SG11202004113VA - Sting modulator compounds, and methods of making and using - Google Patents
Sting modulator compounds, and methods of making and usingInfo
- Publication number
- SG11202004113VA SG11202004113VA SG11202004113VA SG11202004113VA SG11202004113VA SG 11202004113V A SG11202004113V A SG 11202004113VA SG 11202004113V A SG11202004113V A SG 11202004113VA SG 11202004113V A SG11202004113V A SG 11202004113VA SG 11202004113V A SG11202004113V A SG 11202004113VA
- Authority
- SG
- Singapore
- Prior art keywords
- making
- methods
- modulator compounds
- sting modulator
- sting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762584559P | 2017-11-10 | 2017-11-10 | |
US201862718613P | 2018-08-14 | 2018-08-14 | |
US201862754623P | 2018-11-02 | 2018-11-02 | |
PCT/IB2018/058846 WO2019092660A1 (en) | 2017-11-10 | 2018-11-09 | Sting modulator compounds, and methods of making and using |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202004113VA true SG11202004113VA (en) | 2020-06-29 |
Family
ID=64604678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202004113VA SG11202004113VA (en) | 2017-11-10 | 2018-11-09 | Sting modulator compounds, and methods of making and using |
Country Status (17)
Country | Link |
---|---|
US (1) | US11542293B2 (es) |
EP (1) | EP3707151B1 (es) |
JP (1) | JP7195317B2 (es) |
KR (1) | KR20200098511A (es) |
CN (1) | CN111566119A (es) |
AU (1) | AU2018364708A1 (es) |
BR (1) | BR112020009126A2 (es) |
CA (1) | CA3082351A1 (es) |
CL (1) | CL2020001234A1 (es) |
CO (1) | CO2020006523A2 (es) |
EC (1) | ECSP20029790A (es) |
IL (1) | IL274570A (es) |
MX (1) | MX2020004858A (es) |
PE (1) | PE20210156A1 (es) |
SG (1) | SG11202004113VA (es) |
TW (1) | TW201922263A (es) |
WO (1) | WO2019092660A1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
CA3084582A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
US10519187B2 (en) * | 2018-02-13 | 2019-12-31 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
CA3093888A1 (en) | 2018-04-06 | 2019-10-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
AU2019371206A1 (en) | 2018-10-29 | 2021-05-27 | Venenum Biodesign, LLC | Novel sting agonists |
US11110106B2 (en) | 2018-10-29 | 2021-09-07 | Venenum Biodesign, LLC | Sting agonists for treating bladder cancer and solid tumors |
JP2022538690A (ja) | 2019-07-05 | 2022-09-05 | タンボ・インコーポレイテッド | トランス-シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
EP4134098A4 (en) | 2020-04-10 | 2024-05-15 | Ono Pharmaceutical Co | CANCER THERAPY METHODS |
EP4192506A1 (en) | 2020-08-07 | 2023-06-14 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
PE20231947A1 (es) | 2020-11-09 | 2023-12-05 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco |
US20230227480A1 (en) * | 2021-10-05 | 2023-07-20 | Sanegene Bio Usa Inc. | Polyhydroxylated cyclopentane derivatives and methods of use |
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WO2005030186A2 (en) | 2003-07-28 | 2005-04-07 | Univ Maryland | Method for attenuating virulence of microbial pathogens and for inhibiting microbial biofilm formation |
US7592326B2 (en) | 2004-03-15 | 2009-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
CA2560058C (en) | 2004-03-15 | 2011-10-18 | David K.R. Karaolis | A method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
US20090012038A1 (en) | 2004-10-18 | 2009-01-08 | Spormann Alfred M | Methods for microbial biofilm destruction and interference with microbial cellular physiology |
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BR112018068748B1 (pt) * | 2016-03-18 | 2024-01-16 | The Board Of Regents Of The University Of Texas System | Composto dinucleotídeo cíclico, composição farmacêutica, e, uso de um composto |
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AR113224A1 (es) | 2017-04-28 | 2020-02-19 | Novartis Ag | Conjugados de anticuerpo que comprenden un agonista de sting |
TWI808092B (zh) | 2017-08-30 | 2023-07-11 | 中國大陸商北京軒義醫藥科技有限公司 | 作為干擾素基因調節劑之刺激劑的環狀二核苷酸 |
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JP7316263B2 (ja) | 2017-08-31 | 2023-07-27 | ブリストル-マイヤーズ スクイブ カンパニー | 抗癌剤としての環状ジヌクレオチド |
MX2020002869A (es) | 2017-09-15 | 2020-07-24 | Aduro Biotech Inc | Compuestos de pirazolopirimidinona y usos de los mismos. |
EP4242212A3 (en) | 2018-03-23 | 2023-11-15 | Takeda Pharmaceutical Company Limited | Sting modulator compounds with sulfamate linkages, and methods of making and using |
EP3996718A1 (en) | 2019-07-09 | 2022-05-18 | Takeda Pharmaceutical Company Limited | Administration of sting agonist and checkpoint inhibitors |
-
2018
- 2018-11-09 CN CN201880073336.7A patent/CN111566119A/zh active Pending
- 2018-11-09 TW TW107139917A patent/TW201922263A/zh unknown
- 2018-11-09 KR KR1020207016227A patent/KR20200098511A/ko not_active Application Discontinuation
- 2018-11-09 PE PE2020000488A patent/PE20210156A1/es unknown
- 2018-11-09 JP JP2020526002A patent/JP7195317B2/ja active Active
- 2018-11-09 EP EP18814686.4A patent/EP3707151B1/en active Active
- 2018-11-09 AU AU2018364708A patent/AU2018364708A1/en not_active Abandoned
- 2018-11-09 CA CA3082351A patent/CA3082351A1/en active Pending
- 2018-11-09 US US16/762,710 patent/US11542293B2/en active Active
- 2018-11-09 BR BR112020009126-0A patent/BR112020009126A2/pt not_active Application Discontinuation
- 2018-11-09 SG SG11202004113VA patent/SG11202004113VA/en unknown
- 2018-11-09 WO PCT/IB2018/058846 patent/WO2019092660A1/en unknown
- 2018-11-09 MX MX2020004858A patent/MX2020004858A/es unknown
-
2020
- 2020-05-08 CL CL2020001234A patent/CL2020001234A1/es unknown
- 2020-05-10 IL IL274570A patent/IL274570A/en unknown
- 2020-05-28 CO CONC2020/0006523A patent/CO2020006523A2/es unknown
- 2020-06-08 EC ECSENADI202029790A patent/ECSP20029790A/es unknown
Also Published As
Publication number | Publication date |
---|---|
BR112020009126A2 (pt) | 2020-10-20 |
EP3707151A1 (en) | 2020-09-16 |
PE20210156A1 (es) | 2021-01-26 |
JP7195317B2 (ja) | 2022-12-23 |
CL2020001234A1 (es) | 2020-12-04 |
EP3707151B1 (en) | 2022-01-05 |
AU2018364708A1 (en) | 2020-05-21 |
MX2020004858A (es) | 2020-10-01 |
ECSP20029790A (es) | 2020-09-30 |
US11542293B2 (en) | 2023-01-03 |
WO2019092660A1 (en) | 2019-05-16 |
IL274570A (en) | 2020-06-30 |
CO2020006523A2 (es) | 2020-08-21 |
TW201922263A (zh) | 2019-06-16 |
CA3082351A1 (en) | 2019-05-16 |
KR20200098511A (ko) | 2020-08-20 |
CN111566119A (zh) | 2020-08-21 |
US20210171565A1 (en) | 2021-06-10 |
JP2021502383A (ja) | 2021-01-28 |
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