KR20190085107A - Sting 작용제로서의 환상 다이뉴클레오티드 - Google Patents

Sting 작용제로서의 환상 다이뉴클레오티드 Download PDF

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Publication number
KR20190085107A
KR20190085107A KR1020197018101A KR20197018101A KR20190085107A KR 20190085107 A KR20190085107 A KR 20190085107A KR 1020197018101 A KR1020197018101 A KR 1020197018101A KR 20197018101 A KR20197018101 A KR 20197018101A KR 20190085107 A KR20190085107 A KR 20190085107A
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South Korea
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compound
mmol
cancer
mixture
added
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English (en)
Korean (ko)
Inventor
질스 씨. 빅난
피터 코놀리
제임스 패트릭 에드워드
스튜어트 엠마뉴엘
실비 래쿼리
티안바오 루
마크 릭터
레오니드 베이겔만
산토쉬 쿠마르 타티콘다
광위 왕
밍홍 종
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얀센 바이오테크 인코포레이티드
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Publication of KR20190085107A publication Critical patent/KR20190085107A/ko
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020197018101A 2016-11-25 2017-11-21 Sting 작용제로서의 환상 다이뉴클레오티드 Abandoned KR20190085107A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426350P 2016-11-25 2016-11-25
US62/426,350 2016-11-25
US201762502983P 2017-05-08 2017-05-08
US62/502,983 2017-05-08
US201762555232P 2017-09-07 2017-09-07
US62/555,232 2017-09-07
PCT/US2017/062901 WO2018098203A1 (en) 2016-11-25 2017-11-21 Cyclic dinucleotides as sting agonists

Publications (1)

Publication Number Publication Date
KR20190085107A true KR20190085107A (ko) 2019-07-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197018101A Abandoned KR20190085107A (ko) 2016-11-25 2017-11-21 Sting 작용제로서의 환상 다이뉴클레오티드

Country Status (13)

Country Link
US (2) US11472830B2 (enExample)
EP (1) EP3544989A1 (enExample)
JP (2) JP7316936B2 (enExample)
KR (1) KR20190085107A (enExample)
CN (1) CN110291096A (enExample)
AU (1) AU2017365158B2 (enExample)
BR (1) BR112019010606A2 (enExample)
CA (1) CA3044693A1 (enExample)
JO (1) JOP20170188A1 (enExample)
MX (1) MX2019006082A (enExample)
TW (1) TW201831192A (enExample)
UY (1) UY37495A (enExample)
WO (1) WO2018098203A1 (enExample)

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US20230144627A1 (en) 2023-05-11
WO2018098203A1 (en) 2018-05-31
AU2017365158B2 (en) 2022-02-17
EP3544989A1 (en) 2019-10-02
US11472830B2 (en) 2022-10-18
JP7316936B2 (ja) 2023-07-28
JP2020500862A (ja) 2020-01-16
CN110291096A (zh) 2019-09-27
JP2022110131A (ja) 2022-07-28
MX2019006082A (es) 2019-11-12
BR112019010606A2 (pt) 2019-09-17
UY37495A (es) 2018-05-31
AU2017365158A1 (en) 2019-06-06
CA3044693A1 (en) 2018-05-31
TW201831192A (zh) 2018-09-01
US20180162899A1 (en) 2018-06-14
JOP20170188A1 (ar) 2019-01-30

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