JP7316936B2 - Stingアゴニストとしての環状ジヌクレオチド - Google Patents

Stingアゴニストとしての環状ジヌクレオチド Download PDF

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JP7316936B2
JP7316936B2 JP2019528031A JP2019528031A JP7316936B2 JP 7316936 B2 JP7316936 B2 JP 7316936B2 JP 2019528031 A JP2019528031 A JP 2019528031A JP 2019528031 A JP2019528031 A JP 2019528031A JP 7316936 B2 JP7316936 B2 JP 7316936B2
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JP2020500862A5 (enExample
JP2020500862A (ja
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シー. ビグナン,ギルス
コノリー,ピーター
パトリック エドワーズ,ジェームス
エマニュエル,スチュアート
ラケール,シルヴィー
ルー,ティエンバオ
リヒター,マーク
ベイゲルマン,レオニード
クマール タティコンダ,サンソッシュ
ワン,グアンイ
ゾン,ミンホン
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ヤンセン バイオテツク,インコーポレーテツド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2019528031A 2016-11-25 2017-11-21 Stingアゴニストとしての環状ジヌクレオチド Active JP7316936B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022082784A JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201662426350P 2016-11-25 2016-11-25
US62/426,350 2016-11-25
US201762502983P 2017-05-08 2017-05-08
US62/502,983 2017-05-08
US201762555232P 2017-09-07 2017-09-07
US62/555,232 2017-09-07
PCT/US2017/062901 WO2018098203A1 (en) 2016-11-25 2017-11-21 Cyclic dinucleotides as sting agonists

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JP2022082784A Division JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

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JP2020500862A JP2020500862A (ja) 2020-01-16
JP2020500862A5 JP2020500862A5 (enExample) 2021-01-07
JP7316936B2 true JP7316936B2 (ja) 2023-07-28

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JP2022082784A Pending JP2022110131A (ja) 2016-11-25 2022-05-20 Stingアゴニストとしての環状ジヌクレオチド

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US (2) US11472830B2 (enExample)
EP (1) EP3544989A1 (enExample)
JP (2) JP7316936B2 (enExample)
KR (1) KR20190085107A (enExample)
CN (1) CN110291096A (enExample)
AU (1) AU2017365158B2 (enExample)
BR (1) BR112019010606A2 (enExample)
CA (1) CA3044693A1 (enExample)
JO (1) JOP20170188A1 (enExample)
MX (1) MX2019006082A (enExample)
TW (1) TW201831192A (enExample)
UY (1) UY37495A (enExample)
WO (1) WO2018098203A1 (enExample)

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Nat. Chem. Biol., 2014年,Vol.10, No.12,p.1043-1048

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AU2017365158B2 (en) 2022-02-17
US11472830B2 (en) 2022-10-18
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US20230144627A1 (en) 2023-05-11
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