UY37495A - Dinucleótidos cíclicos como agonistas de sting - Google Patents

Dinucleótidos cíclicos como agonistas de sting

Info

Publication number
UY37495A
UY37495A UY0001037495A UY37495A UY37495A UY 37495 A UY37495 A UY 37495A UY 0001037495 A UY0001037495 A UY 0001037495A UY 37495 A UY37495 A UY 37495A UY 37495 A UY37495 A UY 37495A
Authority
UY
Uruguay
Prior art keywords
sting agonists
cyclic dinucleotides
compounds
sting
dinucleotides
Prior art date
Application number
UY0001037495A
Other languages
English (en)
Inventor
Tianbao Lu
patrick edwards James
Gilles Bignan
Peter Connolly
Stuart Emanuel
Sylvie Laquerre
Mark Richter
Leonid Beigelman
Kumar Thatikonda Santhosh
Guangyi Wang
Minghong Zhong
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of UY37495A publication Critical patent/UY37495A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se describen compuestos, composiciones y métodos para tratar infecciones virales, enfermedades, síndromes o trastornos afectados por la modulación de STING. Tales compuestos se representan por la Fórmula (I) a continuación: en donde R1A, R1B, R1c, B1, R2A y R2B se definen en la presente descripción.
UY0001037495A 2016-11-25 2017-11-24 Dinucleótidos cíclicos como agonistas de sting UY37495A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662426350P 2016-11-25 2016-11-25
US201762502983P 2017-05-08 2017-05-08
US201762555232P 2017-09-07 2017-09-07

Publications (1)

Publication Number Publication Date
UY37495A true UY37495A (es) 2018-05-31

Family

ID=60937846

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001037495A UY37495A (es) 2016-11-25 2017-11-24 Dinucleótidos cíclicos como agonistas de sting

Country Status (13)

Country Link
US (2) US11472830B2 (es)
EP (1) EP3544989A1 (es)
JP (2) JP7316936B2 (es)
KR (1) KR20190085107A (es)
CN (1) CN110291096A (es)
AU (1) AU2017365158B2 (es)
BR (1) BR112019010606A2 (es)
CA (1) CA3044693A1 (es)
JO (1) JOP20170188A1 (es)
MX (1) MX2019006082A (es)
TW (1) TW201831192A (es)
UY (1) UY37495A (es)
WO (1) WO2018098203A1 (es)

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Also Published As

Publication number Publication date
BR112019010606A2 (pt) 2019-09-17
CA3044693A1 (en) 2018-05-31
TW201831192A (zh) 2018-09-01
JOP20170188A1 (ar) 2019-01-30
JP2022110131A (ja) 2022-07-28
EP3544989A1 (en) 2019-10-02
MX2019006082A (es) 2019-11-12
WO2018098203A1 (en) 2018-05-31
JP2020500862A (ja) 2020-01-16
US11472830B2 (en) 2022-10-18
US20230144627A1 (en) 2023-05-11
KR20190085107A (ko) 2019-07-17
US20180162899A1 (en) 2018-06-14
CN110291096A (zh) 2019-09-27
AU2017365158A1 (en) 2019-06-06
JP7316936B2 (ja) 2023-07-28
AU2017365158B2 (en) 2022-02-17

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