PE20210156A1 - Compuestos moduladores de sting y metodos de elaboracion y uso - Google Patents

Compuestos moduladores de sting y metodos de elaboracion y uso

Info

Publication number
PE20210156A1
PE20210156A1 PE2020000488A PE2020000488A PE20210156A1 PE 20210156 A1 PE20210156 A1 PE 20210156A1 PE 2020000488 A PE2020000488 A PE 2020000488A PE 2020000488 A PE2020000488 A PE 2020000488A PE 20210156 A1 PE20210156 A1 PE 20210156A1
Authority
PE
Peru
Prior art keywords
hydrogen
methods
fluoro
preparation
modulating compounds
Prior art date
Application number
PE2020000488A
Other languages
English (en)
Inventor
Stepan Vyskocil
Jeffrey Ciavarri
Courtney Cullis
Dylan Bradley England
Alexandra E Gould
Paul Greenspan
Yongbo Hu
Steven Langston
Gang Li
Hirotake Mizutani
Masanori Okaniwa
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of PE20210156A1 publication Critical patent/PE20210156A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion se refiere a compuestos que pueden ser utiles como moduladores/agonistas de STING (estimulador de los genes del interferon), metodos de sintesis y metodos de uso para la profilaxis o el tratamiento del cancer y otras enfermedades. Estos compuestos presentan la formula de la Figura 1 o una sal farmaceuticamente aceptable, en donde: X1 es SH u OH; X2 es SH u OH; Ya es O, S, o CH2; Yb es O, S, -NH, o NRa; R1 es hidrogeno, fluoro, OH, NH2, ORb, o NHRb; R2 es hidrogeno o fluoro; R3 es hidrogeno; R4 es hidrogeno, fluoro, OH, NH2, ORb, o NHRb; o R3 y R4 se toman juntos para formar CH2O; R5 es hidrogeno o fluoro; el anillo A y el anillo B son como se indica en el texto de la reivindicacion.
PE2020000488A 2017-11-10 2018-11-09 Compuestos moduladores de sting y metodos de elaboracion y uso PE20210156A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762584559P 2017-11-10 2017-11-10
US201862718613P 2018-08-14 2018-08-14
US201862754623P 2018-11-02 2018-11-02
PCT/IB2018/058846 WO2019092660A1 (en) 2017-11-10 2018-11-09 Sting modulator compounds, and methods of making and using

Publications (1)

Publication Number Publication Date
PE20210156A1 true PE20210156A1 (es) 2021-01-26

Family

ID=64604678

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000488A PE20210156A1 (es) 2017-11-10 2018-11-09 Compuestos moduladores de sting y metodos de elaboracion y uso

Country Status (17)

Country Link
US (1) US11542293B2 (es)
EP (1) EP3707151B1 (es)
JP (1) JP7195317B2 (es)
KR (1) KR20200098511A (es)
CN (1) CN111566119A (es)
AU (1) AU2018364708A1 (es)
BR (1) BR112020009126A2 (es)
CA (1) CA3082351A1 (es)
CL (1) CL2020001234A1 (es)
CO (1) CO2020006523A2 (es)
EC (1) ECSP20029790A (es)
IL (1) IL274570A (es)
MX (1) MX2020004858A (es)
PE (1) PE20210156A1 (es)
SG (1) SG11202004113VA (es)
TW (1) TW201922263A (es)
WO (1) WO2019092660A1 (es)

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EP3707151B1 (en) 2022-01-05
JP2021502383A (ja) 2021-01-28
IL274570A (en) 2020-06-30
CN111566119A (zh) 2020-08-21
ECSP20029790A (es) 2020-09-30
US20210171565A1 (en) 2021-06-10
AU2018364708A1 (en) 2020-05-21
JP7195317B2 (ja) 2022-12-23
US11542293B2 (en) 2023-01-03
KR20200098511A (ko) 2020-08-20
BR112020009126A2 (pt) 2020-10-20
TW201922263A (zh) 2019-06-16
CA3082351A1 (en) 2019-05-16
CO2020006523A2 (es) 2020-08-21
CL2020001234A1 (es) 2020-12-04
WO2019092660A1 (en) 2019-05-16
MX2020004858A (es) 2020-10-01
SG11202004113VA (en) 2020-06-29
EP3707151A1 (en) 2020-09-16

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