|
HUE060396T2
(hu)
|
2016-03-18 |
2023-02-28 |
Immune Sensor Llc |
Ciklikus DI-nukleotid vegyületek és azok felhasználási módszerei
|
|
EP3507367A4
(en)
|
2016-07-05 |
2020-03-25 |
Aduro BioTech, Inc. |
CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
|
|
CN117402852A
(zh)
|
2016-10-14 |
2024-01-16 |
精密生物科学公司 |
对乙肝病毒基因组中的识别序列特异性的工程化大范围核酸酶
|
|
JOP20170192A1
(ar)
|
2016-12-01 |
2019-01-30 |
Takeda Pharmaceuticals Co |
داي نوكليوتيد حلقي
|
|
US11021511B2
(en)
*
|
2017-01-27 |
2021-06-01 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as sting agonists
|
|
JP7275031B2
(ja)
*
|
2017-01-27 |
2023-05-17 |
ヤンセン バイオテツク，インコーポレーテツド |
Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド
|
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
|
AU2018323053A1
(en)
*
|
2017-08-30 |
2020-03-19 |
Beijing Xuanyi Pharmasciences Co., Ltd |
Cyclic di-nucleotides as stimulator of interferon genes modulators
|
|
WO2019084060A1
(en)
|
2017-10-24 |
2019-05-02 |
Silverback Therapeutics, Inc. |
CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS
|
|
KR20200098511A
(ko)
|
2017-11-10 |
2020-08-20 |
다케다 야쿠힌 고교 가부시키가이샤 |
Sting 조절제 화합물, 및 제조 및 사용 방법
|
|
AU2018392213B2
(en)
|
2017-12-20 |
2021-03-04 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
|
|
CN111511754B
(zh)
|
2017-12-20 |
2023-09-12 |
捷克共和国有机化学与生物化学研究所 |
活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸
|
|
ES2962605T3
(es)
|
2018-02-26 |
2024-03-20 |
Gilead Sciences Inc |
Compuestos de pirrolizina sustituidos como inhibidores de la replicación del VHB
|
|
WO2019195181A1
(en)
|
2018-04-05 |
2019-10-10 |
Gilead Sciences, Inc. |
Antibodies and fragments thereof that bind hepatitis b virus protein x
|
|
TW202005654A
(zh)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
２，２，─環二核苷酸
|
|
TWI818007B
(zh)
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-環二核苷酸
|
|
TWI833744B
(zh)
|
2018-04-06 |
2024-03-01 |
捷克科學院有機化學與生物化學研究所 |
3'3'-環二核苷酸
|
|
US11142750B2
(en)
|
2018-04-12 |
2021-10-12 |
Precision Biosciences, Inc. |
Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome
|
|
TW202014193A
(zh)
|
2018-05-03 |
2020-04-16 |
捷克科學院有機化學與生物化學研究所 |
包含碳環核苷酸之2’3’－環二核苷酸
|
|
KR20210015937A
(ko)
|
2018-06-01 |
2021-02-10 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
방광암을 치료하기 위한 방법
|
|
TW202030199A
(zh)
*
|
2018-07-17 |
2020-08-16 |
美商健生生物科技公司 |
作為ｓｔｉｎｇ促效劑之環狀二核苷酸
|
|
WO2020028097A1
(en)
|
2018-08-01 |
2020-02-06 |
Gilead Sciences, Inc. |
Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
|
|
CA3099904A1
(en)
|
2018-08-16 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Salts of compounds and crystals thereof
|
|
KR20210081332A
(ko)
|
2018-09-12 |
2021-07-01 |
실버백 테라퓨틱스, 인크. |
면역 자극성 접합체를 사용한 질환의 치료를 위한 조성물
|
|
BR112021005208A2
(pt)
|
2018-09-21 |
2021-06-08 |
Shanghai De Novo Pharmatech Co., Ltd. |
análogo de dinucleotídeo cíclico, composição farmacêutica do mesmo, e aplicação
|
|
WO2020092127A1
(en)
*
|
2018-10-29 |
2020-05-07 |
Venenum Biodesign, LLC |
Novel sting agonists
|
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
|
BR112021008255A2
(pt)
|
2018-10-31 |
2021-08-03 |
Gilead Sciences, Inc. |
compostos de 6-azabenzimidazol substituídos como inibidores de hpk1
|
|
JP7273172B2
(ja)
|
2018-10-31 |
2023-05-12 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｈｐｋ１阻害活性を有する置換６－アザベンゾイミダゾール化合物
|
|
WO2020135715A1
(zh)
*
|
2018-12-29 |
2020-07-02 |
上海济煜医药科技有限公司 |
作为肿瘤免疫类的化合物及其应用
|
|
US12318403B2
(en)
|
2019-03-07 |
2025-06-03 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2′3′-cyclic dinucleotides and prodrugs thereof
|
|
WO2020178770A1
(en)
|
2019-03-07 |
2020-09-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotides and prodrugs thereof
|
|
US11766447B2
(en)
|
2019-03-07 |
2023-09-26 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
|
TWI751517B
(zh)
|
2019-04-17 |
2022-01-01 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
TWI751516B
(zh)
|
2019-04-17 |
2022-01-01 |
美商基利科學股份有限公司 |
類鐸受體調節劑之固體形式
|
|
CN109929894B
(zh)
*
|
2019-04-17 |
2021-06-01 |
中国农业科学院兰州兽医研究所 |
一种猪源第二信使分子2′3′-cGAMP的制备及活性鉴定方法
|
|
MA55805A
(fr)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V Inc |
Métodes de modulation de l'activité immunitaire
|
|
JP7621974B2
(ja)
|
2019-05-09 |
2025-01-27 |
アリゴス セラピューティクス インコーポレイテッド |
Ｓｔｉｎｇモジュレータとしての修飾環状ジヌクレオシド化合物
|
|
CN114173824A
(zh)
|
2019-05-10 |
2022-03-11 |
武田药品工业株式会社 |
抗体药物缀合物
|
|
EP3972695A1
(en)
|
2019-05-23 |
2022-03-30 |
Gilead Sciences, Inc. |
Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
|
|
MX2021015452A
(es)
|
2019-06-25 |
2022-02-11 |
Gilead Sciences Inc |
Proteinas de fusion flt3l-fc y metodos de uso.
|
|
CA3145889A1
(en)
|
2019-07-05 |
2021-01-14 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
|
US20220296619A1
(en)
|
2019-08-19 |
2022-09-22 |
Gilead Sciences, Inc. |
Pharmaceutical formulations of tenofovir alafenamide
|
|
IL315295A
(en)
|
2019-09-30 |
2024-10-01 |
Gilead Sciences Inc |
Hbv vaccines and methods treating hbv
|
|
WO2021067644A1
(en)
|
2019-10-01 |
2021-04-08 |
Silverback Therapeutics, Inc. |
Combination therapy with immune stimulatory conjugates
|
|
WO2021113765A1
(en)
|
2019-12-06 |
2021-06-10 |
Precision Biosciences, Inc. |
Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome
|
|
JP7735291B2
(ja)
|
2020-02-21 |
2025-09-08 |
エーアールエス ファーマシューティカルズ、インコーポレイテッド |
ネクチン－４抗体コンジュゲートおよびその使用
|
|
JP2023518433A
(ja)
|
2020-03-20 |
2023-05-01 |
ギリアード サイエンシーズ， インコーポレイテッド |
４’－ｃ－置換－２－ハロ－２’－デオキシアデノシンヌクレオシドのプロドラッグ並びにその製造法及び使用法
|
|
JPWO2021206158A1
(enExample)
|
2020-04-10 |
2021-10-14 |
|
|
|
US20230226218A1
(en)
|
2020-05-11 |
2023-07-20 |
Erytech Pharma |
Red Cell Extracellular Vesicles (RCEVs) Containing Cargoes and Methods of Use and Production Thereof
|
|
CA3183993A1
(en)
|
2020-07-01 |
2022-01-06 |
Peter R. Baum |
Anti-asgr1 antibody conjugates and uses thereof
|
|
EP4192474B1
(en)
|
2020-08-07 |
2025-09-10 |
Gilead Sciences, Inc. |
Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use
|
|
US20230256109A1
(en)
|
2020-08-07 |
2023-08-17 |
Tambo, Inc. |
Trans-Cyclooctene Bioorthogonal Agents and Uses in Cancer and Immunotherapy
|
|
WO2022083584A1
(zh)
*
|
2020-10-20 |
2022-04-28 |
泰励生物科技（上海）有限公司 |
多功能环二核苷酸及其用途
|
|
IL302390A
(en)
|
2020-11-09 |
2023-06-01 |
Takeda Pharmaceuticals Co |
Drug antibody conjugates
|
|
TW202310852A
(zh)
|
2021-05-13 |
2023-03-16 |
美商基利科學股份有限公司 |
ＴＬＲ８調節化合物及抗ＨＢＶ ｓｉＲＮＡ療法之組合
|
|
TW202313094A
(zh)
|
2021-05-18 |
2023-04-01 |
美商基利科學股份有限公司 |
使用ＦＬＴ３Ｌ—Ｆｃ融合蛋白之方法
|
|
KR20240005901A
(ko)
|
2021-06-23 |
2024-01-12 |
길리애드 사이언시즈, 인코포레이티드 |
디아실글리세롤 키나제 조절 화합물
|
|
KR20240023629A
(ko)
|
2021-06-23 |
2024-02-22 |
길리애드 사이언시즈, 인코포레이티드 |
디아실글리세롤 키나제 조절 화합물
|
|
CR20230585A
(es)
|
2021-06-23 |
2024-02-19 |
Gilead Sciences Inc |
Compuestos Moduladores de Diacilglicerol Quinasa.
|
|
EP4359411A1
(en)
|
2021-06-23 |
2024-05-01 |
Gilead Sciences, Inc. |
Diacylglyercol kinase modulating compounds
|
|
WO2025007108A2
(en)
*
|
2023-06-30 |
2025-01-02 |
Immunogenesis, Inc. |
Compositions comprising sting agonists and methods of use for treating glioma
|
|
WO2025240242A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies with ribavirin
|
|
US20250345390A1
(en)
|
2024-05-13 |
2025-11-13 |
Gilead Sciences, Inc. |
Combination therapies
|
|
WO2025240246A1
(en)
|
2024-05-13 |
2025-11-20 |
Gilead Sciences, Inc. |
Combination therapies with ribavirin
|
|
US20250345389A1
(en)
|
2024-05-13 |
2025-11-13 |
Gilead Sciences, Inc. |
Combination therapies
|