JP2020500862A5 - - Google Patents

Download PDF

Info

Publication number
JP2020500862A5
JP2020500862A5 JP2019528031A JP2019528031A JP2020500862A5 JP 2020500862 A5 JP2020500862 A5 JP 2020500862A5 JP 2019528031 A JP2019528031 A JP 2019528031A JP 2019528031 A JP2019528031 A JP 2019528031A JP 2020500862 A5 JP2020500862 A5 JP 2020500862A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
pharmaceutical composition
compound
acceptable salt
salt form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019528031A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020500862A (ja
JP7316936B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/062901 external-priority patent/WO2018098203A1/en
Publication of JP2020500862A publication Critical patent/JP2020500862A/ja
Publication of JP2020500862A5 publication Critical patent/JP2020500862A5/ja
Priority to JP2022082784A priority Critical patent/JP2022110131A/ja
Application granted granted Critical
Publication of JP7316936B2 publication Critical patent/JP7316936B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019528031A 2016-11-25 2017-11-21 Stingアゴニストとしての環状ジヌクレオチド Active JP7316936B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022082784A JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426350P 2016-11-25 2016-11-25
US62/426,350 2016-11-25
US201762502983P 2017-05-08 2017-05-08
US62/502,983 2017-05-08
US201762555232P 2017-09-07 2017-09-07
US62/555,232 2017-09-07
PCT/US2017/062901 WO2018098203A1 (en) 2016-11-25 2017-11-21 Cyclic dinucleotides as sting agonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022082784A Division JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

Publications (3)

Publication Number Publication Date
JP2020500862A JP2020500862A (ja) 2020-01-16
JP2020500862A5 true JP2020500862A5 (enExample) 2021-01-07
JP7316936B2 JP7316936B2 (ja) 2023-07-28

Family

ID=60937846

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019528031A Active JP7316936B2 (ja) 2016-11-25 2017-11-21 Stingアゴニストとしての環状ジヌクレオチド
JP2022082784A Pending JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022082784A Pending JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

Country Status (13)

Country Link
US (2) US11472830B2 (enExample)
EP (1) EP3544989A1 (enExample)
JP (2) JP7316936B2 (enExample)
KR (1) KR20190085107A (enExample)
CN (1) CN110291096A (enExample)
AU (1) AU2017365158B2 (enExample)
BR (1) BR112019010606A2 (enExample)
CA (1) CA3044693A1 (enExample)
JO (1) JOP20170188A1 (enExample)
MX (1) MX2019006082A (enExample)
TW (1) TW201831192A (enExample)
UY (1) UY37495A (enExample)
WO (1) WO2018098203A1 (enExample)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL280430B2 (en) 2016-03-18 2023-11-01 Univ Texas Cyclic dinucleotide compounds and methods of use
EP3507367A4 (en) 2016-07-05 2020-03-25 Aduro BioTech, Inc. CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
KR20230010826A (ko) 2016-10-14 2023-01-19 프리시젼 바이오사이언시스 인코포레이티드 B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제
WO2018100558A2 (en) 2016-12-01 2018-06-07 Takeda Pharmaceutical Company Limited Cyclic dinucleotide
ES2891326T3 (es) * 2017-01-27 2022-01-27 Janssen Biotech Inc Dinucleótidos cíclicos como agonistas de la STING
ES2924186T3 (es) * 2017-01-27 2022-10-05 Janssen Biotech Inc Dinucleótidos cíclicos como agonistas de STING
US20200055883A1 (en) 2017-02-17 2020-02-20 Eisai R&D Management Co., Ltd. Cyclic di-nucleotides derivative for the treatment of cancer
TWI808092B (zh) * 2017-08-30 2023-07-11 中國大陸商北京軒義醫藥科技有限公司 作為干擾素基因調節劑之刺激劑的環狀二核苷酸
WO2019084060A1 (en) 2017-10-24 2019-05-02 Silverback Therapeutics, Inc. CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
PH12020550585A1 (en) 2017-11-10 2021-04-19 Takeda Pharmaceuticals Co Sting modulator compounds, and methods of making and using
US11203610B2 (en) 2017-12-20 2021-12-21 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
JP7037667B2 (ja) 2017-12-20 2022-03-16 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. Stingアダプタータンパク質を活性化するホスホン酸結合を有する3’3’環状ジヌクレオチド
JP7050165B2 (ja) 2018-02-26 2022-04-07 ギリアード サイエンシーズ, インコーポレイテッド Hbv複製阻害剤としての置換ピロリジン化合物
WO2019195181A1 (en) 2018-04-05 2019-10-10 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis b virus protein x
TW202005654A (zh) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2,2,─環二核苷酸
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
US11142750B2 (en) 2018-04-12 2021-10-12 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
WO2019211799A1 (en) 2018-05-03 2019-11-07 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide
US12251394B2 (en) 2018-06-01 2025-03-18 Eisai R&D Management Co., Ltd. Methods for the treatment of bladder cancer
TW202030199A (zh) * 2018-07-17 2020-08-16 美商健生生物科技公司 作為sting促效劑之環狀二核苷酸
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
KR102783784B1 (ko) 2018-08-16 2025-03-21 에자이 알앤드디 매니지먼트 가부시키가이샤 화합물의 염 및 이의 결정
SG11202101980VA (en) 2018-09-12 2021-03-30 Silverback Therapeutics Inc Methods and composition for the treatment of disease with immune stimulatory conjugates
MA53659A (fr) 2018-09-21 2022-02-23 Shanghai De Novo Pharmatech Co Ltd Analogue dinucléotidique cyclique, composition pharmaceutique associée et utilisation
US11110106B2 (en) 2018-10-29 2021-09-07 Venenum Biodesign, LLC Sting agonists for treating bladder cancer and solid tumors
EP3873484B1 (en) 2018-10-29 2023-08-23 Venenum Biodesign, LLC Novel sting agonists
EP3873608A1 (en) 2018-10-31 2021-09-08 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds having hpk1 inhibitory activity
EP4371987B9 (en) 2018-10-31 2025-11-26 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
WO2020135715A1 (zh) * 2018-12-29 2020-07-02 上海济煜医药科技有限公司 作为肿瘤免疫类的化合物及其应用
CN113574063B (zh) 2019-03-07 2025-03-18 捷克共和国有机化学与生物化学研究所 3’3’-环二核苷酸及其前药
WO2020178769A1 (en) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3'-cyclic dinucleotides and prodrugs thereof
WO2020178768A1 (en) 2019-03-07 2020-09-10 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
CN109929894B (zh) * 2019-04-17 2021-06-01 中国农业科学院兰州兽医研究所 一种猪源第二信使分子2′3′-cGAMP的制备及活性鉴定方法
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
CN114127082A (zh) 2019-05-09 2022-03-01 阿里戈斯治疗公司 作为sting调节剂的经修饰的环状二核苷化合物
TWI925817B (zh) 2019-05-10 2026-05-21 日商武田藥品工業股份有限公司 抗體藥物結合物
US11453681B2 (en) 2019-05-23 2022-09-27 Gilead Sciences, Inc. Substituted eneoxindoles and uses thereof
CN114245807B (zh) 2019-06-25 2025-05-02 吉利德科学公司 Flt3l-fc融合蛋白和使用方法
WO2021007160A1 (en) 2019-07-05 2021-01-14 Tambo, Inc. Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
US20220296619A1 (en) 2019-08-19 2022-09-22 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
HRP20241379T1 (hr) 2019-09-30 2024-12-20 Gilead Sciences, Inc. Cjepiva za hbv i postupci za liječenje hbv
WO2021067644A1 (en) 2019-10-01 2021-04-08 Silverback Therapeutics, Inc. Combination therapy with immune stimulatory conjugates
US12410418B2 (en) 2019-12-06 2025-09-09 Precision Biosciences, Inc. Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
US11179473B2 (en) 2020-02-21 2021-11-23 Silverback Therapeutics, Inc. Nectin-4 antibody conjugates and uses thereof
KR102987126B1 (ko) 2020-03-20 2026-07-07 길리애드 사이언시즈, 인코포레이티드 4'-c-치환된-2-할로-2'-데옥시아데노신 뉴클레오시드의 프로드러그 및 이의 제조 및 사용 방법
US20230141284A1 (en) 2020-04-10 2023-05-11 Ono Pharmaceutical Co., Ltd. Cancer therapeutic method
AU2021270347A1 (en) 2020-05-11 2022-12-15 Erytech Pharma Red cell extracellular vesicles (RCEVs) containing cargoes and methods of use and production thereof
KR20230047361A (ko) 2020-07-01 2023-04-07 아르스 파마슈티컬스 인크. 항-asgr1 항체 접합체 및 이의 용도
JP2023537066A (ja) 2020-08-07 2023-08-30 タンボ・インコーポレイテッド トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
LT4192474T (lt) 2020-08-07 2025-11-25 Fosfonamidų nukleotidų analogų provaistai ir jų farmacinis panaudojimas
JP7875196B2 (ja) * 2020-10-20 2026-06-17 タイリガンド バイオサイエンス(シャンハイ)リミテッド 多機能環状ジヌクレオチド及びその使用
JP7397996B2 (ja) 2020-11-09 2023-12-13 武田薬品工業株式会社 抗体薬物コンジュゲート
US20240269142A1 (en) 2021-05-13 2024-08-15 Gilead Sciences, Inc. COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS
WO2022245671A1 (en) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Methods of using flt3l-fc fusion proteins
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
MX2023014762A (es) 2021-06-23 2024-01-15 Gilead Sciences Inc Compuestos moduladores de diacilglicerol quinasa.
CN117355531A (zh) 2021-06-23 2024-01-05 吉利德科学公司 二酰基甘油激酶调节化合物
JP7651018B2 (ja) 2021-06-23 2025-03-25 ギリアード サイエンシーズ, インコーポレイテッド ジアシルグリセロールキナーゼ調節化合物
CN122180515A (zh) * 2023-06-30 2026-06-09 免疫原公司 包含sting激动剂的组合物和用于治疗神经胶质瘤的使用方法
WO2025240246A1 (en) 2024-05-13 2025-11-20 Gilead Sciences, Inc. Combination therapies with ribavirin
US20250345390A1 (en) 2024-05-13 2025-11-13 Gilead Sciences, Inc. Combination therapies
TW202608468A (zh) 2024-05-13 2026-03-01 美商基利科學股份有限公司 組合療法
WO2025240242A1 (en) 2024-05-13 2025-11-20 Gilead Sciences, Inc. Combination therapies with ribavirin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1645561A1 (en) * 2003-07-15 2006-04-12 Mitsui Chemicals, Inc. Method of synthesizing cyclic bisdinucleoside
JP2016506408A (ja) * 2012-12-19 2016-03-03 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 哺乳動物の環状ジヌクレオチドシグナル伝達経路の薬学的標的化
JP2016524593A (ja) 2013-04-29 2016-08-18 メモリアル スローン−ケタリング キャンサー センター セカンドメッセンジャーのシグナル伝達を変えるための組成物及び方法
EP2996472B1 (en) * 2013-05-18 2019-03-27 Aduro Biotech, Inc. Compositions and methods for inhibiting "stimulator of interferon gene" dependent signalling
CU24377B1 (es) * 2013-05-18 2018-12-05 Aduro Biotech Inc Dinucléotidos de purina cíclicos y composiciones de los mismos útiles para inducir la producción de interferón de tipo i dependientes de sting
AU2014340269B2 (en) 2013-10-21 2018-06-21 Drexel University Use of STING agonists to treat chronic hepatitis B virus infection
DK3233882T3 (da) * 2014-12-16 2020-01-27 Kayla Therapeutics Fluorinerede cykliske dinukleotider til cytokininduktion
EP3233089A4 (en) * 2014-12-17 2018-11-14 Lipogen LLC Method of treating cancer with cgamp or cgasmp
GB201501462D0 (en) * 2015-01-29 2015-03-18 Glaxosmithkline Ip Dev Ltd Novel compounds
CN108137641B (zh) * 2015-08-13 2022-04-01 默沙东公司 作为sting激动剂的环状双核苷酸化合物
KR20180066241A (ko) * 2015-10-28 2018-06-18 아두로 바이오테크, 인코포레이티드 “인터페론 유전자의 자극제”-의존성 신호전달을 활성화시키기 위한 조성물 및 방법
JP6411676B2 (ja) * 2015-12-03 2018-10-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited Stingの調節因子としての環状プリンジヌクレオチド
IL280430B2 (en) * 2016-03-18 2023-11-01 Univ Texas Cyclic dinucleotide compounds and methods of use

Similar Documents

Publication Publication Date Title
JP2020514316A5 (enExample)
CN111989332A (zh) 作为cdk抑制剂的大环化合物、其制备方法及其在医药上的应用
JP2020097577A5 (enExample)
JP2021063088A5 (enExample)
JP2018021046A5 (enExample)
JP2016534063A5 (enExample)
CN114072396A (zh) 作为dna-pk抑制剂的喹啉和噌啉衍生物
JP2022512482A5 (enExample)
JP2014500861A5 (enExample)
JP2024516371A5 (enExample)
JP2017518334A5 (enExample)
CN113365998A (zh) 用于parp抑制剂的吲哚并七元酰肟类似物
JP2018150331A5 (enExample)
JP2019537570A5 (enExample)
JP2009502743A5 (enExample)
JP2008501705A5 (enExample)
JP2015534578A5 (enExample)
JP2017531619A5 (enExample)
JP2018517686A5 (enExample)
JP2012504133A5 (enExample)
JP2020506951A5 (enExample)
JP2016501221A5 (enExample)
JP2019516739A5 (enExample)
JP2016537432A5 (enExample)
JP2016537338A5 (enExample)