CA3044693A1 - Cyclic dinucleotides as sting agonists - Google Patents
Cyclic dinucleotides as sting agonists Download PDFInfo
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- CA3044693A1 CA3044693A1 CA3044693A CA3044693A CA3044693A1 CA 3044693 A1 CA3044693 A1 CA 3044693A1 CA 3044693 A CA3044693 A CA 3044693A CA 3044693 A CA3044693 A CA 3044693A CA 3044693 A1 CA3044693 A1 CA 3044693A1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US201662426350P | 2016-11-25 | 2016-11-25 | |
| US62/426,350 | 2016-11-25 | ||
| US201762502983P | 2017-05-08 | 2017-05-08 | |
| US62/502,983 | 2017-05-08 | ||
| US201762555232P | 2017-09-07 | 2017-09-07 | |
| US62/555,232 | 2017-09-07 | ||
| PCT/US2017/062901 WO2018098203A1 (en) | 2016-11-25 | 2017-11-21 | Cyclic dinucleotides as sting agonists |
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| JP (2) | JP7316936B2 (enExample) |
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| HUE060396T2 (hu) | 2016-03-18 | 2023-02-28 | Immune Sensor Llc | Ciklikus DI-nukleotid vegyületek és azok felhasználási módszerei |
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| CN117402852A (zh) | 2016-10-14 | 2024-01-16 | 精密生物科学公司 | 对乙肝病毒基因组中的识别序列特异性的工程化大范围核酸酶 |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| US11021511B2 (en) * | 2017-01-27 | 2021-06-01 | Janssen Biotech, Inc. | Cyclic dinucleotides as sting agonists |
| JP7275031B2 (ja) * | 2017-01-27 | 2023-05-17 | ヤンセン バイオテツク，インコーポレーテツド | Ｓｔｉｎｇアゴニストとしての環状ジヌクレオチド |
| US20200055883A1 (en) | 2017-02-17 | 2020-02-20 | Eisai R&D Management Co., Ltd. | Cyclic di-nucleotides derivative for the treatment of cancer |
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| WO2019084060A1 (en) | 2017-10-24 | 2019-05-02 | Silverback Therapeutics, Inc. | CONJUGATES AND METHODS OF USE FOR THE SELECTIVE DELIVERY OF IMMUNOMODULATORY AGENTS |
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| US11766447B2 (en) | 2019-03-07 | 2023-09-26 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
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| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| KR20240023629A (ko) | 2021-06-23 | 2024-02-22 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
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| WO2025007108A2 (en) * | 2023-06-30 | 2025-01-02 | Immunogenesis, Inc. | Compositions comprising sting agonists and methods of use for treating glioma |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| US20250345390A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
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| US20060167241A1 (en) * | 2003-07-15 | 2006-07-27 | Mitsui Chemicals, Inc. | Method for synthesizing cyclic bisdinucleoside |
| RU2015129030A (ru) * | 2012-12-19 | 2017-01-26 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Фармацевтическое направленное воздействие на путь передачи сигнала циклических динуклеотидов млекопитающих |
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- 2017-11-21 MX MX2019006082A patent/MX2019006082A/es unknown
- 2017-11-21 AU AU2017365158A patent/AU2017365158B2/en not_active Ceased
- 2017-11-21 WO PCT/US2017/062901 patent/WO2018098203A1/en not_active Ceased
- 2017-11-22 US US15/820,592 patent/US11472830B2/en active Active
- 2017-11-23 TW TW106140679A patent/TW201831192A/zh unknown
- 2017-11-24 UY UY0001037495A patent/UY37495A/es unknown
-
2022
- 2022-05-20 JP JP2022082784A patent/JP2022110131A/ja active Pending
- 2022-10-17 US US17/967,443 patent/US20230144627A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW201831192A (zh) | 2018-09-01 |
| US20180162899A1 (en) | 2018-06-14 |
| UY37495A (es) | 2018-05-31 |
| CN110291096A (zh) | 2019-09-27 |
| AU2017365158B2 (en) | 2022-02-17 |
| US11472830B2 (en) | 2022-10-18 |
| JP2022110131A (ja) | 2022-07-28 |
| KR20190085107A (ko) | 2019-07-17 |
| JP7316936B2 (ja) | 2023-07-28 |
| US20230144627A1 (en) | 2023-05-11 |
| JOP20170188A1 (ar) | 2019-01-30 |
| BR112019010606A2 (pt) | 2019-09-17 |
| JP2020500862A (ja) | 2020-01-16 |
| WO2018098203A1 (en) | 2018-05-31 |
| EP3544989A1 (en) | 2019-10-02 |
| AU2017365158A1 (en) | 2019-06-06 |
| MX2019006082A (es) | 2019-11-12 |
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