EP2347774B1
(en)
|
2005-12-13 |
2017-07-26 |
The President and Fellows of Harvard College |
Scaffolds for cell transplantation
|
JP6104806B2
(en)
|
2010-10-06 |
2017-03-29 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
Injectable pore-forming hydrogel for material-based cell therapy
|
EP2838515B1
(en)
|
2012-04-16 |
2019-11-20 |
President and Fellows of Harvard College |
Mesoporous silica compositions for modulating immune responses
|
IN2014MN02492A
(en)
|
2012-06-08 |
2015-07-17 |
Aduro Biotech |
|
EP2931738B1
(en)
|
2012-12-13 |
2019-02-06 |
Aduro Biotech, Inc. |
Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
|
SG11201508165VA
(en)
|
2013-04-29 |
2015-11-27 |
Sloan Kettering Inst Cancer |
Compositions and methods for altering second messenger signaling
|
WO2014179760A1
(en)
|
2013-05-03 |
2014-11-06 |
The Regents Of The University Of California |
Cyclic di-nucleotide induction of type i interferon
|
US9549944B2
(en)
|
2013-05-18 |
2017-01-24 |
Aduro Biotech, Inc. |
Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
|
MX354057B
(en)
|
2013-05-18 |
2018-02-09 |
The Regents Of The Univ Of California Star |
Compositions and methods for activating "stimulator of interferon gene"-dependent signalling.
|
WO2015017652A1
(en)
|
2013-07-31 |
2015-02-05 |
Memorial Sloan-Kettering Cancer Center |
Sting crystals and modulators
|
EP3049442A4
(en)
|
2013-09-26 |
2017-06-28 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
US20160287623A1
(en)
*
|
2013-11-19 |
2016-10-06 |
The University Of Chicago |
Use of sting agonist as cancer treatment
|
WO2015109391A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
JOP20200094A1
(en)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
Antibody molecules to pd-1 and uses thereof
|
JOP20200096A1
(en)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
Antibody molecules to tim-3 and uses thereof
|
JP7348708B2
(en)
|
2014-04-30 |
2023-09-21 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
Combination vaccine device and method for killing cancer cells
|
US10450341B2
(en)
|
2014-06-04 |
2019-10-22 |
Glaxosmithkline Intellectual Property Development Limited |
Cyclic di-nucleotides as modulators of STING
|
CN107206071A
(en)
|
2014-09-13 |
2017-09-26 |
诺华股份有限公司 |
The conjoint therapy of ALK inhibitor
|
MA41044A
(en)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT
|
ES2952717T3
(en)
|
2014-10-14 |
2023-11-03 |
Novartis Ag |
Antibody molecules against PD-L1 and uses thereof
|
US11058758B2
(en)
*
|
2014-11-20 |
2021-07-13 |
National Institutes Of Biomedical Innovation, Health And Nutrition |
TH1-inducing adjuvant comprising combination of different nucleic acid adjuvants, and use of same
|
EP3233882B1
(en)
|
2014-12-16 |
2019-10-30 |
Kayla Therapeutics |
Fluorinated cyclic dinucleotides for cytokine induction
|
GB201501462D0
(en)
*
|
2015-01-29 |
2015-03-18 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
EP3250250A4
(en)
*
|
2015-01-30 |
2019-05-22 |
President and Fellows of Harvard College |
Peritumoral and intratumoral materials for cancer therapy
|
US10130663B2
(en)
|
2015-02-11 |
2018-11-20 |
The John Hopkins University |
Bacteria over-expressing c-di-AMP and therapeutic methods
|
MY190404A
(en)
|
2015-03-10 |
2022-04-21 |
Aduro Biotech Inc |
Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
|
JP7094533B2
(en)
|
2015-04-10 |
2022-07-04 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
Immune cell capture device and its manufacture and use
|
DK3326641T3
(en)
|
2015-04-22 |
2019-09-30 |
Curevac Ag |
RNA-Containing Composition for the Treatment of Tumor Diseases
|
WO2017019897A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
CN114272371A
(en)
|
2015-07-29 |
2022-04-05 |
诺华股份有限公司 |
Combination therapy comprising anti-PD-1 antibody molecules
|
LT3317301T
(en)
|
2015-07-29 |
2021-07-26 |
Novartis Ag |
Combination therapies comprising antibody molecules to lag-3
|
CN106692967A
(en)
*
|
2015-08-12 |
2017-05-24 |
聊城市奥润生物医药科技有限公司 |
Application of cyclic dinucleotide cGAMP combined PD1 antibody (Nivolumab) in preparation of antitumor drugs
|
EP3334745B1
(en)
*
|
2015-08-13 |
2024-05-15 |
Merck Sharp & Dohme LLC |
Cyclic di-nucleotide compounds as sting agonists
|
US11453697B1
(en)
|
2015-08-13 |
2022-09-27 |
Merck Sharp & Dohme Llc |
Cyclic di-nucleotide compounds as sting agonists
|
CN106540255A
(en)
*
|
2015-09-18 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
Ring dinucleotide cGAMP combines application of the Avastin in antitumor
|
EP3368072A4
(en)
|
2015-10-28 |
2019-07-03 |
Aduro BioTech, Inc. |
Compositions and methods for activating "stimulator of interferon gene"-dependent signalling
|
MA44334A
(en)
|
2015-10-29 |
2018-09-05 |
Novartis Ag |
ANTIBODY CONJUGATES INCLUDING A TOLL-TYPE RECEPTOR AGONIST
|
CN107849084B
(en)
|
2015-12-03 |
2021-09-14 |
葛兰素史密斯克莱知识产权发展有限公司 |
Cyclic purine dinucleotides as STING modulators
|
KR20180107102A
(en)
|
2015-12-16 |
2018-10-01 |
그릿스톤 온콜로지, 인코포레이티드 |
Identification of new antigens, manufacture, and uses
|
US20180369268A1
(en)
*
|
2015-12-16 |
2018-12-27 |
Aduro Biotech, Inc. |
Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production
|
EP3389712B1
(en)
|
2015-12-17 |
2024-04-10 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
WO2017122130A1
(en)
|
2016-01-11 |
2017-07-20 |
Novartis Ag |
Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof
|
US10723756B2
(en)
|
2016-01-11 |
2020-07-28 |
Innate Tumor Immunity Inc. |
Cyclic dinucleotides for treating conditions associated with STING activity such as cancer
|
KR20180097751A
(en)
|
2016-01-11 |
2018-08-31 |
인네이트 튜머 이뮤니티, 인코포레이티드 |
RTI ID = 0.0 > STING < / RTI > activity,
|
CN106544319A
(en)
*
|
2016-01-24 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
A kind of compositionss for stimulating maturing dendritic cell and its method for stimulating maturing dendritic cell
|
JP7138864B2
(en)
|
2016-02-06 |
2022-09-20 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
Recapitulation of the hematopoietic niche to reconstitute immunity
|
KR102530488B1
(en)
*
|
2016-03-18 |
2023-05-08 |
이뮨 센서, 엘엘씨 |
Cyclic di-nucleotide compounds and methods of use
|
CN106540256A
(en)
*
|
2016-03-27 |
2017-03-29 |
聊城市奥润生物医药科技有限公司 |
Ring dinucleotide-application of the liposome conjugated monoclonal antibodies in antitumor
|
KR20180132783A
(en)
|
2016-04-07 |
2018-12-12 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
Heterocyclic amides useful as protein modulators
|
KR102527784B1
(en)
|
2016-04-07 |
2023-04-28 |
글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 |
Heterocyclic amides useful as protein modulators
|
WO2017184735A1
(en)
|
2016-04-19 |
2017-10-26 |
Ifm Therapeutics, Inc |
Nlrp3 modulators
|
BR112018071347A2
(en)
|
2016-04-19 |
2019-02-05 |
Innate Tumor Immunity Inc |
nlrp3 modulators
|
US10696985B1
(en)
|
2016-06-06 |
2020-06-30 |
Vanderbilt University |
Reversibly crosslinked endosomolytic polymer vesicles for cytosolic drug delivery
|
WO2018009466A1
(en)
|
2016-07-05 |
2018-01-11 |
Aduro Biotech, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
WO2018009652A1
(en)
*
|
2016-07-06 |
2018-01-11 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
MX2019000216A
(en)
*
|
2016-07-06 |
2019-11-12 |
Sperovie Biosciences Inc |
Compounds, compositions, and methods for the treatment of disease.
|
CN109789092A
(en)
|
2016-07-13 |
2019-05-21 |
哈佛学院院长等 |
Antigen presenting cell simulates bracket and its preparation and application
|
NL2017267B1
(en)
|
2016-07-29 |
2018-02-01 |
Aduro Biotech Holdings Europe B V |
Anti-pd-1 antibodies
|
NL2017270B1
(en)
|
2016-08-02 |
2018-02-09 |
Aduro Biotech Holdings Europe B V |
New anti-hCTLA-4 antibodies
|
WO2018029256A1
(en)
|
2016-08-09 |
2018-02-15 |
Aarhus Universitet |
Modulation of ifi16 and sting activity
|
EP3922279A1
(en)
|
2016-08-30 |
2021-12-15 |
Dana Farber Cancer Institute, Inc. |
Drug delivery compositions and uses thereof
|
WO2018053508A1
(en)
|
2016-09-19 |
2018-03-22 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for inducing an immune response
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
CR20190168A
(en)
|
2016-10-04 |
2019-05-17 |
Merck Sharp & Dohme |
BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
|
WO2018065360A1
(en)
|
2016-10-07 |
2018-04-12 |
Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb Gmbh |
Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways
|
AU2017341735B2
(en)
|
2016-10-11 |
2022-01-13 |
Helmholtz Center for Infection Research |
Hepatitis C virus immunogenic compositions comprising as an adjuvant a cyclic dinucleotide or an archaeosome and methods of use thereof
|
JOP20170188A1
(en)
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
Cyclic dinucleotides as sting agonists
|
JP2018090562A
(en)
*
|
2016-12-01 |
2018-06-14 |
武田薬品工業株式会社 |
Cyclic dinucleotide
|
JOP20170192A1
(en)
*
|
2016-12-01 |
2019-01-30 |
Takeda Pharmaceuticals Co |
Cyclic dinucleotide
|
WO2018118664A1
(en)
*
|
2016-12-20 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Combinations of pd-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment
|
RU2019122598A
(en)
*
|
2016-12-20 |
2021-01-22 |
Мерк Шарп И Доум Корп. |
CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT
|
AU2018212788A1
(en)
*
|
2017-01-27 |
2019-07-25 |
Janssen Biotech, Inc. |
Cyclic dinucleotides as STING agonists
|
ES2891326T3
(en)
|
2017-01-27 |
2022-01-27 |
Janssen Biotech Inc |
Cyclic dinucleotides as STING agonists
|
US20190351039A1
(en)
|
2017-02-01 |
2019-11-21 |
Modernatx, Inc. |
Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
|
US20200055883A1
(en)
|
2017-02-17 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Cyclic di-nucleotides derivative for the treatment of cancer
|
TWI674261B
(en)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 modulators
|
JP2018131427A
(en)
*
|
2017-02-17 |
2018-08-23 |
国立研究開発法人理化学研究所 |
Technology for controlling immune cells
|
US10933078B2
(en)
|
2017-02-21 |
2021-03-02 |
Board Of Regents, The University Of Texas System |
Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling
|
CN106727331B
(en)
*
|
2017-03-13 |
2022-02-01 |
杭州星鳌生物科技有限公司 |
Composition of immunoliposome-cycloddinucleotide, preparation method and application of immunoliposome-cycloducleotide in resisting tumor
|
CN110651036A
(en)
|
2017-03-20 |
2020-01-03 |
健诺西生物科学公司 |
Method of treatment
|
JOP20190218A1
(en)
|
2017-03-22 |
2019-09-22 |
Boehringer Ingelheim Int |
Modified cyclic dinucleotide compounds
|
AU2018252546A1
(en)
|
2017-04-13 |
2019-10-10 |
Sairopa B.V. |
Anti-SIRPα antibodies
|
EP3610022A1
(en)
|
2017-04-14 |
2020-02-19 |
Tollnine, Inc. |
Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
|
UY37695A
(en)
|
2017-04-28 |
2018-11-30 |
Novartis Ag |
BIS 2’-5’-RR- (3’F-A) (3’F-A) CYCLE DINUCLEOTIDE COMPOUND AND USES OF THE SAME
|
AR113224A1
(en)
|
2017-04-28 |
2020-02-19 |
Novartis Ag |
ANTIBODY CONJUGATES INCLUDING A STING AGONIST
|
AR111651A1
(en)
|
2017-04-28 |
2019-08-07 |
Novartis Ag |
CONJUGATES OF ANTIBODIES THAT INCLUDE TOLL TYPE RECEIVER AGONISTS AND COMBINATION THERAPIES
|
EP3621624B1
(en)
|
2017-05-12 |
2023-08-30 |
Merck Sharp & Dohme LLC |
Cyclic di-nucleotide compounds as sting agonists
|
WO2018210279A1
(en)
*
|
2017-05-16 |
2018-11-22 |
科济生物医药(上海)有限公司 |
Use of toll-like receptor agonist combined with immune effector cell
|
WO2018229715A1
(en)
|
2017-06-16 |
2018-12-20 |
Novartis Ag |
Compositions comprising anti-cd32b antibodies and methods of use thereof
|
CN110785187B
(en)
|
2017-06-22 |
2024-04-05 |
诺华股份有限公司 |
Antibody molecules against CD73 and uses thereof
|
WO2018237173A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
AU2018301681B2
(en)
|
2017-07-14 |
2022-07-14 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
EP3431484A1
(en)
*
|
2017-07-21 |
2019-01-23 |
Ludwig-Maximilians-Universität München |
A fluorescent cyclic dinucleotide and its use in methods of identifying substances having an ability to modulate the cgas/sting pathway
|
KR20200032180A
(en)
*
|
2017-07-28 |
2020-03-25 |
브리스톨-마이어스 스큅 컴퍼니 |
Cyclic dinucleotide as an anticancer agent
|
AU2018311965A1
(en)
|
2017-08-04 |
2020-02-13 |
Merck Sharp & Dohme Llc |
Combinations of PD-1 antagonists and benzo[b]thiophene sting antagonists for cancer treatment
|
US11285131B2
(en)
|
2017-08-04 |
2022-03-29 |
Merck Sharp & Dohme Corp. |
Benzo[b]thiophene STING agonists for cancer treatment
|
JP7311514B2
(en)
|
2017-08-30 |
2023-07-19 |
ベイジン シュエンイー ファーマサイエンシズ カンパニー, リミテッド |
Cyclic Dinucleotides as Interferon Gene Stimulator Modulators
|
EP3676279B1
(en)
*
|
2017-08-31 |
2021-12-01 |
Bristol-Myers Squibb Company |
Cyclic dinucleotides as anticancer agents
|
ES2945140T3
(en)
*
|
2017-08-31 |
2023-06-28 |
Bristol Myers Squibb Co |
Cyclic dinucleotides as anticancer agents
|
US11638716B2
(en)
|
2017-08-31 |
2023-05-02 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
AU2018330188C1
(en)
|
2017-09-08 |
2024-02-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
ENPP1 inhibitors and their use for the treatment of cancer
|
WO2019051489A1
(en)
|
2017-09-11 |
2019-03-14 |
Sperovie Biosciences, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
US11584774B2
(en)
|
2017-09-11 |
2023-02-21 |
F-star Therapeutics, Inc. |
Compounds, compositions, and methods for the treatment of disease
|
BR112020006780A2
(en)
|
2017-10-05 |
2020-10-06 |
Glaxosmithkline Intellectual Property Development Limited |
modulators of the interferon gene stimulator (sting)
|
EP3692033A1
(en)
|
2017-10-05 |
2020-08-12 |
GlaxoSmithKline Intellectual Property Development Limited |
Modulators of stimulator of interferon genes (sting) useful in treating hiv
|
CN111465989A
(en)
|
2017-10-10 |
2020-07-28 |
磨石肿瘤生物技术公司 |
Identification of neoantigens using hot spots
|
US20210040205A1
(en)
|
2017-10-25 |
2021-02-11 |
Novartis Ag |
Antibodies targeting cd32b and methods of use thereof
|
WO2019092660A1
(en)
|
2017-11-10 |
2019-05-16 |
Takeda Pharmaceutical Company Limited |
Sting modulator compounds, and methods of making and using
|
EA038805B1
(en)
*
|
2017-11-21 |
2021-10-21 |
Такеда Фармасьютикал Компани Лимитед |
Cyclic dinucleotides as sting (stimulator of interferon genes) agonists
|
EP3714275A4
(en)
|
2017-11-22 |
2021-10-27 |
Gritstone bio, Inc. |
Reducing junction epitope presentation for neoantigens
|
US11633473B2
(en)
|
2017-11-27 |
2023-04-25 |
Children's Medical Center Corporation |
Stimulator of Interferon Genes (STING) ligands and uses thereof
|
WO2019123340A1
(en)
|
2017-12-20 |
2019-06-27 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
WO2019125974A1
(en)
|
2017-12-20 |
2019-06-27 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
US11203610B2
(en)
|
2017-12-20 |
2021-12-21 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
|
WO2019136118A2
(en)
*
|
2018-01-04 |
2019-07-11 |
Academia Sinica |
Cell-associating immunologic adjuvants for treatment enhancement
|
JP2021512144A
(en)
*
|
2018-01-26 |
2021-05-13 |
ザ リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニアThe Regents of the University of California |
Intranasal delivery of tuberculosis vaccine containing cyclic dinucleotide adjuvant
|
CN111936156A
(en)
|
2018-02-02 |
2020-11-13 |
诺华股份有限公司 |
Combination of STING agonists and IL-15/IL15-Ra for the treatment of cancer
|
EP3749681A1
(en)
*
|
2018-02-06 |
2020-12-16 |
STipe Therapeutics ApS |
Modulation of p62 and sting activity
|
TW201946650A
(en)
|
2018-03-12 |
2019-12-16 |
美商詹森藥物公司 |
Vaccines against intra-abdominal infections
|
CN110272462B
(en)
*
|
2018-03-15 |
2023-03-10 |
南开大学 |
Process for preparing compounds
|
IL309265A
(en)
|
2018-03-23 |
2024-02-01 |
Codiak Biosciences Inc |
Extracellular vesicles comprising sting-agonist
|
CN111989338A
(en)
|
2018-03-27 |
2020-11-24 |
勃林格殷格翰国际有限公司 |
Modified cyclic dinucleotide compounds
|
CN111971291A
(en)
|
2018-03-27 |
2020-11-20 |
勃林格殷格翰国际有限公司 |
Cyclic dinucleotide compounds containing 2-aza-hypoxanthine or 6H-pyrazolo [1,5-D ] [1,2,4] triazin-7-one as STING agonists
|
BR112020020085A8
(en)
|
2018-04-03 |
2023-04-11 |
Merck Sharp & Dohme |
COMPOUND, PHARMACEUTICAL COMPOSITION, AND METHODS FOR INDUCING AN IMMUNE RESPONSE, FOR INDUCING STING-DEPENDENT TYPE I INTERFERON PRODUCTION, AND FOR TREAT A CELL PROLIFERATION DISORDER
|
US11702430B2
(en)
|
2018-04-03 |
2023-07-18 |
Merck Sharp & Dohme Llc |
Aza-benzothiophene compounds as STING agonists
|
WO2019195658A1
(en)
|
2018-04-05 |
2019-10-10 |
Dana-Farber Cancer Institute, Inc. |
Sting levels as a biomarker for cancer immunotherapy
|
TWI818007B
(en)
*
|
2018-04-06 |
2023-10-11 |
捷克科學院有機化學與生物化學研究所 |
2'3'-cyclic dinucleotides
|
CA3093888A1
(en)
|
2018-04-06 |
2019-10-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotides
|
TW202005654A
(en)
|
2018-04-06 |
2020-02-01 |
捷克科學院有機化學與生物化學研究所 |
2'2'-cyclic dinucleotides
|
CN112074516A
(en)
|
2018-04-25 |
2020-12-11 |
先天肿瘤免疫公司 |
NLRP3 modulators
|
CN108310378A
(en)
*
|
2018-04-28 |
2018-07-24 |
杭州星鳌生物科技有限公司 |
The preparation and its application of a kind of conjuncted antitumor original new drug of novel immune
|
TW202014193A
(en)
|
2018-05-03 |
2020-04-16 |
捷克科學院有機化學與生物化學研究所 |
2’3’-cyclic dinucleotides comprising carbocyclic nucleotide
|
GB201807924D0
(en)
|
2018-05-16 |
2018-06-27 |
Ctxt Pty Ltd |
Compounds
|
US20210214459A1
(en)
|
2018-05-31 |
2021-07-15 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
CN112512531B
(en)
|
2018-06-01 |
2024-04-09 |
卫材R&D管理有限公司 |
Methods for the treatment of bladder cancer
|
CA3110102A1
(en)
*
|
2018-06-20 |
2019-12-26 |
Yale University |
Rig-i agonists and treatments using same
|
JP7482122B2
(en)
|
2018-07-03 |
2024-05-13 |
アイエフエム デュー インコーポレイテッド |
Compounds and compositions for treating conditions associated with STING activity
|
TW202014408A
(en)
|
2018-07-03 |
2020-04-16 |
美商Ifm Due有限公司 |
Compounds and compositions for treating conditions associated with sting activity
|
KR20210030973A
(en)
*
|
2018-07-11 |
2021-03-18 |
액팀 테라퓨틱스, 인코퍼레이티드 |
Engineered immunostimulatory bacterial strains and uses thereof
|
WO2020037091A1
(en)
|
2018-08-16 |
2020-02-20 |
Innate Tumor Immunity, Inc. |
Imidazo[4,5-c]quinoline derived nlrp3-modulators
|
CA3099904A1
(en)
|
2018-08-16 |
2020-02-20 |
Eisai R&D Management Co., Ltd. |
Salts of compounds and crystals thereof
|
CN112996567A
(en)
|
2018-08-16 |
2021-06-18 |
先天肿瘤免疫公司 |
Imidazo [4,5-C ] quinoline-derived NLRP 3-modulators
|
MX2021001581A
(en)
|
2018-08-16 |
2021-04-19 |
Innate Tumor Immunity Inc |
SUBSTITUED 4-AMINO-<i>1H</i>-IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND IMPROVED METHODS FOR THEIR PREPARATION.
|
EP3841112A1
(en)
|
2018-08-24 |
2021-06-30 |
Codiak BioSciences, Inc. |
Extracellular vesicles targeting dendritic cells and uses thereof
|
CN112714649A
(en)
|
2018-09-06 |
2021-04-27 |
第一三共株式会社 |
Novel cyclic dinucleotide derivatives and antibody drug conjugates thereof
|
WO2020049534A1
(en)
|
2018-09-07 |
2020-03-12 |
Novartis Ag |
Sting agonist and combination therapy thereof for the treatment of cancer
|
CN112770771A
(en)
*
|
2018-09-17 |
2021-05-07 |
丘拉提斯股份有限公司 |
Immune adjuvant containing interferon gene stimulating protein agonist and vaccine composition
|
CA3113425A1
(en)
*
|
2018-09-21 |
2020-03-26 |
Shanghai De Novo Pharmatech Co., Ltd. |
Cyclic dinucleotide analogue, pharmaceutical composition thereof, and application
|
US11110106B2
(en)
|
2018-10-29 |
2021-09-07 |
Venenum Biodesign, LLC |
Sting agonists for treating bladder cancer and solid tumors
|
WO2020092379A1
(en)
|
2018-10-29 |
2020-05-07 |
Genocea Biosciences, Inc. |
Treatment methods
|
WO2020092127A1
(en)
|
2018-10-29 |
2020-05-07 |
Venenum Biodesign, LLC |
Novel sting agonists
|
WO2020092633A1
(en)
|
2018-10-30 |
2020-05-07 |
Vanderbilt University |
Graft copolymers, methods of forming graft copolymers, and methods of use thereof
|
CN113348181A
(en)
|
2018-10-31 |
2021-09-03 |
诺华股份有限公司 |
DC-SIGN antibody conjugates comprising a STING agonist
|
US11596692B1
(en)
|
2018-11-21 |
2023-03-07 |
Incyte Corporation |
PD-L1/STING conjugates and methods of use
|
WO2020117624A1
(en)
*
|
2018-12-07 |
2020-06-11 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
WO2020117623A1
(en)
*
|
2018-12-07 |
2020-06-11 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
EP3891164A4
(en)
*
|
2018-12-07 |
2022-08-24 |
Merck Sharp & Dohme Corp. |
Cyclic di-nucleotide compounds as sting agonists
|
JP7224688B2
(en)
*
|
2019-01-10 |
2023-02-20 |
南▲開▼大学 |
Cyclic dinucleotide prodrug molecules, methods of making and uses thereof
|
JP2022517112A
(en)
|
2019-01-14 |
2022-03-04 |
イネイト・テューマー・イミュニティ・インコーポレイテッド |
NLRP3 modulator
|
WO2020150113A1
(en)
|
2019-01-14 |
2020-07-23 |
Innate Tumor Immunity, Inc. |
Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer
|
ES2930151T3
(en)
|
2019-01-14 |
2022-12-07 |
Innate Tumor Immunity Inc |
NLRP3 heterocyclic modulators, for use in cancer treatment
|
WO2020150115A1
(en)
|
2019-01-14 |
2020-07-23 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
WO2020150417A2
(en)
|
2019-01-17 |
2020-07-23 |
Ifm Due, Inc. |
Compounds and compositions for treating conditions associated with sting activity
|
US10998091B2
(en)
|
2019-02-07 |
2021-05-04 |
Sandeep Patil |
Systems for monitoring compliance with a patch dosage regimen and methods of using the same
|
JP7350872B2
(en)
*
|
2019-03-07 |
2023-09-26 |
インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール,ヴイ.ヴイ.アイ. |
3'3'-cyclic dinucleotide and its prodrug
|
WO2020178769A1
(en)
|
2019-03-07 |
2020-09-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
2'3'-cyclic dinucleotides and prodrugs thereof
|
WO2020178768A1
(en)
|
2019-03-07 |
2020-09-10 |
Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. |
3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
|
CA3134216A1
(en)
|
2019-03-18 |
2020-09-24 |
Janssen Pharmaceuticals, Inc. |
Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof
|
EP4253554A3
(en)
|
2019-03-18 |
2024-01-17 |
Janssen Pharmaceuticals, Inc. |
Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof
|
EP3941937A2
(en)
|
2019-03-21 |
2022-01-26 |
Codiak BioSciences, Inc. |
Extracellular vesicles for vaccine delivery
|
CA3133314A1
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Extracellular vesicle conjugates and uses thereof
|
WO2020191369A1
(en)
|
2019-03-21 |
2020-09-24 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
EP3946324A4
(en)
|
2019-04-04 |
2022-11-30 |
Merck Sharp & Dohme LLC |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
TW202104214A
(en)
|
2019-04-05 |
2021-02-01 |
英商葛蘭素史密斯克藍智慧財產發展有限公司 |
Chemical compounds
|
EP3962493A2
(en)
|
2019-05-03 |
2022-03-09 |
Flagship Pioneering Innovations V, Inc. |
Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor
|
CA3137119A1
(en)
|
2019-05-09 |
2020-11-12 |
Aligos Therapeutics, Inc. |
Modified cyclic dinucleoside compounds as sting modulators
|
MX2021013657A
(en)
|
2019-05-10 |
2022-02-21 |
Takeda Pharmaceuticals Co |
Antibody drug conjugates.
|
JP2022535743A
(en)
|
2019-05-29 |
2022-08-10 |
アイエフエム デュー インコーポレイテッド |
Compounds and compositions for treating conditions associated with STING activity
|
WO2021003445A1
(en)
|
2019-07-03 |
2021-01-07 |
Codiak Biosciences, Inc. |
Extracellular vesicles targeting t cells and uses thereof
|
EP3993834A1
(en)
|
2019-07-05 |
2022-05-11 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
GB201910304D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
GB201910305D0
(en)
|
2019-07-18 |
2019-09-04 |
Ctxt Pty Ltd |
Compounds
|
CN114585623A
(en)
|
2019-08-02 |
2022-06-03 |
梅尔莎纳医疗公司 |
Bis [ N- ((5-carbamoyl) -1H-benzo [ d ] imidazol-2-yl) pyrazole-5-carboxamide ] derivatives and related compounds as STING (interferon gene stimulator) agonists for the treatment of cancer
|
US20210047425A1
(en)
|
2019-08-12 |
2021-02-18 |
Purinomia Biotech, Inc. |
Methods and compositions for promoting and potentiating t-cell mediated immune responses through adcc targeting of cd39 expressing cells
|
WO2021041532A1
(en)
|
2019-08-26 |
2021-03-04 |
Dana-Farber Cancer Institute, Inc. |
Use of heparin to promote type 1 interferon signaling
|
EP3785719A1
(en)
*
|
2019-08-28 |
2021-03-03 |
Helmholtz-Zentrum für Infektionsforschung GmbH |
New use of cyclic dinucleotides
|
US20230103726A1
(en)
|
2019-09-25 |
2023-04-06 |
Codiak Biosciences, Inc. |
Methods of producing extracellular vesicles
|
MX2022003570A
(en)
|
2019-09-25 |
2022-07-11 |
Codiak Biosciences Inc |
Extracellular vesicle compositions.
|
EP4034247A1
(en)
|
2019-09-25 |
2022-08-03 |
Codiak BioSciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
AU2020351729A1
(en)
|
2019-09-25 |
2022-04-21 |
Lonza Sales Ag |
STING agonist comprising exosomes combined with IL-12 displaying exosomes for treating a tumour
|
KR20220107166A
(en)
|
2019-10-02 |
2022-08-02 |
얀센 백신스 앤드 프리벤션 비.브이. |
Staphylococcus Peptides and Methods of Use
|
WO2021074695A1
(en)
|
2019-10-16 |
2021-04-22 |
Avacta Life Sciences Limited |
PD-L1 INHIBITOR - TGFβ INHIBITOR BISPECIFIC DRUG MOIETIES.
|
EP4069683A1
(en)
|
2019-12-06 |
2022-10-12 |
Mersana Therapeutics, Inc. |
Dimeric compounds as sting agonists
|
EP4087842A1
(en)
|
2020-01-10 |
2022-11-16 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
JP7485771B2
(en)
|
2020-01-16 |
2024-05-16 |
ヤンセン ファーマシューティカルズ,インコーポレーテッド |
FimH mutants, compositions thereof, and uses thereof
|
CA3169523A1
(en)
|
2020-02-28 |
2021-09-02 |
Jaume Pons |
Transglutaminase-mediated conjugation
|
MX2022009597A
(en)
|
2020-03-06 |
2022-09-02 |
Daiichi Sankyo Co Ltd |
Antibody-drug conjugate including novel cyclic dinucleotide derivative.
|
US20230114434A1
(en)
|
2020-03-13 |
2023-04-13 |
Codiak Biosciences, Inc. |
Extracellular vesicles for treating neurological disorders
|
JP2023518414A
(en)
|
2020-03-20 |
2023-05-01 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
Extracellular vesicles for therapy
|
WO2021206158A1
(en)
|
2020-04-10 |
2021-10-14 |
小野薬品工業株式会社 |
Method of cancer therapy
|
US11857618B2
(en)
|
2020-04-17 |
2024-01-02 |
Emory University |
Boosting immunogenicity of vaccines using saponins and agonists of the intracellular stimulator of interferon genes pathway
|
JP2023526250A
(en)
|
2020-05-13 |
2023-06-21 |
マサチューセッツ インスティテュート オブ テクノロジー |
Compositions of polymer microdevices and their use in cancer immunotherapy
|
WO2021237100A1
(en)
|
2020-05-21 |
2021-11-25 |
Codiak Biosciences, Inc. |
Methods of targeting extracellular vesicles to lung
|
EP4192506A1
(en)
|
2020-08-07 |
2023-06-14 |
Tambo, Inc. |
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy
|
KR20230061360A
(en)
|
2020-09-02 |
2023-05-08 |
다이이찌 산쿄 가부시키가이샤 |
Novel endo-β-N-acetylglucosaminidase
|
IL308201A
(en)
|
2020-09-17 |
2024-01-01 |
Janssen Pharmaceuticals Inc |
Multivalent vaccine compositions and uses thereof
|
CA3192470A1
(en)
|
2020-09-23 |
2022-03-31 |
Tim SOOS |
Methods of producing extracellular vesicles
|
US20230366794A1
(en)
|
2020-09-23 |
2023-11-16 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
WO2022066928A2
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Process for preparing extracellular vesicles
|
WO2022066883A1
(en)
|
2020-09-23 |
2022-03-31 |
Codiak Biosciences, Inc. |
Extracellular vesicles comprising kras antigens and uses thereof
|
EP4228681A1
(en)
|
2020-10-14 |
2023-08-23 |
Boehringer Ingelheim International GmbH |
Combination of a sting agonist and a complex comprising a cell penetrating peptide, a cargo and a tlr peptide agonist
|
EP3984535A1
(en)
|
2020-10-16 |
2022-04-20 |
Albert-Ludwigs-Universität Freiburg |
Nlrp3 activators for use in the treatment of infectious diseases or cancer by activating nlrp3 inflammasome
|
US20240059729A1
(en)
|
2020-10-20 |
2024-02-22 |
Tyligand Bioscience (Shanghai) Limited |
Multifunctional cyclic dinucleotide and use thereof
|
JP2023548310A
(en)
|
2020-10-30 |
2023-11-16 |
アバクタ・ライフ・サイエンシーズ・リミテッド |
FAP activated serum half-life extended therapeutic conjugate
|
MX2023005381A
(en)
|
2020-11-09 |
2023-05-23 |
Takeda Pharmaceuticals Co |
Antibody drug conjugates.
|
JP2023554396A
(en)
|
2020-12-17 |
2023-12-27 |
トラスティーズ オブ タフツ カレッジ |
FAP-activated radiotheranostics and related uses
|
KR20230125842A
(en)
|
2021-01-12 |
2023-08-29 |
얀센 파마슈티칼즈, 인코포레이티드 |
FimH mutants, compositions comprising them and uses thereof
|
TW202241454A
(en)
|
2021-02-01 |
2022-11-01 |
日商第一三共股份有限公司 |
Novel method for producing antibody-immunostimulator conjugate
|
KR20230164108A
(en)
|
2021-04-01 |
2023-12-01 |
얀센 파마슈티칼즈, 인코포레이티드 |
Production of E. coli O18 bioconjugate
|
EP4326769A1
(en)
|
2021-04-20 |
2024-02-28 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
EP4326321A1
(en)
|
2021-04-20 |
2024-02-28 |
Institut Curie |
Compositions and methods for use in immunotherapy
|
WO2022234003A1
(en)
|
2021-05-07 |
2022-11-10 |
Avacta Life Sciences Limited |
Cd33 binding polypeptides with stefin a protein
|
US20220313724A1
(en)
*
|
2021-05-17 |
2022-10-06 |
Highlight Therapeutics, S.L. |
Compositions for intratumoral administration and related methods
|
WO2023056468A1
(en)
|
2021-09-30 |
2023-04-06 |
Codiak Biosciences, Inc. |
Extracellular vesicle comprising cholesterol tagged sting-agonist
|
TW202334196A
(en)
|
2021-10-07 |
2023-09-01 |
英商阿法克塔生命科學有限公司 |
Pd-l1 binding polypeptides
|
CN114106140A
(en)
*
|
2021-11-23 |
2022-03-01 |
哈尔滨医科大学附属肿瘤医院 |
Expression specific STING isomer, cell line, preparation method and application
|
WO2023154799A1
(en)
|
2022-02-14 |
2023-08-17 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Combination immunotherapy for treating cancer
|
WO2023218243A1
(en)
|
2022-05-12 |
2023-11-16 |
Avacta Life Sciences Limited |
Lag-3/pd-l1 binding fusion proteins
|