JP2019529490A5 - - Google Patents

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JP2019529490A5
JP2019529490A5 JP2019517075A JP2019517075A JP2019529490A5 JP 2019529490 A5 JP2019529490 A5 JP 2019529490A5 JP 2019517075 A JP2019517075 A JP 2019517075A JP 2019517075 A JP2019517075 A JP 2019517075A JP 2019529490 A5 JP2019529490 A5 JP 2019529490A5
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compound
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formula
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salt
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JP2019529490A (ja
JP7061115B2 (ja
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JP2019517075A 2016-09-30 2017-09-29 嚢胞性線維症膜コンダクタンス制御因子の調節因子、医薬組成物、処置の方法、及び当該調節因子を作製するためのプロセス Active JP7061115B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662402838P 2016-09-30 2016-09-30
US62/402,838 2016-09-30
US201662410353P 2016-10-19 2016-10-19
US62/410,353 2016-10-19
US201662415409P 2016-10-31 2016-10-31
US62/415,409 2016-10-31
US201662419935P 2016-11-09 2016-11-09
US62/419,935 2016-11-09
PCT/US2017/054611 WO2018064632A1 (en) 2016-09-30 2017-09-29 Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator

Publications (3)

Publication Number Publication Date
JP2019529490A JP2019529490A (ja) 2019-10-17
JP2019529490A5 true JP2019529490A5 (enExample) 2020-11-12
JP7061115B2 JP7061115B2 (ja) 2022-04-27

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JP2019517075A Active JP7061115B2 (ja) 2016-09-30 2017-09-29 嚢胞性線維症膜コンダクタンス制御因子の調節因子、医薬組成物、処置の方法、及び当該調節因子を作製するためのプロセス

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US (3) US10570115B2 (enExample)
EP (1) EP3519401B1 (enExample)
JP (1) JP7061115B2 (enExample)
KR (1) KR102531491B1 (enExample)
CN (1) CN109803962B (enExample)
AU (1) AU2017336156B2 (enExample)
BR (1) BR112019006213A2 (enExample)
CA (1) CA3037986C (enExample)
CL (1) CL2019000827A1 (enExample)
CO (1) CO2019004065A2 (enExample)
CY (1) CY1124862T1 (enExample)
DK (1) DK3519401T3 (enExample)
DO (1) DOP2019000081A (enExample)
EC (1) ECSP19028690A (enExample)
ES (1) ES2900263T3 (enExample)
GE (1) GEP20217329B (enExample)
HR (1) HRP20211683T1 (enExample)
HU (1) HUE056716T2 (enExample)
IL (1) IL265627B (enExample)
JO (1) JOP20190042B1 (enExample)
LT (1) LT3519401T (enExample)
MA (1) MA46357B1 (enExample)
MD (1) MD3519401T2 (enExample)
MX (1) MX387060B (enExample)
NZ (1) NZ752486A (enExample)
PE (1) PE20191147A1 (enExample)
PL (1) PL3519401T3 (enExample)
PT (1) PT3519401T (enExample)
RS (1) RS62670B1 (enExample)
SA (1) SA519401446B1 (enExample)
SG (1) SG10201913595YA (enExample)
SI (1) SI3519401T1 (enExample)
SM (1) SMT202100646T1 (enExample)
TN (1) TN2019000079A1 (enExample)
TW (1) TWI766886B (enExample)
UA (1) UA124708C2 (enExample)
UY (1) UY37428A (enExample)
WO (1) WO2018064632A1 (enExample)
ZA (1) ZA201902124B (enExample)

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EP3774825A1 (en) 2018-04-13 2021-02-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
BR112021009145A2 (pt) 2018-11-14 2021-08-10 Vertex Pharmaceuticals Incorporated métodos de tratamento para fibrose cística
AR118555A1 (es) * 2019-04-03 2021-10-20 Vertex Pharma Agentes moduladores del regulador de la conductancia transmembrana de la fibrosis quística
WO2020214921A1 (en) 2019-04-17 2020-10-22 Vertex Pharmaceuticals Incorporated Solid forms of modulators of cftr
TWI867024B (zh) * 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
CA3150162A1 (en) * 2019-08-14 2021-02-18 Vertex Pharmaceuticals Incorporated Crystalline forms of cftr modulators
CA3150738A1 (en) * 2019-08-14 2021-02-18 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
HUE066896T2 (hu) 2019-08-14 2024-09-28 Vertex Pharma Eljárás CFTR modulátorok elõállítására
CR20230120A (es) 2020-08-07 2023-09-01 Vertex Pharma Moduladores del regulador de la conductancia transmembrana de la fibrosis quística
MX2023001744A (es) 2020-08-13 2023-04-19 Vertex Pharma Formas cristalinas de moduladores de regulador de conductancia transmembrana de la fibrosis quística (cftr).
IL301755A (en) * 2020-10-07 2023-05-01 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
US12324802B2 (en) 2020-11-18 2025-06-10 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
CA3201793A1 (en) * 2020-11-18 2022-05-27 Vertex Pharmaceuticals Incorporated Macrocycles containing a 1,3,4-oxadiazole ring for use as modulators of cystic fibrosis transmembrane conductance regulator
WO2022125826A1 (en) 2020-12-10 2022-06-16 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
US20250221971A1 (en) * 2022-02-03 2025-07-10 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
EP4472983A1 (en) 2022-02-03 2024-12-11 Vertex Pharmaceuticals Incorporated Methods of preparing and crystalline forms of (6a,12a)-17-amino-12-methyl-6,15-bis(trifluoromethyl)-13,19-dioxa-3,4,18-triazatricyclo[ 12.3.1.12,5]nonadeca-1(18),2,4,14,16-pentaen-6-ol
US20250122218A1 (en) 2022-02-08 2025-04-17 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator
EP4525858A1 (en) 2022-05-16 2025-03-26 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
AU2023272562A1 (en) 2022-05-16 2024-11-07 Vertex Pharmaceuticals Incorporated Solid forms of a macrocyclic compounds as cftr modulators and their preparation

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