CN113365998A - 用于parp抑制剂的吲哚并七元酰肟类似物 - Google Patents
用于parp抑制剂的吲哚并七元酰肟类似物 Download PDFInfo
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- CN113365998A CN113365998A CN202080011966.9A CN202080011966A CN113365998A CN 113365998 A CN113365998 A CN 113365998A CN 202080011966 A CN202080011966 A CN 202080011966A CN 113365998 A CN113365998 A CN 113365998A
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
公开了一类用作PARP抑制剂的吲哚并七元酰肟化合物，具体公开了式(II)所示化合物及其药学上可接受的盐。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310525511.4A CN116804019A (zh) | 2019-02-02 | 2020-02-03 | 用于parp抑制剂的吲哚并七元酰肟类似物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019101079475 | 2019-02-02 | ||
| CN201910107947 | 2019-02-02 | ||
| CN2019101115768 | 2019-02-12 | ||
| CN201910111576 | 2019-02-12 | ||
| CN201910684020 | 2019-07-26 | ||
| CN2019106840208 | 2019-07-26 | ||
| PCT/CN2020/074220 WO2020156577A1 (zh) | 2019-02-02 | 2020-02-03 | 用于parp抑制剂的吲哚并七元酰肟类似物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310525511.4A Division CN116804019A (zh) | 2019-02-02 | 2020-02-03 | 用于parp抑制剂的吲哚并七元酰肟类似物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113365998A true CN113365998A (zh) | 2021-09-07 |
| CN113365998B CN113365998B (zh) | 2023-04-14 |
Family
ID=71840842
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310525511.4A Pending CN116804019A (zh) | 2019-02-02 | 2020-02-03 | 用于parp抑制剂的吲哚并七元酰肟类似物 |
| CN202080011966.9A Active CN113365998B (zh) | 2019-02-02 | 2020-02-03 | 用于parp抑制剂的吲哚并七元酰肟类似物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310525511.4A Pending CN116804019A (zh) | 2019-02-02 | 2020-02-03 | 用于parp抑制剂的吲哚并七元酰肟类似物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220144850A1 (zh) |
| EP (1) | EP3919495A4 (zh) |
| JP (1) | JP2022519268A (zh) |
| KR (1) | KR20210125024A (zh) |
| CN (2) | CN116804019A (zh) |
| AU (1) | AU2020214351A1 (zh) |
| BR (1) | BR112021015149A2 (zh) |
| CA (1) | CA3128435A1 (zh) |
| IL (1) | IL285223A (zh) |
| SG (1) | SG11202108399PA (zh) |
| WO (1) | WO2020156577A1 (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021318572A1 (en) * | 2020-07-31 | 2023-02-16 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Indolo heptamyl oxime analog crystal as PARP inhibitor and method for preparing same |
| CN113461597B (zh) * | 2021-08-02 | 2023-07-21 | 天津太平洋化学制药有限公司 | 一种尼拉帕尼中间体的制备方法 |
| WO2023226940A1 (zh) * | 2022-05-23 | 2023-11-30 | 正大天晴药业集团股份有限公司 | 吲哚并七元酰肟类似物的用途及其药物组合 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342161A (zh) * | 1999-01-11 | 2002-03-27 | 阿古龙制药公司 | 聚(adp－核糖)聚合酶的三环抑制剂 |
| CN1374961A (zh) * | 1999-09-28 | 2002-10-16 | 巴斯福股份公司 | 氮杂䓬吲哚衍生物,它们的制备和应用 |
| CN1870991A (zh) * | 2003-09-04 | 2006-11-29 | 安万特药物公司 | 作为多聚(adp－核糖)聚合酶(parp)抑制剂的被取代的吲哚类化合物 |
| CN103492376A (zh) * | 2011-04-21 | 2014-01-01 | 阿斯特克斯治疗有限公司 | 双环杂环化合物及其治疗用途 |
| WO2015166398A1 (en) * | 2014-04-30 | 2015-11-05 | Aurigene Discovery Technologies Limited | 3h-imidazo[4,5-b]pyridine derivatives as dihydroorotate dehydrogenase inhibitors |
-
2020
- 2020-02-03 WO PCT/CN2020/074220 patent/WO2020156577A1/zh active Application Filing
- 2020-02-03 SG SG11202108399PA patent/SG11202108399PA/en unknown
- 2020-02-03 EP EP20749766.0A patent/EP3919495A4/en active Pending
- 2020-02-03 US US17/427,269 patent/US20220144850A1/en active Pending
- 2020-02-03 KR KR1020217027553A patent/KR20210125024A/ko unknown
- 2020-02-03 CN CN202310525511.4A patent/CN116804019A/zh active Pending
- 2020-02-03 CN CN202080011966.9A patent/CN113365998B/zh active Active
- 2020-02-03 BR BR112021015149-4A patent/BR112021015149A2/pt unknown
- 2020-02-03 JP JP2021544943A patent/JP2022519268A/ja active Pending
- 2020-02-03 CA CA3128435A patent/CA3128435A1/en active Pending
- 2020-02-03 AU AU2020214351A patent/AU2020214351A1/en not_active Withdrawn
-
2021
- 2021-07-29 IL IL285223A patent/IL285223A/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1342161A (zh) * | 1999-01-11 | 2002-03-27 | 阿古龙制药公司 | 聚(adp－核糖)聚合酶的三环抑制剂 |
| CN1374961A (zh) * | 1999-09-28 | 2002-10-16 | 巴斯福股份公司 | 氮杂䓬吲哚衍生物,它们的制备和应用 |
| CN1870991A (zh) * | 2003-09-04 | 2006-11-29 | 安万特药物公司 | 作为多聚(adp－核糖)聚合酶(parp)抑制剂的被取代的吲哚类化合物 |
| CN103492376A (zh) * | 2011-04-21 | 2014-01-01 | 阿斯特克斯治疗有限公司 | 双环杂环化合物及其治疗用途 |
| WO2015166398A1 (en) * | 2014-04-30 | 2015-11-05 | Aurigene Discovery Technologies Limited | 3h-imidazo[4,5-b]pyridine derivatives as dihydroorotate dehydrogenase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3919495A1 (en) | 2021-12-08 |
| SG11202108399PA (en) | 2021-09-29 |
| IL285223A (en) | 2021-09-30 |
| KR20210125024A (ko) | 2021-10-15 |
| EP3919495A4 (en) | 2022-10-19 |
| AU2020214351A1 (en) | 2021-09-09 |
| WO2020156577A1 (zh) | 2020-08-06 |
| JP2022519268A (ja) | 2022-03-22 |
| CN116804019A (zh) | 2023-09-26 |
| US20220144850A1 (en) | 2022-05-12 |
| CN113365998B (zh) | 2023-04-14 |
| CA3128435A1 (en) | 2020-08-06 |
| BR112021015149A2 (pt) | 2021-09-28 |
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