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017213633A Division JP6559756B2 (ja) | 2013-11-08 | 2017-11-06 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2020069560A Division JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016537338A JP2016537338A (ja) | 2016-12-01 |
| JP2016537338A5 true JP2016537338A5 (enExample) | 2017-12-14 |
| JP6691044B2 JP6691044B2 (ja) | 2020-04-28 |
Family
ID=51952031
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016528225A Active JP6691044B2 (ja) | 2013-11-08 | 2014-11-07 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2017213633A Active JP6559756B2 (ja) | 2013-11-08 | 2017-11-06 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2020069560A Active JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2021156357A Active JP7170811B2 (ja) | 2013-11-08 | 2021-09-27 | 置換ｎ－アセチル－ｌ－システイン誘導体及び関連化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017213633A Active JP6559756B2 (ja) | 2013-11-08 | 2017-11-06 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2020069560A Active JP6952825B2 (ja) | 2013-11-08 | 2020-04-08 | 置換ｎ−アセチル−ｌ−システイン誘導体及び関連化合物 |
| JP2021156357A Active JP7170811B2 (ja) | 2013-11-08 | 2021-09-27 | 置換ｎ－アセチル－ｌ－システイン誘導体及び関連化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (7) | US9630937B2 (enExample) |
| EP (2) | EP3674297A1 (enExample) |
| JP (4) | JP6691044B2 (enExample) |
| AU (3) | AU2014346591B2 (enExample) |
| CA (1) | CA2929655C (enExample) |
| DK (1) | DK3066089T3 (enExample) |
| ES (1) | ES2765236T3 (enExample) |
| HU (1) | HUE048345T2 (enExample) |
| LT (1) | LT3066089T (enExample) |
| PL (1) | PL3066089T3 (enExample) |
| PT (1) | PT3066089T (enExample) |
| SI (1) | SI3066089T1 (enExample) |
| WO (1) | WO2015070034A1 (enExample) |
| ZA (1) | ZA201705288B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5978136B2 (ja) * | 2010-03-10 | 2016-08-24 | プロメンテイス・フアーマシユーテイカルズ・インコーポレイテツド | プロピオン酸、プロピオン酸エステルおよび関連化合物 |
| LT3066089T (lt) | 2013-11-08 | 2020-02-25 | Promentis Pharmaceuticals, Inc. | Pakeistieji n-acetil-l-cisteino dariniai ir giminingi junginiai |
| US10512637B2 (en) | 2015-06-05 | 2019-12-24 | China Medical University | Use of inhibitor of cystine-glutamate transporter |
| WO2018107040A1 (en) * | 2016-12-09 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | 1-(2-fluorophenyl)-n-[1-(2-fluoro-4-pyridyl)pyrazol-3-yl]cyclopropanecarboxamide, its solid forms and pharmaceutical uses thereof |
| TW201833087A (zh) * | 2016-12-09 | 2018-09-16 | 美商維泰克斯製藥公司 | 用於減少非常長鏈脂肪酸含量之1,3-取代吡唑化合物 |
| US20190177295A1 (en) * | 2017-12-08 | 2019-06-13 | Vertex Pharmaceuticals Incorporated | Process for the preparation of a 1,3-disubstituted pyrazole compound |
| US20240425857A1 (en) | 2021-10-29 | 2024-12-26 | Vib Vzw | Means and Methods for Chronic Wound Healing |
| CN116535998B (zh) * | 2023-06-20 | 2024-05-17 | 安徽省阳明达新材料科技有限公司 | 一种热熔复合石材玻璃耐热eva胶片的制备方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1493697A1 (de) * | 1965-02-25 | 1969-11-20 | Hoechst Ag | Verfahren zur Spaltung von Thiolestern aromatischer Carbonsaeuren |
| IT1194117B (it) | 1981-11-20 | 1988-09-14 | Isnardi Pietro & C Spa | Derivati salicilici di n-acetilcisteina |
| CN85107378A (zh) | 1984-09-13 | 1987-03-18 | 陶氏化学公司 | 从原煤中回收有用煤的起泡剂组合物和泡沫浮选方法 |
| US5637616A (en) | 1993-06-18 | 1997-06-10 | Arcturus Pharmaceutical Corporation | Method for treating diseases mediated by proteases |
| AU1447095A (en) | 1993-12-30 | 1995-07-17 | Arcturus Pharmaceutical Corporation | Methods for the treatment of the central nervous system or eye involving pathogenic oxidation pathways |
| AU2825295A (en) | 1994-06-13 | 1996-01-05 | Arcturus Pharmaceutical Corporation | Method for the treatment, prevention or minimization of hair loss |
| JP3608021B2 (ja) * | 1996-09-05 | 2005-01-05 | 参天製薬株式会社 | 新規含硫黄アミノ酸誘導体 |
| KR19990078146A (ko) | 1998-03-24 | 1999-10-25 | 마키노 아라타 | 프로필렌계 수지 조성물 및 이를 사용한 연신필름 |
| AU754086B2 (en) * | 1998-06-29 | 2002-11-07 | Parker Hughes Institute | Alkyl ketones as potent anti-cancer agents |
| EP1209147A1 (en) * | 1999-07-26 | 2002-05-29 | Toray Industries, Inc. | Carboxylic acid derivatives and adhesion molecule inhibitors containing the same as the active ingredient |
| US20050032708A1 (en) | 2001-09-27 | 2005-02-10 | Bush Ashley I. | Modulation of physiological processes and agents useful for same |
| IL162319A0 (en) | 2001-12-04 | 2005-11-20 | Univ Ben Gurion | Amphiphilic compounds and vesicles/liposomes for organ-specific drug targeting |
| CN1233629C (zh) | 2002-11-22 | 2005-12-28 | 贵州省中国科学院天然产物化学重点实验室 | 具有神经营养作用的硫酯类化合物及其它的合成方法和应用 |
| FR2856592B1 (fr) | 2003-06-27 | 2008-04-25 | Oreal | Composition cosmetique a base de percuseur(s) de radical thiyl pour la deformation permanente des fibres keratiniques |
| US8993627B2 (en) | 2005-04-21 | 2015-03-31 | Sentient Lifesciences, Inc. | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress |
| WO2006116353A2 (en) | 2005-04-21 | 2006-11-02 | Goldstein Glenn | N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress |
| CA2620899A1 (en) | 2005-10-12 | 2007-04-19 | Biolipox Ab | Benzoxazoles useful in the treatment of inflammation |
| EP2068903A4 (en) * | 2006-10-03 | 2010-11-03 | Galleon Pharmaceuticals Inc | S-NITROSOTHIOL COMPOUNDS AND RELATED DERIVATIVES |
| US7829709B1 (en) | 2007-08-10 | 2010-11-09 | Marquette University | Cysteine prodrugs to treat schizophrenia and drug addiction |
| JP5796881B2 (ja) * | 2008-02-07 | 2015-10-21 | マーケット ユニバーシティー | 統合失調症を治療するため及び薬物渇望を低減するためのシステイン及びシスチンプロドラッグ |
| WO2009137251A2 (en) | 2008-04-16 | 2009-11-12 | Marquette University | Cysteine and cystine bioisosteres to treat schizophrenia and reduce drug cravings |
| CN102316730A (zh) | 2008-05-09 | 2012-01-11 | 天雅瑞药业有限公司 | 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释 |
| CA2755069A1 (en) | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| AU2011210567B2 (en) | 2010-01-29 | 2015-04-16 | Dana-Farber Cancer Institute, Inc. | Small molecules for the modulation of MCL-1 and methods of modulatiing cell death, cell division, cell differentiation and methods of treating disorders |
| JP5978136B2 (ja) | 2010-03-10 | 2016-08-24 | プロメンテイス・フアーマシユーテイカルズ・インコーポレイテツド | プロピオン酸、プロピオン酸エステルおよび関連化合物 |
| WO2012033235A1 (ko) | 2010-09-06 | 2012-03-15 | 서울대학교 산학협력단 | Ｎ-아세틸-ｌ-시스테인 또는 이의 유도체를 포함하는 불안 장애 치료용 약학 조성물 |
| WO2012065110A2 (en) | 2010-11-12 | 2012-05-18 | Promentis Pharmaceuticals, Inc. | S-protected cysteine analogs and related compounds |
| JP2014502958A (ja) * | 2010-11-12 | 2014-02-06 | プロメンテイス・フアーマシユーテイカルズ・インコーポレイテツド | Ｓ−ｔ−ブチル保護システインジペプチド類似体および関連化合物 |
| CN103415532B (zh) | 2011-01-20 | 2016-05-04 | 万德-生物技术及制药有限公司 | 抗氧化、抗炎、抗辐射、金属螯合的化合物及其用途 |
| JP2014524936A (ja) | 2011-07-28 | 2014-09-25 | プロメンテイス・フアーマシユーテイカルズ・インコーポレイテツド | システインプロドラッグ |
| WO2014209412A1 (en) | 2013-06-29 | 2014-12-31 | Viva Pharmaceutical, Inc. | N-acetyl l-cysteine chelates and methods for making and using the same |
| WO2015006569A2 (en) | 2013-07-10 | 2015-01-15 | Sentient Lifesciences, Inc. | Use of n-acetylcysteine amide in the treatment of penetrating head injury |
| US20150133558A1 (en) | 2013-10-15 | 2015-05-14 | Glenn A. Goldstein | Use of n-acetylcysteine amide for decreasing intracranial pressure |
| LT3066089T (lt) * | 2013-11-08 | 2020-02-25 | Promentis Pharmaceuticals, Inc. | Pakeistieji n-acetil-l-cisteino dariniai ir giminingi junginiai |
| WO2015112724A1 (en) | 2014-01-24 | 2015-07-30 | Brighton Biotech, Inc. | Naca for the treatment of chronic or acute cognitive dysfunction |
| WO2015112715A1 (en) | 2014-01-24 | 2015-07-30 | Brighton Biotech, Inc. | Naca for the treatment of chronic or low impact brian trauma |
-
2014
- 2014-11-07 LT LTEP14802771.7T patent/LT3066089T/lt unknown
- 2014-11-07 HU HUE14802771A patent/HUE048345T2/hu unknown
- 2014-11-07 AU AU2014346591A patent/AU2014346591B2/en not_active Ceased
- 2014-11-07 US US14/535,855 patent/US9630937B2/en active Active
- 2014-11-07 WO PCT/US2014/064581 patent/WO2015070034A1/en not_active Ceased
- 2014-11-07 PT PT148027717T patent/PT3066089T/pt unknown
- 2014-11-07 US US14/535,953 patent/US9012674B1/en active Active
- 2014-11-07 CA CA2929655A patent/CA2929655C/en active Active
- 2014-11-07 PL PL14802771T patent/PL3066089T3/pl unknown
- 2014-11-07 ES ES14802771T patent/ES2765236T3/es active Active
- 2014-11-07 DK DK14802771.7T patent/DK3066089T3/da active
- 2014-11-07 EP EP19207221.3A patent/EP3674297A1/en not_active Withdrawn
- 2014-11-07 JP JP2016528225A patent/JP6691044B2/ja active Active
- 2014-11-07 EP EP14802771.7A patent/EP3066089B1/en active Active
- 2014-11-07 SI SI201431469T patent/SI3066089T1/sl unknown
-
2017
- 2017-03-15 US US15/459,840 patent/US10112897B2/en active Active
- 2017-04-07 US US15/481,728 patent/US10358414B2/en active Active
- 2017-08-04 ZA ZA2017/05288A patent/ZA201705288B/en unknown
- 2017-11-06 JP JP2017213633A patent/JP6559756B2/ja active Active
-
2018
- 2018-12-21 AU AU2018282446A patent/AU2018282446B2/en not_active Ceased
-
2019
- 2019-06-17 US US16/443,793 patent/US10961187B2/en active Active
-
2020
- 2020-04-08 JP JP2020069560A patent/JP6952825B2/ja active Active
- 2020-10-21 AU AU2020257084A patent/AU2020257084A1/en not_active Abandoned
-
2021
- 2021-03-29 US US17/216,285 patent/US20210395194A1/en not_active Abandoned
- 2021-09-27 JP JP2021156357A patent/JP7170811B2/ja active Active
-
2023
- 2023-10-17 US US18/488,215 patent/US20240059649A1/en active Pending