JP2009524691A5 - - Google Patents
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- Publication number
- JP2009524691A5 JP2009524691A5 JP2008552564A JP2008552564A JP2009524691A5 JP 2009524691 A5 JP2009524691 A5 JP 2009524691A5 JP 2008552564 A JP2008552564 A JP 2008552564A JP 2008552564 A JP2008552564 A JP 2008552564A JP 2009524691 A5 JP2009524691 A5 JP 2009524691A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- heterocyclyl
- cycloalkyl
- heterocyclylalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76305106P | 2006-01-27 | 2006-01-27 | |
| US11/625,889 US7615556B2 (en) | 2006-01-27 | 2007-01-23 | Piperazinyl derivatives as modulators of chemokine receptor activity |
| PCT/US2007/061014 WO2007087585A1 (en) | 2006-01-27 | 2007-01-25 | Piperazinyl derivatives as modulators of chemokine receptor activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009524691A JP2009524691A (ja) | 2009-07-02 |
| JP2009524691A5 true JP2009524691A5 (enExample) | 2010-03-11 |
Family
ID=37969746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552564A Withdrawn JP2009524691A (ja) | 2006-01-27 | 2007-01-25 | ケモカインレセプター活性のモジュレータとしてのピペラジニル誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7615556B2 (enExample) |
| EP (1) | EP1973880B1 (enExample) |
| JP (1) | JP2009524691A (enExample) |
| KR (1) | KR20080090538A (enExample) |
| AU (1) | AU2007208031A1 (enExample) |
| NO (1) | NO20083358L (enExample) |
| WO (1) | WO2007087585A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8067237B2 (en) | 2005-12-13 | 2011-11-29 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
| US7601844B2 (en) * | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
| CN101808991A (zh) * | 2007-07-24 | 2010-08-18 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶基衍生物 |
| JP5292400B2 (ja) * | 2007-07-24 | 2013-09-18 | ブリストル−マイヤーズ スクイブ カンパニー | ケモカイン受容体活性のモジュレーターとしてのピペリジン誘導体 |
| EP2254602B1 (en) | 2008-02-13 | 2018-11-21 | President and Fellows of Harvard College | Continuous cell programming devices |
| US8492550B2 (en) | 2008-03-07 | 2013-07-23 | Bristol-Myers Squibb Company | Hydroxyalkanyl amides as modulators of chemokine receptor activity |
| KR101672884B1 (ko) * | 2008-03-19 | 2016-11-04 | 오림드 파마, 인코포레이티드 | 중추신경계 질환 및 질병 치료에 유효한 신규 화합물 |
| US20210130285A1 (en) | 2008-03-19 | 2021-05-06 | Aurimmed Pharma, Inc. | Novel compounds advantageous in the treatment of central nervous system diseases and disorders |
| US10793515B2 (en) | 2008-03-19 | 2020-10-06 | Aurimmed Pharma, Inc. | Compounds advantageous in the treatment of central nervous system diseases and disorders |
| TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
| WO2011014871A1 (en) * | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
| US8642622B2 (en) | 2010-06-16 | 2014-02-04 | Bristol-Myers Squibb Company | Piperidinyl compound as a modulator of chemokine receptor activity |
| CA2813751C (en) | 2010-10-06 | 2019-11-12 | President And Fellows Of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| KR20130064689A (ko) * | 2011-12-08 | 2013-06-18 | 삼성전자주식회사 | 광굴절 복합체, 상기 광굴절 복합체를 포함하는 공간광 변조기 및 홀로그램 디스플레이 장치 |
| FR2985256B1 (fr) * | 2011-12-30 | 2016-03-04 | Pitty Marc Henry | Derives piperazinyles pour le traitement de cancers |
| CN107137357B (zh) | 2012-04-16 | 2020-11-24 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| US8716235B2 (en) | 2012-04-18 | 2014-05-06 | Albert Einstein College Of Medicine Of Yeshiva University | Method for inhibiting metastasis by using anti-CCL3 antibodies |
| WO2015046595A1 (ja) * | 2013-09-30 | 2015-04-02 | 国立大学法人東京大学 | アディポネクチン受容体活性化化合物 |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| WO2016123573A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
| EP3280464A4 (en) | 2015-04-10 | 2018-09-26 | President and Fellows of Harvard College | Immune cell trapping devices and methods for making and using the same |
| CN115487351A (zh) | 2016-02-06 | 2022-12-20 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
| DK3484448T3 (da) | 2016-07-13 | 2025-06-10 | Harvard College | Antigenpræsenterende cellemimetiske stilladser og fremgangsmåder til fremstilling og brug af disse |
| JP7274214B2 (ja) | 2016-08-02 | 2023-05-16 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫応答を調節するための生体材料 |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9104656D0 (en) | 1991-03-05 | 1991-04-17 | Zambeletti Spa L | Pharmaceuticals |
| DE4243858A1 (de) | 1992-12-23 | 1994-06-30 | Thomae Gmbh Dr K | Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US5459151A (en) | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
| US5777112A (en) | 1994-06-13 | 1998-07-07 | Merck & Co., Inc | Piperazine compounds promote release of growth hormone |
| WO1997003060A1 (en) * | 1995-07-13 | 1997-01-30 | Senju Pharmaceutical Co., Ltd. | Piperazine derivatives and use of the same |
| FR2740134B1 (fr) * | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
| DE69628050T2 (de) * | 1995-10-25 | 2004-04-01 | Senju Pharmaceutical Co., Ltd. | Angiogenese Hemmer |
| WO1997038665A2 (en) | 1996-04-03 | 1997-10-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU4722197A (en) | 1996-10-22 | 1998-05-15 | Daiichi Pharmaceutical Co., Ltd. | Novel remedies for infectious diseases |
| US5847148A (en) | 1997-04-10 | 1998-12-08 | Pharmacia & Upjohn Company | Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation |
| ZA987385B (en) | 1997-08-19 | 2000-04-18 | Lilly Co Eli | Growth hormone secretagogues. |
| ZA987383B (en) | 1997-08-19 | 2000-02-17 | Lilly Co Eli | Treatment of congestive heart failure with growth hormone secretagogues. |
| DE69819349T2 (de) * | 1997-08-29 | 2004-07-22 | Tularik Ltd. | 1-amino-7-isochinolin-derivate als serin protease inhibitoren |
| CN1305473A (zh) * | 1998-04-16 | 2001-07-25 | 得克萨斯生物技术公司 | 抑制整联蛋白与其受体结合的n,n－二取代的酰胺 |
| US6391865B1 (en) | 1999-05-04 | 2002-05-21 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
| JP2003505435A (ja) | 1999-06-04 | 2003-02-12 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン−４受容体ゴニストとしての置換ピペリジン |
| DE10041402A1 (de) * | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| DE19939910A1 (de) | 1999-08-23 | 2001-03-01 | Morphochem Ag | Neue Verbindungen, die Tryptase-Aktivität hemmen |
| AUPQ386899A0 (en) * | 1999-11-04 | 1999-11-25 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds |
| JP2001354657A (ja) | 2000-06-09 | 2001-12-25 | Sds Biotech:Kk | 置換ピペラジン誘導体及び農園芸用殺菌剤 |
| DE10056312A1 (de) * | 2000-11-14 | 2002-05-16 | Bayer Ag | Substituierte Amidoalkyluracile und ihre Verwendung |
| US6861424B2 (en) * | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| ATE411021T1 (de) | 2001-07-18 | 2008-10-15 | Merck & Co Inc | Überbrückte piperidinderivate als melanocortin- rezeptor-agonisten |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| WO2003022835A1 (en) | 2001-09-06 | 2003-03-20 | Schering Corporation | 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases |
| MXPA04005158A (es) * | 2001-11-30 | 2004-08-11 | Schering Corp | Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol. |
| ATE458483T1 (de) | 2001-12-20 | 2010-03-15 | Osi Pharm Inc | Selektive pyrimidin-a2b-antagonistenverbindungen, ihre synthese und verwendung |
| DE60236458D1 (de) | 2001-12-20 | 2010-07-01 | Osi Pharm Inc | Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung |
| US7041681B2 (en) | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
| US20050256130A1 (en) | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| GB0224917D0 (en) | 2002-10-25 | 2002-12-04 | Novartis Ag | Organic compounds |
| CA2512886A1 (en) | 2003-02-28 | 2004-09-10 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
| WO2004113323A1 (en) | 2003-06-13 | 2004-12-29 | Schering Aktiengesellschaft | Quinolyl amide derivatives as ccr-5 antagonists |
| GB0315203D0 (en) | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
| CN1942186B (zh) * | 2004-03-09 | 2010-10-06 | 国家卫生研究院 | 吡咯烷化合物 |
| GB0412468D0 (en) | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
| US7723360B2 (en) | 2004-08-06 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Alkyl-and piperidine-substituted benzimidazole derivatives |
-
2007
- 2007-01-23 US US11/625,889 patent/US7615556B2/en active Active
- 2007-01-25 JP JP2008552564A patent/JP2009524691A/ja not_active Withdrawn
- 2007-01-25 AU AU2007208031A patent/AU2007208031A1/en not_active Abandoned
- 2007-01-25 KR KR1020087020838A patent/KR20080090538A/ko not_active Withdrawn
- 2007-01-25 EP EP07710312.5A patent/EP1973880B1/en active Active
- 2007-01-25 WO PCT/US2007/061014 patent/WO2007087585A1/en not_active Ceased
-
2008
- 2008-07-31 NO NO20083358A patent/NO20083358L/no not_active Application Discontinuation
-
2009
- 2009-08-05 US US12/536,070 patent/US8609664B2/en active Active - Reinstated